New Treatments of Hepatitis C PHM 142 Fall 2015 Presented by: Chantel Asamoah (1002875365) Sarah He (1000762917) Liborio Borsellino (1002875418) Theresia Wibowo (1000653027) PHM142 Fall 2015 Coordinator: Dr. Jeffrey Henderson Instructor: Dr. David Hampson
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PHM 142 Fall 2015 Presented by: Chantel Asamoah (1002875365) Sarah He (1000762917) Liborio Borsellino (1002875418) Theresia Wibowo (1000653027) PHM142.
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New Treatments of Hepatitis C
PHM 142Fall 2015
Presented by: Chantel Asamoah (1002875365) Sarah He (1000762917)
PHM142 Fall 2015Coordinator: Dr. Jeffrey HendersonInstructor: Dr. David Hampson
What is Hepatitis C?
Hepatitis C is a disease caused by a virus that infects hepatocytes. It can lead to liver scarring, cirrhosis (nodules), liver failure, and liver cancer.1
Hepatitis C Virus (HCV) is a positive strand RNA virus encoding for a polyprotein that undergoes a polypeptide cleavage to 10 polypeptides, each with different functions1
• Structural proteins: consist of 2 envelope proteins E1 & E2.1 Both envelope proteins target host antibody response.1
• Non-structural proteins: NS2, NS3, NS4A, NS4B, NS5A, NS5B1 Form a complex with viral RNA to initiate viral replication.1
The Life Cycle of Hepatitis C
What does it do to the body? 1) Virus goes to liver and starts to reproduce using host machinery
2) Sends immune cells to attack the virus and the liver cells infected with the virus1
3) These liver cells become inflamed and then die1
4. Cada, Dennis J., Jasen Cong, and Danial E. Baker. “Sofosbuvir.” Hospital Pharmacy 49.5 (2014): 46
5. Stedman, Catherine. “Sofosbuvir, a NS5B Polymerase Inhibitor in the Treatment of Hepatitis C: A Review of Its Clinical Potential.” Therapeutic Advances in Gastroenterology 7.3 (2014): 131–140. PMC. Web. 10 Nov. 2015
6. Jean-Michel Pawlotsky, NS5A inhibitors in the treatment of hepatitis C, Journal of Hepatology, Volume 59, Issue 2, August 2013, Pages 375-382, ISSN 0168-8278, http://dx.doi.org/10.1016/j.jhep.2013.03.030.
7. Ying Huang, Kirk Staschke, Raffaele De Francesco, Seng-Lai Tan, Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication?, Virology, Volume 364, Issue 1, 20 July 2007, Pages 1-9, ISSN 0042-6822, http://dx.doi.org/10.1016/j.virol.2007.01.042.
8. P. Targett-Adams, E.J. Graham, J. Middleton, A. Palmer, S.M. Shaw, H. Lavender, et al.Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action. J Virol, 85 (2011), pp. 6353–6368