Perturbateurs endocriniens environnementaux et obésité 1 er Congrès Santé-Environnement, Marseille, Charles Sultan 1 - Unité d’Endocrinologie - Gynécologie Pédiatriques, Service de Pédiatrie I, Hôpital A. de Villeneuve, Montpellier, France 2 - Service d’ Hormonologie (Développement et Reproduction) , Hôpital Lapeyronie, Montpellier, France 3 - Institut de Génétique Humaine, CNRS UPR1142, Montpellier, France
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Perturbateurs endocriniens environnementaux et obésité
Perturbateurs endocriniens environnementaux et obésité. Charles Sultan 1 - Unité d’Endocrinologie - Gynécologie Pédiatriques, Service de Pédiatrie I, Hôpital A. de Villeneuve, Montpellier, France 2 - Service d’ Hormonologie (Développement et Reproduction) , - PowerPoint PPT Presentation
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Perturbateurs endocriniens environnementaux et obésité
The « environmental » basis of obesity
1 – An emerging hypothesis is that the obesity epidemic could be due to the interaction of nutrition and chemical exposures during vulnerable windows in development
2 – Environmental agents and/or nutrition act during development to:
- Alter the pathways responsible for control of adipose tissue development
- Increase the number of fat cells
- Alter food intake and metabolism
- Alter insulin sensitivity and lipid metabolism via effects on pancreas, adipose tissue, liver, Gl tract, brain and
muscle
Perturbateurs endocriniens environnementaux et obésité
There is accumulative evidence that factors that influence long-term risk of obesity begin very early in life
- in utero nutrition
- prenatal period = an important window of vulnerability for adult obesity
development origins of adult disease paradigm
Perturbateurs endocriniens environnementaux et obésité
Animal studies
Mice treated in utero with - DES
- tributyltene (TBT)
- perfluorooctanoic acid (PFA)
increase in body weight as adults,
. elevated lipid accumulation in adult
. low neonatal body weight adult obesity
Perturbateurs endocriniens environnementaux et obésité
DES = a good model compound to study the effects of EED / obesity
1 – Low dose of DES , prenatal life
pubertal obesity
excessive abdominal fat
2 – Prior to overweight / obesity
leptin
adiponectin
IL-6
glucose levels
3 – Balance of activity levels / food intake
food intake
Perturbateurs endocriniens environnementaux et obésité
DES = a good model compound to study the effects of EED / obesity
4 – Developmental genes / origin of obesity ++
alteration of gene expression involved
in programing adipocytes development
genes involved in fat distribution
EED play a role in regulating
the expression of obesity-related genes during development
Perturbateurs endocriniens environnementaux et obésité
Obesogens = molecules that inappropriately regulate lipid metabolism