Pharmacokinetics of anti-tuberculosis drugs in HIV-positive and HIV-negative adults in Malawi J.J. van Oosterhout 1,2 , F. Dzinjalamala 3 , A. Dimba 4 , D. Waterhouse 5 , G. Davies 6,7 , M. Molyneux 5,6 , E. Molyneux 8 , S. Ward 7 1 College of Medicine, Department of Medicine, Blantyre, Malawi, 2 Dignitas International, Zomba, Malawi, 3 College of Medicine, Department of Biochemistry, Blantyre, Malawi, 4 National Tuberculosis Control Program, Lilongwe, Malawi, 5 Liverpool School of Tropical Medicine, Liverpool, United Kingdom, 6 Malawi-Liverpool-Wellcome Trust Clinical Research Programme Unit, Blantyre, Malawi, 7 University of Liverpool, Liverpool, United Kingdom, 8 College of Medicine, Department of Pediatrics, Blantyre, Malawi
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Pharmacokinetics of anti-tuberculosis drugs in HIV-positive and HIV-negative adults in Malawi
Pharmacokinetics of anti-tuberculosis drugs in HIV-positive and HIV-negative adults in Malawi. J.J. van Oosterhout 1,2 , F. Dzinjalamala 3 , A. Dimba 4 , D. Waterhouse 5 , G. Davies 6,7 , M. Molyneux 5,6 , E. Molyneux 8 , S. Ward 7 - PowerPoint PPT Presentation
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Pharmacokinetics of anti-tuberculosis drugs in HIV-positive and HIV-negative adults in Malawi
J.J. van Oosterhout 1,2, F. Dzinjalamala 3, A. Dimba 4, D. Waterhouse 5, G. Davies 6,7, M. Molyneux 5,6, E. Molyneux 8, S. Ward7
1College of Medicine, Department of Medicine, Blantyre, Malawi,2Dignitas International, Zomba, Malawi,3 College of Medicine, Department of Biochemistry, Blantyre, Malawi, 4National Tuberculosis Control Program, Lilongwe, Malawi, 5Liverpool School of Tropical Medicine, Liverpool, United Kingdom, 6Malawi-Liverpool-Wellcome Trust Clinical Research Programme Unit, Blantyre, Malawi, 7University of Liverpool, Liverpool, United Kingdom, 8College of Medicine, Department of Pediatrics, Blantyre, Malawi
Background• High HIV prevalence and high TB-HIV co-infection rate in Malawi• High prevalence of malnutrition• Few pharmacokinetic studies of TB drugs sub-Saharan Africa• Some data suggest HIV infection affects TB drug levels
Aims• Pharmacokinetic profiles of 4 drugs of Malawi first line TB treatment
regimen (RHZE)• Impact of HIV status and other factors on TB drug pharmacokinetics