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Persistence of bioluminescent bacteria on and around degradable and non-degradable surgical meshes in a murine model BioInterface 2012, Dublin, october 23-25 Jelmer Sjollema University Medical Center Groningen dep. Biomedical Engineering Groningen The Netherlands
Grade 3: Permanent synthetic repair material generally not recommended; potential advantage to biologic repair material Grade 4: Permanent synthetic repair material not recommended; biologic repair material should be considered
Grade 1: Choice of repair material by surgeon preference and patient factors Grade 2: Increased risk for surgical site occurrence suggests additive risk of permanent synthetic repair material, and potential advantage for appropriate biologic reinforcement Breuing et al. Surgery, 2010, Volume 148, Number 3
Biofilm formation in vitro • Numbers of viable cells on degradable meshes were higher than on non-degradable meshes. • Bioluminescence from bacteria show the same significant difference.
• The persistence of a bioluminescent S. aureus strain on and around surgical meshes develops differently for degradable than for non-degradable mesh materials.
• Degradation of an implant appears to create the conditions in which the immune responses are sufficiently effective again to clear the surrounding tissue from infecting staphylococci.
• Bacteria in the peri-implant region seem to need a biomaterial to survive.
This research forms part of the Project P4.01 NANTICO of the research program of the BioMedical Materials institute, co-funded by the Dutch Ministry of Economic Affairs, Agriculture and Innovation.
Acknowledgements
UMCG Biomedical Engineering Mojtaba Daghighi René Dijkstra Gooitzen van Dam Henny van der Mei Henk Busscher Acedemic Medical Center, University of Amsterdam Sebastiaan Zaat Valory de Boer Leonie Jaspers