A.R. Life Sciences Group CORPORATE PROFILE
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A.R. Life Sciences Group
CORPORATE PROFILE
Index
� Brief Profile
�Operating Verticals
� Infrastructure
� Products – API’s
� Research & Development
� Quality Systems/ GMP Certifications
� Regulatory Affairs
� Pollution Control Health and Safety Standards
A.R. Life Group
A.R. LIFE SCIENCES (ARLS) – Brief Profile
� Evolution of A R Life - 1996.
� LeadershipMr. Kallam Subba Reddy, Managing Director ,Strong legacy working with Dr. Reddy’s for over
20 years
Mr. Krishna Chaitanya, Executive Director Marketing & Operations. From India's premier institute - IIT Roorkee
� Product Verticals - Intermediates & APIs
� Acquired Dymes Pharmachem Ltd (Dymes) in 2014
� Global Network
� Total employees: 100 to 120
� Aim – GLOBAL LEADER IN Intermediates and APIs
A.R. Life Group
PRODUCT VERTICALS
APIs: Current Portfolio : 2
Under Development: 3
INTERMEDIATES:Current Portfolio : 27 Intermediates
Under Development : 12 Intermediates
COSMETICS & PRESERVATIVESCosmetics Ingredients : 10Preservative under development: 1
Pharmaceutical IntermediatesActive Pharmaceutical Ingredients
Key Business Segments
A.R. Life Group
ARLS - Infrastructure Intermediates Manufacturing Facility with Multi product
manufacturing capabilities.Operations
� Total Plant Area : 4047 Sq Mts
� Total No of Reactors : 20 (15 SSR & 5 GLR)� Reaction Volume with Concurrent scaling-up and Piloting: Over 35
KL
� Complete Onsite QA/QC/RA/R&D Support
� No of Employees : 60
� Dedicated block to carry out high pressure reactionsQuality Control:
Dedicated Analytical and Wet Lab with the following Major Analytical
Equipment� HPLC – 3 Nos
� GC – 2 Nos
� Potentiometer – 1 Nos� Others – KF Titrator, Melting range
apparatus, UV chamber, pH meter, Ovens, muffle furnace, etc.,
A.R. Life Group
Dymes - Infrastructure Operations
� Total Plant Area : 5466 Sq Mts
� Total No of Reactors : 25� Reaction Volume with Concurrent scaling-up and Piloting
:50KL
� No of production blocks : 2� Pharma area : 2 clean room
� Complete Onsite QA/QC/RA/R&D Support
� No of Employees : 65One dedicated block to carry out high pressure reactions (upto40 kg), cryogenic reactions (upto -80 Deg C) available
Quality Control:
� Dedicated Analytical and Wet Lab with the following Major Analytical Equipment
� HPLC – 3 Nos (Including one with RI
detector)
� GC – 2 Nos� IR – 1 Nos� Others – KF Titrator, Melting range
apparatus, UV chamber, pH meter, Ovens, muffle furnace, weighing balances, etc A.R. Life Group
Intermediates Product ListHigh Quality intermediates for following APIs
Commercialised :
� Ondansetron� Racecadotril
� Dabigatran
� Ibandronate Sodium� Zoledronic acid
� Mirabegron
� Clopidogrel bi sulphate� Sitagliptin
� Dabigatran
Developed in lab to be commercialized:
� Quetiapine Fumarate
� Tenofovir� Bendamustine
� Dasatinib
A.R. Life Group
API Product List*
GENERIC NAME CAS NO SPECIFICATION THERAPEUTIC USAGE STATUS
Clopidogrel bi sulphate 120202-66-6 USP Cardiovascular Commercial
Sitagliptin phosphate 654671-77-9 In-house Anti-Diabetic Lab Scale
Dabigatran Etexilate
Mesylate872728-81-9 In-house Anti-Coagulant
Under
Development
Quetiapine fumarate 111974-72-2 IP / USP Anti-psychoticUnder
Development
Rosuvastatin Calcium 147098-20-2 IP Anti-lip emicUnder
Development
A.R. Life Group
Research & Development
Fully Integrated & Qualified R&D Team of 12 Scientists
Key Functions� Identification and Development� Characterization and Synthesizing of Impurities� Analytical methods developments
Key Initiatives of On site R&D team � Cost Reduction & Quality Improvement� Technology Transfer from R&D to Plant (Scale up &
Validations)� Troubleshooting� Customer support
A.R. Life Group
DYMES - PHOTOS
A.R. Life Group
DYMES -PHOTOS
A.R. Life Group
CLEAN ROOM -PHOTOS
A.R. Life Group
ARLS -PHOTOS
A.R. Life Group
Reaction Capabilities
� Grignard reactions
� Hydrogenation
� Alkylation reactions
� Halogenations reactions.
� Oxidation reactions
� Reduction reactions
� Esterification reactions
� Hydrolysis reactions
� Condensation reactions
� De-hydrogination reactions.
� Allylic bromination reactions
� Cyclization reactions
A.R. Life Group
Regulatory Affairs
� Regulatory system in place for preparation and filing of DMF, CEP, CTD, etc
� Open part DMF level documentation support for intermediates also
A.R. Life Group
Quality Systems
� Both Plants meet International Standards
� World Class Quality Assurance team Complying to GMP guidelines
� ISO Certification for both units and GMP &WHO GMP certification for Dymes plant
� Quality control department equipped with instruments like HPLC, and GC
� Extensive SOPs including � Change control� Equipment qualification and calibration � Process validation� Deviation handling� Customer complaint handling
� GMP trainings conducted from time to time
A.R. Life Group
GMP Certifications / Compliance
� ISO 9001 -2008 Certified
� WHO GMP certificate (India)
� Approved Vendor for Various Major Pharmaceutical companies World Wide including Dr Reddy’s Laboratories Ltd, Teva API, Moehs, Cipla, Torrent, Cadila,etc.,
A.R. Life Group
Pollution Control, Health and safety
StandardsPollution Control
� Fully Integrated ETF plant ensures zero discharge� Solid waste sent to State approved disposal facility� Scrubbing systems in place to ensure acidic vapours do not
go into atmosphere
Health
� Nose Masks, hand gloves and goggles worn� Regular health check-up � Regular Trainings session on care to be taken in chemical
plant
Safety
� PPE for all employees including casual labour� Earthing wherever there is a possibility of static electricity � Safety trainings (Education on static electricity and its
avoidance, use of fire extinguishers, Mock drills, etc.,) conducted from time to time
A.R. Life Group
THANK YOU
Registered Office:
H.No. 8-3-222/1/5, Behind Allahabad Bank, Madhuranagar, Yousufguda Road,
Hyderabad - 500 038.
(Email: [email protected])
Sites Address 1: Sites Address 2:
A R Life Sciences Pvt Ltd: Dymes Pharmachem Ltd:
Plot No. 338, Plot No. 33,
S.V. Co-operative Industrial Estate, S.V. Co-operative Jeedimetla,
Hyderabad - 500 055. Jeedimetla, Hyderabad - 500 055.
Telangana. India Telangana, India.
A.R. Life Group
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