1 PET Radionuclides Production PET Radionuclides Production Cyclotron Selection and Location Cyclotron Selection and Location Carlos Gonzalez Lepera, Ph.D. CYCLOTOPE and Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center Houston, TX 1. Cyclotron Selection a. Nuclear Reactions b. Production Methods c. PET Radionuclides d. Selection Criteria e. Radionuclide Production Yield 2. Cyclotron Site a. Large Vault Design b. Self-Shielded Option c. Facility Layout 3. PET Radionuclides Production a. Gas Targets b. Liquid Targets c. Solid Targets α, 3n α, 2n 3He, n α, n p, n p, γ d, n 3He, np α, np t, n 3He, p p, t p, pn γ, n n, 2n Original Nucleus n, n d, p n, γ t, np t, p p,α n, t γ, np n, d γ, p n, p t, 3He Displacement Caused by Nuclear Bombardment Reactions d, α n, np t, He n, α n, n 3He n, 3He n, pd p n Charged Particle (Accelerator) Neutron Irradiation (Reactor) Radionuclides Production Stars Formation Cosmic Rays Nuclear Reactor Cyclotron Cyclotron Accelerator
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PET Radionuclides Production Cyclotron Selection and … · 1 PET Radionuclides Production Cyclotron Selection and Location Carlos Gonzalez Lepera, Ph.D. CYCLOTOPE and Experimental
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PET Radionuclides ProductionPET Radionuclides Production
Cyclotron Selection and LocationCyclotron Selection and Location
Carlos Gonzalez Lepera, Ph.D.CYCLOTOPE and
Experimental Diagnostic Imaging,The University of Texas MD Anderson Cancer Center
Houston, TX
1. Cyclotron Selection
a. Nuclear Reactionsb. Production Methodsc. PET Radionuclides d. Selection Criteriae. Radionuclide Production Yield
2. Cyclotron Site
a. Large Vault Designb. Self-Shielded Optionc. Facility Layout
3. PET Radionuclides Production
a. Gas Targetsb. Liquid Targetsc. Solid Targets
α, 3nα, 2n
3He, nα, n
p, np, γd, n
3He, np
α, npt, n
3He, p
p, tp, pnγ, n
n, 2n
OriginalNucleus
n, n
d, pn, γt, np
t, p
p,αn, t
γ, npn, dγ, p
n, pt, 3He
Displacement Caused by Nuclear Bombardment Reactions
d, α n, npt, He
n, αn, n 3He
n, 3Hen, pd
p
n
Charged Particle (Accelerator)
Neutron Irradiation (Reactor)
Radionuclides Production
Stars FormationCosmic Rays
Nuclear Reactor
CyclotronCyclotron
Accelerator
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Common PET RadioisotopesCommon PET Radioisotopes
Radioisotope Half-life Decay (%) β+ Endpoint (MeV) Principal Nuclear Reactions