NEUROPHYSIOLOGY Dr. Steven Resnick, D.O. Neurology Resident Jackson Memorial Hospital
May 10, 2015
NEUROPHYSIOLOGY
Dr. Steven Resnick, D.O.
Neurology Resident
Jackson Memorial Hospital
LECTURE OUTLINE• I INTRO - OVERVIEW OF THE
NERVOUS SYSTEM• II NEURON• III ACTION POTENTIAL• IV SYNAPSE• V BRAIN• VI SPINAL CORD• VII AUTONOMIC NERVOUS SYSTEM• VIII CRANIAL NERVES• IX CONCLUSION
Basic Functions of the Nervous System
• Sensory Function– Detection of both internal and external stimuli
• Interpretive Function– Analyzes, stores, and makes decisions based on
sensory information
• Motor Function (Response)– Response to interpretive data
Nervous System
• Afferent (sensory) Neurons – Carry impulses toward the CNS
• Efferent (Motor) Neurons – Carry impulses from the CNS
• Interneurons – conduct impulses within the spinal cord (between afferent and efferent) (Syn. Association, Internuncial)
• Ganglia are small masses of nervous tissue located outside the brain and spinal cord.
Fine Anatomy of the Nervous SystemThree kinds of neurons:
– Sensory
– Motor
– Interneurons
Neurons
Sensory Motor Interneurons
1) Sensory: Sensory organs to CNS“Receptors”
2) Motor: CNS to muscles and organs“Effectors”
3) Interneurons: Connections within CNS“Processors”
Sensory Neurons
• INPUT From sensory organs to the brain and spinal cord.
Somatosensory neuron - spinalVision, hearing, taste and smell -
cranial
SpinalCord
BrainSensoryNeuron
Touch receptors in skin
Motor Neurons
• OUTPUT From the brain and spinal cord to muscles and glands
SpinalCord
Brain
MotorNeuron
Motor neurons in spinal cord
Interneurons
• PROCESSING Relay information between other neurons
SpinalCord
Brain
Inter-Neurons
Interneurons in brain
General Organisation of the Nervous System
The Nervous System
Central Nervous System Peripheral Nervous System
Brain Spinal Cord Somatic Autonomic
Sensory MotorParasympathetic
Sympathetic
The Nervous System
• Two subsystems– Central nervous system (CNS)
• Brain and Spinal Cord– Integrate, correlate, and respond to many different kinds
of sensory information
– Source of thoughts, emotions, and memories
– Peripheral nervous system (PNS)• Includes all nervous tissue outside of the CNS
– Cranial nerves, spinal nerves, etc.
Divisions of the PNS
• Somatic Nervous System (SNS)– Sensory neurons that convey information from
sensory receptors in the head, body wall and limbs to the CNS
– Motor neurons from the CNS that conduct impulses to the skeletal (voluntary) muscles only.
Divisions of the PNS
• Autonomic Nervous System (ANS)– The motor portion of the ANS consists of two
divisions• Sympathetic (thoracolumbar region)
– Fight/flight (prepares the body to cope with stressful situations)
• Parasympathetic (craniosacral region)– Rest/Repose (generally an opposite response to the
sympathetic nervous system)
Divisions of the PNS
• Autonomic Nervous System (ANS)– Sensory neurons convey information from
receptors in the viscera (internal organs), to the CNS.
– Motor neurons then convey information from the CNS to smooth muscle, cardiac muscle, glands, etc.
– Motor functions in the ANS are not normally under conscious control; they are involuntary.
{sensorysensory
motormotor
autonomicautonomicnervousnervoussystemsystem
{somaticsomaticnervousnervoussystemsystem{somaticsomaticnervousnervoussystemsystem
{brainbrain
spinalspinalcordcord
{afferentafferentnervesnerves
efferentefferentnervesnerves{
parasympatheticparasympatheticnervous systemnervous system
sympatheticsympatheticnervous systemnervous system
peripheral nervousperipheral nervoussystem (PNS)system (PNS)
nervousnervoussystemsystem
central nervouscentral nervoussystem (CNS)system (CNS)
Major Divisions of the Nervous SystemMajor Divisions of the Nervous SystemMajor Divisions of the Nervous SystemMajor Divisions of the Nervous System
Peripheral Nervous System:Afferent and Efferent Neurons
Neurons
– “Functional unit” of nervous system
– Several Types– Conduct nerve
impulses– Electrical excitability – Structures
• Cell body• Axon• Dendrites
The Nerve Cell Body
• An enlarged part of the nerve cell containing abundant cytoplasm and cell organelles. It is sometimes called the soma.
• Receives information from dendrites and sends messages out through the axon.
• The primary site for maintaining the life of the nerve cell which support the dendrites and axon.
Nervous Tissue
• Cell body– Nucleus surrounded by
cytoplasm
– Contain organelles such as lysosomes, mitochondria, Golgi complexes, and rough ER (Nissl bodies) for protein production.
– No mitotic apparatus
The Dendrite
• An incoming nerve cell process that can act as a receptor or connect to separate specialized receptors.
• Conducts stimulus information to the nerve cell body.
• Produces voltage changes in response to various stimuli and assists in nerve impulse formation.
Nervous Tissue
• Dendrites (little trees)
– Receiving end of the neuron
– Conduct impulses toward the cell body
– Short and highly branched
– Also contain organelles
The Axon Hillock
• The junction site between the nerve cell body and the axon.
• Processes voltage changes , or generator potentials (GP’s) from the cell body and dendrites, and assists the formation of a transmittable nerve impulse.
The Axon
• Conducts nerve impulses away from the nerve cell to the axon terminals.
• Is very small in diameter, but can be very long (e.g. the length of a leg).
• Each nerve cell has only one axon.
• If an axon is cut, the distal portion degenerates due a disruption of the cytoplasm extending from the cell body.
Axon
• Conducts impulses away from the cell body toward another neuron, muscle fiber or gland cell.
• Also contains organelles
• “Axon hillock – where the axon joins the cell body.
• The “initial segment” is the beginning of the axon.
• The “trigger zone” is the junction between the axon hillock and the initial segment.
Axon Terminals
• Axon terminals are bulbous distal endings of the many branches that extend from the end of an axon. These bulb-like structures can also be called synaptic knobs, boutons or even “end feet”.
• The axon terminal serves as a secretory component that releases neurotransmitters in response to nerve impulses.
Nervous Tissue
• Axon Terminals– Site of communication
between two neurons or between a neuron and an effector cell.
Representative neuronin
out
Soma
“cell body”
Neuron thatDelivers signalTo the synapse
Region where anAxon termimalMeets its targetCell
The cell thatReceives thesignal
Nervous Tissue (2 Types)
• Neuroglia = “glue” • Smaller than neurons but more numerous
• Do not generate or conduct nerve impulses
• Support neurons
• Form myelin sheath
• Participate in phagocytosis
Neuroglia• CNS
– Astrocytes-maintain chemical environment (Ca & K) - Blood Brain Barrier
– Oligodendrocytes-produce myelin in CNS – Microglia-participate in phagocytosis – Epedymal cells-form and circulate CSF
• PNS– Schwann cells-produces myelin in PNS – Satellite cells-support neurons in PNS
Astrocytes:NutrientTake up K+ And Neuro-TransmittersFrom ECF
GLIAL CELLS OF THE CNS
GLIAL CELLS OF THE CNS
Ependymal Cells:Epithelial CellsCreate SelectivelyPermeable BarrierBetween CompartmentsOf the Brain
GLIAL CELLS OF THE CNS
Oligodendrocytes:Support andInsulate axonsBy creating myelin
In CNS, oneOligodentrocyteForms myelinAround portions ofSeveral Axons
Glial Cells• Peripheral nervous system:
– Schwann cells: produce myelin sheath of peripheral nerve fibers; wrap around the axon**spaces between adjacent sections of myelin where the axon’s plasma membrane is exposed to extracellular frluid are the Nodes of Ranvier.
Each Schwann cell associates with a single axon.– Satellite cells:nonmyelinating Schwann cell: Form
supportive capsules around nerve cell bodies that are located in the ganglia, outside the CNS
The Schwann Cell
• A specialized cell that supports and maintains the fibers (axons and dendrites) of nerve cells in the peripheral nervous system (PNS). Contains myelin material.
• Assists the in repair and regeneration of fibers.
• Wraps around a section of a nerve fiber and creates a protective myelin sheath.
Nodes of Ranvier
• A Node of Ranvier is a space or gap found on a nerve cell process (axon or dendrite) and is located between the myelin sheaths formed by cells such as the Schwann Cell.
• The exposed cell membrane located in the node can facilitate the formation and transmission of nerve impulses.
The Myelin Sheath
• The Schwann Cell wraps around a section of nerve cell fiber in “jellyroll”fashion resulting in a tight coil of concentric membranes called the Myelin Sheath.
• The whitish, fatty myelin material acts as an excellent insulator and protector of the nerve cell fiber.
Myelin Sheath
– Cover for a nerve fiber– Lipid (white matter) and
Protein– Insulates and increases
impulse speed– Formed by Schwann cell
membranes (PNS)– Oligodendrocytes (CNS)
• Multiple Sclerosis– Autoimmune destruction
of myelin sheaths
The Neurilemma
• The most external portion of the plasma or cell membrane of the Schwann Cell.
• This specialized membrane surrounds the myelin sheath.
• The neurilemma is sometimes called the sheath of the Schwann Cell or a neuron “husk”.
Myelination
• 1 mm in length• Up to 100 layers• Neurolemma (sheath of Schwann) assists with regeneration of
damaged neurons
Nerve Tissue Regeneration
• At birth, the cell bodies of neurons lose their mitotic features (Can not be replaced by daughter cells)
• To regenerate, neurons must:– Be myelinated– Have intact cell body– Have functional Schwann cells
Regeneration
• Wallerian Degeneration is anterograde degeneration characterized by the disappearance of axons and myelin sheaths and secondary proliferation of Schwann cells (occurs in CNS and PNS)
• Chromatolysis- the result of retrograde degeneratin in the neurons of the CNS and PNS.
Regeneration
• CNS- Effective regeneration does not occur in the CNS. For examaple, there is no regeneration of the optic nerve or no basement membrane/endoneural surrounding the axons of the CNS
• PNS- Regeneration does not occur in the PNS. The proximal tip of a severed axon grows into the endoneural tube which consists of Schwann basement membrane and endonerium.
Nerve Tissue Regeneration
The axons sprout grows at the rate of 3 mm/day
Nerve Tissue Regeneration
• Axons in the CNS do not form neurilemmas, so they do not survive axonal damage.
• Damaged Neurons in the CNS are also rapidly converted to scar tissue (proliferation of astrocytes)
ACTION POTENTIAL• Nerve signals are transmitted by action
potentials that are abrupt, pulse-like changes in the membrane potential that last a few ten thousandths of a second.
• Action potentials can be divided into three phases: the resting or polarized state, depolarization, and repolarization
• The amplitude of an action potential is nearly constant and is not related to the size of the stimulus, so action potentials are all-or-nothing events.
ACTION POTENTIAL
• Cell membranes of excitable tissue, including neurons, contain ion channels that are responsible for generating action potentials
• These membrane channels are guarded by voltage-dependent gates that open and close with change in the membrane potential
• There are separate voltage-gated channels for the sodium., potassium, and calcium channels.
Membrane potential• 2 factors influence membrane potential:
• 1.) Concentration gradients of different ions across the membrane
• 2.) The permeability of the membrane to these ions
Cell Membrane in resting state
K+
Na+ Cl-K+A-
Outside of Cell
Inside of Cell
Na+ Cl-
Ionic Concentration Gradients
0 mV
RESTING MEMBRANE POTENTIAL
• Approximately -70mV, cell negative
• is the result of the high resting conductance to K+, which drives the membrane potential toward the K+ equilibrium potential
• At rest, the Na+, channels are closed and Na+ conductance is low
Cell Membrane at rest
Na+ Cl-K+
Na+
Cl-K+ A-
Outside of Cell
Inside of Cell
Potassium (K+) can pass through open channels to equilibrate its concentration
Sodium and Chlorine cannot pass through
Result - inside is negative relative to outside
- 70 mV
The Resting Potential: Ionic Gradients & a Semi-Permeable Membrane
Resting Potential
ACTION POTENTIAL
• • K+ is high inside so increased K+ permeability causes more K+ to leave cell (inside becomes negative).
• Na+ is high outside so increased Na+ permeability causes more Na+ to enter cell (inside becomes positive).
• Membrane potential is a compromise based on which ion is more permanent
UPSTROKE OF A.P.1) Inward current depolarizes the membrane
potential to threshold
2) Depolarization causes rapid opening of the activation gates of the Na channel, and the Na+ conductance of the membrane promptly increases.
3) The Na+ conductance becomes higher than the K conductance and so the membrane potential is driven toward the Na+ equilibrium potential of +65 mV
** The rapid depolarization during the upstroke is caused by an inward NA+ current
REPOLARIZATION OF A.P.• Depolarization also closes the inactivation gates of
the Na+ channel (more slowly than it opens the activation gates). Closure of the inactivation gates means that the Na+ channels close, and so Na+ conductance returns toward zero
• Depolarization slowly opens K+ channels and increases K+ conductance to even higher levels that at rest.
• The combined effect of closing the Na channels and greater opening of the K channels makes the K conductance higher than the Na conductance and the membrane potential is repolarized.
** Repolarization is caused by an outward K current
Action potential initiation
S.I.Z.
Action potential terminationThink
“votes”
Positive feedback loop
Reach “threshold”?
If YES, then...
Action Potential
Absolute Refractory Period.• Is the period during which another action
potential cannot be elicited no matter how large the stimulus
• coincides with almost the entire duration of the action potential
• Explanation: the inactivation gates of the Na channel are closed and will remain closed until repolarization occurs. No action potential can occur until the inactivation gates open.
Relative refractory period• Begins at the end of the absolute refractory
period and continues until the membrane potential returns to the resting level
• An action potential can be elicited during this period if a stronger than usual current is provided
• Explanation: The K+ conductance is higher than at rest, the membrane potential is closer to the K equilibrium potential and farther away for threshold; more current is required to bring the membrane to threshold.
Refractory periods
Saltatory Conduction• Propagation of action potentials occurs by spread of local currents to adjacent areas of membrane, which are then depolarized to threshold and generate action potentials.
• Conduction velocity is increased by:
1) increasing diameter of a verve fiber resuts in decreased internal resistance and so conduction velocity down the nerve is faster
2) Myelination. Myelin acts as an insulator around nerve axons and increases conduction velocity. Myelinated nerve exhibits saltatory conduction because action potentials can be generated only at the nodes of Ranvier, where there are gaps in the myelin sheath.
Saltatory Conduction
Terminology
• Synapse– Region at which neurons come nearly together to
communicate. (neuron or effector organ)
• Synaptic Cleft– Gap between neurons (at a synapse)
– Impulses can not propagate across a cleft
• Synaptic Vesicle– Packets of neurotransmitter in presynaptic neuron
Terminology
• Presynaptic Neuron– Neuron sending a signal (before the synapse)
• Postsynaptic Neuron– Neuron receiving a signal (after the synapse)
• Neurotransmitter– Substance that tends to cause excitement– Required to transmit impulses across a synaptic
cleft
Direction of chemical synapse
• One Direction– Synaptic vesicles are only located in the pre-
synaptic nerve ending. – Only the post-synaptic neuron contains
receptors for the neurotransmitters
Chemical Synapses• An action potential in the presynaptic cell
causes depolarization of the presynaptic terminal
• As a result of the depolarization, Ca enters the presynaptic terminal Ca entry causes release of neurotransmitter in the presynaptic cleft
• Neurotransmitter diffuse across the synaptic cleft and combines with receptors on the postsynaptic cell membrane, causing a change in its permeablilty to ions and its membrane potential.
Syn
apti
c P
hysi
olog
y
Locks and Keys• Neurotransmitter
molecules have specific shapes
positive ions (NA+ ) depolarize the neuron negative ions (CL-) hyperpolarize
When NT binds to receptor, ions enter
Receptor molecules have binding sites
Synaptic transmission• Excitatory postsynaptic potentials(EPSP)/
Inhibitory postsynaptic potentials (IPSP) are inputs that depolarize/heperpolarize the postsynaptic cell bringing it closer/away from firing an action potential
• EPSP are cause by opening of channels that are permeable to Na and K
Neurotransmitters :Ach, NE, Epinephrine, dopamine, serotonin
• IPSP are cause by opening Cl channels
Neurotransmitters: GABA and glycine
Postsynaptic Inhibition
IPSP
EPSP
Types of Neurotransmitters• Acetylcholine
• Serotonin
• Norepinephrine
• Dopamine
• Endorphins
• GABA
• Glutamate
Acetylcholine
• Found at neuro-muscular junction– Involved in muscle
movements (nicotine, curare)
• In CNS: recticular activating system– Slow excitation of cerebral
neurons (muscarine, atropine)– Memory
Neuromuscular Junction
• Is the synapse between axons of motorneurons and skeletal muscle. The neurotransmitter released from the presynaptic terminal Ach, and the receptor on the postsynaptic membrane is nicotinic
Neuromuscular Junction and Ach
1. Synthesis and storage of Ach in the presynpatic terminal
choline acetylransferase catalyzes the formation from acetyl coA and choline in the presynaptic terminal.
2. Depolarization of the presynaptic terminal and Ca uptake
3. Calcium uptake causes release of Ach into the synaptic cleft
4. Diffusion of Ach to the poststnaptic membrane (muscle end-plate) and binding to specific receptors
5. depolarization of adjacent membrane to threshold
6. Degradation of Ach to acetyl CoA and choline by acetylcholinesterase (acheE) on the muscle end plate
Myasthenia gravis• Is characterized by skeletal muscle
weakness and fatigability resulting from a reduced number of Ach receptors on the muscle end plate ( due to autoimmune antibodies against acetylcholine receptors at the neuromusclar juntion
• Diagnosis and treatment involves Acetylchlinesterase inhibitors (neostigmine)- prolong the action of Ach at the muscle end plate.
Synaptic Function - Drug Effects• 1) Release Inhibitors - ex: Botulinum toxin (in botulism)
• 2) Acetylcholinesterase Inhibitors - ex: Nerve Gas
• 3) Postsynaptic Blockers - ex: Curare and most Snake venoms
• 4) Sodium Channel Blockers - ex: Pufferfish venom and red tide toxins
Serotonin• Involved in mood, depression
– Prozac works by blocking reuptake– Ecstasy (MDMA) kills 5-HT terminals in
forebrain, releasing massive amounts
• Pain regulation (descending brainstem)
• Involved in regulation of cortical activity (sleep?)
Dopamine
• Involved in movement, attention, learning, motivation, reward
• Overactive dopamine:– Schizophrenia
• Underactive (loss of) dopamine:– Parkinson’s Disease
• Loss of dopamine neurons in the substantia nigra
• Symptoms:– difficulty starting/stopping voluntary movements– tremors at rest– stooped posture– rigidity– poor balance
Parkinson’s Disease
• Main inhibitory neurotransmitter in CNS
• Benzodiazepines (Valium) and alcohol agonise GABA receptor complexes
• Also some anti-epileptic drugs
Gamma-Aminobutyric Acid (GABA)
Huntington’s Chorea• Involves loss of neurons in
striatum that utilize GABA
• Symptoms:– jerky involuntary movements– mental deterioration
Central Nervous System• Cerebral ganglia (brain)
• Spinal Cord
dorsalcaudal orposterior
rostral oranterior
ventraldorsal
neuraxisdorsal
ventral
lateralmedialmedial
lateral
dorsallateralmedialmedial
lateral
ventral
caudal orposterior
caudal orposterior
dorsalvent
ral
rostral oranterior
neuraxis
Basic DirectionsBasic DirectionsBasic DirectionsBasic Directions
Basic DirectionsBasic DirectionsBasic DirectionsBasic Directions
dorsal
ventraldorsal
ventral
caudal
caudal
rostral
rostraldorsal
ventral
coronal plane(frontal or coronal section)
horizontal ortransverse plane
coronal plane(cross section)
sagittal plane
Basic DirectionsBasic DirectionsBasic DirectionsBasic Directions
X
FIGURES 4.3 & 4.4 on FIGURES 4.3 & 4.4 on pgs. 90-91pgs. 90-91
dorsal
ventral
CNS - The REAL Forebrain
This is Your Brain
• 1.5kg of water, lipids and protein contained in your cranium
• The most important and complex organ in your body
• 100 billion neurons• 100 million billion
connections between neurons
Top Bottom
Side Middle
6 Major Regions of the Brain
• 1.) Cerebrum
• 2.) Diencephalon
• 3.) Midbrain
• 4.) Pons
• 5.) Cerebellum
• 6.) Medulla Oblongata
Brain• White matter
– Mostly axons– Myelin sheaths– Bundles of axons that connect different regions
of the CNS are TRACTS
• Gray Matter:– Unmyelinated– Dendrites, Axon terminals
• Ascending tracts= carry sensory information from cord to the brain
• Descending tracts = carry efferent (motor) signals from brain to cord
Functions of Brain Structures
• Sulcus ----------- A depression or groove in the surface of the cerebrum that helps increase surface area of the
cerebrum.
• Gyrus ------------ An elevated ridge that projects upwards between the sulci of the cerebrum and also helps
increase surface area of the cerebrum..
• Central Sulcus ------- a deep groove that serves as a dividing line between the frontal and
parietal lobe.
The Lobes of the CortexThe Lobes of the CortexThe Lobes of the CortexThe Lobes of the Cortex
Functions of Brain Structures Continued:
• Frontal Lobe ----- controls conscious muscle action, planning for movements, motor memory, voluntary eye movements.
• Parietal Lobe ----- Controls conscious interpretation of sensation from muscles, tongue and cutaneous areas.
• Temporal Lobe --- conscious interpretation of auditory and olfactory sensations. Memory of sounds and smells.
• Occipital Lobe ------- the most posterior lobe of the cerebrum which deals with conscious seeing, eye focus and integrating visual memory with other sensations.
Cerebrum
Lobes of the Cerebrum
• Frontal Lobe-voluntary and involuntary control of skeletal muscles, speaking & writing
• Parietal Lobe-general sensations• Temporal Lobe-sound and smell• Occipital lobe-sight• All Lobes-Memory, emotions, reasoning, and intelligence
Function of Brain Structures Continued
• Cerebral Cortex ----- the outer layer of the cerebrum that consists of gray matter which deals with conscious motor action, sensation, memory, communication, reasoning, emotions, intelligence
• Sensory Area of the Cerebral Cortex -- Located in areas posterior to the central sulcus. Receives and
interprets conscious sensory impulses. The postcentral gyrus of the parietal lobe is a key ridge of gray matter that allows a person to judge the source of sensory stimuli.
• Motor Area of the Cerebral Cortex --- Located in areas anterior to the central sulcus. Plans and initiates impulses for conscious motor movements. The precentral gyrus of the frontal lobe is a another key ridge of gray matter that allows a person to operate specific areas of the body.
(Parietal)
Brain Parts
Cerebrum
• Left and Right
cerebral Hemispheres
• Connected at the Corpus Callosum
Cerebrum• Corpus
Callosum– Transverse
fibers of white matter that connects the cerebral hemispheres
Cerebral Cortex• Thick blanket of neural cortex
• Covers the cerebrum
• Outer surface:– Series of elevated ridges or gyri separated by
shallow depressions called sulci, or deeper grooves called fissures
Cerebrum• Cortex
– Superficial layer of gray matter (6 layers)
Cerebrum• Gyrus (gyri)
(Convolutions)
– Out-folds or ridges in the gray matter
– Gray matter grows faster that white during development
Cerebrum• Sulcus
– Shallow grooves in gray matter
• Fissure– Deep grooves– The “longitudinal
fissure” separates left and right hemispheres (halves)
– Transverse fissure separates the cerebrum from the cerebellum
Hemispheric Lateralization (split-brain)
• The two hemispheres of the brain share performance of many functions but they also specialize in performing certain unique functions.
• Left hemisphere– Language, numerical and scientific skills, reasoning,
control of right-side skeletal muscles
• Right hemisphere– Musical and artistic awareness, perception, recognition,
emotional content of language, mental imaging from sound, touch, taste, smell, and control of left-side skeletal muscles
Cerebral Lateralization• Language/Verbal = left
Dominant for Right handed people
Spatial Skills = Right
• Right hemisphere = synthesis
• E.G., drawing, map reading, perception, recognition
Damage to Cerebral Cortex• Damage to primary somatic sensory cortex
= reduced sensitivity of the skin on the opposite side of the body
• Damage to primary motor cortices= frontal lobes = skeletal muscle and voluntary movementExample: StrokeParalysis of the opposite side occurs
Cerebrum• Interior of cerebrum contains 3 clusters of
cell bodies:• 1.) Basal ganglia = corpus striatum
– Control of movement
• 2.) Amygdala = emotion and memory• 3.) Hippocampus = learning and memory
Basal Ganglia (Cerebral Nuclei)• Masses of gray matter located mainly in each hemisphere
that control gross, unconscious movements of skeletal muscles. (swing arms while walking, talking with your hands, etc.)
Thalamus• The thalamus functions a relay station for
all sensory impulses (except smell-hypothalamus) to the cerebral cortex.
• The thalamus also functions as a center for impulses such as pain, temperature, and crude touch and pressure.
Limbic System• Region of the cerebrum that surrounds the
brain stem
• Includes several groups of neurons- limbic cortex-cingulate gyrus, parahippocampal gyrus, uncus and associated subcortical strucures- thalamus, hypothalamus, amygdala
Limbic System• Also includes centers within the
hypothalamus responsible for:– 1.) emotional states—rage, fear, and sexual
arousal– 2.) control of reflexes that can be consciously
activated like chewing, licking, and swallowing
Limbic System
Brain Parts• Cerebellum
– “Little Brain”
– Inferior to cerebrum
– Posterior to brain stem
– Separated from the cerebrum by the transverse fissure
Cerebellum• Subconscious level
• Adjusts postural muscles, maintains balance and equilibrium
• Coordinates complex movements
Similarities of the Cerebellum and Cerebrum
• Two hemispheres
• Lobes
• Sulci, fissures, and convolutions (folia)
• Gray matter cortex
• White matter (cerebellar nuclei)
Functions of the Cerebellum
• Coordination
• Posture
• Proprioception – Awareness of movement, equilibrium and
position
• Balance
Cerebellum
Brain Parts• Brain Stem
(3 parts)– Superior to
the spinal cord
– Midbrain
– Pons
– Medulla Oblongta (medulla)
Brain Stem• Contains important processing centers and
relay stations for information passing from or to cerebrum or cerebellum and controls vital functions such as breathing and digestive activities
Functions of Brain Structures Continued• Medulla Oblongata ------ The most inferior part of the
brain stem which relays information between the spinal cord, the pons and cerebellum. The medulla also contains control centers for regulating “ vital signs” such heart rate, blood pressure and primary respiration rate.
• Pons -------------- A part of the brain stem that serves as a relay between the medulla oblongata, cerebellum and the midbrain. The pons also contains the pneumotaxic and apneustic center for secondary control of breathing.
• Midbrain ------------------- A central section in the brain interior that is located between the pons and
thalamus. This brain region is the most superior part of the brain stem and contains visual reflex centers, auditory reflex centers and motor control centers (e.g. substantia nigra
Medulla• Medulla has two external bulges called the
pyramids.The pyramids are formed by the largest motor tracts.
• Axons from the left pyramid cross over to the right and axons on the right cross over to the left. (Decussation of Pyramids)– Left hemisphere of brain controls right side muscles;
right hemisphere controls left side.– Lateral to each pyramid is an oval-shaped swelling
called an “olive”. The swelling is caused by the “inferior olivary nucleus”. They carry signals from proprioceptors in muscles to the cerebellum.
Medulla• Contains reflex centers that function in
regulating– Heartbeat, force of cardiac contraction,
diameter of blood vessels (Cardiovascular center), rhythm of breathing, and reflex centers for vomiting, coughing, and sneezing.
• Controls input and output of 5 of 12 cranial nerves (VIII, IX, X, XI, XII)
Pons• Lies directly above the medulla and anterior to
the cerebellum (2.5 cm).• Bridge connecting the spinal cord with the brain
and parts of the brain with each other. • Together with the medulla, areas in the pons help
control breathing.• Origin of 4 cranial nerves (V, VI, VII, VIII)
– Chewing, head and face sensations, certain eyeball movements, taste, salivation, facial expression, and equilibrium
Midbrain• Extends from the pons to the diencephalon (2.5
cm).• The cerebral aqueduct passes through the
midbrain thereby connecting the third and fourth ventricles.
• Reflex center for eyes, head, and neck• Origin of 2 cranial nerves (III, IV)
Oxygen And Glucose Requirements Of The Brain
• The brain is very active and uses about 20% of the total oxygen supply in the body.
• The primary nutrient of the brain is glucose. Glucose is broken down aerobically in presence of the abundant brain oxygen supply in order to yield large quantities of ATP.
External Support For Nervous Tissue
• BONE Casing:
Skull or cranium –brain
Vertebral column – spinal cord
Brain Structure Functions Continued
• Gray Matter ---------- Dark tissue of the brain made up of cell bodies and nuclei.
• White Matter --------- Light tissue of the brain made up of myelinated nerve cell processes (dendrites and axons).
• Dura Mater ------------ The tough, outermost meningeal membrane that covers and protects the
surface of the brain and spinal cord (“the tough mother membrane”).
• Arachnoid Mater ------ The middle meningeal membrane that contains web-like spaces for storing and
circulating CSF (“the spider web membrane”).
Brain Structure Functions Continued
• Pia Mater -------------- The innermost meningeal membrane that covers the surface of the brain and spinal cord in a very close, protective fashion (“the gentle mother membrane”).
• Association Areas ----- Regions of the cerebral cortex that analyze, recognize and act on sensory input and
communicate with the motor areas. Examples include the visual and auditory association areas.
External Support For Nervous Tissue
• Between bones and tissue of the CNS: three layers of connective tissue membrane: meninges– 1.) dura mater: forms the outermost covering
of the CNS. Inner and outer layers are separated by an area of loose connective tissue that contains tissue fluids and blood vessels
External Support for Nervous Tissue
• 2.) Arachnoid membrane: Spidery web of collagen and elastic fibers that fills the underlying subarachnoid space. The subarachnoid space is filled with cerebrospinal fluid.
External Support for Nervous Tissue
• 3.) pia mater: below the subarachnoid space is the innermost meningeal layer. This layer is firmly attached to the neural tissue of the CNS, supports the blood vessels serving the brain, and spinal cord.
Brain Structure Functions Continued
• Ventricles ----------------------- Hollow spaces in the brain which store cerebral spinal fluid ( CSF ) for support, protection and circulation of extracellular fluid (ECF).
• Cerebral Spinal Fluid ( CSF ) - A specialized extracellular fluid produced by choroid plexi which bathes, supports and protects the interior of the brain and spinal cord.
• Choroid Plexus ------------------ A cluster of specialized capillaries enclosed by specialized cells that line the brain ventricles. These circulatory bodies produce cerebral spinal fluid ( CSF ).
External Support for Nervous Tissue
• Cerebrospinal Fluid (CSF)
• Salty solution continuously secreted into ventricles (hollow cavities) of the brain
CSF• 1.) Physical protection
• 2.) Regulate extracellular fluid environment:– Concenctrations of K+, Ca+, HCO3-, and
glucose are lower, and H+ is higher in CSF as compared to plasma
– CSF contains very little protein, and no blood cells
Composition of CSF vs Plasma
Substance Plasma CSF
Protein mg/dl 7500 20
Na (Meq/L) 145 141
Cl- 101 124
K+ 4.5 2.9
HCO3 25 24
pH 7.4 7.32
Glucose (mg/dl) 92.0 61.0
Ventricles
• Fluid filled cavities within the brain
2 lateral ventricles, one in each cerebral Hemisphere; no direct connection betweenThe 2, but both open into the third ventricle of The diencephalon
Midbrain has a slender canal known as the cerebralAqueduct which connects the third ventricle with the Fourth ventricle of the pons and superior portionOf the medulla oblongata
Within the medulla oblongata the fourth ventricleNarrows and joins the central canal of the spinal cord
Choroid Plexus• Choroid plexus: specialized tissue found on the
walls of the ventriclesSecretes CSFConsists of capillaries and transporting epithelium: EpendymaEpendyma actively pump Na and other solutes into the ventricles, creating an osmotic gradient that draws water into the ventricles
CNS - Flow of CSF in CNS1) Choroid Plexus makes CSF in Lateral Ventricle
2) CSF moves around fornix3) Joins fluids from choroid plexus in 3rd Ventricle4) Down cerebral aqueduct5) Joins 4th Ventricle fluids from choroid plexus6) Leaves aperatures or goes down central canal in spine7) Circulates in arachnoid8) Reabsorbed into blood of dural sinus by arachnoid villi
Arachnoid Villi• CSF is gradually reabsorbed
into the blood through the arachnoid villi (finger-like projections that project into the dural sinuses) example: superior sagital sinus
• 20 mL/hr reabsorption rate• Pressure remains constant
because reabsorption and formation rates are the same.