CONSERVATIVE MANAGEMENT OF CANCER PATIENTS Dr. Vinod K Ravaliya, MPT Assistant Professor, KMPIP Karamsad Saturda y 10 th November 2012
May 13, 2015
CONSERVATIVE MANAGEMENT OF CANCER PATIENTS
Dr. Vinod K Ravaliya, MPT
Assistant Professor, KMPIP
Karamsad
Saturday 10th November 2012
Why needed?
Cancer survival rates >50%.
Willingness to discuss cancer and the needs of the patient.
Thrust in cancer care is not simply on survival, but on QoL of survivors.
Cancer Rehabilitation: Definition
Cancer Rehabilitation defined as helping a person with cancer to help himself or herself to obtain maximum physical, social, psychological, and vocational functioning within the limits imposed by disease and its treatment.
Cromes GF Jr. Implementation of interdisciplinary cancer rehabi- litation. Rehabil Counseling Bull 1978; 21: 230–237.
Quality of life (QOL) is defined as an individual’s perceptions of his position in life, in the context of the culture and value systems in which he lives and in relation to his goals, expectations, standards and concerns
Quality of life (QOL)
Owing to the potentially progressive nature of cancer
successful outcomes depend upon timely recognition of functional problems
and prompt referral for rehabilitation
Rehabilitation Aims:
Restorative care aims to return the individual to premorbid function with a minimum of functional impairment.
Supportive care aims to reduce functional difficulties and compensate for permanent deficits
Palliative treatment, usually of the terminal patient, works to eliminate or reduce complications, especially pain
Preventive rehabilitation would include for example, preoperative education regarding maintenance of strength and range of motion in the upper extremity following breast surgery
Common Rehabilitation Problems Seen in Cancer Patients
Chemotherapy/Radiotherapy Induced Side Effects Myopathies Neuropathies & Plexopathies Pain Edema Fatigue Immobility/Generalized Deconditioning Bone Destruction Depression
System Specific Problems
Chemotherapy- Side Effects
Nausea and Vomiting Fatigue Hair loss Susceptibility to infections Decrease in Blood Cell Counts Mouth sores and ulcers
Decrease in Blood Cell Counts
Exercise training : Increase total Hb and red cell mass, which enhances
oxygen-carrying capacity. Possible mechanisms: Stimulated erythropoiesis with hyperplasia of the
hematopoietic bone marrow Improvement of the hematopoietic microenvironment
induced by exercise training, and hormone- and cytokine-accelerated erythropoiesis.
Need for further investigation- chemotherapy/Radiation therapy
Acta Haematol. 2012;127(3):156-64. Epub 2012 Jan 31.Effects of exercise training on red blood cell production: implications for anemia.Hu M, Lin W.
Decrease in Blood Cell Counts
Duration of neutropenia and thrombopenia after adjuvant chemotherapy are significantly shorter in the Aerobic Exercise training group than in controls
Common Rehabilitation Problems Seen in Cancer Patients
Chemotherapy/Radiotherapy Induced Side Effects Fatigue Myopathies Neuropathies & Plexopathies Pain Edema Immobility/Generalized Deconditioning Bone Destruction Depression
System Specific Problems
Rehabilitation- Radiation therapy
Skin & Soft Tissue Fibrosis Effects of Radiation
Loss of Elasticity, Vascularity & Moisture Tissue Thickening & Edema • Contracture
Management Moisturizing Creams Splinting & Orthotics Stretching Exercises
Common Rehabilitation Problems Seen in Cancer Patients
Chemotherapy/Radiotherapy Induced Side Effects Fatigue Myopathies Neuropathies & Plexopathies Pain Edema Immobility/Generalized Deconditioning Bone Destruction Depression
System Specific Problems
Rehabilitation- Fatigue
Defined as the feeling of extraordinary exhaustion associated with a high level of distress, disproportionate to the patients' activity, and is not relieved by sleep or rest.
Up to 70% of cancer patients during chemo and radiotherapy
Inactivity Muscle catabolism Perpetuate Fatigue
Self care and social activities QoL
Fatigue Burden….
Oncologist. 2007;12 Suppl 1:4-10.Cancer-related fatigue: the scale of the problem.Hofman M, Ryan JL, Figueroa-Moseley CD, Jean-Pierre P, Morrow GR.
Management of Fatigue:
Bed rest or Aerobic Exercise Energy Conservation
Techniques Activity/Exercise Program Diversional Activities Rest/Sleep Patterns Stress Management Nutritional management
Common Rehabilitation Problems Seen in Cancer Patients
Chemotherapy/Radiotherapy Induced Side Effects Fatigue Myopathy Neuropathies & Plexopathies Pain Edema Immobility/Generalized Deconditioning Bone Destruction Depression
System Specific Problems
Rehabilitation- Myopathy
Tumor Infiltration Paraneoplastic
Carcinomatous Myopathy & Neuromyopathy
Radiation Steroids & Other Chemotherapy
The Role of Exercise Adaptive Equipment etc.
Common Rehabilitation Problems Seen in Cancer Patients
Chemotherapy/Radiotherapy Induced Side Effects Fatigue Myopathies Neuropathies & Plexopathies Pain Edema Immobility/Generalized Deconditioning Bone Destruction Depression
System Specific Problems
Rehabilitation- Neuropathy & Plexitis
Causes Neurotoxic Chemotherapy Direct Invasion – Radiation Compression – Paraneoplastic
Management Pain Control – Bracing Adaptive Devices – Other
Common Rehabilitation Problems Seen in Cancer Patients
Chemotherapy/Radiotherapy Induced Side Effects Fatigue Myopathies Neuropathies & Plexopathies Pain Edema Immobility/Generalized Deconditioning Bone Destruction Depression
System Specific Problems
Rehabilitation-Pain
Physical Modalities– Electrical Stimulation Heat Modalities
Relative Contraindication to Therapeutic Heat
J Pain Symptom Manage. 2009 Apr;37(4):746-53. Epub 2008 Sep 14.
A cochrane systematic review of transcutaneous electrical nerve stimulation for cancer pain.
Robb K, Oxberry SG, Bennett MI, Johnson MI, Simpson KH, Searle RD.
There is insufficient available evidence to determine the effectiveness of TENS in treating cancer-related pain. Further research is needed to help guide clinical practice, and large multi-center RCTs are required to assess the value of TENS in the management of cancer-related pain in adults.
What Evidence Says- Does TENS relieves Cancer Pain ?
Cochrane Database Syst Rev. 2012 Mar 14;3:CD006276.
Transcutaneous electric nerve stimulation (TENS) for cancer pain in adults.
Hurlow A, Bennett MI, Robb KA, Johnson MI, Simpson KH, Oxberry SG.
Despite the one additional RCT, the results of this updated systematic review remain inconclusive due to a lack of suitable RCTs. Large multi-centre RCTs are required to assess the value of TENS in the management of cancer-related pain in adults.
What Evidence Says- Does TENS relieves Cancer Pain ?
What Evidence Says- Does Acupuncture relieves Cancer Pain ?
Acupuncture as an effective analgesic adjunctive method for cancer patients is not supported by the data currently available from the majority of rigorous clinical trials.
Widespread acceptance, appropriately powered RCTs needed.
Eur J Pain. 2005 Aug;9(4):437-44. Epub 2004 Nov 11.Acupuncture for the relief of cancer-related pain--a systematic review.Lee H, Schmidt K, Ernst E.
Common Rehabilitation Problems Seen in Cancer Patients
Chemotherapy/Radiotherapy Induced Side Effects Fatigue Myopathies Neuropathies & Plexopathies Pain Edema Immobility/Generalized Deconditioning Bone Destruction Depression
System Specific Problems
Rehabilitation- Lymphedema
Management Elevation Active Exercises Compressive Garments & Pumps Manual Lymph Drainage,
Massage and Other Treatments
Caution: Risk of Mobilizing Tumor Cells
Common Rehabilitation Problems Seen in Cancer Patients
Chemotherapy/Radiotherapy Induced Side Effects Fatigue Myopathies Neuropathies & Plexopathies Pain Edema Immobility/Generalized Deconditioning Bone Destruction Depression
System Specific Problems
Rehabilitation- Immobility
Effects of Immobility Prevention of Related Problems
Contractures – Decubiti Muscle Atrophy – Deconditioning
Role of Exercise & Mobilization
Common Rehabilitation Problems Seen in Cancer Patients
Chemotherapy/Radiotherapy Induced Side Effects Fatigue Myopathies Neuropathies & Plexopathies Pain Edema Immobility/Generalized Deconditioning Bone Destruction Depression
System Specific Problems
Rehabilitation- Bone Destruction
Evaluation X-Ray –Bone Scan – CT
Management
- Pain Unweighting Assistive Devices Surgical Considerations
- Stability- Bracing
>50% Cortical
Loss
3 cm
> 60% of Bone
Diameter
Rehabilitation- Orthotics
Splinting to Maintain Position Orthotics to Restore Function
E.g. AFO to lock the knee during stance phase
“The important thing is not how many years in your life but how much life in your years.”
~Edward J. Stieglitz
Rehabilitation of Lung Cancer
Patients with inoperable lung cancer now account for a large group of patients who use this type of medical intervention and can significantly improve the quality of life and the method shows positive impact on the survival rate.
Jastrzębski D, Ziora D, Hydzik G, Pasko E, Bartoszewicz A, Kozielski J, Nowicka J.Pulmonary rehabilitation in patients with lung cancer. Pneumonol Alergol Pol. 2012;80(6):546-554.
Abstract
METHODS:
twice-weekly sessions of aerobic exercise and weight training over an 8-week period.
functional capacity, measured by the 6-minute walk test and muscle strength, as well as quality of life, lung cancer symptoms and fatigue, measured by the Functional Assessment of Cancer Therapy-lung and Functional Assessment of Cancer Therapy-fatigue scales.
CONCLUSIONS:
Those who completed the program experienced an improvement in their lung cancer symptoms. Community-based or briefer exercise interventions may be more feasible in this population.
J Thorac Oncol. 2009 May;4(5):595-601.A structured exercise program for patients with advanced non-small cell lung cancer.Temel JS, Greer JA, Goldberg S, Vogel PD, Sullivan M, Pirl WF, Lynch TJ, Christiani DC, Smith MR.
Abstract
Lung cancer survivors exhibit poor functional capacity, physical functioning, and quality of life (QoL).
The primary outcomes focused on feasibility including eligibility and recruitment rate, loss to follow-up, measurement completion, exercise adherence, and program evaluation. Secondary outcomes addressed preliminary efficacy and included changes in muscular strength (1 repetition maximum), muscular endurance (repetitions at 70% of 1 repetition maximum), body composition (DXA scan), physical functioning (6-minute-walk-test, up-and-go, sit-to-stand, arm curls), and patient-reported outcomes including QoL (SF-36, FACT-L), fatigue (FACT-F), PRET is a feasible intervention with potential health benefits for a small proportion of lung cancer survivors in the post-treatment setting.
Lung Cancer. 2012 Jan;75(1):126-32. Epub 2011 Jun 28.Feasibility and preliminary efficacy of progressive resistance exercise training in lung cancer survivors.Peddle-McIntyre CJ, Bell G, Fenton D, McCargar L, Courneya KS.