2010 Conference - CDISC and Industry Standards Discussion Club - Tuesday, October 19th 2010 Empowering Translational Research Empowering Translational Research through through Distributed Collaborative Distributed Collaborative Computing Computing Dr. Ed Conley Dr. Ed Conley Distributed Collaborative Computing Research 1 & Severnside Translational Research Alliance Schools of Computer Science 1 and Medicine 2 Cardiff and Bristol Universities, UK [email protected]
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PhUSE 2010 Conference - CDISC and Industry Standards Discussion Club - Tuesday, October 19th 2010 Empowering Translational Research through Distributed.
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PhUSE 2010 Conference - CDISC and Industry Standards Discussion Club - Tuesday, October 19th 2010
PhUSE 2010 Conference - CDISC and Industry Standards Discussion Club - Tuesday, October 19th 2010
Sintero Server is a prototype distributed clinical computing platform funded by Wellcome Trust Translational Programme
It tries to Simplify INTEROperability in large-scale healthcare & clinical research applications
It aims to be highly cost-efficient with low ‘footprint’to ‘defragment’ collaborative processes
It is based on an internationalised software “stack” intended to work the same way everywhere
PhUSE 2010 Conference - CDISC and Industry Standards Discussion Club - Tuesday, October 19th 2010
Sintero is an internationally-distributed collaborative computing platform. For assisting translation, it is targeted equally into two areas:
1. Affordable healthcare initiatives - providing new “low-cost and scalable” options for open source clinical data “node” infrastructures and patient-centred service hosting. For example, “commodity interoperability” solutions that are portable. Through internationalised software “stack” implementations they work the same way everywhere.
2. Standard computational workflows for translational research – i.e. chained blocks of standard executable server code harmonising multi-site (especially international) clinical research collaborations. These absolutely depend on assisting the collaboration “nodes” to use single semantic/syntax standards. Sintero is designed to implement/deploy any externally defined semantic model and work with multiple EHR’s and EDC systems.
Distributed Collaborative Computing
Low-costreplicable‘STACK’
~creates‘LOCAL’
TRUSTEDSERVER‘NODES’
e.g. Collaboration Ae.g. Collaboration B
Trusted nodes are portable:
and reconfigurable:
…and scalable:LOCAL DATA STORAGE NODE
PhUSE 2010 Conference - CDISC and Industry Standards Discussion Club - Tuesday, October 19th 2010
‘Nodes’ Can Improve Interoperability
Sets InternalINTER-NODE
TRANSACTIONSEMANTICS
External (global)SEMANTIC
REFERENCESTANDARD(S)
…to deploy at scale:
PhUSE 2010 Conference - CDISC and Industry Standards Discussion Club - Tuesday, October 19th 2010
L4: Executable Code WorkflowsRe-stream Aggrg. DataRe-stream Aggrg. Data
RBAC Boolean queriesRBAC Boolean queries
INPUTSINPUTS
OUTPUTS
PhUSE 2010 Conference - CDISC and Industry Standards Discussion Club - Tuesday, October 19th 2010
STUDYFEASIBILITY
STUDYFEASIBILITY
LOCAL Aggregation Layer 3
(EHR-linked-pseudonymised)
BENEFIT: Attribute-level subject recruitment
SECOND STREAMSECOND STREAM
= Limited complexity database
STREAMINFERABLEDATA L2-L3
STREAMINFERABLEDATA L2-L3
Globally consistent syntax (Boolean)Inclusion, Exclusion on Code/Value
Globally consistent syntax (Boolean)Inclusion, Exclusion on Code/Value
LAYER 1 VERBOSEDATA DOCUMENTS
CDA / ODMON TIMELINE
L2
PhUSE 2010 Conference - CDISC and Industry Standards Discussion Club - Tuesday, October 19th 2010
BENEFIT: EHR outcomes modelling
Compute Y = function (X) Rank variables
Rank variables
nodeID’s,PSID’s,codes,values,timestamps
TimeXDS XDS
Longitudinalentries
MEASURES= X-variables
XDS
OUTCOME = Y-variable
X YX
Model for Outcome Y
PhUSE 2010 Conference - CDISC and Industry Standards Discussion Club - Tuesday, October 19th 2010
Summary
DCC Group
2011-Q1 2011-Q22010-Q4TIMELINE
Firstrelease
NEXT STEPS• Community of practice funding for internationally-distributed computing• esp. Pharma programmers who analyse results of clinical trials• Regulatory developments (end-to-end)• Information governance for research networks (pseudonymisation)
Funded by
Acknowledgements - Sintero Team
STEERING & ADVISORY GROUP
Charlie McCayHL7 UK
Dave Iberson-HurstCDISC
Prof. FoxCancer ResearchUK + Infermed
Graham Kennedy NWIS
Malcolm NewburyIHE-UK
Funded by
THANKS to PhUSE!THANKS to PhUSE!
Dr. Ed ConleyDr. Ed Conley
Distributed Collaborative Computing Research1 &Severnside Translational Research Alliance