1 Physiology of additive drugs Cocaine, methamphetamine, marijuana, and opiates influence the neurotransmitter dopamine. Neurotransmitter: dopamine Dopamine - a neurotransmitter associated with several functions, including muscle control and feelings of reward axon terminal of dopamine neuron Neurotransmitter: dopamine Dopamine - a neurotransmitter associated with several functions, including muscle control and feelings of reward Schizophrenia, manic depression are associated with too much dopamine. Antipsychotic drugs block dopamine receptors. reward pathways Dopamine and reward Neurons here use dopamine To signal the pleasure center here
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Physiology of additive drugs Neurotransmitter: dopaminesraylman/physiology/4CNSland.pdf · 2019. 1. 14. · Physiology of additive drugs Cocaine, methamphetamine, marijuana, and ...
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Physiology of additive drugs
Cocaine, methamphetamine, marijuana, and opiates influence the neurotransmitter dopamine.
Neurotransmitter: dopamineDopamine - a neurotransmitter associated with several functions, including muscle control and feelings of reward
axon terminal ofdopamine neuron
Neurotransmitter: dopamineDopamine - a neurotransmitter associated with several functions, including muscle control and feelings of reward
Schizophrenia, manic depression are associated with too much dopamine. Antipsychotic drugs block dopamine receptors.
reward pathways
Dopamine and reward
Neurons here use dopamine
To signal the pleasure center here
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Cocaine and methamphetamines prevent reuptake of dopamine.
Neurotransmitter: dopamineNeurons using serotonin are associated with mood, sleep, & appetite
Antidepressants often enhance levels of serotonin (Zoloft, Prozac, Paxil)
Neurotransmitter: serotonin
All are monoamines
Three main neurotransmitters of mood
Ecstasy temporarily increases serotonin, but body makes less serotonin in response
Neurotransmitter: serotonin
ecstasy blocking reuptake of serotonin
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THC binds to cannabinoid (CB) receptors, mimicking endocannabinoids (from body)
(anadaminde, arachidonate lipids)
CB receptors are in pleasure pathway (VTA), motor coordination (cerebellum) and memory (hippocampus) areas
Signaling bw neurons during learning is disrupted (GABA neurons w CB1 receptors)
Cannabis effects
Drug tolerance – occurs because the body tries to maintain homeostasis in presence of high neurotransmitter levels
What makes drugs addictive? Repeated drug use causes elevated dopamine
What makes drugs addictive?
Body decreases # dopamine receptors, dopamine prod’n “Down regulation”