Performance Report 2011 - MedUni Wien · Performance Report 2011 ... important to understand the pathophysiology of disease. The Institute of Pathophysiology ... Kathrin Burger, ...

Performance Report 2011

Department of Pathophysiology &

Allergy Research

Center of Pathophysiology, Infectiology and Immunology

Medical University Vienna

Coordinated by:

Marion Sack

1

Content Page

Introduction 2 Organigram 7 Personnel 10

1. Detailed Reports of Divisions 11

1.1 Division for Comparative Immunology and Oncology 11

1.2. Division for Cellular and Molecular Pathophysiology 31

1.3 Division for Immunopathology 51

1.4 Division for Medical Biotechnology 72

Performance Report 2011 Introduction

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Science knows no country, because knowledge belongs to humanity, and is the torch which illuminates the world.

Louis Pasteur

If we are to develop effective therapeutic strategies to combat physiological disorders, it is

important to understand the pathophysiology of disease. The Institute of Pathophysiology

and Allergy Research (IPA) has a history of outstanding research, both basic and

translational, in cellular and molecular pathophysiology, immunopathology, comparative

immunology, oncology, medical biotechnology and allergology.

The year 2011 was particularly successful for the IPA: in total, 21 independent groups

performed competitive research in different aspects of the abovementioned fields. Their

excellent results are reflected in their numerous scientific publications in peer-reviewed high-

impact journals, in 34 research awards, and in their many contributions to prestigious

scientific meetings. Alongside these successes, IPA members have continued or initiated

new collaborative scientific work, both nationally and internationally. Several research

projects funded by the Austrian Science Fund (FWF) and other funding agencies, e.g. the

Österreichische Nationalbank or the medizinisch-wissenschaftlicher Fonds des

Bürgermeisters der Stadt Wien, were granted to principal investigators at the IPA.

Over the years, the IPA’s work has gained an excellent international reputation. Figure 1

shows an overview of the total sum of the IPA’s impact factors for the period 2004-2011.

Figure 1

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2004 2005 2006 2007 2008 2009 2010 2011

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In addition to its outstanding scientific performance, the IPA has also delivered education of

an exceptionally high quality to medical students. The total numbers of semester hours held

at the Medical University from 2004-2011 are illustrated in Figure 2; they reflect the IPA’s

members’ ongoing commitment to teaching.


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Figure 2

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2004 2005 2006 2007 2008 2009 2010 2011

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Academic teaching of the next generation of scientists is an important IPA focus, and is

demonstrated by the training of a high number of bachelor’s, diploma and PhD students. In

2011, a total of 110 young researchers were educated at the IPA. Figure 3 shows the

numbers of diploma (red bars) and PhD (yellow bars) students. And for the first time in 2011,

bachelor students (blue bar) were also supervised at the IPA.

Figure 3

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2004 2005 2006 2007 2008 2009 2010 2011

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The increasing numbers of diploma and PhD theses supervised at the IPA reflects the

importance of education at our institute. The participation of several of our members in very

competitive international doctoral programs funded by the FWF attracts outstanding, highly

motivated national and international students to the IPA. All students have the opportunity to

learn a great variety of state-of-the-art laboratory techniques in their research specializations.

Beyond that, they gain insights into the broad spectrum of research activities at the IPA. This

is accelerated by the “Impulse Seminars” organized by the IPA at regular intervals. These

seminars are also regarded as advanced training for medical doctors both within the IPA and

outside it.


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The IPA is also active in training physicians for specializations in pathophysiology and

immunology. Furthermore, members of the IPA are active in teaching and examining not only

at the Medical University but at other universities, too, including universities of applied

sciences. Several IPA members also act as reviewers of external diploma and PhD theses,

Habilitations, scientific manuscripts, and research grants, and are active on editorial and

advisory boards and on the boards of national and international research societies.

Apart from the IPA’s exceptional achievements in research and education, several highlights

of the year 2011 should be mentioned: one was the successful completion of the

Sonderforschungsbereich (SFB) F18 “Molecular and immunological strategies for prevention,

diagnosis and treatment of Type I allergies” coordinated by Univ. Prof. Dr. Rudolf Valenta.

This SFB program had been financed by the Austrian Science Fund (FWF) for the maximum

funding period of 12 years. Several group leaders of the IPA (Barbara Bohle, Heimo

Breiteneder, Erika Jensen-Jarolim, Rudolf Valenta, Susanne Vrtala) were members of this

excellent research programme. The completion of SFB-F18 was followed by the successful

implementation of a new FWF-funded SFB-F46 programme, “Towards prevention and

therapy of allergy”, coordinated by Univ. Prof. Dr. Rudolf Valenta. Again, several group

leaders of the IPA (Barbara Bohle, Heimo Breiteneder, Sabine Flicker, Karin Hoffmann-

Sommergruber, Erika Jensen-Jarolim, Rudolf Valenta, Susanne Vrtala) are part of this highly

competitive, multidisciplinary research programme. Another highlight in 2011 was the start of

Ass. Prof. Dr. Enikö Kallay as manager of the EU-7RP people 2010 ITN-project “The role of

the Calcium Sensing Receptor in health and disease, implications for translational medicine”.

Enikö Kallay coordinates a consortium consisting of 7 international academic partners and 3

industrial partners. This EU project will last for 4 years and will investigate various aspects of

the Calcium Sensing Receptor´s biochemistry, physiology and pathophysiology.

Two further highlights in 2011 were the appointment of Heimo Breiteneder as University

Professor for Medical Biotechnology in May, and in August, that of Erika Jensen- Jarolim as

University Professor for Comparative Medicine, a joint position at the Messerli Research

Institute of the Veterinary University of Vienna, the Medical University of Vienna and the

University Vienna. To fully focus on her new challenges and duties, Univ. Prof. Erika Jensen-

Jarolim stepped down from the position as head of the IPA. Prof. Peter Pietschmann

temporary headed the IPA until 1.12.2012, when I became the new head. At the same time,

the Division of Experimental Allergology was founded.


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I wish to express my sincere thanks to all who have contributed to the very high quality of the

IPA’s scientific and teaching work. Additionally, I would like to acknowledge all those

members of the IPA who have contributed to our success by their ongoing efforts and

support in administrative, organizational, and financial matters, as well as the cleaning staff

and those taking care of the animal facility. Their tremendous backup has significantly

contributed to the high performance of the IPA in research and education.

Special thanks to

the Institutsreferentin Marion Sack, the team in the Leitstelle

Marion Krones Julia Krüger Andreas Kunrath …and the facility team!

Katharina Reinberger Andrea Vlasaty Brigitte Schwarz


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I am convinced that the unstinting engagement of all members of the IPA will guarantee the

Institute’s continuing success in delivering an outstanding quality of basic and translational

research and education. Our strong team spirit is reflected in the IPA’s motto for the future:

“Succeeding together”.

Barbara Bohle

Performance Report 2011 Organigram

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Organigramm (December 2011) Head: Barbara Bohle, PhD, Professor for Cellular Allergology Deputy Head: Peter Pietschmann, MD, Assoc. Professor Department Secretary: Marion Sack Check point: Andreas Kunrath Student Secretary: Marion Krones, Julia Krüger

Division for Comparative Immunology and Oncology Head: Erika Jensen-Jarolim, MD, Professor for Pathophysiology, Professor for Comparative Medicine Secretary: Nora Diallo , substituted by Katica Josipovic Erika Bajna, CTA, 50%

WG AllergoOncology: Head: Erika Jensen-Jarolim, MD, Professor Beatrix Pfanzagl, Ass. Professor Josef Singer, PhD-Student Krisztina Szalai, PhD Durga Krishnamurthy, PhD-Student Franziska Roth-Walter, PhD Kathrin Thell, Diploma Student Philipp Starkl, PhD Janis Kinkel, Diploma Student Marlene Weichselbaumer, PhD Ferdinand Felix, Diploma Student Anna Lukschal, PhD-Student Anna Willensdorfer, CTA Caroline Stremnitzer, PhD-Student Miroslawa Matz, Tech. Ass.

WG Tumor Pathology: Head: Enikö Kallay, PhD, Ass. Professor Giovanna Bises, PhD Samawansha Tennakoon, PhD-Student Julia Höbaus, PhD-Student Abhishek Aggarwal, PhD-Student Doris Hummel, PhD-Student Teresa Manhardt, CTA Ursula Thiem, PhD-Student Maria Elena Manfredini, Project manager Irfete Fetahu, PhD-Student

WG Gastrointestinal Immunology: Head: Eva Untersmayr-Elsenhuber, MD, Priv.-Doz. Susanne Diesner, MD Kristina Kreiner, Diploma Student Vera Elisabeth Assmann, Diploma Student Cornelia Schultz, BMA

WG Nutritional Immunology: Head: Isabella Pali-Schöll, PhD, Priv.-Doz. Helen Szöllösi, Diploma Student

WG Molecular System Biology and Pathophysiology Head: Diana Mechtcheriakova, PhD, Priv.-Doz. Martin Svoboda, PhD Tamara Kaufmann, Diploma Student Anastasia Meshcheryakova, PhD-Student

Division for Cellular and Molecular Pathophysiology Head: Peter Pietschmann, MD, Assoc. Professor Secretary: Birgit Schwarz Erika Bajna, CTA, 50%

WG Bone, Cartilage and conn. Tissue Research: Head: Peter Pietschmann, MD, Assoc. Professor Ursula Föger-Samwald, MSci Helene Mayr, Diploma Student Ursula Semrad-Azizi, PhD- Student Sena Mukaddam, Diploma Student Eduardo Maldonado-Gonzalez, PhD-Student Nadine Ortner, Diploma Student Julian Diebler, Diploma Student Josef Sillipp, Diploma Student Michael Kurz, Diploma Student Andrea Kapfenberger, CTA


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WG Cell Biology: Head: Renate Fuchs, PhD, Assoc. Professor Leszek Gajdzik, Technician Thomas Spanberger, Diploma Student Manuel Jalali, Diploma Student

WG Pathophysioloy of the Placenta: Head: Isabella Ellinger, PhD, Assoc, Professor Andreas Heindl, PhD-Student Hana Uhrova, BMA

WG Cellular Pathology and Pharmacokinetics: Head: Theresia Thalhammer, PhD, Assoc. Professor Erdentetsetseg Rentsen, PhD-Student Johann Gründsteidl, Diploma Student Juliane Riha, PhD-Student Dilek Kalayci, Diploma Student Madonna Awad, Diploma Student Leonard Ndue, Diploma Student Kathrin Burger, Diploma Student Sultan Sirag, Diploma Student Yasemin Durmaz, Diploma Student Wenyi Zhang, Diploma Student

Division for Immunopathology Head: Rudolf Valenta, MD, Professor for Allergology Secretary: Doris Werjant Editorial Secretary: Sanna Lippert SFB-Secretary: Anna Guentcheva

WG Molecular Immunopathology: Head: Rudolf Valenta, MD, Professor Birgit Linhart, PhD Eva Wollmann, PhD-Student Christian Lupinek, MD Kuan Wei-Chen, PhD-Student Raffaela Campana, PhD Bharani Srinivasan, PhD-Student Katarzyna Niespodziana, PhD Isabella Breyer, Diploma-Student Mirela Curin, PhD, Mareike Appel, Diploma-Student Julia Eckl-Dorna, MD, PhD Marina Schuschnig, Diploma-Student Tetiana Garmatiuk, MD Sandra Gutfreund, Diploma-Student Daniela Gallerano, PhD-Student Hannes Mayerhofer, Diploma-Student Clarissa Cabauattan, PhD-Student Milena Weber, CTA Meena Narayanan, PhD-Student Renata Kiss, CTA

WG Immunotechnology: Head: Susanne Vrtala, PhD, Ass. Professor Irene Mittermann, PhD Srinita Banerjee, PhD-Student Alexandra Schmidhuber, PhD-Student Yvonne Resch, PhD-Student Sandra Pahr, PhD-Student

WG Immunochemistry: Head: Margarete Focke-Tejkl, PhD, Univ.-Doz. Katharina Marth, MD Verena Hameter, Diploma-Student

WG Immune Recognition: Head: Ines Swoboda, PhD, Univ.-Doz. Teresa Twaroch, PhD-Student

WG Antibody Research Head: Sabine Flicker, PhD, Priv.-Doz. Elisabeth Gadermaier, PhD-Student Christoph Madritsch, PhD-Student


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Division for Medical Biotechnology Head: Heimo Breiteneder, PhD, Professor for Medical Biotechnology Secretary: Carina Baderer

WG Biotechnology & Biochemical Diagnostics: Head: Heimo Breiteneder, PhD, Professor Merima Bublin, PhD Daniele Pucciarelli, PhD-Student Christine Hafner, MD Maria Kostadinova, PhD-Student Ursula Smole, PhD Daniela Ackerbauer, Diploma Student Barbara Gepp, PhD-Student Nina Lengger, BMA

WG Molecular Allergology: Head: Karin Hoffmann-Sommergruber, PhD, Ass. Professor Christiane Agreiter, Diploma Student Magdolna Vermes, ARat Maria Berneder, Diploma Student Gerlinde Hofstetter, BMA

WG Experimental Immunobiology: Head: Stefan Wagner, PhD, Ass. Professor Kazem Ashjaei, PhD-Student

WG Biochemistry and Bioinformatics: Head: Christian Radauer, PhD, Priv.-Doz. Eva Gushl, PhD-Student

WG Molecular Research in Traditional Chinese Medicine: Head: Yan Ma, PhD, Priv.-Doz. Administration TCM: Linda Lam Karoline Peter, PhD-Student Kristina Marchart, Diploma Student

Division for Experimental Allergology Head: Barbara Bohle, PhD, Professor for Cellular Allergology Secretary: Dorothea Angelides CD-Laboratory Secretary: Bana Haddad Birgit Nagl, BMA

WG Allergy Research: Head: Barbara Bohle, PhD Claudia Kitzmüller, PhD Julia Kalser, Diploma-Student Stephan Deifl, PhD-Student Christian Walterskirchen, Diploma-Student Brinda Subbarayal, PhD-Student Christian Zwicker, Diploma Student Nora Zulehner, PhD-Student Sandra Heizer, BMA Dagmar Kollmann, Diploma Student

WG Cellular Allergology: Head: Beatrice Jahn-Schmid, PhD, Priv.-Doz. Dries van Hemelen, PhD-Student

Facility Services and Animal Keeping:

Katharina Reinberger Brigitte Schwarz Andrea Vlasaty

Performance Report 2011 Personnel

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a) Personnel of IPA (between January and December 2011)1

Personnel (p.) 01.01.2011 31.12.2011

MUW total female total female

Univ.Prof. (full professors) RV, EJJ, BB 3.00 2.00 RV, EJJ, BB, HB 4.00 2.00 Ao.Univ.Prof (Assoc.Prof) HB, IE, RF, PP,

TT 5.00 3.00 IE, RF, PP, TT 4.00 3.00

Univ./Priv.Doz. (Assoc.Prof) EUE, BJS 2.00 2.00 2.00 2.00

Assistant professors BP,KHS,EK,SV,

SW 5.00 4.00 5.00 4.00

Univ.Assistants BL, CR, YM 3.00 2.00 3.00 2.00 Technical personnel NB,LG,TM,MM,

MV,AK,BN,MW,

EB

9.00 8.00 9.00 8.00

Administrative personnel CB,MS,ND,BS, AK,DW,BS½

6.50 5.50 CB,MS,KJ,MK½,

JK½,AK, DW,DA,BS½

7.50 6.50

Supportive personnel AV, KR, BS 3.00 3.00 3.00 3.00

36.50 29.50 37.50 30.50

Third party funded p. Scientific personnel Univ.Doz.

(Assoc.Prof)

MFT, IS, SF, DM, IP

5.00 5.00 Univ.Doz.

(Assoc.Prof)

MFT, SF, DM, IP

4.00 4.00

PostDoc 14.00 12.00 17.00 14.00 Doctoral students

2 37.00 28.00 34.00 26.00

Technical personnel BMA 3.00 3.00 5.00 5.00 CTA 3.00 3.00 2.00 2.00 Administrative personnel MM, BH,SL 3.00 3.00 AG, BH, SL 3.00 3.00 Project employees MS, LL 0.30 0.30 MS, MEM, UFS 1.25 1.25 Diploma students (FB

3) 9.00 6.00 10.00 7.00

74.30 60.30 76.25 62.25

Other scientific coworkers

Doctoral students 4.00 3.00 6.00 4.00

Diploma students 10.00 7.00 15.00 6.00

Student apprentices

2.00 1.00 2.00 1.00

16.00 11.00 23.00 11.00

MUW personnel total 126.80 100.80 136.75 103.75

At the end of 2011 27,4% of the entire personnel was MUV-paid personnel. Of all IPA-employees 75,9% were female.

1 in full time equivalents “FTE” 40 h = 1 FTE 2 due to novel rules by FWF PhD students are employed 75 % FTE to be able to spend time for education 3 FB: Forschungsbeihilfe: defined financial support

Performance Report 2011 Comparative Immunology and Oncology

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1. Detailed Reports of Divisions

1.1 Division for Comparative Immunology and Oncology Head: Erika Jensen-Jarolim, MD, Professor

1. Publications4

IF Number Top/Std/Subst

Erika Jensen-Jarolim 19.117 7 2x Top,3x St,2x SSt

Enikö Kállay 6.964 2 2x St

Isabella Pali-Schoell 6.297 1 1x Top

Eva Untersmayr-E. 0 1 1x SSt

Diana Mechtcheriakova 4.411 1 1x St

Sum 26.061 12

Top point score 2 - among top 20 % of journal in field

Standard point score 1 - between 21-60 %, Substandard point score 0,2

2. Supervision of bachelor, diploma and doctoral students

Bachelor st. Diploma st. Doctoral st.

Erika Jensen-Jarolim - 3 8

Enikö Kállay - - 7

Isabella Pali-Schoell 1 - -

Eva Untersmayr-E. - 3 2

Diana Mechtcheriakova - 1 1

Sum 1 7 18

3. Teaching SS* WS* total W+S oral Exams

Erika Jensen-Jarolim 2.16 6.00 8.16 - Enikö Kállay 7.00 8.98 15.98 - Isabella Pali-Schoell 2.05 1.22 3.27 -

Eva Untersmayr-E. 0.00 6.35 6.35 2

Diana Mechtcheriakova 1.41 2.42 3.83 -

Sum 12.62 24.97 37.59 2

4 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the

given sum of the division represents the net value of IFs without overlaps due to joint publications.


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1.1.1. Publications a) Peer-reviewed original articles : n = 6 Nr. Article IF Class

1. M., Weichselbaumer, M. Willmann, M. Reifinger, J. Singer, E. Bajna, Y. Sobanov, D. Mechtcheriakova, E. Selzer, J. G. Thalhammer, R. Kammerer, E.* Jensen-Jarolim. Phylogenetic discordance of human and canine carcinoembryonic antigen (CEA, CEACAM) families, but striking identity of the CEA receptors will impact comparative oncology studies. PLOS Currents, 2011 Mar 16;3:RRN1223.

n.d. St.

3. C., Nemeth, S. Humpeler, E. Kallay, I. Mesteri, M. Svoboda, O. Rögelsperger, N. Klammer , T. Thalhammer, C. Ekmekcioglu. Decreased expression of the melatonin receptor 1 in human colorectal adenocarcinomas. J Biol Regul Homeost Agents. 2011 Oct-Dec;25(4):531-42.

2.825 St.

4. A., Lukschal, J. Fuhrmann, J. Sobanov, D. Neumann, J. Wallmann, R. Knittelfelder, W. Hemmer, O. Scheiner, M. Vogel, B. M. Stadler, E. Jensen-Jarolim and K. Szalai. Anti-idiotypic Fab fragments image a conserved N-terminal epitope patch of grass pollen allergen Phl p 1.The Open Allergy Journal, [DOI: 10.2174/1874838401104010016]

n.d. -

5. P., Starkl, D. Krishnamurthy, O. Hantschel, F. Felix, D. Oberthuer, H. A. Sampson, T. Schweighoffer, I. Swoboda, C. Betzel, G. S. Superti-Furga, E. Untersmayr, E. Jensen-Jarolim. Heating influences the structure, intestinal epithelial binding, signaling and immunogenicity of the major peanut allergen Ara h 2. Open Allergy Journal. [DOI: 10.2174/1874838401104010024].

n.d. -

6. D., Mechtcheriakova, Y. Sobanov, G. Holtappels, E. Bajna, M. Svoboda, M. Jaritz, C. Bachert, E. Jensen-Jarolim (2011) Activation-induced cytidine deaminase (AID)-associated multigene signature to assess impact of AID in etiology of diseases with inflammatory component. PLoS One 6: e25611. 10.1371/journal.pone.0025611 [doi];PONE-D-11-10751 [pii].

4.411 St.

sum 7.236

b) Invited Articles & Reviews with IF: n = 4

Nr. Article IF Class

1. E., Jensen-Jarolim, J. Singer, Cancer Vaccines inducing antibody production: More Pros than Cons, Exp. Rev. of Vaccines 10 (9), 1281-1289, 2011

4.214

St.

2. E., Jensen-Jarolim, J. Singer, Why could passive IgE antibody therapy be safe in clinical oncology? Clin Exp Allergy. 2011 May 5. doi: 10.1111/j.1365-2222.2011.03764.x

4.195 Top

3. I., Pali-Schöll, E. Jensen-Jarolim, Anti-acid medication as a risk factor for food allergy. Review. Allergy, 2011; 66:469-477

6.297 Top

4. H. S., Cross, T. Nittke, E. Kallay Colonic vitamin D metabolism: implications for the pathogenesis of inflammatory bowel disease and colorectal cancer., Mol Cell Endocrinol. 2011 Dec 5;347(1-2):70-9. Epub 2011 Jul 27

4,119 St.

sum 18.825


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c) Invited Articles & Reviews without IF: n = 0 d) Book contributions: n = 0 e) Abstracts, printed in periodicals: n = 1 1. Smole U., D. Mechtcheriakova, Y. Sobanov, C. Radauer, N. Balazs, M. Bublin, S.

Wagner, K. Hoffmann-Sommergruber, E. Jensen-Jarolim, and H. Breiteneder. 2010. The major birch pollen allergen, Bet v 1.0101, is sufficient to induce a Th2-promoting phenotype in monocyte-derived dendritic cells of birch pollen allergic donors. 29th Congress of the European Academy of Allergy and Clinical Immunology –London 2010; Allergy 2010;65 (Suppl. 92):12

f) Abstracts, in congress proceedings or abstract books and posters: n = 65 1. Diesner SC, Untersmayr E, Oostingh GJ, Selzle K, Pfaller T, Schultz C, Zhang Y,

Krishnamurthy D, Starkl P, Knittelfelder R, Förster-Waldl E, Pollak A, Scheiner O, Pöschl U, Jensen-Jarolim E, Duschl A. Nitration of ovalbumin decreases the risk for sensitization via the oral route in a mouse food allergy model. Food Allergy and Anaphylaxis Meeting, (Feb 17-19, 2011, Venice, Italy, oral presentation)

2. Starkl P, Krishnamurthy D, Szalai K, Felix F, Lukschal A, Oberthuer D, Sampson HA, Swoboda I, Betzel C, Untersmayr E and Jensen-Jarolim E. Heating influences the structure of the major peanut allergen Ara h 2 and increases its intestinal epithelial adsorption and immunogenicity, Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, 2011

3. Pali-Schöll I, Szöllösi H, Scheicher B, Stremnitzer C, Starkl P, Zimmer A, Jensen-Jarolim E. Protamine-based nanoparticles with CpG-oligodesoxynucleotides are suitable for the induction of a Th1-mediated immune response. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011

4. Roth-Walter F, Starkl P, Zuberbier T, Brunner R, Pali-Schöll I, Kinkel J, Felix F, Jensen-Jarolim E, Kinaciyan T. Naturally occurring glutathione expose linear ovomucoid IgE-epitopes relevant in persistent egg allergy. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011

5. Stremnitzer C, Szalai K, Starkl P, Lukschal A, Willensdorfer A, Mildner M, Tschachler E, Reichart U, Brandner JM, Knapp S, Jensen-Jarolim E. The molecular requirements of house dust mite allergens Der p 1 and Der p 2 to induce allergic skin inflammation. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011

6. Krishnamurthy D, Lukschal A, Starkl P, Diesner SC, Pali I, Untersmayr E, Jensen-Jarolim E. Anti-acid medications increase the risk of food allergy to orally applied milk allergen casein in a BALB/c mouse model, Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011

7. Diesner SC, Schultz C, Wang X-Y, Ratzinger G, Starkl P, Assmann V, Kreiner K, Roth-Walter F, Pali-Schöll I, Jensen-Jarolim E, Gabor F, Untersmayr E. Allergen-loaded microparticles functionalized with the M-Cell targeting substance neuraminidase as novel oral immunotherapy of allergy. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011

8. Diesner SC, Olivera A, Dillahunt S, Schultz C, Watzlawek T, Förster-Waldl E, Pollak A, Jensen-Jarolim E, Untersmayr E , Rivera J. Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a murine food allergy model. Annual Meeting of


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the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011

9. Krishnamurthy D, Starkl P, Szalai K, Roth-Walter F, Mannhalter C, Diesner SC, Untersmayr E , Jensen-Jarolim E. Monitoring neutrophils and platelets participatation during casein-induced anaphylaxis in an experimental BALB/c mouse model. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011

10. Singer J, Szalai K, Thell K, Willensdorfer A, Stremnitzer C, Szöllösi H, Michaelis U, Weghofer M, Ritter M, Jensen-Jarolim E. Evaluation of anti-tumor vaccines using Adeno-associated virus like particles (AAVLP) as carrier for HER-2 mimotopes. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, 2011

11. Thell K, Szalai K, Singer J, Ritter M, Pfanzagl B, Willensdorfer A, Stremnitzer C, Michaelis U, Jensen-Jarolim E. New carriers for B-cell vaccines: Immunogenicity and safety aspects of Adeno-associated virus-like particles: new carriers for B-Cell vaccines (AAVLPs). Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011

12. Roth-Walter F, Starkl P, Zuberbier T, Brunner R, Pali-Schöll I, Kinkel J, Felix F, Jensen-Jarolim E, Kinaciyan T. Glutathione in egg exposes linear ovomucoid IGE-Epitopes relevant in persistent egg allergy. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011

13. Svoboda M, Sobanov Y, Holtappels G, Bajna E, Jaritz M, Bachert C, Jensen-Jarolim E, Mechtcheriakova D. Activation-induced cytidine deaminase (AID) in inflammatory process: multigene signature approach to delineate the role of AID-driven events. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011

14. Svoboda M., Kaufmann T., Meshcheryakova A., Bajna E., Jensen-Jarolim E., Mechtcheriakova D. Activation-induced cytidine deaminase (AID) at the crosstalk between immunity and cancer: multigene signature approach to assess role of aid in tumorigenicity and pluripotency of epithelial cells. Annual Symposium 2011 Verein zur Förderung von Wissenschaft und Forschung in den neuen Wiener Universitätskliniken am Allgemeinen Krankenhaus der STADT WIEN; Vienna, Austria

15. Svoboda M., Kaufmann T., Meshcheryakova A., Bajna E., Mechtcheriakova D. Activation-induced cytidine deaminase (AID) from immunity to cancer: Does AID facilitate tumorigenesis and/or pluripotency of epithelial cells? Annual Meeting OEGAI 2011, Graz, Austria (oral presentation)

16. Svoboda M., Sobanov Y., Holtappels G., Bajna E., Jaritz M., Bachert C., Jensen-Jarolim E., Mechtcheriakova D. Activation-induced cytidine deaminase (AID) in inflammatory process. Joint Annual Meeting DGfI and SIICA 2011, Riccione, Italy

17. Jensen-Jarolim E, Singer J, Weichselbaumer M, Willmann M, Thalhammer J, Comparative medicine to speed up drug development, zur 45 Annual Meeting of the Austrian Society of Tropical Medicine and Parasitology, Vienna, Austria, November 17-19, 2011

18. Stremnitzer C, Szalai K, Starkl P, Lukschal A, Willensdorfer A, Mildner M, Tschachler E, Reichart U, Brandner JM, Knapp S, Jensen-Jarolim E. The molecular requirements of house dust mite allergens Der p 1 and Der p 2 to induce allergic skin inflammation. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011

19. Diesner SC, Schultz C, Krishnamurthy D, Assmann V, Kreiner K, Weichselbaumer M, Starkl P, Pollak A, Jensen-Jarolim E, Pali-Schöll I, Untersmayr E. Anaphylactic Reponses in an oral OVA food allergy model under acid-suppression in BALB/c mice


15

are based on IgE rather than IgG1 antibodies. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, 2011

20. Starkl P, Krishnamurthy D, Szalai K, Felix F, Lukschal A, Oberthuer D, Sampson HA, Swoboda I, Betzel C, Untersmayr E and Jensen-Jarolim E. Heating influences the structure of the major peanut allergen Ara h 2 and increases its intestinal epithelial adsorption and immunogenicity, Retreat of the Center of Pathophysiology, Infectiology and Immunology, Austria, 2011

21. Roth-Walter F, Starkl P, Zuberbier T, Brunner R, Pali-Schöll I, Kinkel J, Felix F, Jensen-Jarolim E, Kinaciyan T. Glutathione in egg exposes linear ovomucoid IgE-Epitopes relevant in persistent egg allergy. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Graz, Austria, September 15-17, 2011

22. Diesner SC, Olivera A, Dillahunt S, Schultz C, Watzlawek T, Förster-Waldl E, Pollak A, Jensen-Jarolim E, Untersmayr E, Rivera J. Sphingosine 1 phosphate homeostasis influences intestinal allergen uptake and oral sensitization in a mouse food allergy model. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011

23. Diesner SC, Schultz C, Wang X-Y, Ratzinger G, Starkl P, Assmann V, Kreiner K, Roth-Walter F, Pali-Schöll I, Jensen-Jarolim E, Gabor F, Untersmayr E. Allergen-loaded microparticles functionalized with the M-Cell targeting substance neuraminidase as novel oral immunotherapy of allergy. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011

24. Pali-Schöll I, Szöllösi H, Scheicher B, Starkl P, Stremnitzer C, Zimmer A, Jensen-Jarolim E. Protamine-based nanoparticles in conjunction with CpG ODN are useful tools to induce an allergen-specific TH1-response in BALB/c-mice. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011

25. Lukschal A, Mari A, Harwanegg C, Wallmann J, Palazzo P, Liso M, Pali I, Jensen-Jarolim E. Evaluation of prevalence of IgE IgG4 and IgG reactivity to Phl/p/5 protein and its mimotope H32 in a large population of allergic patients. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011

26. Thell K, Szalai K, Singer J, Ritter M, Pfanzagl B, Willensdorfer A, Stremnitzer C, Michaelis U, Jensen-Jarolim E. Immunogenicity and safety aspects of Adeno-Associated virus-like particles: new carriers for B-Cell vaccines, Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011

27. Singer J, Szalai K, Thell K, Willensdorfer A, Stremnitzer C, Szöllösi H, Michaelis U, Weghofer M, Ritter M, Jensen-Jarolim E. Evaluation of Adeno-Associated Virus Like Particles (AAVLP) as carriers for HER-2 mimotope cancer vaccines. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011

28. Krishnamurthy D, Lukschal A, Starkl P, Diesner SC, Pali I, Untersmayr E, Jensen-Jarolim E. Anti-acid medications increase the risk for milk allergy in a mouse model. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011

29. Roth-Walter F, Starkl P, ZuberbierT, Brunner R, Pali-Schöll I, Kinkel J, Felix F, Jensen-Jarolim E, Kinaciyan T. Glutathione exposed sequential epitopes of ovomucoid are relevant for persistent egg-allergic patients. XXII. World Allergy Congress, December 4-8, Cancun, Mexico, 2011

30. Diesner SC, Schultz C, Wang X, Ratzinger G, Starkl P, Assmann V, Kreiner K, Roth-Walter F, Pali I, Jensen-Jarolim E, Gabor F, Untersmayr E. M-cell targeting by neuraminidase functionalized microparticles for future application in oral immunotherapy. XXII. World Allergy Congress, Cancun, Mexico, December 4-8, 2011.


16

31. Smole U, Balazs N, Radauer C, Sobanov Y, Bublin M, Gaier S, Hoffmann-Sommergruber K, Jensen-Jarolim E, Mechtcheriakova D, Breiteneder H. Specific recognition of the major birch pollen allergen Bet v 1 programs dendritic cells to induce either Th2 or tolerogenic responses. XXII. World Allergy Congress, Cancun, Mexico, December 4-8, 2011

32. Smole U., N. Balazs, Y. Sobanov, C. Radauer, M. Bublin, K. Hoffmann-Sommergruber, E. Jensen-Jarolim, D. Mechtcheriakova and Heimo Breiteneder. 2011. Lipid raft mediated uptake of the major birch pollen allergen Bet v 1.0101 activates Th2-polarizing signaling pathways in dendritic cells of allergic donors. 30th Congress of the European Academy of Allergy and Clinical Immunology – Istanbul 2011 (oral presentation)

33. Jensen-Jarolim E, Szalai K, Thell K, Singer J, Ritter M, Pfanzagl B, Willensdorfer A, Stremnitzer C, Michaelis U. Immunogenicity and safety aspects of adeno-associated virus–like particles (AAVLPs) as carriers for B-cell vaccines. XXII. World Allergy Congress, Cancun, Mexico, December 4-8, 2011.

34. Singer J, Plum M, Braren I, Karagiannis P, Mechtcheriakova D, Knittelfelder R, Spillner E, Jensen-Jarolim E. Comparing antibody mediated-cytotoxicity and -phagocytosis of anti-EGFR IgG and IgE antibodies in a flow cytometric assay. 9th EAACI- GA²LEN Immunology Winter School, Basic Immunology Research in Allergy, Davos, Switzerland, February 3-6, 2011.

35. Weichselbaumer M, Singer J, Stockner T, Mechtcheriakova D, Sobanov Y, Bajna E, Wrba F, Horvat R, Thalhammer JG, Willmann M, Jensen-Jarolim E. ErbB-1 and ErbB-2 expression in canine mammary cancer and their role as targets in comparative oncology. Second AACR International Conference on Frontiers in Basic Cancer Research, San Francisco, CA, September 14-18, 2011.

36. Weichselbaumer M, Willmann M, Reifinger M, Singer J, Bajna E, Sobanov Y, Mechteriakova D, Selzer E, Thalhammer JG, Kammerer R, Jensen-Jarolim E. Comparative analysis of the target of anti-human carcinoembryonic antigen (CEA) antibody Col-1 and CEA receptor (CEAR) in canine and human mammary cancer. ESVONC Annual Congress of the European Society of Veterinary Oncology, Glasgow, Scotland, March 24-26, 2011

37. Petricevic B, Längle J, Singer J, Steger G, Jensen-Jarolim E, Bergmann M. Evaluation of trastuzumab mediated antibody dependent cytotoxicity in metastatic breast cancer patient using a rapid FACS-based analysis. ACO/ASSO Meeting by the Austrian Society of Oncologic Surgery, St. Wolfgang/OÖ, October 15, 2011.

38. Weichselbaumer M, Braun A, Aleksic D, Blaschke L, Zimmermann W, Handler J, Jensen-Jarolim E, Kammerer R. Possibilities and limitations of the CEA gene family in comparative medicine. 21st Annual International CEA Symposium, Konstanz, Germany, September 18-21, 2011

39. Weichselbaumer M, Willmann M, Reifinger M, Singer J, Bajna E, Sobanov Y, Mechteriakova D, Selzer E, Thalhammer JG, Kammerer R, Jensen-Jarolim E. Carcinoembryonic antigen: challenging biomarker in comparative medicine. 45. Austrian Society of Tropical Medicine and Parasitology, Vienna, Austria, November 17-19, 2011

40. Comparative medicine to speed up drug development. Jensen-Jarolim E, Singer J, Weichselbaumer M, Willmann M, Thalhammer J. 45. Austrian Society of Tropical Medicine and Parasitology, Vienna, Austria, November 17-19, 2011

41. Krishnamurthy D, Lukschal A, Starkl P, Diesner SC, Pali I, Untersmayr E , Jensen-Jarolim E. Anti-acid medications increase the risk of food allergy to orally applied milk allergen casein in a BALB/c mouse model. PhD Symposium, Vienna, Austria, June 15-16, 2011


17

42. Kathrin Thell K, Krisztina Szalai K, Josef Singer J, Mirko Ritter M, Beatrix Pfanzagl B, Anna Willensdorfer A, Caroline Stremnitzer C, Uwe Michaelis U, Erika Jensen-Jarolim E. Adeno-associated virus–like particles (AAVLPs) as carriers for B-cell vaccines: Immunogenicity and safety aspects. 7. PhD Symposium, Vienna, Austria, 2011

43. Stremnitzer C, Szalai K, Starkl P, Lukschal A, Willensdorfer A, Mildner M, Tschachler E, Reichart U, Brandner JM, Knapp S, Jensen-Jarolim E. The molecular requirements of house dust mite allergens Der p 1 and Der p 2 to induce allergic skin inflammation, PhD Symposium, Vienna, Austria, June 15-16, 2011

44. Diesner SC, Olivera A, Dillahunt S, Schultz C, Förster-Waldl E, Jensen-Jarolim E, Rivera J, Untersmayr E. Sphingosine-kinase 1 and 2 play a pivotal role in oral sensitization and effector phase in a mouse model of food allergy. 7th PhD Symposium (June 15-16 2010, Vienna, Austria)

45. Szöllösi H, Scheicher B, Starkl P, Felix F, Zimmer A, Jensen-Jarolim E, Pali-Schöll I: Protamine Based Nanoparticles Enhance a Th1 Mediated Immune Response. 7th PhD-Symposium, 15-16 June 2011, Vienna, Austria.

46. Jensen-Jarolim E, Nittke T, Wegmann M, Kiefer F, Klein J, Epstein MM, Esterbauer H, Fehrenbach H, Wallmann J. Metabolic cages are suitable to monitor acute hyperventilation of asthmatic mice upon allergen challenge. 30. Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, 11-16 May, 2011

47. Roth-Walter F, Starkl P, Gartner M, Brunner R, Singer J, Felix F, Zuberbier T, Jensen-Jarolim E, Kinaciyan T. Enhanced recognition of linearized, but not of native ovomucoid upon cooking. 30. Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, 11-16 May, 2011

48. Krishnamurthy D, Starkl P, Szalai K, Roth-Walter F, Untersmayr E, Diesner SC, Mannhalter C , Jensen-Jarolim E. Neutrophils and platelets participate in anaphylaxis in a BALB/c mouse model. 30. Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, 11-16 May, 2011

49. Zennaro D, Capalbo C, Scala E, Liso M, Spillner E, Penichet M, Singer J, Ingke B, Daniels T R., Plum M, Santoro M, Scoppola A, Marchetti P, Jensen-Jarolim E, Mari A. IgE, IgG4 and IgG response to tissue-specific and environmental antigens in patients affected by cancer. 30. Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, 11.-16 May, 2011

50. Singer J, Weichselbaumer M, Stockner T, Mechtcheriakova D, Sobanov Y, Wrba F, Horvat R, Thalhammer JG, Willmann M, Jensen-Jarolim E. ErbB-1 and ErbB-2 homologues are expressed in cancer of dog and recognized by cetuximab and trastuzumab antibodies. 30 Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, 11-15 June, 2011

51. Singer J, Weichselbaumer M, Stockner T, Mechtcheriakova D, Sobanov Y, Wrba F, Horvat R, Thalhammer JG, Willmann M, Jensen-Jarolim E. Evaluation of ErbB-1 and ErbB-2 homologue expression in canine cancer and their role as possible targets in comparative oncology. University lectures of vfwf 2011, General Hospital Vienna, Austria, December 2, 2011

52. Untersmayr E, Vestergaard H, Malling HJ, Bjerremann LJ, Platzer MH, Boltz-Nitulescu G, Scheiner O, Skov PS, Jensen-Jarolim E, Poulsen LK. Hindered gastric digestion represents a risk for severe reactions in food allergic patients. Verein zur Förderung von Wissenschaft und Forschung in den neuen Universitätskliniken am AKH der Stadt Wien (December 2, 2011, Vienna, Austria)

53. Lukschal A, Mari A, Harwanegg C, Wallmann J, Palazzo P, Liso M, Pali I, Jensen-Jarolim E. Prevalence of IgE, IgG4 and IgG reactivitiy to grass pollen allergen PHL P


18

and its mimotope H32 in an population of Italian allergic patients. University lectures of vfwf, December 2, 2011

54. Pali-Schöll I, Szöllösi H, Starkl P, Scheicher B, Stremnitzer C, Hofmeister A, Roth-Walter A, Zimmer A, Jensen-Jarolim E. Protamine-based nanoparticles as suitable carriers in therapy of allergy. University lectures of vfwf 2011, General Hospital Vienna, Austria, December 2, 2011

55. Shakeri-Leidenmühler S, Lukschal A, Schultz C, Bohdjalian A, Greisenegger E, Langer F, Birsan T, Diesner SC, Kopp T, Scheiner O, Jensen-Jarolim E, Prager G, Untersmayr E. Surgical elimination of the gastric digestion leads to an increased risk of food protein sensitization. Verein zur Förderung von Wissenschaft und Forschung in den neuen Universitätskliniken am AKH der Stadt Wien (December 2, 2011, Vienna, Austria)

56. Svoboda M, Kaufmann T, Meshcheryakova, Bajna E, Mechtcheriakova D. Activation-induced cytidine deaminase (AID) from immunity to cancer. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011

57. Meshcheryakova A, Svoboda M, Mechtcheriakova D. Multigene signature approach for systemic analysis of multifaceted roles of sphingolipids in disease etiology. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011

58. Höbaus J, Nittke T, Manhardt T, Hummel D, Kallay E. Gene amplification and epigenetic modifications: Mechanisms behind unbalanced expression of the proto-oncogene CYP24A1 in colorectal tumor. 102 Annual Meeting of the American Cancer Association, Orlando, Florida, April 2-6, 2011

59. Höbaus J, Nittke T, Khorchide M, Kallay E. Epigenetic Regulation of the Vitamin D degrading Proto-Oncogen 1,25-Hydroxyvitamin D3 24-Hydroxylase in vitro. E.16 Jahrestagung der Österreichischen Gesellschaft für Endokrinologie und Stoffwechsel, Vienna, Austria, May 12-13, 2011.

60. Höbaus J, Fetahu I, Hummel D, Manhardt T, Kallay E. Overexpression and methylation of the vitamin D degrading enzyme CYP24A1 in colorectal cancer. International Summit Conference on Calcium and Vitamin D of the Austrian Society for Bone and Mineral Research, Vienna, Austria, November, 2011,

61. Fetahu I Sh, Höbaus J, Hummel D, Manhardt T, Kallay E. Epigenetic regulation of the calcium sensing receptor. Poster presentation, Retreat of Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, September 27, 2011

62. Fetahu I Sh, Höbaus J, Hummel D, Manhardt T, Kallay E. Epigenetic regulation of the calcium sensing receptor in colorectal cancer. Oral presentation, Annual meeting of Austrian Society and Mineral research & International Summit Conference on Calcium and Vitamin D, Vienna, Austria, November 25-26, 2011

63. Thiem U, Höbaus J, Hummel D, Nittke T, Fetahu I, Manhardt T, Borchhardt K, Kállay E. In vitro effect of 1,25-dihydroxyvitamin D3 on the catabolism of tryptophan. International Summit Conference on Calcium and Vitamin D of the Austrian Society for Bone and Mineral Research, Vienna, Austria, November, 2011

64. Hummel D, Schrewe H, Kallay E. Effects of colon-specific knockout and overexpression of 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) on vitamin D signaling in mice. June 2012, Vienna, Austria: 7th YSA-PhD-Symposium

65. Hummel D, Höbaus J, Thiem U, Fetahu I Sh, Manhardt T, Mesteri I, Kallay E. Impact of high dietary vitamin D on the effect of AOM and DSS treatment in mouse colon tissue. November 2011, Vienna, Austria: International Summit Conference on Calcium and Vitamin D of the Austrian Society for Bone and Mineral Research


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g) Teaching Scripts and Books: n = 0 h) Articles in Medical Journals: n = 0 i) Public activity Diana Mechtcheriakova MUW Open Day 2011 „Science Dabei“. Multigene-Signaturen – eine Brücke von der Forschung zur personalisierten Medizin. Erika Jensen-Jarolim Eine Medizin für Mensch und Tier. Opening der Wiener Science Lectures.

Print:

Eine Medizin für Mensch und Tier. Opening der Wiener Science Lectures. In: Unsere Hunde 12, Dezember 2011.

Medical Tribune, "Schulterschluss von Veterinär- und Humanmedizin - RotePfote gegen Krebs", 04/2011 Nr. 14

Die Presse am Sonntag, "Der Hund als Patient", April 29, 2011

der Standard, "Mensch und Hund teilen sich einen Tumormarker", April 19, 2011

Der Jagdspaniel, "Eine Krebserkrankung ist kein Mysterium - Drei Jahre vergleichende Krebsforschung", Ausgabe 02-2011, Seite 50-54

Breeder Special, "Eine Krebserkrankung ist kein Mysterium - Drei Jahre vergleichende Krebsforschung", Ausgabe 01-2011, Seite 16-20

online:

Professur für Erika Jensen-Jarolim. 01. August 2011. 12:51. http://derstandard.at/1311802419481/Wien-Professur-fuer-Erika-Jensen-Jarolim

Forschung auf neuen Wegen. http://www.forschen-entdecken.at/Forschung-auf-neuen-Wegen.4241.0.html

Tumormarker bei Mensch und Hund gleich. 18.04.2011 | 16:37 | (DiePresse.com) http://diepresse.com/home/gesundheit/651444/Tumormarker-bei-Mensch-und-Hund-gleich

www.ots.at, "Verein "Rote Pfote- Krebsforschung für das Tier" mit Spendengütesiegel ausgezeichnet", April 21, 2011

www.austropharm.com, "Verein "Rote Pfote- Krebsforschung für das Tier" mit Spendengütesiegel ausgezeichnet", April 21, 2011

www.wuff.at, ""RotePfote - Krebsforschung für das Tier" mit Spendengütesiegel ausgezeichnet. Umgang mit Spenden entspricht höchsten Qualitätsstandards", April 21, 2011

www.pr-inside.com, "Verein "Rote Pfote- Krebsforschung für das Tier" mit Spendengütesiegel ausgezeichnet", April 21, 2011

www.tieraerztekammer.at, "Erste klinische Studien laufen bereits –

http://www.magazinmeinhaustier.at/archiv_03_04_11.php: „Verein rote Pfote, Gemeinsame Krebsforschung für Zwei- und Vierbeiner . März/April Ausgabe 2011

http://www.4-pfoten-lebensrecht.at/3.html. Abschluss der Feldbacher Adventaktion für "RotePfote", 14. Dezember 2011

http://www.kleinezeitung.at/steiermark/fuerstenfeld/ottendorf_an_der_rittschein/2885241/benefizaktion-fuer-tiere.story. Benefizaktion für Tiere. 24.11.2011.

http://www.rote-pfote.at/images/files/diepresse-29-05-11-tumor-hund.pdf

http://diepresse.com/home/gesundheit/651444/Tumormarker-bei-Mensch-und-Hund-gleich

http://www.ots.at/

http://www.austropharm.com/

http://www.wuff.at/

http://www.pr-inside.com/

http://www.tieraerztekammer.at/

http://www.magazinmeinhaustier.at/archiv_03_04_11.php

http://www.4-pfoten-lebensrecht.at/3.html

http://www.kleinezeitung.at/steiermark/fuerstenfeld/ottendorf_an_der_rittschein/2885241/benefizaktion-fuer-tiere.story

http://www.kleinezeitung.at/steiermark/fuerstenfeld/ottendorf_an_der_rittschein/2885241/benefizaktion-fuer-tiere.story


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http://www.austropharm.at/en/apa_show.html?ap=wik.OTS0132-20110421. Verein "Rote Pfote- Krebsforschung für das Tier" mit Spendengütesiegel ausgezeichnet

http://www.ots.at/presseaussendung/OTS_20111004_OTS0223/roche-austria-publizistikpreis-2011-an-veronika-schmidt-bild Eva Untersmayr-Elsenhuber

1. Die Wiener Zeitung „Hätte lieber einen Tumor gehabt“ 16.8.2011 http://www.wienerzeitung.at/themen_channel/wzwissen/leben/389444_Haette-lieber-einen-Tumor-gehabt.html

2. Springer Professional Media „Lebensmittel auf Krankenschein“ 25.8.2011

3. Austria Innovativ „Essen mit Nebenwirkungen“, S.24 Vol. 6/2011 j) Radio and TV interviews: n = 1 Erika Jensen-Jarolim 1. OE1, Interview Radiodoktor, Medizin und Gesundheit "Immunsystem", January 3, 2011 k) Lay Information: Brochures and Workshops: n = 1 Eva Untersmayr-Elsenhuber/Isabella Pali 1. REVAN (Richtig essen von Anfang an): Allergien vorbeugen in Schwangerschaft, Stillzeit

und Säuglingsalter

1.1.2 Research Awards: n = 5

1. Pali-Schöll Isabella: Kardinal Innitzer Förderungspreis 2011. Kardinal Innitzer

Studienfonds

2. Diana Mechtcheriakova: Otto-Kraupp-Preis, May 2011, Vienna, Austria

3. Josef Singer: poster prizes. 30th Congress of the European Academy of Allergy of Allergy and Clinical Immunology, June 11-15, 2011, Turkey, Istanbul (Poster Presentation, Poster Prize); 7thPhD-Symposium, Young Scientist Association of the Medical University of Vienna, June 15-16, Vienna, Austria (Poster Presentation, Poster Prize Winner)

4. Julia Höbaus: 16. Jahrestagung der Österreichischen Gesellschaft für Endokrionologie und Stoffwechsel: Auszeichnung für die Präsentation des Abstracts mit dem Titel "Epigenetic Regulation of the Vitamin D Degrading Proto-Oncogene 1,25-Hydroxyvitamin D3 24-Hydroxylase in Vitro" and CePII Retreat: Posterpreis für Poster mit dem Titel "Overexpression and Methylation of the Vitamin D Degrading Enzyme CYP24A1 in Colorectal Cancer

5. Giovanna Bises: award - Science2business Award (3rd place) at the LifeScienceSuccess 2011, TechGate, Vienna

1.1.3. Invited lectures: n = 21 Erika Jensen-Jarolim 1. Techno, Beat and Cinnamon. Pirquet Club of the Austrian Society of Allergology and

Immunology, March 4, 2011.

http://www.austropharm.at/en/apa_show.html?ap=wik.OTS0132-20110421

http://www.ots.at/presseaussendung/OTS_20111004_OTS0223/roche-austria-publizistikpreis-2011-an-veronika-schmidt-bild

http://www.ots.at/presseaussendung/OTS_20111004_OTS0223/roche-austria-publizistikpreis-2011-an-veronika-schmidt-bild

http://www.wienerzeitung.at/themen_channel/wzwissen/leben/389444_Haette-lieber-einen-Tumor-gehabt.html

http://www.wienerzeitung.at/themen_channel/wzwissen/leben/389444_Haette-lieber-einen-Tumor-gehabt.html


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2. Women in Science. Office for Gender Affairs of Austrian Medical Student Association (ÖH). March 16, 2011

3. Anti-Acids and Food Allergy. International Meeting on Food Allergy. RIRAAF Seminar, IIS-FJD Fundacion Jimenez Diaz, Madrid, Spain, April 14, 2011.

4. Der Darm als Primärorgan der Sensibilisierung oder als Schaltstelle für Immuntoleranz - wie verstehen wir die Mechanismen derzeit? Pirquet Club Spezial. Vienna, May 7, 2011.

5. Gender difference and immediate type hypersensitivity reactions. European Academy of Allergy and Clinical Immunology, Geneva, Switzerland. June 17, 2011.

6. Hormone und allergisches Asthma bronchiale: Sex matters. Annual Congress of the Austrian Society of Pulmonology. Vienna, September 8, 2011.

7. Techno-Allergie: Neue Sensibilisierung mit alten Allergenen. Grazer Allergietag at Annual Meeting of the Austrian Society of Allergology and Immunology. Graz, Austria, September 17, 2011.

8. Comparative strategies to speed up Allergology and AllergoOncology. Seminar at Istituto Dermopatico DelÌmmacolata (IDI), Rome, Italy. September 20, 2011.

9. Disco Fog. 32. Meeting of Working group for Indoor Air of Austrian Ministry of Agriculture, Environment and Water. September 26, 2011

10. Allergy – the immune system overreacts. 3rd Autumn School “Current Concepts in Immunology” by the German Society of Immunology. Bad Schandau, October 12, 2011.

11. Comparative Medicine – challenge and chance for translational studies. SFB-Transregio22 Symposium, Lübeck, Germany. 28. October 2011.

12. The Messerli Research Institute. 2nd Retreat of the Center of Pathophysiology, Infectiology and Immunology. September 27, 2011.

13. Comparative Medicine – Speeding up drug development. 45. Annual Meeting of the Society of Parasitology and Tropical Medicine. Society of Physicians, Vienna. November 17, 2011.

14. Allergische Reaktionen durch Duftöle in Nebelmaschinen, 4. Meeting of the Special Dept. Chemicals in Products, Ministry of BMASK Vienna. October 18, 2011,

15. Krebsimpfstoffe, warum gibt es sie noch nicht? 26. pädiatrischer Samstag, University of Linz, Austria. November 19, 2011.

16. Eine Medizin für Mensch und Tier. Vergleichende Medizin als Chance. Vienna Science Lecture. Vienna, Austria. November 23, 2011.

Eva Untersmayr

1. Food allergy and beyond: IgE and the intestine. Munich Allergy Research Center Seminar, ZAUM, TU München (15. März 2011, München, Deutschland)

2. Functional Food 2.0 – Lebensmittel auf Krankenschein? Immunologische Aspekte. BILLA Special Lecture „Functional Food 2.0 – Lebensmittel auf Krankenschein“. Gesundheitsgespräche des Europäischen Forum Alpbach (19.08.2011, Alpbach, Österreich)


22

Enikö Kallay 1. 2011, May 3-5 Beirut & Byblos, Lebanon: Keynote Speaker at the Conference:

Research Trends in Food Safety & Security. “New Trends in the Physiology of Vitamin D”.

2. 2011, May 3-5 Beirut & Byblos, Lebanon: Keynote Speaker at the Conference: Research Trends in Food Safety & Security. “Vitamin D and Cancer: The New State of the Art“

3. 2011. May. 18th BMA House, London, UK, International Meeting: Vitamin D & Cancer - Treatment & Prevention. “Vitamin D and cancer: promise or reality”.

1.1.4. Congress organization

Division member Name:

National congress Name, date

Function

Intern. congress, Name, date

Function

Enikö Kallay - - Multifaceted CaSR Cancer WP meeting

04/26/2011

Host, Organisation

1.1.5. Hosting speakers

division member Speaker´s name Affiliation Date

Erika Jensen-Jarolim Prof. Dr. Ursula Wiedermann Inst. für Spez. Prophylaxe und Tropenmedizin, MeduniWien

04/19/2011

Erika Jensen-Jarolim Prof. Dr. Maria Sibilia

Comprehensive Cancer Center MeduniWien

05/31/2011

Erika Jensen-Jarolim Dr. Barbara Wollenberg Univ. Klinikum Lübeck 07/07/2011

Erika Jensen-Jarolim Prof. Dr. Ludwig Huber Messerli Research Institute, Vienna

14/11/2011

Diana Mechtcheriakova

Dr. Philip Zimmermann ETH Zürich/Nebion, Zürich 04/07/2011


DI Radu Rogojanu TissueGnostics, Vienna 04/13/2011

1.1.6. Mobility

Name Program University, Land Time frame Division In Out

Vera Elisabeth Assmann

FWF Paris Lodron Universität, Salzburg

04/11/2011-05/06/2011

1 x

1.1.7. Activities in Advisory Boards

Name Society/Institute/Journal Function Erika Jensen-Jarolim Medical University Vienna Member of Senate


23

Erika Jensen-Jarolim




Research Center Borstel

Until May 2011: University Council of the Veterinary

University Vienna

Wiener Wirtschaftsförderungs- und Technologiefonds (WWTF)

Science jury of the county of

Lower Austria

Member of Advisory Board

Deputy Chair of Council

Kuratorium

Juror

1.1.8. Editorial Activities

Name Journal Function







Isabella Pali-Schöll

WAO Journal

Wiener Med. Wochenschrift

Int. Archs Allergy & Immunology

Allergo Journal

Immunology Letters

The Open Allergy Journal

Bentham Science Publisher

Associate Editor

Associate Editor

Associate Editor

Associate Editor

Associate Editor

Associate Editor

reviewer for the e-book proposal “Immunology of Pregnancy”

1.1.9. Review Activities

Name Grants/Thesis/Habilitation

Jensen-Jarolim Medizinisch Wissenschaftlicher Fonds des Bürgermeisters der Stadt

Wien (2x)

Jensen-Jarolim Jubiläumsfonds der Österreichischen Nationalbank

Jensen-Jarolim Belgian Research Fund FWG

Jensen-Jarolim Wissenschaftspreise Niederösterreich

Jensen-Jarolim SFB/TR22, Marburg, Germany

Jensen-Jarolim LOEWE Schwerpunkt “Tumor und Entzündung” Hessen, Germany

Jensen-Jarolim Professorship (Marburg, Germany)

Jensen-Jarolim Professorship (Wayne State University)

Jensen-Jarolim Professorship (UCLA, CA, USA)

Jensen-Jarolim Master Thesis (Romina Kalod, VetmeduniVienna)

Jensen-Jarolim Bachelor Thesis (H. Szöllösi, VetmeduniVienna)

Kallay Bürgermeisterfond

Kallay Research Foundation Flanders

Kallay K.U. Leuven: Junior Research Professorship

Kallay Cancer Research UK


24

1.1.10. Filed and granted patents not disclosed

Name Patent

1.1.11. Grants Funding agency Title of project Principal investigator

FWF, doctoral college, CCHD

Cellular interactions decisive for immune response to oral antigens


FWF Allergen mimotopes for epitope studies and vaccination. III.


Biomedical International R&D GmbH

Proof of Concept-Studien für Mimotop Impfstoffe I. Erika Jensen-Jarolim

Biomedical International R&D GmbH

Proof of Concept-Studien für Mimotop Impfstoffe II. Erika Jensen-Jarolim

FWF Targeting ERbB-1 and ERbB-2 overexpressed in cancer of dog by passive immunotherapy with lgG versus lgE antibodies. passive immunotherapy with lgG versus lgE antibodies.


FWF Development of mimotope vaccines for preclinical and comparative medicine studies. comparative medicine studies.


FWF Is cyp24a1 a proto-oncogene? A novel role for the catabolic vitamin D3 hydroxylase in colorectal tumourigenesis

Enikö Kallay

Herzfelder’sche Familienstiftung

Is the calcium sensing receptor a tumour suppressor in colorectal cancer?

Enikö Kallay

EU-Marie Curie The role of the Calcium Sensing Receptor (CaSR) in health and diseases, implications for translational medicine.

Enikö Kallay

FWF Activation-induced cytidine deaminase (AID): from inflammation to solid cancer.


FWF Signature of sphingolipid-related genes in cancer Diana Mechtcheriakova

FWF, Hertha Firnberg

Anti-acids induce food allergy in newborns Isabella Pali-Schöll

FFG, Bionanoinitiative Österreich

Nanohealth - NanoVac Isabella Pali-Schöll, Erika Jensen-Jarolim

FWF The impact of protein nitration on food allergy induction.

Eva Untersmayr-Elsenhuber

FWF Microparticles for oral immunotherapy of type I food allergy

Eva Untersmayr-Elsenhuber

1.1.12. Career Developments a) Habilitations: n = 0 b) Habilitations in progress: n = 0


25

c) Professorships: n= 1

Joint Professorship for Comparative Medicine to Erika Jensen-Jarolim, at Messerli Research Institute of the Veterinary University Vienna, Medical University Vienna and University Vienna.

d) Qualification Agreement: n= 0

1.1.13. Teaching a) Bachelor students: n = 1 Isabella Pali-Schöll: Helen Szöllösi: 100% Bachelor thesis (01/02/2011 – 31/07/2011), “Protamine-based nanoparticles with CpG-Oligodesoxynucleotidies as a suitable carrier system for the induction of a Th1-mediated immune response” b) Diploma, MDiploma and Master students: n = 7 Erika Jensen-Jarolim: Kathrin Thell: MSc Thesis. Proof of concept studies of tumor mimotope vaccines (start 2010 - ongoing). Medical University Vienna

Kinkel Janis: MDiploma Thesis: Das Sensibilisierungspotenzial von durch Prozessierung veränderten Nahrungsmitteln. 2009-Ongoing. Medical University of Vienna.

Felix Ferdinand: MDiploma Thesis: Der Einfluss von Prozessierung auf die Allergenität von Nahrungs-Proteinen. 2009-Ongoing. Medical University of Vienna. Diana Mechtcheriakova: Tamara Kaufmann: Diploma Thesis: Activation-induced cytidine deaminase (AID): potential novel biomarker and/or target during epithelial-to-mesenchymal transition program. 2011-Ongoing University of Vienna Eva Untersmayr: Kristina Kreiner: 100% Bachelorarbeit (01/04/2011 - 30/09/2011), "The role of sphingomyelin and its metabolites in the development of food allergies“

Vera Elisabeth Assmann: 100% Diplomand (01/04/2011 – ongoing), "Intestinal bacterial composition contributes to food allergy elicited by gastric acid suppression in a murine model“

Kristina Kreiner: 100% Diplomand (01/10/2011 – ongoing), "Prophylactic application of functionalized microparticles for prevention of food allergy“


26

c) PhD, MDSci, MD students: n = 19

Erika Jensen-Jarolim: Caroline Stremnitzer: PhD thesis: Molecular characteristics and biology of house dust mite allergens Der p1 and 2 (start: 2010 - ongoing). Medical University Vienna

Hadzijusufovic Emir: PhD thesis: Targeted therapy of mast cell neoplasms. (Start: 2008 - 2011). University of Veterinary Medicine Vienna.

Singer Josef: PhD thesis: The role of IgE in cancer and allergy. (2010 - ongoing). Medical University of Vienna.

Krishnamurthy Durga: PhD thesis: The role of the liver in the induction and control of food allergy. (Start: 10/2007 - in progress). Medical University of Vienna.

Starkl Philipp: PhD thesis: Cellular and molecular mechanisms of the intestinal uptake of food allergens. (01/2007 - 09/2011). Medical University of Vienna.

Lukschal Anna: PhD thesis: Epitop specific IgE detection. (2008 - in progress). Medical University of Vienna.

Weichselbaumer Marlene: DVM Thesis: Immunization with carcinoembryonic antigen (CEA) mimotope vaccine inhibits growth of CEA positive mammary carcinomas in canine patients. (2008 - 2011). University of Veterinary Medicine Vienna.

Bevyl Isabella: Co-Supervisor; The role of plasma surfactant protein D in lung transplant recipients during rejection and infection. Medical University of Vienna. Eva Untersmayr: Susanne Diesner: PhD Dissertation 50%: Perspectives on immunomodulation of the Th2 biased immune response in early life“ (10/2008 – ongoing)

Philipp Starkl: PhD Dissertation: 30%: “Molecular Allergology: Sudies on Allergen-Enterocyte Interaction, Sensitization and Effector Mechanisms” (12/2006 – 09/2011) Enikö Kallay: Nittke Thomas: PhD Thesis: Nutritional impact on vitamin D receptor and pregnane X receptor-dependent regulation for prevention of colon tumourgenesis (09/2006 – in progress). Medical University of Vienna.

Julia Höbaus: PhD Thesis: Mechanisms of 25-Hydroxyvitamin D3-24-Hydroxylase Overexpression in Colorectal Cancer (in progress)

Doris Hummel: PhD Thesis: Is the vitamin D 25 hydroxylase an oncogene? (in Progress)


27

Ursula Thiem: Co-Supervisor: Vitamin D and the immune system: Evaluation of the effects of high-dose vitamin D3 therapy in the immune response in vitamin D deficient kidney transplant recipients.

Irfete Fetahu: PhD Thesis: “Regulators of the Calcium Sensing Receptor in colorectal cancer”

Samawansha Tennakoon: PhD Thesis: "Ligand-dependent CaSR signalling in colonocytes"

Abishek Aggarwal: PhD Thesis: "Role of CaSR in proliferation of Colon Cancer Cells" Diana Mechtcheriakova: Anastasia Meshcheryakova: PhD Thesis: “Definition of novel breakpoints in the sphingolipid machinery associated with malignancy” (08/2011 - in progress) Medical University of Vienna.

1.1.14. Exams a) Oral examinations: n = 2 b) Bachelor, Diploma and Thesis-Examinations: n= 10 Evelyn Dixit, Diploma Thesis (MedUniWien)

Evren Karayel, Diploma Thesis (MedUniWien)

Jörg Puffing, Diploma Thesis, 27.04.2010.

Helen Szöllösi, Bachelor Thesis, 28.09.2011

Ursula Thiem, Diploma Thesis, 08.07.2010; Matrikelnummer: 0351588.

Almira Kovacevic, MD Diplom-Prüfungen (MedUniWien)

Sabrina Weiss, MD Diplom-Prüfungen (MedUniWien)

Nergius Rehan Ghanin, MD Diplom-Prüfungen (MedUniWien)

DVM Diss: S. Liederer (VetmedUni)

Leticia Tordesillas Villuendas, PhD (Univ. Madrid)

c) Exam supervising: n=14

Performance Report 2011 – Division 1 Comparative Immunology and Oncology

28

1.1.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr.

SS 2011 Jensen-Jarolim Erika 4.00 1.00 808.004 SSM 3 Projektstudie (Wahlpflichtteil)

Jensen-Jarolim Erika 4.00 0.28 860.117 Basic Seminar CCHD

Jensen-Jarolim Erika 6.00 0.11 860.202 CCHD Doctoral Seminar

Jensen-Jarolim Erika 2.00 0.67 902.707 Journal Club und Progress Report – New developments

Jensen-Jarolim Erika 2.00 0.07 902.708 Basisvorlesung Immunologie

Jensen-Jarolim Erika 2.00 0.03 902.733 CCHD Journal Club

Kallay Enikö 2.00 0.23 860.400 Basic Seminar Malignant Diseases II

Kallay Enikö 1.00 0.33 860.034 Journal Club (N090, N094 and N0790)

Mechtcheriakova Diana 2.00 0.66 902.707 Journal Club and Progress Report – New developments

Mechtcheriakova Diana 6.00 0.06 860.202 CCHD Doctoral Seminar

Mechtcheriakova Diana 2.00 0.04 902.733 CCHD Journal Club

Pali-Schöll Isabella 2.00 0.40 648.010 Dissertantenseminar: New Developments and highlights in allergolocy, oncology and immunology

Pali-Schöll Isabella 2.00 0.40 648.029 Progress Report in Experimental Immunology and Oncology

Pali-Schöll Isabella 3.00 1.00 648.950 Immunpathologisches Seminar – Immunpathologisches Seminar (Wahlausbildung gem. § 13/1 lit.a StG.)

Pali-Schöll Isabella 2.00 0.10 860.971 CCHD Journal Club – SS 2011

Pali-Schöll Isabella 2.67 0.15 891.016 Module I – Immunologie, Allergologie, Onkologie

Untersmayr-Elsenhuber Eva 2.00 0.40 648.010 Dissertantenseminar: New Developments and highlights in allergolocy, oncology and immunology

Untersmayr-Elsenhuber Eva 2.00 0.40 648.029 Progress Report in Experimental Immunology and Oncology

Untersmayr-Elsenhuber Eva 5.00 2.00 648.031 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten gem. § 13/1 lit. a StG)

Untersmayr-Elsenhuber Eva 3.00 1.00 648.950 Immunpathologisches Seminar - Immunpathologisches Seminar (Wahlausbildung gem. § 13/1 lit.a StG.)

Untersmayr-Elsenhuber Eva 2.00 0.10 860.971 CCHD Journal Club - SS 2011

Untersmayr-Elsenhuber Eva 3.00 0.21 896.005 Gender - Basics in Gender Medizin

Untersmayr-Elsenhuber Eva 2.00 0.50 902.707 Journal Club und Progress Report - New developments and highlights in allergology, oncology and immunology

Sum 10.14


29

WS 2011/12 Jensen-Jarolim Erika 2.00 0.18 502.282 Propedeutics in Human Medicine III – Linking Biology and Medicine

Jensen-Jarolim Erika 1.00 0.25 514.094 Pathophysiologie der Allergie

Jensen-Jarolim Erika 2.00 0.20 562.019 BVo: Immunologie

Jensen-Jarolim Erika 3.00 0.75 648.011 Immunpathologische Laboratoriumstechnik mit Demonstrationen

Jensen-Jarolim Erika 5.00 2.50 648.012 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten)

Jensen-Jarolim Erika 5.8 0.40 803.002 BL8-Krankheit, Krankheitsursachen und Krankheitsbilder

Jensen-Jarolim Erika 2.00 0.67 860.057 Journal Club und Progress Report

Jensen-Jarolim Erika 2.00 0.50 860.079 Dissertantenseminar: New Developments and highlights in allergology, oncology and immunology

Jensen-Jarolim Erika 4.00 0.28 860.117 Basic Seminar CCHD

Jensen-Jarolim Erika 6.00 0.11 860.600 DTS CCHD Doctoral Seminar – WS 2010

Jensen-Jarolim Erika 2.00 0.14 860.946 JC CCHD WS 2010

Jensen-Jarolim Erika 2.00 0.02 902.563 Progress Report in Experimental Immunology and Oncology

Kallay Enikö 5.00 5.00 514.051 Wachstumsregulation humaner Kolontumorzellen - (Wahlfachausbildung gem. § 13 StG)

Kallay Enikö 5.80 0.27 803.002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Kallay Enikö 2.20 1.07 803.003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Kallay Enikö 2.00 2.00 803.009 Problemorientiertes Lernen - 3. Semester

Kallay Enikö 1.00 0.33 860.011 Creative and critical Journal Club I

Kallay Enikö 2.00 0.40 860.061 TS: New Developments and comparative aspects in allergology, oncology and immunology

Kallay Enikö 2.00 0.20 860.966 Basisseminar Zelluläre Signaltransduktion

Pali-Schöll Isabella 1.00 0.20 514.094 Pathophysiologie der Allergie

Pali-Schöll Isabella 3.00 0.09 805.000 BL13-Ernährung und Verdauung

Pali-Schöll Isabella 2.00 0.40 860.061 TS: New Developments and comparative aspects in allergology, oncology and immunology

Pali-Schöll Isabella 2.00 0.29 860.060 JC New Developments and comparative aspects in allergology, oncology and immunology

Pali-Schöll Isabella 6.00 0.24 860.600 DTS CCHD Doctoral Seminar

Mechtcheriakova Diana 3.00 0.75 648.011 Immunopathologische Laboratoriumstechnik mit Demonstrationen

Mechtcheriakova Diana 2.00 0.66 860.057 Journal Club and Progress Report

Mechtcheriakova Diana 2.00 0.50 860.079 Dissertantenseminar: New Developments and highlights in allergology, oncology and immunology

https://campus.meduniwien.ac.at/med.campus/lv.detail?clvnr=262598&sprache=1

https://campus.meduniwien.ac.at/med.campus/lv.detail?clvnr=262664&sprache=1


30

Mechtcheriakova Diana 6.00 0.06 860.600 DTS CCHD Doctoral Seminar

Mechtcheriakova Diana 2.00 0.04 860.946 JC CCHD WS2010

Mechtcheriakova Diana 2.00 0.66 902.563 Progress Report in Experimental Immunology and Oncology

Untersmayr-Elsenhuber Eva 1.00 0.50 514.094 Pathophysiologie der Allergie

Untersmayr-Elsenhuber Eva 3.00 1.00 648.011 Immunpathologische Laboratoriumstechnik - mit Demonstrationen (Wahlfach gem. § 13/1 lit. a StG)

Untersmayr-Elsenhuber Eva 5.00 2.50 648.012 Wissenschaftliche Arbeiten (Wahlfach für Dissertanten gem. § 13/1 lit. a StG)

Untersmayr-Elsenhuber Eva 2.00 0.29 860.060 JC New Developments and comparative aspects in allergology, oncology and immunology

Untersmayr-Elsenhuber Eva 2.00 0.40 860.061 TS: New Developments and comparative aspects in allergology, oncology and immunology

Untersmayr-Elsenhuber Eva 1.00 800.000 Senior-Mentoring Humanmedizin

Untersmayr-Elsenhuber Eva 6.00 0.29 860.599 TS: CCHD Doctoral Seminar - WS 2011

Sum 24.14

Total sum SS+WS 34.28

https://campus.meduniwien.ac.at/med.campus/lv.detail?cperson_nr=97687&clvnr=262598

Performance Report 2011 Cellular and Molecular Pathophysiology

31

1.2. Division for Cellular and Molecular Pathophysiology Head: Peter Pietschmann, MD, Associate Professor

1. Publications5

IF Number Top/Std/Subst

Isabella Ellinger 2.423 1 1x St

Renate Fuchs 3.305 1 1x St

Peter Pietschmann 20.421 7.2 1x Top, 5x St, 1x SSt

Theresia Thalhammer 28.148 10.2 1xTop 8x St, 1xSSt

Sum Division 54.297 19.4

Top point score 2 – among top 20 % of journal in field

Standard point score 1 – between 21-60 %, Substandard point score 0,2

2. Supervision of bachelor, diploma and doctoral students

Bachelor st. Diploma st. Doctoral st.

Isabella Ellinger 1 0 2 Renate Fuchs 1 2 0 Peter Pietschmann 0 7 3

Theresia Thalhammer 3 13 3

Sum 5 22 8


Isabella Ellinger 1.67 10.08 11.75 0 Renate Fuchs 1.84 11.93 13.77 0 Peter Pietschmann 4.91 6.41 11.32 3

Theresia Thalhammer 6.99 5.66 12.65 0

Sum 15.41 34.08 49.49 3




32

1.2.1. Publications a) Peer-reviewed original articles: n = 16


1. Patsch, J.M., F.W. Kiefer, P. Varga, P. Pail, M. Rauner, D. Stupphann, H. Resch, D. Moser, P.K. Zysset, TM Stulnig, and P. Pietschmann. Increased bone resorption and impaired bone microarchitecture in short-termin and extended high-fat-diet induced obesity. Metabolism, 2011, 60 (2):243-249

2.538 St

2. Patsch, J.M., T. Kohler, A. Berzlanovich, C. Muschitz, C. Bieglmayr, P. Roschger, H. Resch, and P. Pietschmann. Trabecular bone microstructure and local gene expression in iliac crest biopsies of men with idiopathic osteoporosis. J Bone

Miner Res, 2011, 26 (7):1584-1592. doi: 10.1002/jbmr.344.

7.084 Top

3. Sipos, W. E. Kralicek, M. Rauner, C. Duvigneau, H. Worliczek, D. Schamall, R. Hartl, I. Sommerfeld-Stur, E. Dall’Ara, P. Varga, H. Resch, P. Zyssett, and P. Pietschmann. Bone and cellular immune system of multiparous sows are insensitive to ovariectomy and nutritive calcium shortage. Horm Metab Res, 2011, 43:404-409

2.414 St

4. Sipos, W., P. Zysset, P. C. Kostenuik, E. Mayrhofer, C. Bogdan, M. Rauner, M. Stolina, D. Dwyer, I. Sommerfeld-Stur, G. Pendl, H. Resch, E. Dall’Ara, P. Varga, and P. Pietschmann. OPG-Fc treatment in growing pigs leads to rapid reduction in bone resorption markers, serum calcium, and bone formation markers. Horm Metab Res, 2011, 43:944-949

2.414 St

5. Kubista, B., F. Klinglmüller, M. Bilban, M. Pfeiffer, R. Lass, A. Giurea, P.T. Funovics, C. Toma, M. Dominkus, R. Kotz, T. Thalhammer, K. Trieb, T. Zettl, and C.F. Singer. Microarray analysis identifies dinstinct gene expression profiles associated with histological subtype in human osteosarcoma. Int Orthop, 2011, 35(3):401-411. doi: 10.1007/s00264-010-0996-6

1.561 St

6. Wlcek, K., M. Svoboda, J. Riha, S. Zakaria, U. Olszewski, Z. Dvorak, F. Sellner, I. Ellinger, W. Jäger, and T. Thalhammer. The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer. Cancer Biol Ther, 2011, 11(9):801-811. http://dx.doi.org/10.4161/cbt.11.9.15176

2.907 St

7. Rögelsperger, O., K. Wlcek, C. Ekmekcioglu, S. Humpeler, M. Svoboda, R. Königsberg, M. Klimpfinger, W. Jäger, and T. Thalhammer. Melatonin receptors, melatonin metabolizing enzymes and cyclin D1 in human breast cancer. J Recept Signal Transduct Res, 2011, 31(2):180-187. PMID:21385053

1.822 St

8. Böhmdorfer, M., A. Maier-Salamon, B. Taferner, G. Reznicek, T. Thalhammer, S. Hering, A. Hüfner, W. Schühly, and W. Jäger. In vitro metabolism and disposition of honokiol in rat and human livers. J Pharm Sci, 2011, 100(8):3506-3516. doi:10.1002/jps.22536

3.031 St

9. Maier-Salamon, A., M. Böhmdorfer, T. Thalhammer, T. Szekeres, and W.Jäger. Hepatic glucuronidation of resveratrol: interspecies comparison of enzyme kinetic profiles in human,

2.558 St


33

mouse, rat, and dog. Drug Metab Pharmacokinet, 2011, 26(4):364-373.PMID:21512262

10. Kounnis, V., E. Ioachim, M. Svoboda, A. Tzakos, I. Sainis, T. Thalhammer, G. Steiner, and E. Briasoulis. Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals an new class of potential therapeutic targets. Onco Targets Ther, 2011, 4:27-32.

0.176 SSt.

11. Svoboda, M., K. Wlcek, B. Taferner, S. Hering, B. Stieger, D. Tong, R. Zeillinger, T. Thalhammer, and W. Jäger. Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport. Biomed Pharmacother, 2011, 65(6):417-426. PMID:21719246

2.208 St.

12. Schmid, D., M. Svoboda, A. Sorgner, I. Moravcevic, T. Thalhammer, P. Chiba, and T. Möslinger. Glibenclamide reduces proinflammatory cytokines in an ex vivo model of human endotoxinaemia under hypoxaemic conditions. Life Sci, 2011, 7:89(19-20):725-734. PMID:21925514

2.451 St.

13. Nemeth, C., S. Humpeler, E. Kallay, I. Mesteri, M. Svoboda, O. Rögelsperger, N. Klammer, T. Thalhammer, and C. Ekmekcioglu. Decreased expression of the melatonin receptor 1 in human colorectal adenocarcinomas. J Biol Regul Homeost Agents, 2011, 25(4):531-542. PMID:22217986

2.825 St.

14. Schulten, V., I. Lauer, S. Scheurer, T. Thalhammer, and B. Bohle. A food matrix reduces digestion and absorption of food allergens in vivo. Mol Nutr Food Res, 2011, 55(10):1484-1491. doi:10.1002/mnfr.201100234

4.713 Top

15. Khan, A.G., A. Pickl-Herk, L. Gajdzik, T.C. Marlovits, R. Fuchs, and D. Blaas. Entry of a heparan sulphate-binding HRV8 variant strictly depends on dynamin but not on clathring, caveolin, and flotillin. Virology, 2011, 412(1):55-67. PMID:21262518

3.305 St.

16. Schepelmann, M., L. Molcan, H. Uhrova, M. Zeman, and I. Ellinger. The presence and localization of melatonin receptors in the rat aorta. Cell Mol Neurobiol, 2011, 31(8):1257-65. doi.10.1007/s10571-011-9727-9

2.423 St.

sum 44.43 b) Invited Articles & Reviews with IF: n = 4 Nr. Article IF Class

1. Diesner S.C., E. Untersmayr, P. Pietschmann, E. Jensen-Jarolim. Food allergy: Only a pediatric disease? Gerontology, 2011, 57(1):28-32

2.203 St.

2. Azizi-Semrad U., J. Grillari, B. Grubek-Loebenstein, P. Pietschmann. Biogerontology in Austria. Biogerontology, 2011, 12(1):3-10

3.411 St.

3. Kerschan-Schindl K., P. Pietschmann. Rehabilitation bei Osteoporose. Phys Med Rehab Kuror, 2011, 21:139-150

0.357 SSt.

4. Svoboda, M., J Riha, K. Wcek, W. Jäger, and T. Thalhammer. Organic anion transporting polypeptides (OATPs): regulation of expression and function. Curr Drug Metab, 2011, 12(2):139-153. PMID:21395542

3.896 St.

sum 9.867


34

c) Invited Articles & Reviews without IF: n = 3 1. Patsch J.M., J. Deutschmann, P. Pietschmann. Gender aspects of osteoporosis

and bone strength. Wien Med Wochenschr, 2011,161/5-6:117-123

2. Bröll H., H. Resch, P. Bernecker, M. Blauth, H. Concin, P. Dimai, H. Dobnig, L. Erlacher, A. Fahrleitner-Pammer, R. Gasser, M. Herold, G. Holzer, J. Huber, B. Jilma, M. Kraenzlin, B. Leeb, S. Leodolter, H. Minne J. Patsch, P. Pietschmann, E. Preisinger, R. Windhager. Experten Statement (2011) Denosumab – aktueller Stellenwert in der Osteoporosebehandlung. Österreichische Ärztezeitung, 2011, (6):2-7

3. Bröll J., H. Resch, P. Bernecker, H. Concin, P. Dimai, H. Dobnig, L. Erlacher, A. Fahrleitner-Pammer, R. Gasser, M. Herold, L.C. Hofbauer, G. Holzer, J. Huber, M. Köller, M. Kränzlin, S. Leodolter, R. Maier, P.F. Peichl, M. Peterlik, P. Pietschmann, E. Preisinger, A. Rieder, A. Wicker, R. Windhager. Konsensus Osteoporose – Prävention & Therapie. Österreichische Ärztezeitung, 2011, (12):3-16

d) Book contributions: n = 9

1. Patsch J, P. Pietschmann. Degenerative und altersassoziierte Erkrankungen. In:

Marian B (ed). Krankheit, Krankheitsursachen und –bilder (MCW Block 8). Facultas Verlag 2011, pp. 422-426

2. Erlacher I, Azizi-Semrad U, Pietschmann P. Bausteine des Bindegewebes. In: Dunky A, Graninger W, Herold M, Smolen J, Wanivenhaus A (eds).Praktische Rheumatologie. SpringerWienNewYork 2011, pp. 9-13

3. Heindl A, Schepelmann M, Ecker R, Pietschmann P, Ellinger I, Seewald AK, Thalhammer T. Towards the automated detection and characterization of osteoclasts in microscopic images. In: Pietschmann P (ed). Principles of Osteoimmunology – Molecular Mechanisms and Clinical Applications. SpringerWienNewYork 2011, pp. 27-48

4. Azizi-Semrad U, Pietschmann P, Willheim M. Effects of vitamin D in the immue system. In: Pietschmann P (ed). Principles of Osteoimmunology – Molecular Mechanisms and Clinical Applications. SpringerWienNewYork 2011, pp. 63-90

5. Bertl K, Pietschmann P, Matejka M. Osteoimmunological aspects of peridontal diseases. In: Pietschmann P (ed). Principles of Osteoimmunology – Molecular Mechanisms and Clinical Applications. SpringerWienNewYork 2011, pp. 241-267

6. Patsch J: RANKL und Osteoprotegerin in der Pathogenese der Osteoporose. In: Pietschmann P (ed): Osteoimmunologie – Zytokine und Biologika in der Osteologie. UNI-MED Verlag Bremen – London – Boston, 2011, 2nd edition, pp 66-72

7. Pietschmann P, Nanoff C, Dudczak R, Kainberger F: Knochen- und Kalzium-Stoffwechsel. In: Ludvik B, Bischof M, Kraupp M, Luger A (eds): Endokrinologie und Stoffwechsel, Facultas Verlag 2011, 5nd edition, pp 195-208

8. Pietschmann P: Autoimmunendokrinologie. In: Ludvik B, Bischof M, Kraupp M, Luger A (eds): Endokrinologie und Stoffwechsel, Facultas Verlag 2011, 5nd edition, pp 209-216

9. Pietschmann P, Kerschan-Schindl K, Redlich K, Aringer M: Osteoporose und weitere metabolische Osteopathien. In: Stummvoll G, Pretterklieber ML, Kainberger F(eds): Bewegung und Leistung (MCW Block 21), Facultas Verlag 2011, 8nd edition, pp 172-184


35

e) Abstracts, printed in periodicals: n = 9

1. Schepelmann M, Heindl A, Seewald A , Nussbaumer A, Bises G, Rogojanu R, Pietschmann P, Ellinger I , Thalhammer T (2011). Influence of melatonin on murine osteoclast formation in culture – Automated detection and quantification by a novel image analysis system. Bone 48: P112-S, p. 133

2. Heindl A, Schepelmann M, Stumberger R, Nussbaumer A, Pietschmann P, Bises G, Rogojanu R, Thalhammer T, Seewald A, Ellinger I (2011). Automated detection, quantification and characterization of osteoclasts in cultures using a combined image-processing and machine-learning strategy. Bone 48:PP082-S, p. 125

3. Schepelmann M, Heindl A, Uhrova H, Pohl V, Rogojanu R, Seewald A, Helmer H, Ellinger I (2011). The neonatal IgG Fc-receptor (FcRn) is expressed in the syncytiotrtophoblast, fetal endothelial cells and Hofbauer cells of human term placental chorionic villi. Placenta 32(9):A54

4. Sipos W, Kralicek E, Rauner M, Duvigneau CJ, Worliczek HL, Schamall D, Hartl RT, Sommerfeld-Stur I, Dall’Ara E, Varga P, Resch H, Zysset P, Pietschmann P (2011). The skeleton of multiparous sows is protected from effects of ovariectomy and calcium deprivation. Bone 48:P313-S, p. 198

5. Föger-Samwald U, Patsch JM, Deutschmann J, Hornek L, Salem S, Becker P, Pail P, Schamall D, Mousavi M, Becker S, Kainberger FM, Pietschmann P (2011). Gene expression and bone architecture in men with osteoporotic hip fractures. Journal für Mineralstoffwechsel 18 (3), p. 7

6. Heindl A, Schepelmann M, Seewald A, Burger K, Bises , Rogojanu R, Ecker R, Pietschmann P, Thalhammer T, Ellinger I (2011) A machine learning-based approach to automatically discriminate In Silicio murine osteoclasts and their precursor cells by nuclei-based features. Journal für Mineralstoffwechsel 18 (3), p. 8

7. Kurz M, Rauner M, Brünner-Kubath C, Kapfenberger A, Föger-Samwald U, Schamall D, Varga P, Kudlacek S, Wutzl A, Höger H, Sipos W, Zysset PK, Shi GP, Pietschmann P (2011) Cathepsin S-deficient mice exhibit a bone and fat phenotype. Journal für Mineralstoffwechsel 18 (3), p. 10

8. Kerschan-Schindl I, Riss P, Krestan C, Rauner M, Bieglmayer C, Gleiss A, Fialka-Moser V, Niederle B, Pietschmann P (2011) Bone metabolism in patients with primary hyperparathyroidism before after surgery. Journal für Mineralstoffwechsel 18 (3), p. 10

9. Schamall D, Pietschmann P, Moser D, Dockner M, Teschler-Nicola M (2011) Monteggia fracture and multiple traumata in mediaeval skeletal remains analysed by µCT and histology. Journal für Mineralstoffwechsel 18 (3), p. 14

f) Abstracts, in congress proceedings or abstract books: n = 29 1. Brabec-Zaruba M, Niapir M, Ellinger I, Ellinger A, Blaas D, Fuchs R.

Characterization of human replication vesicles. 11th Hunter Meeting, Pokolbion, Australia, March 22-25, 2011, Abstract Book

2. Brabec-Zaruba M, Niapir M, Ellinger I, Ellinger A, Blaas D, Fuchs R. Characterization of human replication vesicles. (Poster) Gordon Research Conference „Viruses and Cells, Ciocco, Italy, May 29 – June 3, 2011

3. Schepelmann M, Heindl A, Seewald , Nussbaumer A, Bises G, Rogojanu R, Pietschmann P, Ellinger I , Thalhammer T. Influence of melatonin on murine osteoclast formation in culture – Automated detection and quantification by a novel image analysis system. 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, Athen, Greece, May 7-11


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4. Heindl A, Schepelmann M, Stumberger R, Nussbaumer A, Pietschmann P, Bises G, Rogojanu R, Thalhammer T, Seewald A, Ellinger I. Automated detection, quantification and characterization of osteoclasts in cultures using a combined image-processing and machine-learning strategy. 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, Athen, Greece, May 7-11

5. Sipos W, Kralicek E, Rauner M, Duvigneau CJ, Worliczek HL, Schamall D, Hartl RT, Sommerfeld-Stur I, Dall’Ara E, Varga P, Resch H, Zysset P, Pietschmann P. The skeleton of multiparous sows is protected from effects of ovariectomy and calcium deprivation. (Poster) 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, Athen, Greece, May 7-11, 2011

6. Svoboda M, Wlcek K, Riha J, Tong DC, Zeillinger R, Jäger W, Thalhammer T. OATP Transportproteine in hepatischen und extrahepatischen Tumoren. Bad Herrenalber Transporter- und Barriere-Tage 2011, Bad Herrenalb, Germany, June 1, 2011. Abstract Book.

7. Jäger W, Wlcek K, Svoboda M, Taferner B, Hering S, Thalhammer T. Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport (V07). CESAR Annual Meeting, Greifsfeld, Germany, June 16-18, 2011, abstract book

8. Heindl A, Schepelmann M, Pietschmann P, Bises G, Rogojanu R, Seewald A, Ellinger I, Thalhammer T. Automated detection of osteoclasts in-vitro in large-scale experiments using a combined image-processing and machine-learning approach. 7. PhD Symposium, Vienna, June 15-16, 2011. Abstracts S9, p. 44

9. Rogojanu R, Mesteri I, Ellinger I, Thalhammer T, Heindl A, Seewald A, Bises G, The relation between epithelial and stromal area is important for colorectal cancer diagnosis and therapeutic considerations. 7. PhD Symposium, Vienna, June 15-16, 2011. Abstracts P181, p. 144

10. Jäger W, Wlcek K, Svoboda M, Taferner B, Hering S, Thalhammer T. Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport (V07).(Poster). 7th International Research Conference “Membrane Transporters in Drug Discovery”, Grindelwald, Switherland, August, 7-11, 2011

11. Schepelmann M, Heindl A, Uhrova H, Pohl V, Rogojanu R, Seewald A, Helmer H, Ellinger I. The neonatal IgG Fc-receptor (FcRn) is expressed in the sycytiotrophoblast fetal endothelial cells and Hofbauer cells of human term placental chorionic villi. (Poster) 14th IFPA Meeting in Norway, September 14-17, 2011

12. Jungmann D, Gajdzik L, Blaas D, Fuchs R. The sodium-proton exchange inhibitor EIPA affects multiple steps in the replication cycle of human rhinovirus (HRV2) (Poster) EMBO Conference “Dynamic Endosomes – Mechanisms Controlling Endocytosis”, Kreta, Greece, September 25 – 28, 2011

13. Föger-Samwald U, Patsch JM, Deutschmann J, Hornek L, Salem S, Becker P, Pail P, Schamall D, Mousavi M, Becker S, Kainberger FM, Pietschmann P. Gene expression and bone architecture in men with osteoporotic hip fractures. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011

14. Kurz M, Rauner M, Brünner-Kubath C, Kapfenberger A, Föger-Samwald U, Schamall D, Varga P, Kudlacek S, Wutzl A, Höger H, Sipos W, Zysset PK, Shi GP, Pietschmann P. Cathepsin S-deficient mice exhibit a bone and fat phenotype. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011


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15. Schepelmann M, Heindl A, Uhrova H, Pohl V, Rogojanu R, Seewald A, Helmer H, Ellinger I. The neonatal IgG Fc-receptor (FcRn) is expressed in the sycytiotrophoblast fetal endothelial cells and Hofbauer cells of human term placental chorionic villi. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011

16. Heindl A, Thalhammer T, Bises G, Schepelmann M, Rogojanu R, Ecker R, Seewald A, Ellinger I. A versatile automated detection system for erythrocytes in human tissue sections. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011

17. Heindl A, Schepelmann M, Seewald A, Nussbaumer A, Bises G, Rogojanu R, Ecker R, Pietschmann P, Thalhammer T, Ellinger I. Automated nucle-based in silico discrimination of murine osteoclasts and their precursor cells. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011

18. Rogojanu R, Thiem U, Meseteri I, Ellinger I, Thalhammer T, Heindl A, Seewald A, Bises G. Epithelium/Stroma ratio in colorectal cancer: automated area detection and quantitative analysis. (Poster ) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011

19. Schepelmann M, Heindl A, Seewald A, Nussbaumer A, Bises G, Rogojanu R, Ecker P, Pietschmann P, Ellilnger I, Thalhammer T. Automated detection and quantification of osteoclasts in culture by a novel image analysis system – a pilot study on the influence of the hormone melatonin on osteoclast formation. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011

20. Thiem U., Rogojanu R, Meseteri I, Ellinger I, Thalhammer T, Heindl A, Seewald A, Bises G. Is intra-tumoral budding correlated with liver metastasis in patients with grade 2 colorectal cancer? – A pilot study. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011

21. Gajdzik L, Jungmann D, Blaas D, Fuchs R. The sodium-proton exchange inhibitor eipa affects multiple steps in the replication cycle of human rhinovirus 2 (HRV2). (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011

22. Svoboda M, Riha J, Jäger W, Castilo-Tong DC, Zeillilnger R, Van Gorp T, Vergot I, Braicu I, Sehouli J, Mahner S, Fogel M, Thalhammer T. OATP family members in ovarian cancer and their potential role in tumor therapy. 15th International Symposium on Molecular Medicine, Rhodos, Greece, October 6-8, 2011, printed abstract

23. Bises G, Mesteri I, Thiem U, Ellinger I, Thalhammer T, Heindl A, Seewald A, Rogojanu R. Automated quantitative analysis of epithelial and stromal area in colorectal cancer: putative application for the prognosis of cancer progression. 7th NCRI Cancer Conference , Liverpool, UK, November 6-9, 2011

24. Heindl A, Schepelmann M, Seewald A, Burger K, Bises , Rogojanu R, Ecker R, Pietschmann P, Thalhammer T, Ellinger I. A machine learning-based approach to automatically discriminate In Silicio murine osteoclasts and their precursor cells by nuclei-based features. (Poster) Wissenschaftliche Herbsttagung 2011 der Österr. Gesellschaft für Knochen und Mineralstoffwechsel, November 25 -26, 2011.

25. Kurz M, Rauner M, Brünner-Kubath C, Kapfenberger A, Föger-Samwald U, Schamall D, Varga P, Kudlacek S, Wutzl A, Höger H, Sipos W, Zysset PK, Shi GP, Pietschmann P. Cathepsin S-deficient mice exhibit a bone and fat phenotype. (Poster) Wissenschaftliche Herbsttagung 2011 der Österr. Gesellschaft für Knochen und Mineralstoffwechsel, November 25 – 26, 2011.


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26. Föger-Samwald U, Patsch JM, Deutschmann J, Hornek L, Salem S, Becker P, Pail P, Schamall D, Mousavi M, Becker S, Kainberger FM, Pietschmann P. Gene expression and bone architecture in men with osteoporotic hip fractures. (Poster) Wissenschaftliche Herbsttagung 2011 der Österr. Gesellschaft für Knochen und Mineralstoffwechsel, November 25 – 26, 2011.

27. Kerschan-Schindl I, Riss P, Krestan C, Rauner M, Bieglmayer C, Gleiss A, Fialka-Moser V, Niederle B, Pietschmann P (2011) Bone metabolism in patients with primary hyperparathyroidism before after surgery. Wissenschaftliche Herbsttagung 2011 der Österr. Gesellschaft für Knochen und Mineralstoffwechsel, November 25 – 26, 2011.

28. Schamall D, Pietschmann P, Moser D, Dockner M, Teschler-Nicola M. Monteggia fracture and multiple traumata in mediaeval skeletal remains analysed by µCT and histology. (Poster) Wissenschaftliche Herbsttagung 2011 der Österr. Gesellschaft für Knochen und Mineralstoffwechsel, November 25 – 26, 2011.

29. Jungmann D, Gajdzik L, Blaas D, Fuchs R. The sodium-proton exchange inhibitor EIPA affects multiple steps in the replication cycle of human rhinovirus (HRV2) (Poster) Fakultätsvorlesung, MUW, December 2, 2011

g) Teaching Scripts and Books: n = 2 1. Pietschmann P. Principles of Osteoimmunology – Molecular Mechanisms and

Clinical Applications. SpringerWienNewYork 2011

2. Pietschmann P. Osteoimmunologie – Zytokine und Biologika in der Osteologie. Uni-Med Verlag Bremen-London-Boston 2011, 2nd edition

h) Articles in Medical Journals: n = 0 i) Public activity n = 4 1. Interview Peter Pietschmann „Die Entzündung ist ein Hilfeschrei des Körpers“ Elf

Ärzte diskutieren- Wann braucht der Patient externes Kortison?, Ärzte Woche – Die österreichische Zeitung für Medizin, Politik und Praxis, Nr. 20, 19. Mai 2011, 25. Jahrgang

2. Interview Peter Pietschmann „Zur Beschleunigung der osteologischen Grundlagenforschung – Die ätiologischen Nebel lichten sich“, Spectrum Osteoporose, Seite 6-7, 1/2011

3. “Science Labs – erleben Sie Forschungslabors live – Osteoporose – Warum Knochen brechen – Zellen Zählen”, by Mag. Ursula Föger Samwald, etc. Science dabei – Das große Forschungsfest der MedUni Wien, 7.10.2011

4. Interview Peter Pietschmann “Es muss nicht immer Osteoporose sein”, Universum Innere Medizin, 09/11, Seite 89.

1.2.2. Research Awards: n = 4 1. Dr. Janina Patsch, Wissenschaftspreis 2011 der Österreichischen Gesellschaft für

Wirbelsäulenchirurgie für die Arbeit “Increased bone resorptio and impaired bone microarchitecture in short-term and extended hig-fat diet-induced obesity.

2. Dr. Isabella Ellinger, Nomination by the Medical University of Vienna for the Dr. Wolfgang Houska Price 2010, 24/01/2011

3. Dr. Isabella Ellinger, Science2business-Award at the Life-Science-Success 2011, Vienna, 15/03/2011


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4. DI Radu Rogojanu, Best poster presentation in poster workshop 17 at 7th PhD Symposium 2011, Vienna, 16/06/2011

1.2.3. Invited lectures: n = 38 Isabella Ellinger: 1. A new vista on disease pattern. Novel strategies in automated recognition of complex

tissue and cell structures using the TissueFAXSTM platform. TissueGnostics Tag-AKH, Wien, 30.03.2011

2. Cell-City“ – Was geht ab in der Zelle? Einführung in die Welt der Zellorganellen. Kinderuni, Vienna, 19.07.2011

3. Workshop „Cell-City“ für Volksschüler, Volksschule Julius Meinlgasse 1, 1160 Wien, 18.02.2011

4. Workshop „Cell-City“ für Volksschüler, Volksschule, Hauptstrasse 22, A-3423 Kritzendorf, 02.05.2011

5. Eine neue Sicht auf Krankheitsbilder. Sciencedabei Tag an der Medizinischen Universität Wien, 7.10.2011

6. Workshop „Forschen mit allen Sinnen“,Volksschule Julius Meinlgasse 1, 1160 Wien, 07.12.2011

Andreas Heindl:

1. Automated detection of osteoclasts in-vitro in large-scale experiments using a combined image-processing and machine-learning approach 7. PhD-Symposium Medical University of Vienna, June 15, 2011

2. A machine learning-based approach to automatically disriminate in silico murine osteoclasts and their precursor cells by nuclei-based features . Wissenschaftliche Herbsttagung der ÖGKM, November 2011

Janina Patsch: 1. Ergebnisse der TOMIBA-Studie. Wissenschaftliche Herbsttagung 2011, Wien, 26.

November 2011 Peter Pietschmann: 1. Geriatrie und Gerontologie in Österreich. Perspektiven – Pflegewissenschaft und

Geriatrie (ÖGGG), Haus der Barmherzigkeit, Wien, 28.1.2011

2. Denosumab in der Therapie der postmenopausalen Osteoporose. Osteo ÖGKM Kolleg, Wien, 8.3.2011

3. Physiologie und Pathophysiologie des Knochenstoffwechsels. Osteoporoseseminar 2011, Hafnersee/Keutschach, Kärnten, 18.3.2011

4. Neues in der Osteoporosetherapie. Osteoporoseseminar 2011, Hafnersee /Keutschach, Kärnten, 19.3.2011

5. Low Bone Turn over Frakturen. Osteologie 2011, Fürth, Deutschland, 26.3.2011

6. Spektrum der Osteoporosetherapie. MSD Conference Days 2011, St. Wolfgang, Oberösterreich, 2.4.2011

7. Update in der Osteoporose. Qualitätszirkel der gynäkologischen Kassenärzte, St. Pölten, 2.5.2011


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8. PROLIA – der neue Therapieansatz in der Osteoporose, 6. gemeinsamer österreichisch-deutscher Geriatriekongress Autonomie, Wien, 12.5.2011

9. Pathophysiologie des Knochenstoffwechsels – Genetik der Osteoporose. Zertifizierungskurs I – Osteoporose als wichtigste osteologische Erkrankung, Wien, 17.6.2011

10. Kalzium, Vitamin D und Derivate. Zertifizierungskurs I – Osteoporose als wichtigste osteologische Erkrankung, Wien, 17.6.2011

11. Epidemiologie und Pathophysiologie der Osteoporose. Jahrestagung 2011 der Österreichischen Gesellschaft für Pneumologie (ÖGP), Messe Wien, 9.9.2011

12. Osteoimmunologie. 42. Jahrestagung Innere Medizin mit Herz, Innsbruck, 6.10.2011

13. Kardiovaskuläres System und Knochen: Molekulare Grundlagen, 42. Jahrestagung Innere Medizin mit Herz, Innsbruck, 7.10.2011

14. Pathophysiologie und Differentialdiagnose der Osteoporose, 42. Jahrestagung Innere Medizin mit Herz, Innsbruck, 7.10.2011

15. Osteoporosetherapie der Geriatrie – eine interdisziplinäre Herausforderung, 1. Novartis Geriatrieforum, Irdning, 16. Oktober 2011

16. Aging of Bone. 5.International Scientific and Educational Osteological Symposium. 1. Symposium of Bioregenerative Medicine in Slovakia, Bratislava, Slowakei, 10. November 2011

17. Osteoporose – Bewährtes und neue Therapieoptionen. ÖAK Diplomlehrgang Geriatrie, Akademie der Ärzte, Wien, 12. November 2011

18. Regulationsmechanismen und Pathophysiologie des Knochens. Bone Academy: Neue Ansätze in der Osteoporosetherapie beim geriatrischen Patienten, Wien, 12. November 2011

19. Metabolische Knochenerkrankungen beim geriatrischen Patienten. Masterlehrgang Geriatrie WS 2011/SS2012, Modul B: Klinische Geriatrie. Haus der Barmherzigkeit, 16. November 2011

20. Generation von Osteoklasten und Osteoblasten. Wissenschaftliche Herbsttagung 2011, Wien, 26. November 2011

21. Osteoporose beim Mann – ein Blick in den männlichen Knochen. Die TOMIBA-Studie: Hintergrund und Studiendesign. Wissenschaftliche Herbsttagung 2011, Wien, 26. November 2011

Renate Fuchs: 22. Characterization of human rhinovirus replication vesicles. 11th Hunter Meeting,

Pokolbion, Australia, March, 22 – 25, 2011

23. Structure and function of the endocytic apparatus. Univ. Kinderklinik Gießen, Deutschland, October, 25-17, 2011

Theresia Thalhammer: 24. OATP transport proteins in liver, hepatic and extrahepatic tumors. ESF,

Vorlesungsreihe, Palacky Univeristy Olomouc, Czech Republic, Department of Cell Biology and Genetics, May 3 – 5, 2011

25. OATP Transportproteine in hepatischen und extrahepatischen Tumoren. 13. Bad Herrenalber Transporter- und Barriere Tage, Germany, June 1, 2011


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26. Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for pacltaxel transport (V07). Cesar Annual Meeting, University Greifswald, Germany, June 16-18, 2011

27. Members of the organic anion transporter family: Potential role in cancer progress. P.J. Safarik Univeristy, Kosice, June 20, 2011

28. OATP family members in ovarian cancer and their potential role in tumor therapy. 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine, Rhodos, Greece, October, 8, 2011

29. Arzneistoffmetabolismus - Grundlagen und klinische Anwendung (320067 VO). Sommersemester 2011, Department für Klinische Pharmazie und Diagnostik, Universität Wien




Function

Intern. congress,

Name, date

Function

Isabella Ellinger

WISIA Symposium Interdisziplinäres Symposium zur Vernetzung österreichischer Wissenschafterinnen aus Grundlagen-forschung, angewandter Forschung und Technik, Joanneum, Graz 03/04/2011–03/05/2011

organising committee

Isabella Ellinger

WISIA Symposium Interdisziplinäres Symposium zur Vernetzung österreichischer Wissenschafterinnen aus Grundlagen-forschung, angewandter Forschung und Technik, Medizinische Universität Wien 11/11/2011–11/12/2011

organising committee

Peter Pietschmann

Wissenschaftliche Herbsttagung 2011 der Österreichischen Gesellschaft für Knochen und Mineralstoffwechsel, 11/25/2011–11/26/2011

Congress co-president

1.2.5. Hosting speakers division member Speaker´s name Affiliation Date

Isabella Ellinger Theresia Thalhammer Renate Fuchs

Adolf Ellinger, PhD

Dept. Histol. Embryol. II/MedUniWien 01/21/2011

Isabella Ellinger Peter Pietschmann

Tim Skern, PhD Dept. Medical Biochemistry, Univ. Vienna

201/28/2011


Alexander Seewald, PhD

Seewald Solutions, Vienna 03/18/2011


Andrea Kolbus, MD

Technology Transfer, MedUniWien 04/08/2011

Isabella Ellinger Theresia Thalhammer

Monika Debreczeny; MD and PhD

BOKU, VIBT Imaging center 05/13/2011


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Renate Fuchs

Theresia Thalhammer Carsten Ehrhardt, Dr.

School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin, Ireland

09/30/2011

Theresia Thalhammer Lorenz Auer-Hackenberg, MD

Klinik für Dermatologie, MD Anderson Cancer Center, Dallas, USA

11/04/2011

Isabella Ellinger Theresia Thalhammer Renate Fuchs Peter Pietschmann

Alexander Seewald, PhD

Seewald Solutions, Vienna 11/25/2011

Theresia Thalhammer Simin Tavooni Tehran University of Medical Sciences, Teheran, Iran

12/09/2011

Isabella Ellinger Theresia Thalhammer Renate Fuchs Peter Pietschmann

Herbert Juch, MD Dept. Cell Biol., Histol. and Embryol., Medical University Graz

12/16/2011

1.2.6. Mobility

Name Program University, country Time frame Division In Out

Molcan Lubos Ernst-Mach-Stipendium der Aktion Österreich-Slowakei

Comenius University, Faculty of Sciences, Department of Animal Physiology and Ethology, Bratislava, Slovakia

10/01/2011-01/31/2012

2 x

Danka Obreshkova, Dr.

Erasmus Programme

Medical University of Sofia, Department of Pharmacological Chemistry, Faculty of Pharmacy, Bulgaria

04/10/2011 – 04/15/2011

2 x

Irena Kostova Erasmus Programme

Medical University of Sofia, Department of Pharmacological Chemistry, Faculty of Pharmacy, Bulgaria

04/10/2011 – 04/15/2011

2 x


Name Society/Institute/Journal Function

Pietschmann Peter Habilitationskommission “konservativ I”

(Interne, Pädiatrie, Dermatologie, Radiologie)

Mitglied der Kommission

Pietschmann Peter Bundesministerium für Gesundheit

Beirat für Altersmedizin


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Pietschmann Peter

Pietschmann Peter

Pietschmann Peter

Pietschmann Peter

Wiener Medizinische Wochenschrift Hormone Metabolic Research Zeitschrift für Geriatrie und Gerontologie Journal für Mineralstoffwechsel

Associate Editor Member Editorial Board Member Editorial Board Member Editorial Board



Peter Pietschmann

Peter Pietschmann

Peter Pietschmann Theresia Thalhammer

Theresia Thalhammer

Theresia Thalhammer

Theresia Thalhammer

Deutsche Forschungsgemeinschaft (Grant)

Jubiläumsfonds der Österr. Nationalbank (Grant)

Veterinärmedizinische Universität Wien (Doctoral Thesis)

Jubiläumsfonds der Österr. Nationalbank (Grant)

Medizinisch-Wissenschaftlicher Fonds des Bürgermeisters der Bundeshauptstadt Wien (Grant)

ÖAD (Grant)

Slovak Academia of Sciences (grant)

1.2.10. Filed and granted patents

Name Patent Isabella Ellinger “Metastrukturen in Geweben”

Patent Nr. 1444/2010


FWF, doctoral college, CCHD

Cathepsin S: ein Modulator in der Osteoimmunologie Peter Pietschmann

Österreichische National Bank

Vergleichsstudie von Hüftkopfknochen von Männern Schenkelhalsfrakturen bzw. Hüftarthrosen

Peter Pietschmann

Krankenhaus der Barmherzigen Schwestern II.Medizinische Abteilung (Prim.Univ.Prof. H. Resch)

Microarchtitecture of bone in osteoporotic men: the association between osteoblastic gene expression patterns and treatment effects

Peter Pietschmann

Springer Verlag GmbH

Unterstützung der Errichtung und Betreibung eines Editorials Office für die Wiener Medizinische Wochenschrift und der Publikationstätigkeit der Arbeitsgruppe Knochen-, Gender- und Altersforschung

Peter Pietschmann


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SERVIER & ADIR Strontium ranelate effect on osteoblast-induced differentiation and activity through the modulation of RANKL

Peter Pietschmann

Roche Austria GmbH

Errichtung eines Forschungsnetzwerks auf dem Gebiet der Gerontologie

Peter Pietschmann

Vinforce Research Network Osteology – Gene Expression Substudy. Peter Pietschmann

Amgen Cathepsin S in Osteoimmunology: additional studies Peter Pietschmann

MSD – Merck, Sharp & Dohme

Cathepsin K in Osteoimmunology Peter Pietschmann

FFG Bridge Automatisierte Zellerkennungs-Technologien für Forschung und Diagnose

Isabella Ellinger, Co-Applicant: Theresia Thalhammer, Giovanna Bises

FFG IgG-Lokalisation – generation innovation Praktika, Talente Praktika für Schülerinnen und Schüler (Michaela Jungmann)

Isabella Ellinger

FFG FcRN-Lokalisation generation innovation Praktika (Talente Praktika für Schülerinnen und Schüler (Stefan Grbic)

Isabella Ellinger

Medizinisch-wissenschaftlicher Fonds des Bürgermeisters der Stadt Wien

Proteins of the family of “organic anion transporters (OATP) and their potential role in lung and colon cancer therapy.

Theresia Thalhammer (Cooperation:Dr. Buxhofer-Ausch, SMZ-Ost)

Medizinisch-wissenschaftlicher Fonds des Bürgermeisters der Stadt Wien

Identifikation und Validation therapeutischer Targets beim kleinzelligen Lungenkarzinom

Principle Investigator: Theresia Thalhammer (Cooperation Univ.Prof.Dr. Primar Klaus Geissler, Ludwig Boltzmann Institut, KH Hitzing, 5. Med. Abt. mit Onkologie

1.2.12. Career Developments a) Habilitations: n = 1 Priv.Doz.Dr. Arno Wutzl (supervised in part by Peter Pietschmann) b) Habilitations in progress: n = 0 c) Professorships: n = 0

1.2.13. Teaching a) Bachelor students: n = 5 practical training: Renate Fuchs: Kristina Todtova, FH Campus Vienna, Bachelor study: Molecular Biotechnology, Jan 10 – June 30, 2011 Isabella Ellinger: Julia Mytsko, FH Campus Vienna, Bachelor study: Molecular Biology, Feb, 1 – May 31, 2011


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Theresia Thalhammer: Felicitas Mungenast, FH Campus Vienna, Bachelor study: Molecular Biotechnology, Jan 10 – June 30, 2011

Florian Schadauer, FH Campus Vienna, Bachelor study: Molecular Biotechnology, Jan 10 – June 30, 2011

Madeleine Schölm, FH Campus Vienna, Bachelor study: Moleculra Biotechnology, Jan 10 – June 30, 2011 b) Diploma, MDiploma and Master students: n = 22 Renate Fuchs: Jalali Manuel: MDiploma Thesis. Mechanismus von Virusinfektionen: Einfluß von Ethylisopropylamilorid auf die Infektion von HRB89. (07/2011 – in progress). Medical University of Vienna

Spanberger Thomas: MDiploma Thesis. Mechanismus von Virusinfektionen. (05/2009 – in progress), Medical University of Vienna. Peter Pietschmann: Bogdan Cosmina: MDiploma Thesis. Histomorphometrische Analysen in einem experimentellen Modell zur Therapie der Osteoporose. (01/2009 – 10/2011), Medical University of Vienna.

Diebler Julian: MDiploma Thesis. Effekte verschiedener BMP-Kombinationen auf murine Osteoklasten und Osteoblasten in der Zellkultur (11/2011 – in progress). Medical University of Vienna

Kurz Michael: MDiploma Thesis. Knochenveränderungen bei Cathepsin S Knockout-Mäusen. (01/2010 – in progress), Medical University of Vienna

Mayr Helene: MDiploma Thesis. Knochenhistomorphometrie bei einer experimentellen Osteoporosetherapie. (01/2009 – in progress), Medical University of Vienna.

Mukaddam Sena: MDiploma Thesis. Knochenstruktur bei Morbus Paget: Analyse von historischen Knochenmaterial mittels HRpQCT (10/2008 – in progress). Medical University of Vienna

Ortner Nadine: Diploma Microbiology and Immunology. Osteomacrophages in cathepsin S knock out mice (11/2011 – in progress) University of Vienna.

Sillipp Josef: MDiploma Thesis. Development and evaluation of an automatic method for bone histomorphometry. (05/2010 – in progress). Medical University of Vienna Theresia Thalhammer: Awad Madonna: DiplomaGenetic. OATP-Proteine in soliden Tumoren (04/2011 – in progress) University of Vienna


46

Burger Kathrin:

DiplomaPharm Thesis. Einfluß von Melatonin auf das Wachstum von Osteoklasten: Untersuchungen mittels eines neuen automatisierten Imageanalysesystems. (09/2010 – in progress). University of Vienna.

Durmaz Yasemin: DiplomaPharm Thesis. Expression von Enzymen und Transportproteinen in Tumorzellen und Geweben: Bedeutung für die Therapie. (09/2011 – in progress). University of Vienna

Eskandari Hamidreza: MDiploma thesis: Studies on the expression of organic anion transport polypeptides in human cell lines (11/2008 – in progress), Medical University of Vienna.

Gründsteidel Johann: MDiploma thesis: Prostaglandin transporting OATPs in ovarian cancer. (10/2010 – in progress). Medical University of Vienna

Kalayci Dilek: DiplomaPharm Thesis. Bestimmung von OATP-Transportern in Tumorzellen: Bedeutung für die Aufnahme von Zytostatika. (03/2011 – 12/2011). Univeristy of Vienna

Ndue Leonard: MDiploma. Prostaglandin-Homöostase beim Ovarialkarzinom – Rolle von COX-2 (07/2011 – in progress). Medical University of Vienna Sanlioglu Cihangül: DiplomaPharm Thesis. Expression von Transportproteinen in humanen Tumorgewebe. (03/2010 – 12/2011). University of Vienna.

Sultan Sirag: MDiploma: Prostaglandin-Homöostase beim Ovarialkarzinom – Rolle des Prostaglandintransporters OATP2A1 (07/2011 – in progress). Medical University of Vienna

Türkay Emel: MDiploma thesis. Expression of the transporter OATP 5A1 in normal and malignant human tissue. (11/2008 – in progress), Medical University of Vienna.

Zakaria Susanna: DiplomaPharm Thesis. Proteins of the family of „organic anion transporters (OATP)“ and their potential role in lung and colon cancer therapy. (09/2010 – in progress). University of Vienna.

Zaussinger Siliva: DiplomaPharm Thesis. Charakterisierung eines neuen OATPs (LS-3TM12) in Lebertumoren: Bedeutung für die Tumortherapie. (09/2010 – in progress). University of Vienna.

Zhang Wenyi: MDiploma thesis.Prostaglandin-Homöostase beim Ovarialkarzinom – Rolle des Transporters MRP4. (05/2011 – in progress). Medical University of Vienna c) PhD, MDSci, MD students: n = 8 Isabella Ellinger: Heindl Andreas, Dipl.Ing: PhD Thesis. Automated cell detection technologies for science and diagnostics (03/2009-in progress), Medical University of Vienna


47

Ehresheim Christine, Mag: PhD Thesis. Characterization of the Reelin/Thrombospondin/ApolipoproteinE Receptor2/very low density lipoprotein receptor – signalling pathways in granulosa cells. (08/2010 – in progress), Medical University of Vienna. Peter Pietschmann: Azizi-Semrad Ursula: MD Thesis. Extended cytokine profiling of functional human peripheral blood CD4+ T lymphocytes (Th1, Th2 and Th17) and the effect of different micro-environments on their differentiation. (11/2007 – in progress). Medical University of Vienna.

Patsch Janina, Dr.med.: PhD Thesis. Gene expression, bone microarchitecture and treatment effects in male osteoporosis (01/2007 – 11/2011. Medical University of Vienna.

Maldonado-Gonzalez Eduardo: PhD Thesis. The role of Serotonin transporter (5-HTT) and insulin degrading enzyme (IDE) Polymorphism in vascular diseases (05/2011 – in progress(. Medical University of Vienna. Theresia Thalhammer:

Terezia Kiskova: PhD Thesis. Physiology of animal sciences – studies on chemical induced breast cancer in rats. (02/2011 – in progress) Pavol Jozef Safárik University, Kosice Rentsen Erdentetsetseg: PhD Thesis. Identifikation und Validation therapeutischer Targets beim kleinzelligen Lungenkarzinom. (11/2011 – in progress) Medical University of Vienna

Riha Juliane, Mag.pharm: PhDPharm Thesis. Metebolismus und Transport neuer Zytostatika in humanen Tumorzelllinien in Gewebe (10/2009 – in progress), University of Vienna.

Trainee: Isabella Ellinger: GRBIC Stefan, Academy of Chemical Industry, July 4 – 29, 2011 JUNGMANN Michaela, Academy of Chemical Industry, July 4 – 29, 2011

1.2.14. Exams a) Oral examinations: n = 3

b) Diploma and Thesis-Examinations: n = 9 Peter Pietschmann Mag. Karoline Reich, Thesis Examination of Applied Medical Sciences, 20.4.2011 Thomas Puntus, Diploma Examination of Human Medicine, 22.6.2011 Dr. Janina Patsch, PhD Doctoral Thesis Examination, 22.11.2011 Gerd Pfingstner, Dentistry Diploma Examination, 27.7.2011 Stefanie Salzl, Dentistry Diploma Examination, 27.7.2011


48

Renate Fuchs Sonja Lottermoser, MD Diploma Thesis Examination, 21.11.2011 Dorian Jungmann, MD Diploma Thesis Examination, 29.11.2011 Theresia Thalhammer Lorenz Auer-Hackenberg, Diploma Examination of Human Medicine, 12.10.2011 Bernhard Giessrigl, Doctoral Thesis Examination Pharmacy, University of Vienna, 17.11.2011 c) Exam supervising: n = 4 Isabella Ellinger: SSM 2, 11/03/2011 SIP 2, 30/06/2011 Renate Fuchs: Komm. SIP1, 05/05/2011 Komm. SIP1, 22/09/2011 d) Reviewing of Doctoral Thesis: n = 1 Peter Pietschmann, Review of Doctoral Thesis, University of Veterinary Medicine


49


SS 2011 Pietschmann Peter 2.00 0.08 860.074 JC Endocrinology and Metabolism "SS11 (Pflichtfach)

Pietschmann Peter 2.00 0.13 870.201 Propedeutics in Human Medicine II - Physiology

Pietschmann Peter 2.00 0.13 860.220 Basisvorlesung Immunologie

Pietschmann Peter 1.00 1.00 860.034 Journal Club (N090, N094, and N0790)

Pietschmann Peter 2.53 0.40 804.000 BL 10 - Endokrinologie und Stoffwechsel

Pietschmann Peter 2.27 0.47 806.021 SSM 2 - Methoden der zellulären Pathophysiologie

Pietschmann Peter 2.00 0.70 860.302 Dissertantenseminar: Durchflusszytometrie - Methodik und immunologische Anwendungsmöglichkeiten

Pietschmann Peter 2.00 2.00 648.018 Experimentelle Arbeitstechniken in der Osteologie

Ellinger Isabella 1.00 0.33 860.034 Journal Club (N090, N094, and N0790)

Ellinger Isabella 2.00 0.66 860.036 Journal Club and Progress Report

Ellinger Isabella 2.27 0.68 806.021 SSM 2 - Methoden der zellulären Pathophysiologie

Thalhammer Theresia 1.00 0.33 806.009 Ärztliche Gesprächsführung B

Thalhammer Theresia 2.00 0.66 860.036 Journal Club and Progress Report

Thalhammer Theresia 4.00 1.00 808.004 SSM 3-Projektstudie (Wahlpflichtteil)

Thalhammer Theresia 5.00 5.00 514032 Wissenschaftliche Arbeiten – Pathophysiologie der Wirkung von Umweltgiften, SE

Fuchs Renate 4.00 0.50 808.004 SSM 3-Projektstudie (Wahlpflichtteil)

Fuchs Renate 2.00 0.66 860.036 Journal Club and Progress Report

Fuchs Renate 2.27 0.68 806.021 SSM 2 - Methoden der zellulären Pathophysiologie

Sum 15.41

WS 2011/12 Pietschmann Peter 5,00 0,50 514.053 Anleitung zu wissenschaftlichen Arbeiten - (Wahlfachausbildung gem. § 13/1 lit.a StG.)

Pietschmann Peter 2,00 2,00 648.801 Experimentelle Arbeitstechniken in der Osteologie

Pietschmann Peter 2,00 0,70 653.346 Dissertantenseminar: Durchflusszytometrie - Methodik und immunologische Anwendungsmöglichkeiten

Pietschmann Peter 5,80 0,40 803.002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Pietschmann Peter 4,27 0,27 807.002 02BL 21 - Bewegung und Leistung

Pietschmann Peter 6,10 1,33 825.001 BL Z-1 Kau- und Bewegungsapparat

Pietschmann Peter 1,00 0,33 860.011 Creative and critical Journal Club I


50

Pietschmann Peter 2,00 0,50 860.020 Journal Club and Progress Report I

Pietschmann Peter 2,00 0,07 860.937 Basic Seminar "Endocrinology and Metabolism I" (Wahlpflichtfach) Nummer 860.937

Pietschmann Peter 3,00 0,21 896.006 Gender - Basics in Gender Medizin 1

Pietschmann Peter 2,00 0,10 902.005 Basic Seminar

Ellinger Isabella 1.13 3.07 801001 BL 1 – Gesunde und kranke Menschen, SK

Ellinger Isabella 1.07 0.8 801004 BL 2 – Der menschliche Körper, SK

Ellinger Isabella 1.73 1.87 801006 BL 3 – Vom Molekül zur Zelle, SK

Ellinger Isabella 0.50 1.00 803001 BL 7 – Wissenschaft und Medizin (SSM 1), SK

Ellinger Isabella 2.50 2.50 803074 SSM1-Entstehung von AGEs und ihre Rolle bei chronischen Erkrank..

Ellinger Isabella 1.00 0.34 860011 JC Creative an critical Journal Club, SE

Ellinger Isabella 2.00 0.5 860020 Journal Club and Progress Report, SE

Thalhammer Theresia 2.00 0.66 860020 Journal Club and Progress Report, SE

Thalhammer Theresia 5.00 5.00 514032 Wissenschaftliches Arbeiten – Pathophysiologie der Wirkung von Umweltgiften

Fuchs Renate 2.00 0.07 562019 BVo: Immunologie, VO

Fuchs Renate 1.13 2.93 801001 BL 1 – Gesunde und kranke Menschen, SK

Fuchs Renate 6.27 1.13 801005 BL 3 – Vom Molekül zur Zelle, VO

Fuchs Renate 1.73 4.27 801006 BL 3 – Vom Molekül zur Zelle, SK

Fuchs Renate 2.50 2.50 803051 SSM 1 – Mechanismus von Virusinfektionen, SE

Fuchs Renate 2.27 0.53 805002 BL 14 – Niere und Homöostase, VO

Fuchs Renate 2.00 0.50 860020 Journal Club and Progress Report I, SE

Sum 34.08 Total sum SS+WS 49.49

Performance Report 2011 Immunopathology

51

1.3 Division for Immunopathology Head: Rudolf Valenta, MD, Professor

1. Publications6 IF Number Top/Std/Subst

Rudolf Valenta 161.919 27 23 Top, 4 St.

Beatrice Jahn-Schmid 32.823 5 4 Top, 1 St.

Bohle Barbara 75.411 14 10 Top, 4 St.

Margit Focke-Tejkl 77.617 14 11 Top,3 St.

Ines Swoboda 41.616 8 5 Top, 3 St

Susanne Vrtala 10.683 3 2 Top, 1 St.

Sabine Flicker 20.358 4 4 Top, 0 St.

Sum 420.427 75



2. Supervision of bachelor, diploma and doctoral students Bachelor st. Diploma st. Doctoral st.

Rudolf Valenta 1 3 8 Beatrice Jahn-Schmid 0 0 0 Bohle Barbara 0 5 6

Margit Focke-Tejkl 0 1 0

Ines Swoboda 0 0 0

Susanne Vrtala 0 0 5

Sabine Flicker 0 0 2

Sum 1 9 21 3. Teaching SS* WS* total W+S oral Exams

Rudolf Valenta 14.72 15.13 29.85 Beatrice Jahn-Schmid 0.00 3.00 3.00 1 Bohle Barbara 9.39 7.66 17.05 7

Margit Focke-Tejkl 1.00 0.50 1.5 0

Ines Swoboda 14.00 5.00 19.00 0

Susanne Vrtala 1.00 0.50 1.50 3

Sabine Flicker 0.50 1.00 1.5 1

Sum 40.61 32.79 73.40 12

6 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given

sum of the division represents the net value of IFs without overlaps due to joint publications.


52

1.3.1. Publications a) Peer-reviewed original articles: n=37


1. 1.

Heratizadeh, A.*, I. Mittermann, H. Balaji, K. Wichmann, R. Valenta, and T. Werfel. 2011. The role of T-cell reactivity towards the autoantigen α-NAC in atopic dermatitis. Br. J. Dermatol. 164:316-324.

4.353 Top

2. 2.

Reginald, K., K. Westritschnig, T. Werfel, A. Heratizadeh, N. Novak, M. Focke-Tejkl, A. M. Hirschl, D. Y. M. Leung, O Elisyutina, E. Federenko, and R. Valenta*. 2011. Immunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients. Clin. Exp. Allergy. 41:357-369.

4.195 Top

3. 3.

Campana, R., S. Vrtala, B. Maderegger, Y. DallÁntonia, D. Zafred, K. Blatt, H. Herrman, M. Focke-Tejkl, I. Swoboda, S. Scheiblhofer, A. Gieras, A. Neubauer, W. Keller, P. Valent, J. Thalhamer, S. Spitzbauer, and R. Valenta*. 2011. Altered IgE epitope presentation: a model for hypoallergenic activity revealed for Bet v 1 trimer. Mol. Immunol. 48:431-441.

2.916 St.

4. Madritsch, C., S. Flicker, S. Scheiblhofer, J. Thalhamer, and R. Valenta*. 2011. Recombinant monoclonal human immunoglobulin E to investigate the allergenic activity of major grass pollen allergen Phl p 5. Clin Exp Allergy. 41:270-280.

4.195 Top

5. Vrtala, S., M. Fohr, C. Baumgartner, R. Campana, P. Valent, and R. Valenta*. 2011. Genetic engineering of trimers of hypoallergenic fragments of the major birch pollen allergen, Bet v 1, for allergy vaccination. Vaccine. 29:2140-2148.

3.572 Top

6. Edlmayr, J., K. Niespodziana, T. Popow-Kraupp, V. Krzyzanek, M. Focke-Tejkl, D. Blaas, M. Grote, and R. Valenta*. 2011. Antibodies induced with recombinant VP1 from Human Rhinovirus exhibit cross-neutralization. Eur Respir J. 37:44-52.

5.922 Top

7. Bousquet, J.*, J. Anto, C. Auffray, M. Akdis, A. Cambon-Thomsen, T. Keil, T. Haahtela, B. N. Lambrecht, D. S. Postma, J. Sunyer, R. Valenta, C. A. Akdis, I. Annesi-Maesano, A. Arno, C. Bachert, F. Ballester, X. Basagana, U. Baumgartner, C. Bindslev-Jensen, B. Brunekreef, K. H. Carlsen, L. Chatzi, R. Crameri, E. Eveno, F. Forastiere, J. Garcia-Aymerich, S. Guerra, H. Hammad, J. Heinrich, D. Hirsch, B. Jacquemin, F. Kauffmann, M. Kerkhof, M. Kogevinas, G. H. Koppelman, M. L. Kowalski, S. Lau, K. C. Lodrup-Carlsen, M. Lopez-Botet, J. Lotvall, C. Lupinek, D. Maier, M. J. Makela, F. D. Martinez, J. Mestres, I. Momas, M. C. Nawijn, A. Neubauer, S. Oddie, S. Palkonen, I. Pin, C. Pison, F. Rancé, S. Reitamo, E. Rial-Sebbag, M. Salapatas, V. Siroux, D. Smagghe, M. Torrent, E. Toskala, P. van Cauwenberge, A. J. M. van Oosterhout, R. Varraso, L. von Hertzen, M. Wickman, C. Wijmenga, M. Worm, J. Wright, and T. Zuberbier. 2011. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to system medicine. Allergy. 66:596-604.

6.297 Top

8. Gallerano, D., S. C. Devanaboyina, I. Swoboda, B. Linhart, I. Mittermann, W. Keller, and R. Valenta*. 2011. Biophysical

4.106 St.


53

characterization of recombinant HIV-1 subtype C virus infectivity factor. Amino Acids. 40:981-989.

9. Arkestål, K., E. Sibanda, M. Troye-Blomberg, R. Valenta, H. Grönlund, and M. van Hage*. 2011. Impaired allergy diagnostics among parasite infected patients caused by IgE antibodies to the carbohydrate epitope galactose-α1,3-galactose. J. Allergy Clin. Immunol. 127:1024-1028.

9.273 Top

10. Curin, M., Swoboda, M. Focke-Tejkl, R. Valenta*, and S. Spitzauer. 2011. Skin Prick Test extracts for dog allergy diagnosis show considerable variations regarding the content of major and minor dog allergens. Int. Arch. Allergy Immunol. 154:258-263.

2.235 St.

11. Gieras, A., P. Cejka, K. Blatt, M. Focke-Tejkl, B. Linhart, S. Flicker, A. Stoecklinger, K. Marth, A. Drescher, J. Thalhamer, P. Valent, O. Majdic, and R. Valenta*. 2011. Mapping of conformational IgE epitopes with peptide-specific monoclonal antibodies reveals simultaneous binding of different IgE antibodies to a surface patch on the major birch pollen allergen, Bet. v 1. J. Immunol. 186:5333-5344.

5.745 Top

12. Niespodziana, K., B. Linhart, M. Focke-Tejkl, V. Civaj, K. Blatt, P. Valent, M. van Hage, H. Grönlund, and R. Valenta*. 2011. A hypoallergenic cat vaccine based on Fel d 1-derived peptides fused to hepatitis B PreS. J. Allergy Clin. Immunol. 127:1562-1570.

9.273 Top

13. Gadermaier, E., J. Staikuniene, S. Scheiblhofer, J. Thalhamer, M. Kundi, K. Westritschnig, I. Swoboda, S. Flicker*, and R. Valenta. 2011. Recombinant allergen-based monitoring of antibody responses during injection grass pollen immunotherapy and after 5 years of discontinuation. Allergy. 66:1174-1182.

6.297 Top

14. Korošec, P.*, R. Valenta, I. Mittermann, N. Celesnik, R. Eržen, M. Zidarn, and M. Košnik. 2011. Low sensitivity of commercially available rApi m 1 for diagnosis of honeybee venom allergy. J. Allergy Clin. Immunol. 128:671-673.

9.273 Top

15. Reginald, K., K. Westritschnig, B. Linhart, M. Focke-Tejkl, B. Jahn-Schmid, A. Heratizadeh, A. Stöcklinger, N. Balic, S. Spitzauer, T. Werfel, J. Thalhamer, A. M. Hirschl, and R. Valenta*. 2011. Staphylococcus aureus fibronectin-binding protein specifically binds IgE from patients with atopic dermatitis and requires antigen presentation for cellular immune responses. J. Allergy Clin. Immunol. 128:82-91.

9.273 Top

16. Twaroch, T. E., M. Focke-Tejkl, V. Civaj, N. Balic, A. Mari, S. Quirce, S. Spitzauer, R. Valenta, and I. Swoboda, R. Valenta*. 2011. Carrier-bound, nonallergenic Ole e 1 peptides for vaccination against olive pollen allergy. J. Allergy Clin. Immunol. 128:178-184.

9.273 Top

17. Baranyi, U., M. Gattringer, A. Boehm, K. Marth, M. Focke-Tejkl, B. Bohle, P. Valent, R. Valenta, and T. Wekerle*. 2011. Expression of a major plant allergen as membrane-anchored and secreted protein in human cells with preserved allergenic activity. Int. Arch. Allergy Immunol. 156:259-266, DOI 10.1159/000323733.

2.235 St.

18. Hochwallner, H., U. Schulmeister, I. Swoboda, T. Twaroch, H. Vogelsang, L. Kazemi-Shirazi, M. Kundi, N. Balic, S.

6.297 Top


54

Quirce, H. Rumbold, R. Fröschl, F. Horak, B. Tichatschek, C.L. Stefanescu, Z. Szepfalusi, N. G. Papadopoulos, A. Mari, C. Ebner, G. Pauli, R. Valenta*, and S. Spitzauer. 2011. Patients suffering from non-IgE-mediated cow´s milk protein intolerance cannot be diagnosed based on IgG subclass or IgA responses to milk allergens. Allergy. 66:1201-1207.

19. Resch, Y., M. Weghofer, S. Seiberler, F. Horak, S. Scheiblhofer, B. Linhart, I. Swoboda, W. R. Thomas, J. Thalhamer, R. Valenta, and S. Vrtala*. 2011. Molecular characterization of Der p 10: A diagnostic marker for broad sensitization in house dust mite allergy. Clin. Exp. Allergy. 41:1468-1477.

4.195 Top

20. DallÀntonia, F., A. Gieras, R. Valenta, and W. Keller*. 2011. Prediction of IgE-binding epitopes by means of allergen surface comparison and correlation to cross-reactivity. J. Allergy Clin. Immunol. 128:872-879.e8.

9.273 Top

21. Renz, H*., I. B. Autenrieth, P. Brandtzæg, W. O. Cookson, S. Holgate, E. von Mutius, R. Valenta, and D. Haller. 2011. Gene-environment interaction in chronic disease: A European Science Foundation forward look. J. Allergy Clin. Immunol. 128:S27-49.

9.273 Top

22. Valenta, R. and R. L. Coffman. 2011. Current strategies for allergen-specific immunotherapy at its centenary. Curr. Top. Microbiol. Immunol. 352: v-vi.

4.121 Top

23. Schmetterer, K. G., D. H. Haiderer, V. M. Leb-Reichl, A. Neunkirchner, B. Jahn-Schmid, H. J. Küng, K. Schuch, P. Steinberger, B. Bohle and W. F. Pickl. Bet v 1-specific TCR/Foxp3 double tg T-cells suppress the effector function of Bet v 1-specific T-cells in an activation dependent manner. J. Allergy Clin. Immunol.,2011, 127: 238-245e, DOI: 10.1016/j.jaci.2010.10.023

9.273 Top

24. Neunkirchner, A., V. M. Leb-Reichl, K.G. Schmetterer, S. Mutschlechner, H. J. Kueng, D. Haiderer, K. Schuch, M. Wallner, B. Jahn-Schmid, B. Bohle, and W. F. Pickl. Human TCR transgenic Bet v 1-specific Th1 cells suppress the effector function of Bet v 1-specific Th2 cells. J. Immunol., 2011, 187:4077-4087, DOI: 10.4049/jimmul.1003220

5.745 Top

25. Niespodziana K, Napora K, Cabauatan C, M. Focke-Tejkl, Keller W, Niederberger V, Tsolia M, Christodoulou I, Papadopoulos NG, Valenta R. Misdirected antibody responses against an N-terminal epitope on human rhinovirus VP1 as explanation for recurrent RV infections. FASEB J. 2011 Nov 25.

6.515 Top

26. Sturm GJ, Jin C, Kranzelbinder B, Hemmer W, Sturm EM, Griesbacher A, Heinemann A, Vollmann J, Altmann F, Crailsheim K, M. Focke-Tejkl, Aberer W. Inconsistent results of diagnostic tools hamper the differentiation between bee and vespid venom allergy. PLOS One. 2011;6:e20842

4.411 Top

27. Konakovsky V*, M. Focke-Tejkl *, Hoffmann-Sommergruber K, Schmid R, Scheiner O, Moser P, Jarisch R, Hemmer W. Levels of histamine and other biogenic amines in high-quality red wines. Food Addit Contam A. 2011;28:408-16.

2.230 Top

28. Geroldinger-Simic, M., Zelniker, T., Aberer, W., Ebner, C., Egger, C., Greiderer, A., Prem, N., Lidholm, J., Ballmer-

9.273 Top


55

Weber, B.K., Vieths, S. and Bohle, B. Birch pollen-related food allergy: clinical aspects and the role of allergen-specific IgE and IgG4 antibodies. J Allergy Clin Immunol, 2011, 127:616-622 e1; DOI: 10.1016/j.jaci.2010.10.027

29. Schulten, V., I. Lauer, S. Scheurer, T. Thalhammer, and B. Bohle. A food matrix reduces digestion and absorption of food allergens in vivo. Mol Nutr Food Res, 2011, 55:1484-1491; DOI: 10.1002/mnfr.201100234

4.713 Top

30. Schulten, V., Nagl, B., Scala, E., Bernardi, M.L., Mari, A., Ciardiello, M.A., Lauer, I., Scheurer, S., Briza, P., Jurets, A., Ferreira, F., Jahn-Schmid, B., Fischer, G.F. and Bohle, B. Pru p 3, the nonspecific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut. Allergy. 2011, 66:1005-1013; DOI: 10.1111

6.297 Top

31. Wallner, M., Hauser, M., Himly, M., Zaborsky, N., Mutschlechner, S., Harrer, A., Asam, C., Pichler, U., van Ree, R., Briza, P., Thalhamer, J., Bohle, B., Achatz, G. and Ferreira, F. Reshaping the Bet v 1 fold modulates T(H) polarization. J Allergy Clin Immunol. 2011, 127:1571-1578 e9; DOI: 10.16/j.jaci.2011.01.064

9.273 Top

32. Varga, E.M., Kollmann, D., Zach, M. and Bohle, B. Anaphylaxis to Buckwheat in an Atopic Child: A Risk Factor for Severe Allergy to Nuts and Seeds? Int Arch Allergy Immunol. 2011, 156:112-116; DOI: 10.1159/000321916

2.235 St.

33. Van Hemelen, D., Oude Elberink, J.N., Bohle, B., Heimweg, J., Nawijn, M.C. and van Oosterhout, A.J. Flow cytometric analysis of cytokine expression in short-term allergen-stimulated T cells mirrors the phenotype of proliferating T cells in long-term cultures. J Immunol Methods, 2011, 371:114-121; DOI:10.1016/j.Jim.2011.06.019

2.340 St.

34. Toda, M., Reese, G., Gadermaier, G., Schulten, V., Lauer, I., Egger, M., Briza, P., Randow, S., Wolfheimer, S., Kigongo, V., Del Mar San Miguel Moncin, M., Fotisch, K., Bohle, B., Vieths, S. and Scheurer, S. Protein unfolding strongly modulates the allergenicity and immunogenicity of Pru p 3, the major peach allergen. J Allergy Clin Immunol; 2011, 128:1022-30.e1-7; DOI: 10.1016/j.jaci.2011.04.020

9.273 Top

35. Ilk, N., Schumi, C.T., Bohle, B., Egelseer, E.M. and Sleytr, U.B. Expression of an endotoxin-free S-layer/allergen fusion protein in gram-positive Bacillus subtilis 1012 for the potential application as vaccines for immunotherapy of atopic allergy. Microb Cell Fact. 2011, 10:6; DOI: 101186/1475-2859-10-6

4.544 Top

36. Egger, M., Jurets, A., Wallner, M., Briza, P., Ruzek, S., Hainzl, S., Pichler, U., Kitzmuller, C., Bohle, B., Huber, C.G. and Ferreira, F. Assessing protein immunogenicity with a dendritic cell line-derived endolysosomal degradome. PLoS One. 2011, 6:e17278; DOI: 10.1371/journal.pone.0017278

4.411 Top

37. Cejka, D., Jager-Lansky, A., Kieweg, H., Weber, M., Bieglmayer, C., Haider, D.G., Diarra, D., Patsch, J., Kainberger, F., Bohle, B. and Haas, M. Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemodialysis patients. Nephrol Dial Transplant; 2011, DOI:10.1093/ndt/gfr270

3.564 Top

sum 215.689


56

1.b) Invited Articles & Reviews with IF: n=6


1. 1. Flicker, S., E. Gadermaier, C. Madritsch, and R. Valenta. Passive immunization with allergen-specific antibodies. 2011. Curr Top Microbiol Immunol 352:141-59.

4.121 T

2. 2. Jahn-Schmid, B., W. Pickl and B. Bohle. Interaction of Allergens, Major Histocompatibility Complex Molecules, and T Cell Receptors: A Ménage à Trois That Opens New Avenues for Therapeutic Intervention in Type I Allergy. Int. Arch. Allergy Immunol., 2011, 156:27-42, DOI: 10.1159/000321904

2.235 St.

3. 3. Edlmayr, J., K. Niespodziana, M. Focke-Tejkl, B. Linhart, and R. Valenta*. 2011. Allergen-specific immunotherapy: towards combination vaccines for allergic and infectious diseases. Curr. Top. Microbiol. Immunol. 352:121-140.

4.121 T.

4. Valenta, R.*, B. Linhart, I. Swoboda, and V. Niederberger. 2011. Recombinant allergens for allergen-specific immunotherapy: 10 years anniversary of immunotherapy with recombinant allergens. Allergy. 66:775-783.

6.297 T

5. Baranyi, U., M. Gattringer, R. Valenta, and T. Wekerle*. 2011. Cell-based therapy in allergy. Curr. Top. Microbiol. Immol. 352:161-179.

4.121 T

6. Valenta, R.*, M. Focke-Tejkl, K. Niespodziana, K. Marth, and V. Niederberger. 2011. Recombinant allergens: what does the future hold? J. Allergy Clin. Immunol. 127:860-864.

9.273 T

sum 30.168 c) Invited Articles & Reviews without IF: n = 1

Nr. Article

1. Gadermaier, E. In shape-the art of mapping conformational epitopes. 2011. Int Arch Allergy Immunol DOI:10.1159/000332948

d) Book contributions: n = 0 e) Abstracts, printed in periodicals: n = 0 f) Abstracts, in congress proceedings or abstract books: n = 30

1. Flicker, S. To study allergen structure with monoclonal antibodies. Annual Meeting of the

European Acadamy of Allergology and Clinical Immunology, Istanbul, Turkey, June 2011.

2. Gadermaier, E., C. Lupinek, P. Steinberger, R. Valenta, S. Flicker. Determination of allergen-specificity by heavy chains in grass pollen allergen-specific IgE antibodies. Annual Meeting of the Austrian Society for Allergology and Immunology, Graz, Austria, September 2011.

3. R. Campana, S. Vrtala, B. Maderegger, Y. Dall’Antonia, D. Zafred, K. Blatt, H. Herrmann, M. Focke-Tejkl, I. Swoboda, S. Scheiblhofer, A. Gieras, A. Neubauer, W. Keller, P. Valenta, J. Thalhamer, S. Spitzauer, R. Valenta. Altered IgE epitope presentation: molecular and immunological characterization of a recombinant hypoallergenic trimer of the major birch pollen allergen Bet v 1, EAACI-GA2LEN 9th Immunology Winter School, Davos, Switzerland, February 3 - 6, 2011.


57

4. S. Pahr, C. Constantin, N. Papadopoulus, M. Mäkelä, C. Ebner, A. Mari, I. Mittermann, S. Vrtala, R. Valenta. Characterization of a new wheat food allergen, EAACI Food Allergy and Anaphylaxis Meeting - FAAM 2011, Venice, February 17- 19, 2011

5. A. Schmidhuber, S. Pahr, C. Constantin, N. Papadopoulos, C. Ebner, A. Mari, S. Vrtala, R. Valenta. Isolation, characterization and expression in Escherichia coli of a cDNA coding for a novel major wheat food allergen, First EAACI Food Allergy and Anaphylaxis Meeting, - FAAM 2011, Venice, February 17 - 19, 2011.

6. R. Campana, S. Vrtala, B. Maderegger, P. Jertschin, G. Stegfellner, I. Swoboda, M. Focke-Tejkl, K. Blatt, A. Gieras, D. Zafred, A. Neubauer, P. Valenta, W. Keller, S. Spitzauer, R. Valenta. Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly 30th European Academy of Allergy and Clinical Immunology (EAACI), Istanbul, Turkey, June 06 -15, 2011

7. A. Schmidhuber, S. Pahr, C. Constantin, N. Papadopoulos, C. Ebner, A. Mari, S. Vrtala, R. Valenta Isolation and characterization of the major wheat food allergen Low molecular weight glutenin GluB3-237th PhD symposium, Vienna, June 15 - 16, 2011

8. S. Pahr, C. Constantin, N. Papadopoulus, M. Mäkelä, C. Ebner, A. Mari, I. Mittermann, S. Vrtala, R. Valenta. Characterization of alpha purothionin as a new wheat food allergen, 7th PhD symposium, Vienna, June 15 - 16, 2011

9. Y. Resch, M. Weghofer, S. Seiberler, F. Horak, S. Scheiblhofer, B. Linhart, WR. Thomas, J. Thalhamer, R. Valenta, S. Vrtala. The mite tropomyosin Der p 10 is a diagnostic marker for broad sensitizations to house dust mite allergens, 7th YSA-PhD Symposium, Vienna, June 15 - 16, 2011

10. Y. Resch, M. Weghofer, A. Mari, S. Scheiblhofer, M. Focke, J. Thalhamer, R. Valenta, S. Vrtala. The effect of in vitro-gastro-duodenal digestion of the major shrimp allergen tropomyosin on IgE reactivity and allergenic activity, Annual meeting of the ÖGAI, Vienna, September 15 - 17, 2011

11. S. Banerjee, Y. Resch, K. W. Chen, I. Swoboda, M. Focke Tejkl, S. Scheiblhofer, M. Kronqvist, M. van Hage, A. Mari, A. Purohit, G. Pauli, E. N Sibanda, W. Thomas, A. Adegnika, J. Thalhamer, R. Valenta, S. Vrtala. Striking differences in the molecular IgE recognition profiles revealed with recombinant house dust mite allergens Der p 11 and Der p 14 in different populations. Annual meeting of the ÖGAI, Vienna, September 15 - 17, 2011

12. KW. Chen, K. Blatt, W.R. Thomas, I. Swoboda, P. Valent, R. Valenta, S. Vrtala. Hypoallergenic combination vaccines consisting of reassembled Der p 1 and Der p 2 fragments for immunotherapy of house dust mite allergyAnnual meeting of the ÖGAI, Vienna, September 15 - 17, 2011

13. S. Pahr, C. Constantin, N. Papadopoulus, S. Giavi, M. Mäkelä, C. Ebner, A. Mari, I. Mittermann, S. Vrtala, R. Valenta. Characterization of a novel allergen involved in wheat food allergy. ÖGAI Jahrestagung 2011, Graz, September 15 - 17, 2011

14. A. Schmidhuber, S. Pahr, C. Constantin, S. Giavi, N. Papadopoulos, C. Ebner, A. Mari, S. Vrtala, R. Valenta. Tri a 36: a novel major wheat food allergen. Annual Meeting of the Austrian Society of Allergology and Immunology, Graz, September 15 - 17, 2011

15. S. Pahr, C. Constantin, N. Papadopoulus, S. Giavi, M. Mäkelä, C. Ebner, A. Mari, I. Mittermann, S. Vrtala, R. Valenta. Characterization of a novel allergen involved in wheat food allergy. Zentrumsretreat, Vienna, September 27, 2011

16. C. Kitzmueller, C., B. Nagl, S. Deifl, C. Walterskirchen, B. Jahn-Schmid, G. Zlabinger, B. Bohle. 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Tukey. Human basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1, June 11-15, 2011,

mailto:[email protected]





58

17. Jahn-Schmid, B, M. Hauser, N. Wopfner, R. Asero, C. Ebner, F. Ferreira and B. Bohle. 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Tukey. Antigenicity versus cross-reactivity: Amb a 1, the major ragweed pollen allergen, and its mugwort homologue Art v 6, June 11-15,2011.

18. B. Subbarayal, C. Möbs, NW. de Jong, C. Ebner, N. Reider, RG. van Wijk, W. Pfützner, B. Bohle. Effects of immunotherapy with birch pollen on food-allergen specific antibodies. EAACI Immunology Winterschool, Davos, February 3-6, 2011

19. B. Subbarayal, C. Möbs, NW de Jong, C. Ebner, N. Reider, RG. van Wijk, W. Pfützner, B. Bohle. Effects of immunotherapy with birch pollen on food-allergen specific antibodies. 30th EAACI Congress, Istanbul, Turkey, June 11-15, 2011.

20. S. Deifl, C. Kitzmüller; G. Zlabinger, P. Steinberger, B. Bohle Are all Toll-like receptor (TLR) ligands potential adjuvants in allergy vaccines? EAACI Immunology Winterschool, Davos, February 3-6, 2011

21. S. Deifl, C. Kitzmüller, G. Zlabinger, P. Steinberger, B. Bohle. Are all Toll-like receptor (TLR) ligands potential adjuvants in allergy vaccines? 30th EAACI Congress, Istanbul, Turkey, June 11-15, 2011.

22. S. Deifl, C. Kitzmüller; G. Zlabinger, P. Steinberger, B. Bohle. Searching of TLR ligands with adjuvant activity in allergy vaccines. Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), Graz, Austria, September 15-17, 2011

23. S. Deifl , C. Kitzmüller; G. Zlabinger, P. Steinberger, B. Bohle. Searching for TLR ligands with adjuvant activity in allergy vaccines. CePPII retreat, Vienna, September 27, 2011

24. C. Kitzmueller, M. Wallner, S. Deifl, S. Mutschlechner, G. Zlabinger, F. Ferreira, B. Bohle. Allergen fold affects antigen processing and presentation. EAACI Immunology Winterschool, Davos, February 3-6, 2011

25. C. Kitzmüller, Nagl B., Deifl S., Walterskirchen C., Jahn-Schmid B., Zlabinger G., Bohle B. Human basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1. Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), Graz, September 15-17, 2011

26. C. Kitzmüller, Nagl B., Deifl S., Walterskirchen C., Jahn-Schmid B., Zlabinger G., Bohle B. Human basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1. CePPII retreat, Vienna, September 27, 2011

27. D. Kollmann, C. Ebner, A. Mangold, H.J. Ankersmit, B. Bohle. The role of alpha-Gal in Type I allergy to meat. 30th EAACI Congress, Istanbul, Turkey, June 11-15, 2011.

28. N. Zulehner, B. Nagl, V. Leb-Reichl, C. Walterskirchen, G. Zlabinger, W.F. Pickl, B. Bohle. Human allergen-specific T cell clones show high heterogeneity and plasticity within the Th2 lineage. Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), Graz, September 15-17, 2011

29. N. Zulehner, B. Nagl, V. Leb-Reichl, C. Walterskirchen, G. Zlabinger, W.F. Pickl, B. Bohle.Human allergen-specific T cell clones show high heterogeneity and plasticity within the Th2 lineage. CePPII retreat, Vienna, September 27, 2011

30. M. Schuschnig, Kitzmüller, C., Bohle, B. Expression of pattern recobnition receptors by oral epithelial cell lines, Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), Graz, September 15-17, 2011

g) Teaching Scripts and Books: n = 0 h) Articles in Medical Journals: n = 0


59

i) Public activity n = 12 1. Rudolf Valenta: SIT bei Kindern und Jugendlichen, Ärzte Woche Nr.4, S. 21-22, 2011

2. Rudolf Valenta: Allergen-spezifische Immuntherapie bei Kindern und Jugendlichen, www.springermedizin.at/schwerpunkt/allergologie

3. Rudolf Valenta: Allergie Spezial- 100Jahre spezifische Immuntherapie-Jahrestagung der ÖGAI, Ärzte Woche Nr.4, S. 20, 2011

4. Rudolf Valenta: Allergie Spezial- 100Jahre spezifische Immuntherapie-Jahrestagung der ÖGAI, www.springermedizin.at/

5. Rudolf Valenta: Neue Option für Heuschnupfen-Opfer, Ärzte Woche, Ärzte Woche Nr.4, S. 23, 2011

6. Rudolf Valenta: Neue Option für Heuschnupfen-Opfer, www.springermedizin.at/schwerpunkt/allergologie

7. Rudolf Valenta: Allergie-Impfstoff wird an Patienten geprüft, APA -www.zukunftswissen.apa.at, S.1-2, 2011

8. Rudolf Valenta: Wespen - was tun gegen den allergischen Schock?, Profil 31, S. 69-72

9. Bohle Barbara: „Der Würdigungspreis 2011 des Landes Vorarlberg für Biotechnologin Bohle“, [email protected]

10. Bohle Barbara: „Der Krieg im Körper“, Wann&Wo

11. Bohle Barbara: „In den Schlagzeilen, Barbara Bohle, Weekend, Das Beste am Wochenende

12. Bohle Barbara: „Proteingruppe als Allergie-Multiplikator“, Interessensgemeinschaft Allergenvermeidung

1.3.2. Research Awards: n = 15 1. Katarzyna Niespodziana: Clemens von Pirquet Award 2011 of the Austrian Society for

Allergology and Immunology

2. Katarzyna Niespodziana: Award of Excellence 2011 of the Austrian Federal Minister for Science and Research

3. Katarzyna Niespodziana: Dr. Maria Schaumayer Foundation Award 2011

4. Sandra Pahr: Posteraward at the ÖGAI Jahrestagung 2011, Graz, September 15 – 17, 2011

5. Sandra Pahr: Posteraward at the 2. Zentrumsretreat, Vienna, September 27, 2011

6. Irene Mittermann: Forschungspreis ”Atopische Dermatitis” der Stiftung Pro Derma, Hamburg, 2011

7. Rudolf Valenta: Forschungspreis ”Atopische Dermatitis” der Stiftung Pro Derma, Hamburg, 2011

8. Kitzmüller Claudia: Oral Session Price at the 30th Congress of the European Academy of Allergy and Clinical Immunology (EAACI) in Istanbul, Turkey, June 11- 15, 2011

9. Kitzmüller Claudia: Travel Grant from the Austrian Research Association to attend the 30th Congress of the EAACI in Istanbul, Turkey, June 11-15, 2011

10. Kitzmüller Claudia: ÖGAI Poster Award at the Annual Meeting of the Austrian Society for Allergology and Immunology in Graz, Austria, September 15-17, 2011

11. Kitzmüller Claudia: Poster Award at CePPII retreat, Vienna, September 27, 2011



60

12. Subbarayal Brinda: Exchange Research Fellowship Award of the European Academy of Allergy and Clinical Immunology (EAACI), 2011

13. Subbarayal Brinda: Poster Prize at the 30th Congress of the European Academy of Allergy and Clinical Immunology (EAACI) in Istanbul, Turkey. 2011

14. Kollmann Dagmar: Zuspruch eines MDPhD Exzellenzprogrammes der Med Uni Wien

15. Bohle Barbara: Award for scientific achievements from the country Vorarlberg, Austria

1.3.3. Invited lectures: n = 42

1. Rudolf Valenta: MeDALL kick-off meeting, Centre for Research in Environmental Epidemology (CREAL): “In vitro diagnosis in the definition of the IgE phenotype” and “Characterization of inhalant and food allergens”, January 24-26, 2011, Barcelona, Spain

2. Rudolf Valenta: Wiener Allergiekurs 2011, österreichishe Ärztekammer: “Innovationen”, January 28–29, 2011, Vienna, Austria

3. Rudolf Valenta: Symposium 2011, ICA PhD Program: “Therapeutic strategies for allergy”, February 1, 2011, Salzburg, Austria

4. Rudolf Valenta: The EAACI SummIT 2011, 100 Years of Immunotherapy in Allergy. From noon till dawn…: “Are the new modalities of SIT realistic?”, February 24, 2011, Geneva, Switzerland

5. Rudolf Valenta: ESF-JSPS Frontier Conference for Young Researchers, European Science Foundation (ESF) and the Japan Society for the Promotion of Science (JSPS), Cutting Edge Immunology and its Clinical Application: “Regulation of allergen responses”, March 4-5, 2011, Hulshorst, Netherlands

6. Rudolf Valenta: IFCC-Worldlab EuroMedLab Berlin 2011, 21st International congress of Clinical Chemistry and Laboratory Medicine: “Component-based diagnostics – recombinant allergens as novel diagnostic tools”, May 15-19, 2011, Berlin, Germany

7. Rudolf Valenta: EAACI Congress 2011, European Academy of Allergy and Clinical Immunology, Workshop: “Allergenic molecules: natural or recombinant?, Recombinant forms are better for….”: ”Meet the expert – Rudolf Valenta. Recombinant allergens in allergy diagnosis and treatment”, June11-15, 2011, Istanbul, Turkey

8. Rudolf Valenta: Seminar an der University of Pittsburg, IUIS Council Meeting in Washington: “New forms of diagnosis and therapy for allergy”, June 20-24, Pittsburg and Washington, USA

9. Rudolf Valenta: FAST EU-project meeting, August 22-23, 2011, Madrid, Spain

10. Rudolf Valenta: Deutsche Allergiekongress, Klinisch-Wissenschaftliches Symposium, Inhalationsallergien, In-Vitro Allergie-Diagnostik auf molekularer Ebene: „Inhalationsallergien“, September 8-9, 2011, Wiesbaden, Germany

11. Rudolf Valenta: 55. österreichischer HNO ongreß: „100 Jahre Immunotherapie: eine Erfolgsgeschichte“, September 14-17, 2011, Vienna, Austria

12. Rudolf Valenta: Jahrestagung der österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI): „Zukunft der Immuntherapie – individualisierte Therapie / rekombinante Allergene“, September 15-17, 2011, Graz, Austria

13. Rudolf Valenta: Symposium: „Opportunities for control over asthma today, freedom from asthma tomorrow“, September 29, 2011, Guy´s Hospital, London, United Kingdom

14. Rudolf Valenta: Projekt meeting “Mead Johnson Nutritionals”, October 5-6, 2011, MJN European Headquarters, Amsterdam, Netherlands


61

15. Rudolf Valenta: Annual Meeting of the Croatian Immunological Society: “From immune recognition of allergens to new forms of diagnosis and therapy”, October 6-7, 2011, Rabac, Croatia

16. Rudolf Valenta: Projekt meeting “Phadia”, October 10-11, 2011, Uppsala, Sweden

17. Rudolf Valenta: 40th Annual Congress of the Hungarian Society for Immunology (HSI): “Towards side-effect free allergy vaccines”, October 12-13, 2011, Kecskemet, Hungary

18. Rudolf Valenta: 2nd EFIS-EJI African International Conference on Immunity (AICI): “Immunity in infectious diseases and allergy – diagnosis, treatment and prevention”, November 3-7, 2011, Victoria Falls, Zimbabwe

19. Rudolf Valenta: Annual Meeting of SEAIC 2011, Symposium International de Alergia Alimentaria: “Towards side effect-free allergen specific immunotherapy”, November 10, 2011, Barcelona, Spain

20. Rudolf Valenta: Journal of Internal Medicine (JIM) Symposium: “New approaches to immune modulation in allergic disease”, November 11-12, 2011, Stockholm, Schweden

21. Rudolf Valenta: Komponentenworkshop, Phadia: “Pathomechanismen der Allergie”, November 18, 2011, Vienna, Austria

22. Rudolf Valenta: XXXVIII Congresso Brasileiro de Alergia e Imunopatologia 2011: “Towards side effect-free allergen-specific immunotherapy” and “IgE immunoapheresis for allergy treatment”, November 21-23, 2011, Fortaleza, Brazil

23. Rudolf Valenta: 2nd EFIS-EJI Intensive Educational Course in Clinical Immunology, Advanced Course in Innovative immunologically-based therapies: “Allergy”, November 28- 29, 2011, Paris, France

24. Rudolf Valenta: 22nd World Allergy Congress: “Newest forms of SIT”, December 4-8, 2011, Cancun, Mexico

25. Sabine Flicker: Research Seminar: “Recombinant human antibodies for diagnosis, treatment and prevention of allergy”. Charite, Berlin, Germany, May 30, 2011

26. Susanne Vrtala: “Golnik Symposium 2011” from October 6-8, 2011 in Bled, Slovenia.Title: Recombinant mite allergens for diagnosis and immunotherapy

27. Susanne Vrtala: “Annual Meeting of the French Society for Immunology SFI 2011” from November 8-10, 2011 in Montpellier, FranceTitle: Recombinant mite allergens for diagnosis and immunotherapy

28. Susanne Vrtala: „XXII World Allergy Congress“ from December 4-8, 2011 in Cancún, Mexico.Title: Recombinant allergens for diagnosis

29. Irene Mittermann: “EAACI”, from June 11-14, 2011 in Istanbul, Turkey, Title: Component resolved diagnosis in venom allergy

30. Irene Mittermann: “XXII World Allergy Congress“ from December 4-8, 2011 in Cancún, Mexico.Title: Improving diagnosis of venom allergy with recombinant allergens

31. Beatrice Jahn-Schmid: Dept. of Clinical immunology, Medical University of Wroclaw, Poland, April 2011, Modified allergens and allergen-specific immunotherapy,

32. Margit Focke-Tejkl: Vortrag Pirquet Club. December 12, 2011.“Peptid-Viruscarrier- Immuntherapie gegen Gräserpollenallergie: Theorie,

33. Birgit Linhart: Vortrag Pirquet Club 4.4.2011 “Rekombinante hypoallergene Allergenderivate zur Behandlung von Gräserpollenallergien”, Vortrag Pirquet Club, April 4, 2011,

34. Bohle Barbara: Apples are a peach but can drive birch pollen-allergic patients nuts. PhD Symposium, Salzburg, Austria. February 1, 2011.


62

35. Bohle Barbara: Sekundäre Nahrungsmittelallergie – Relevanz der Kreuzreaktionen. Wiener Pirquet Club Spezial, May 7, 2011

36. Bohle Barbara: Allergen-specific T regulatory cells. 30th EAACI Congress, Istanbul, Turkey, June 11-15, 2011.

37. Bohle Barbara: Local and systemic regulation of the allergic immune response. 30th EAACI Congress, Istanbul, Turkey, June 11-15, 2011.

38. Bohle Barbara: Is the T cell still director in the immunological orchestra? 30th EAACI Congress, Istanbul, Turkey, June 11-15, 2011.

39. Bohle Barbara: Relegation of new players in the antigen-presenting field: Human basophils do not serve as antigen-presenting cells for the major birch pollen allergen Bet v 1. 6. Deutscher Allergie Kongress, Wiesbaden, Germany. September 8, 2011

40. Bohle Barbara: Toll-like receptors (TLR) ligands as adjuvants, 13th Paul Ehrlich Seminar on Allergen Products for Diagnosis and Therapy: Regulation and Science, Washington DC, September 14-17, 2011

41. Bohle Barbara: Dissecting allergen-specific CD4+ T cell responses. Annual meeting of the Catalan Society for Immunology, Barcelona, Spain, November 17.-18, 2011

42. Bohle Barbara: Allergen-spezifische Immuntherapie. Im Rahmen der Tagung „10 Jahre Pädiatrische Allergologie und Pneumologie: Klinische Forschung from Bench to Bedside“, Frankfurt, Germany, November 26, 2011




Function

Intern. Congress, Name, date

Function

Rudolf Valenta “Wiener Allergiekurs”, 01/28/2011-01/29/2011, Vienna

Co-organizer

Rudolf Valenta 2nd

EFIS-EJI African International Conference on Immunity, 11/03/2011-11/017/2011, Victoria Falls, Zimbabwe

Co-organizer

Rudolf Valenta „100 Jahre Antrittsvorlesung Clemens v. Pirquet“, 11/16/2011, Vienna

Co-organizer

Rudolf Valenta “Molekulare Allergologie”, Phadia, 11/18/2011-11/19/2011, Vienna

Co-organizer

Rudolf Valenta SFB-Meeting, Ottenstein, 10/24/2011-11/25/2011

Organizer

Barbara Bohle EAACI Immunology Winter School, Davos, 02/03- 02/06/ 2011

Organizing committee


63


division member Speaker´s name Affiliation Date Rudolf Valenta Dr. Maria A.

Curotto De Lafaille Singarpore Immunology Network Singapore

03/11/2011

Rudolf Valenta Prof. Paul J. Ciclitira

The Rayne Institute St. Thomas`Hospital, London UK

03/18/2011

Rudolf Valenta Dr. Hans Grönlund Dept. of Medicine, Unit of Clinical Immunology and Allergy, Karolinska Institutet, Sweden

04/15/2011

Rudolf Valenta Prof. Marcus Maurer

Dept. of Dermatology and Allergology Charité – Universitätsmedizin Berlin, Germany

05/11/2011

Rudolf Valenta Prof. Fred Finkelman

Cincinnati Children´s Hospital Medical Center&the Cincinnati Veterans Affairs Medical Center, Cicinnati, Ohio.

05/23/2011

Rudolf Valenta Prof. Jörg Lehmann Dept. of Cell Technology, Frauenhofer Inst. For Cell Therapy and Immunology

05/27/2011

Rudolf Valenta Dr. Fred Finkelman Cincinnati Children´s Hospital Medical Center&the Cincinnati Veterans Affairs Medical Center, Cicinnati, Ohio

10/24/2011-10/25/2011

Rudolf Valenta Dr. Simon Hogan Cincinnati Children´s Hospital, Cincinnati, OH 45229, USA

10/24/2011- 10/25/2011

Rudolf Valenta Dr. Marsha Wills-Karp

Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229

10/24/2011- 10/25/2011

Rudolf Valenta Dr. Chris Karp Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229

10/24/2011- 10/25/2011

Rudolf Valenta Dr. Francine Kauffmann

Respiratory and Environmental Epidemiology, CESP-Centre for Research in Epidemiology and PopulationHealth, Inserm, Villejuif, France

12/01/2011

Rudolf Valenta Prof. Gabrielle Pauli

Hôpitaux universitaires de Strasbourg, France

12/20/2011

Rudolf Valenta Prof. Lars K. Poulsen

Allergy Clinic, Copenhagen Hospital at Gentofte

12/21/2011

Rudolf Valenta Dr. Hans-Jørgen Malling

Allergy Clinic, Copenhagen Hospital at Gentofte

12/21/2011

1.3.6. Mobility

Name Program University, Land Time frame Division In Out Silwia

Smolinska Wroclaw Medical University grant

Wroclaw Medical University

Poland

06/20/11 – 09/20/11

3 X

Cabauatan Wissenschaftl. MA Philippinen 04/16/10 – 3 X


64

Clarissa ohne DV 02/19/11

Breyer Isabella MUW-Medizinstudent (Praktikant)

Österreich 09/7/09 – 01/31/11

3 X

Maria Jesus Puy Parache

IFMSA International Federation of Medical Students Association

Universitat de Lleida Spain

07/30/11 – 08/27/11

3 X

Natalia Lucas Collado

IFMSA International Federation of Medical Students Association

Spain 07/4/11 – 07/29/11

3 X

Pretzer Carina Praktikant UNI Wien 08/1/11 – 08/31/11

3 X

Appel Mareike Student UNI Wien 05/31/11 – 12/31/11

3 X

Altrichter Sabine

Charité wissenschaftl. MA

ohne DV

Charié Berlin Dermatologie

10/17/11 – 10/27/11

3 X

Muglia Cecill (BB)

Gastforscher Falcutad de Ciencia Exactas, UNLP,

Argentinien

12/28/10 – 03/24/11

3 X

Debeljak Franka (BB)

Praktikant MUW 0600437

MUW 05/17/11 – 07/08/11

3 X

Gutfreund Sandra

Praktikant 04/04/11 – ongoing

3 X

Narayanan Meena

Balakumari

PhD student India 11/11/11 – ongoing

3 X

Brinda Subbarayal

EAACI Exchange research fellowship

Paul Ehrlich Institut, BRD

05/02/11 – 10/28/11

3 X

Bharani Srinivasan

Doktoratskolleg MUW UNI Wien

08/15/2011 – 02/20/2012

3 X


Name Society/Institute/Journal Function Rudolf Valenta Iranian Journal of Allergy,

Asthma and Immunology” International Board Consultant

Barbara Bohle Wissenschaftlicher Beirat des Paul Ehrlich Instituts, Langen, BRD

Scientific advisor



Rudolf Valenta International Archives of Allergy and Immunology

Editor in Chief

Rudolf Valenta International Archives of Allergy and Immunology

Editorial Board

Rudolf Valenta ACI International Editorial Board


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Rudolf Valenta Allergo Journal Editorial Board

Rudolf Valenta Journal of Investigational Allergology & Clinical Immunology

Editorial Board

Rudolf Valenta European Journal of Clinical Investigation

Editorial Board

Rudolf Valenta Calcium Binding Proteins Editorial Board

Rudolf Valenta International Journal of Immunorehabilitation

Editorial Board

Rudolf Valenta American Journal of Plant Sciences

Editorial Board

Rudolf Valenta Revista Alergia Mexico Editorial Board

Barbara Bohle International Archives of Allergy and Immunology

Managing Editor

Barbara Bohle Clinical and Experimental Allergy

Editorial Board Member

Barbara Bohle Immunotherapy Editorial Board Member


Name Grants/Thesis/Habilitation Rudolf Valenta Habilitation,02/ 2011

Barbara Bohle Research Grant Proposal of the Medical Research Council, UK

Barbara Bohle PhD Thesis of Michael Lichtenauer “Secretome of apoptotic cells causes cardioprotection and inhibits ventricular remodelling after acute myocardial infarction”

Barbara Bohle PhD Thesis committee of Christine Bannert (03/29/2011)

Barbara Bohle PhD Thesis committee of Jiang Zhou (11/16/2011)


Name Patent Susanne Vrtala Patent P9501PC00: Wheat antigens and peptides for diagnosis of

wheat induced hypersensitivity

Rudolf Valenta Microparticles comprising carbohydrate beads covalently linked with allergen for use in immunotherapy and diagnostics", in Canada, CA

2482973 (11/22/2011) Rudolf Valenta Process for the preparation of hypoallergenic mosaic antigens",

Japan, JP 4756864 (June 10, 2011) 3. "Hypoallergenic polypeptides based on fish parvalbumin

Rudolf Valenta Allergen from house dust mites (Der p 21)" in Japan, JP 4713933 (04/01/2011)

Rudolf Valenta Protein allergen derivatives (Head to Tail" in Australien, AU 2005312324 (08/25/2011)

Rudolf Valenta Nutritional formulation comprising a cow’s milk peptide-containing hydrolysate and/ or peptides derived thereof for tolerance induction, US Patent Application No: 2011/0195,153


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Rudolf Valenta Method for identifying allergenic proteins and peptides, US Patent Application No: 2010/0143,262

Rudolf Valenta US Patent No. RE42324 (our ref: P6659US01) COMPUND FOR TREATMENT OF ALLERGY AND ASTHMA, grant date: 05/03/2011.

Rudolf Valenta Japanese Patent No. 4881526 (our ref: P6685JP00) NON-ANAPHYLACTIC FORMS OF GRASS POLLEN Phl p 6 ALLERGEN AND THEIR USE, grant date 12/09/2011

Rudolf Valenta Canadian Patent No. 2441048 (our ref: P6659CA00) NOVEL COMPOUND FOR TREATMENT OF ALLERGY AND ASTHMA, grant date12/13/2011

1.3.11. Grants

Funding agency Title of project Principal investigator

FWF-SFB Coordination project Rudolf Valenta

FWF-SFB Molecular approaches to dissect pathomechanisms of allergy.

Rudolf Valenta

Biomay Impfstoffe und Toleranzstrategien für Typ I Alllergie.

Rudolf Valenta

Phadia Utility of recombinant allergens, wheat and venom allergens.

Rudolf Valenta

Christian Doppler Forschungsgesellschaft

Therapeutic peptide vaccines for allergic asthma. Rudolf Valenta

EU-Kommission/FP7 „Health“

EU Projekt MedAll Rudolf Valenta

EU-Kommission/FP7 „Health“

EU Projekt Predicta Rudolf Valenta

Karger Verlag Personalkosten, Sachkosten Rudolf Valenta FWF Doktoratskolleg Rudolf Valenta FWF Doktoratskolleg Barbara Bohle

FWF-SFB The role of cell-mediated immunity in type I food allergies.

Barbara Bohle

Christian Doppler Gesellschaft und Biomay

Immunmodulation allergischer Erkrankungen Barbara Bohle

FWF Strukturelle Merkmale und Immunogenität von Allergieimpfstoffen

Barbara Bohle

FWF-SFB Molecular, immunological and structural characterization of mite allergens for diagnosis, prevention and specific immunotherapy.

Susanne Vrtala

Christian Doppler Forschungsgesellschaft

Development of allergen chips. Susanne Vrtala

FWF MHC clas II tetramers in allergy research. Beatrice Jahn-Schmid Österreichische National Bank

Einfluss der Hyposensibilisierung auf allergenspezifische Immunantwort bei Pollenallergikern.

Beatrice Jahn-Schmid

European Research Grant Framework

Seventh Towards safe and effective immunotherapy of persistent lifethreatening food allergies.

Ines Swoboda

Bundesministerium für Wissenschaft und Forschung, Eu-Zusatzfinanzierung

Towards safe and effective Immunotherapy . of persistent lifethreatening food allergies.

Ines Swoboda

FWF Regulatory role of allergen-specific antibodies Sabine Flicker FWF Recognition of allergen epitopes in secondary IgE

response. Birgit Linhart


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1.3.12. Career Developments a) Habilitations: n= 0 b) Habilitations in progress: n = 2 1. Mittermann Irene: Molekulare Allergologie, "Molecular characterisation of allergens

for diagnosis and therapy". (2010 – ongoing)

2. Linhart Birgit: Molekulare Allergologie (2010 – ongoing)

c) Professorships: n= 0

1.3.13. Teaching

a) Bachelor students: n = 1 1. Gutfreund Sandra: Bachelor student, (2011 – in progress), Investigation of the

function of Hfq protein by mutational analysis in E.Coli

b) Diploma and MDiploma students: n = 9

1. Appel Mareike: Diploma student (6/2011 – in progress), Entwicklung und Charakterisierung eines IgE-spezifischen Immunotoxins

2. Breyer Isabella: Diploma student, Entwicklung und präklinische Evaluierung neuer Vakzine gegen Allergien, (09/07/2009 – in progress)

3. Hameter Verena: Diploma student, Expression, purification, structural and immunological characterization of a Phl p5 mosaic protein (2011 – in progress)

4. Kalser Julia: Diploma Thesis: Untersuchung der Immunantwort auf Allergen- Modulator-Fusionsproteine (2010-in progress).

5. Kollmann Dagmar: Diploma Thesis: Identification of cross-reactive allergens in buckwheat, poppy and hazelnut (10/2008-05/2011)

6. Mayrhofer Hannes: Diploma student: Erstellung und Charakterisierung von rekombinanten Hybridmolekülen für die Therapie der Gräserpollenallergie, 10/27/2008 – in progress.

7. Schuschnig Marina: Diploma Thesis: Reinigung und Charaktrisierung der Glutathion- S-Transferase aus Birkenpollen (2010-in progress)

8. Walterskirchen Christian: Diploma Thesis: Humoral and cellular characterization of minor allergens in birch pollen. (02/01/2010-in progress).

9. Zwicker Christian: Diploma Thesis: Biochemical and immunological characterization of recombinant Glutathione-S-transferase from birch pollen (10/2011- in progress)

c) PhD, MDSci, MD students: n = 21

1. Banerjee Srinita: PhD student: Production and evaluation of peptide vaccines for house dust mite immunotherapy (2009-in progress)

2. Chen Kuan-Wei: PhD student: Synthesis and characterization of house-dust mite allergen derivatives for immunotherapy, (2006-2011)


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3. Cabauatan Clarissa: PhD student: Pollen Aerobiology and Pollen-Specific Immunoglobulin-E Levels of Selected Allergic Patients in the Philippines (2011 – in progress).

4. Deifl Stephan: Doctoral Thesis: Development of allergy vaccines using Toll-like receptor ligands as immunomodulatory component. (5/2009-in progress)

5. Gadermaier Elisabeth: PhD Thesis: Allergen-specific antibodies (2006-in progress)

6. Gallerano Daniela: PhD student, Towards the definition of HIV-related anitbody- signatures and new immunogens for vaccine design, (2009 – in progress).

7. Geller Beate: PhD Thesis in Molecular Biology: Molecular characterization and epitope mapping of egg allergens (2009 – 6/2011), University of Vienna

8. Geroldinger-Simic Marija Dr.: Doctoral Thesis: Epidemiological, clinical and immunological aspects of birch pollen-related food allergies (03/2008-in progress).

9. Gieras Anna: PhD thesis: Mechanisms of allergic inflammation. (2005 - 2011).

10. Kollmann Dagmar: PhD Thesis: The role of alpha-Gal in allergic reactions to meat (08/2011 – in progress)

11. Madritsch Christoph: PhD Thesis: Isolation of grass pollen specific IgE variable regions to study mechanisms of effector cell degranulation (2009- in progress)

12. Narayanan Meena Balakumari: PhD thesis: Mechanisms underlying secondary antibody responses (12/16/2009 – in progress).

13. Niespodzyana Katarzyna: PhD thesis: Development of viral carrier-based allergy vaccines (2007 - 2011)

14. Pahr Sandra: PhD student: Characterization of wheat food allergens (2010-in progress),

15. Resch Yvonne: PhD student: Chracterization of mite allergens (2010-in progress)

16. Schmidhuber Alexandra: PhD student:: Characterization of wheat allergens, (2009-in progress)

17. Schulten Veroniqué: Doctoral Thesis, Immunological features of in vitro and in vivo digested food allergens. (07/2007- 3/2011)

18. Srinivasan Barani: PhD thesis: Characterization of wheat allergens in celiac disease patients (2008 – in progress).

19. Subarrayal Brinda: Doctoral Thesis, Characterisation of allergen specific IgG4 antibodies. (10/2008-in progress)

20. Twaroch Teresa: PhD Thesis in Nutritional Science: Molecular characterization of inhalative allergens causing severe manifestations of allergy and development of tools for allergy diagnosis and treatment (2006 – 2011), University of Vienna

21. Zulehner Nora: PhD Thesis: Characterization of different phenotypes of allergen- specific Th2 cells (03/2011 – in progress)

2.3.14. Exams a) Oral examinations: n = 2

1. Susanne Vrtala: Oral commissional Exam 01/26/11: 1

2. Susanne Vrtala: Oral commissional Exam 04/01/11: 1

b) Diploma and Thesis-Examinations: n = 13


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1. Sabine Flicker: Nina Steinke, Diploma-Examination

2. Susanne Vrtala: Kuan Wei Chen, Thesis-Examination 11/14/11

3. Barbara Bohle: diploma examination of Stefanie Nickl, 6/28/11, “Increased levels of serum heat shock protein 27 as a possible marker for incipient obstructive pulmonary disease in a risk cohort”

4. Barbara Bohle: thesis defensio of Véronique Schulten, 22/3/11, “Immunological features of in vitro and in vivo digested food allergens”

5. Barbara Bohle: diploma examination of Dagmar Kollmann, 5/9/11, “Identification of cross-reactive allergens in buckwheat, poppy and hazelnut”

6. Barbara Bohle: PhD thesis examination, University of Salzburg of Elisabeth Maier, 10/11/11, “STAT6 controls the expression of the IL-4-regulated genes TCR-1 and IL-31 in naïve CD4+ T cells undergoing Th2 development”

7. Barbara Bohle: diploma examination of Matthias Zimmermann, 10/21/11 “Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70”

8. Barbara Bohle: diploma examination of Martina Schuschnig, 11/28/11, “Expression of pattern recognition receptors by oral epithelial cell lines”

9. Barbara Bohle: diploma examination of Peter Christopher Unterkreuter, 12/1/11 “Genotoxische Auswirkungen von Eisen Nanopartikel (FeCoB) auf humane Fibroblasten”

10. Rudolf Valenta: PhD thesis examination of Niespodzyana Katarzyna

11. Rudolf Valenta: PhD thesis examination of Twaroch Theresa.

12. Rudolf Valenta: PhD thesis examination of Kuan Wei-Chen

13. Rudolf Valenta: PhD thesis examination of Gieras Anna

c) Exam supervising: n= 0


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1.3.15. Lectures, Seminars, Lab courses

SWST pro-rata LV Nr.

SS 2011

Valenta Rudolf 2.00 0.13 860.220 Basisvorlesung Immunologie

Valenta Rudolf 6.00 0.20 802.000 BL 4 - Funktionssysteme und biologische Regulation

Valenta Rudolf 2.00 2.00 902.276 TS Molekulare Allergologie

Valenta Rudolf 10.00 2.50 648.022 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie

Valenta Rudolf 4.00 4.00 648.027 Pathologie des Herz- und Kreislaufsystems - Ausgewählte Kapitel aus funktioneller Pathologie

Valenta Rudolf 5.00 5.00 648.020 Hämathologie - Ausgewählte Kapitel ausFunktioneller Pathologie

Valenta Rudolf 2.00 0.14 901.929 IAI-Basic Seminars

Valenta Rudolf 2.00 0.25 902.241 IAI-Journal Club

Bohle Barbara 2.00 0.13 860.220 Basisvorlesung Immunologie

Bohle Barbara 1.00 1.00 809.061 MS: Methoden der Allergologie

Bohle Barbara 2.00 2.00 648.035 Journal Club und Progress Report

Bohle Barbara 2.00 2.00 648.036 Dissertantenseminar Ziele und Methoden der Allergologie

Bohle Barbara 2.00 2.00 902.211 Dissertantenseminar: Ziele und Methoden der Allergologie

Bohle Barbara 2.00 2.00 902.696 Journal Club and Progress Report

Bohle Barbara 2.00 0.14 901.929 IAI-Basic Seminars

Bohle Barbara 2.00 0.25 902.241 IAI-Journal Club

Vrtala Susanne 2.00 0.50 860.037 Journal Club and Progress Report

Vrtala Susanne 2.00 0.50 648.025 Journal Club und Progress Report

Focke-Tejkl Margarete 2.00 0.50 648.025 Journal Club und Progress Report

Focke-Tejkl Margarete 2.00 0.50 860.037 Journal Club and Progress Report

Swoboda Ines 2.00 2.00 860.037 Journal Club and Progress Report

Swoboda Ines 2.00 2.00 648.025 Journal Club und Progress Report

Swoboda Ines 10.00 10.00 648.022 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie

Flicker Sabine 2.00 0.50 860.037 Journal Club and Progress Report

Lupinek Christian 4.00 0.50 808.004 SSM 3-Projektstudie (Wahlpflichtteil)

Sum 40.61

WS 2011/12

Valenta Rudolf 2.00 0.17 502.282 Medical Propedeutics III - Linking Biology and Medicine

Valenta Rudolf 4.00 4.00 514.002 Pathologie des Herz- und Kreislaufsystems - Ausgewählte Kapitel aus funktioneller Pathologie

Valenta Rudolf 5.00 2.00 514.034 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.)


71

Valenta Rudolf 2.00 2.00 648.001 Journal Club and Progress Report

Valenta Rudolf 4.00 1.00 648.002 Wissensschaftliches Arbeiten

Valenta Rudolf 10.00 2.50 648.005 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie

Valenta Rudolf 5.80 0.40 803.002 BL 8 - Krankheit. Krankheitsursachen und Krankheitsbilder

Valenta Rudolf 3.00 0.40 840.052 Medizinisches Propädeutikum Teil 1

Valenta Rudolf 2.00 0.18 860.008 Special Course: Scientific Presentation

Valenta Rudolf 2.00 0.13 901.929 IAI-Basic Seminars

Valenta Rudolf 2.00 2.00 901.931 Special Course: Advanced Molecular cloning techniques

Valenta Rudolf 2.00 0.17 902.241 1IAI-Journal Club

Valenta Rudolf 2.00 0.18 902.920 Special Course: Basic techniques in molecular and cellular biology


Bohle Barbara 2.00 1.00 648.006 Dissertantenseminar Ziele und Methoder der Allergologie

Bohle Barbara 2.00 0.18 860.008 Special Course: Scientific Presentation

Bohle Barbara 2.00 0.13 901.929 IAI-Basic Seminars

Bohle Barbara 2.00 2.00 901.933 Special Course: Cellular allergology

Bohle Barbara 2.00 2.00 902.211 Dissertantenseminar: Ziele und Methoden der Allergologie

Bohle Barbara 2.00 0.17 902.241 IAI-Journal Club


Bohle Barbara 2.00 0.18 902.920 Special Course: Basic techniques in molecular and cellular biology

Focke-Tejkl Margarete 2.00 0.50 860.023 Journal Club and Progress Report

Vrtala Susanne 2.00 0.50 860.023 Journal Club and Progress Report

Jahn-Schmid Beatrice 2.00 1.00 648.000 Journal Club und Progress Report

Jahn-Schmid Beatrice 2.00 1.00 648.006 Dissertantenseminar Ziele und Methoden der Allergologie

Jahn-Schmid Beatrice 1.00 1.00 902.542 Grundlagen der Allergologie

Swoboda Ines 5.00 1.00 514.034 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.)

Swoboda Ines 4.00 1.00 648.002 Wissensschaftliches Arbeiten

Swoboda Ines 10.00 2.50 648.005 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie

Flicker Sabine 2.00 0.50 860.023 Journal Club and Progress Report

Flicker Sabine 2.00 0.50 860.006 B cells and antibodies

Swoboda Ines 2.00 0.50 860.006 B cells and antibodies

Sum 32.79

Total sum SS+WS 73.40

Performance Report 2011 Medical Biotechnology

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1.4 Division for Medical Biotechnology Head: Heimo Breiteneder, Professor

1. Publications7

IF Number Top/Std/Subst Heimo Breiteneder 34,929 14,2 6xTop, 2xSt, 1xSSt

Karin Hoffmann-S. 33,240 11,4 2xTop, 5xSt, 2xSSt

Yan Ma 0,672 0,2 1xSt

Christian Radauer 7,111 3 1xTop, 1xSt

Stefan Wagner 7,327 3 1xTop, 1xSt

Sum 64,646 26,4



2. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st.

Heimo Breiteneder 1 3 Karin Hoffmann-S. 3 3 0 Yan Ma 4 1 Christian Radauer 1 Stefan Wagner 2

Sum 3 8 7


Heimo Breiteneder 5,40 5,60 11,00 2 Karin Hoffmann-S. 3,90 5,23 9,13 4 Yan Ma 10,84 12,70 23,54 19 Christian Radauer 0,40 1,23 1,63 Stefan Wagner 1,40 0,00 1,40 Sum 21,94 24,76 46,7 25




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1.4.1. Publications a) Peer-reviewed original articles: n = 17


1. Radauer, C., F. Adhami, I. Furtler, S. Wagner, D. Allwardt, E. Scala, C. Ebner, C. Hafner, W. Hemmer, A. Mari, and H. Breiteneder. 2011. Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergy. Mol Immunol (48): 600-609.

2,916 St.

2. Bublin, M., S. Dennstedt, M. Buchegger, M. Antonietta Ciardiello, M. L. Bernardi, L. Tuppo, C. Harwanegg, C. Hafner, C. Ebner, B. K. Ballmer-Weber, A. Knulst, K. Hoffmann-Sommergruber, C. Radauer, A. Mari, and H. Breiteneder. 2011. The performance of a component-based allergen microarray for the diagnosis of kiwifruit allergy. Clin Exp Allergy (41): 129-136.

4,195 Top

3. Bulgheresi, S., H. R. Gruber-Vodicka, N. R. Heindl, U. Dirks, M. Kostadinova, H. Breiteneder, and J. A. Ott. 2011. Sequence variability of the pattern recognition receptor Mermaid mediates specificity of marine nematode symbioses. ISME J (5): 986-998.

6,153 Top

4. D'Avino, R., M. L. Bernardi, M. Wallner, P. Palazzo, L. Camardella, L. Tuppo, C. Alessandri, H. Breiteneder, F. Ferreira, M. A. Ciardiello, and A. Mari. 2011. Kiwifruit Act d 11 is the first member of the ripening-related protein family identified as an allergen. Allergy (66): 870-877.

6,297 Top

5. Collot, M., I. B. Wilson, M. Bublin, K. Hoffmann-Sommergruber, and J. M. Mallet. 2011. Synthesis of cross-reactive carbohydrate determinants fragments as tools for in vitro allergy diagnosis. Bioorg Med Chem (19): 1306-1320.

2,978 St.

6. Le, T. M., P. Fritsche, M. Bublin, C. Oberhuber, S. Bulley, E. van Hoffen, B. K. Ballmer-Weber, A. C. Knulst, and K. Hoffmann-Sommergruber. 2011. Differences in the allergenicity of 6 different kiwifruit cultivars analyzed by prick-to-prick testing, open food challenges, and ELISA. J Allergy Clin Immunol (127): 677-679 e671-672.

9,273 Top

7. van den Driesche, S., W. Witarski, S. Pastorekova, H. Breiteneder, C. Hafner, M.J. Vellekoop. 2011. A label-free indicator for tumor cells based on the CH(2)-stretch ratio. Analyst (136): 2397-2402.

3,913 Top

8. Latzka, J., S. Gaier, G. Hofstetter, N. Balazs, S. Ferrone, O. Scheiner, H. Breiteneder, H. Pehamberger, S. Wagner. 2011. Specificity of mimotope-induced anti-high molecular weight melanoma associated antigen (HMW-MAA) antibodies does not ensure biological activity. PLoS One (6): e19383.

4,411 Top

9. Wurms, K., W. Cui, A. Ah-Chee, J. Rees-George, M. Bublin, H. Breiteneder. 2011. Down Regulation of Putative Defence-Associated Transcripts Correlates with Ripe Rot

0,937 St.

http://www.ncbi.nlm.nih.gov/pubmed/21499645



74

Symptoms on Kiwifruit (Actinidia chinensis). J. Phytopathol 159:435-442.

10. Moritz, K. B., T. Kopp, G. Stingl, M. Bublin, H. Breiteneder, and S. Wohrl. 2011. Anaphylaxis to Malaysian meat loaf. Allergol Immunopathol (Madr) (39): 244-245.

0,779 SSt.

11. Sancho, A. I., A. Wangorsch, B. M. Jensen, A. Watson, Y. Alexeev, P. E. Johnson, A. R. Mackie, A. Neubauer, G. Reese, B. Ballmer-Weber, K. Hoffmann-Sommergruber, P. S. Skov, S. Vieths, and E. N. Mills. 2011. Responsiveness of the major birch allergen Bet v 1 scaffold to the gastric environment: Impact on structure and allergenic activity. Mol Nutr Food Res (55): 1690-1699.

4,713 Top

12. Konakovsky, V., M. Focke, K. Hoffmann-Sommergruber, R. Schmid, O. Scheiner, P. Moser, R. Jarisch, and W. Hemmer. 2011. Levels of histamine and other biogenic amines in high-quality red wines. Food Addit Contam Part A Chem Anal Control Expo Risk Assess (28): 408-416.

2,230 St.

13. Mayer, M., C. Oberhuber, I. Loncaric, B. Heissenberger, M. Keck, O. Scheiner, K. Hoffmann-Sommergruber (corresponding author). 2011. Fireblight (Erwinia amylovora) affects Mal d 1-related allergenicity in apple. Eur J Plant Pathol, (131): 1-7, DOI 10.1007/s10658-011-9784-4.

1,575 St.

14. Worm, M., K. Scherer, A. Kohli-Wiesner, F. Rueff, V. Mahler, L. Lange, R. Treudler, E. Rietschel, Z. Szepfalusi, R. Lang, U. Rabe, T. Reese, N. Schwerk, K. Beyer, S. Hompes, A. Bircher, B. Przybilla, T. Hawranek, G. Hansen, F. Friedrichs, H. Merk, K. Tenbrock, S. Lehmann, M. Gerstlauer, J. Kleine-Tebbe, B. Niggemann, H. Dickel, M. Bucheler, T. Bieber, J. Hanfland, S. Schmitt-Grohe, D. Vlajnic, V. Heckmann, K. Nemat, K. Schakel, A. Nordwig, A. Schuster, S. Schweitzer-Krantz, U. Hillen, M. Kopp, C. Szliska, J. Klinge, I. Neustadter, T. Fuchs, R. Bruns, C. Marsch, B. Kreft, E. Coors, W. Rebien, B. Wedi, C. Pfohler, M. Rett, M. Henzgen, P. Vohringer, R. Folster-Holst, N. Hunzelmann, G. Siebenhaar, S. Nestoris, C. Schirpke, J. Grabbe, G. Stichtenoth, J. Ring, K. Brockow, R. Brehler, I. Yildiz, S. Volkmuth, M. Geissler, M. Polz, F. Riffelmann, S. Thies, U. Lepp, H. Rebmann, T. Spindler, L. Klimek, O. Pfaar, W. Brosi, W. Aberer, E. Varga, N. Reider, I. Huttegger, T. Kinaciyan, K. Hoffmann-Sommergruber, P. Eng, A. Helbling, P. Eigenmann, R. Guggenheim, and P. Schmid-Grendelmeier. 2011. Food-induced anaphylaxis and cofactors - data from the anaphylaxis registry. Allergologie (34): 329-337.

0,143 SSt.

15. Ecker, C., P. Forstenlechner, D. Milić, K. Hoffmann-Sommergruber, M. Cichna-Markl, D. Matković-Čalogović. 2011. Expression, purification and crystallization of wheat profilin (Tri a 12). Croatica Chemica Acta Vol: 84, Issue 3: 419-422.

0,713 SSt.

16. Csupor, D., B. Borcsa, B. Heydel, J. Hohmann, I. Zupkó, Y. Ma, U. Widowitz, R. Bauer R. 2011. Comparison of a

0,672 St.



75

specific HPLC determination of toxic aconite alkaloids in processed Radix aconiti with a titration method of total alkaloids. Pharm Biol. 49 (10):1097-1101.

17. Chruszcz, M., Maleki, S. J., Majorek, K. A., Demas, M., Bublin, M., Solberg, R., Hurlburt, B. K., Ruan, S., Mattison, C. B., Breiteneder, H., and W. Minor. Structural and immunologic characterization of Ara h 1 – a major peanut allergen. J Biol Chem 2011;286(45):39318-27.

5,328 Top

sum 57,226

b) Invited Articles & Reviews with IF: n = 2

Nr. Article IF Class 1. Ballmer-Weber, B. K., and K. Hoffmann-Sommergruber.

2011. Molecular diagnosis of fruit and vegetable allergy. Curr Opin Allergy Clin Immunol (11): 229-235.

3,431 St.

2. Hoffmann-Sommergruber, K., K. Paschinger, and I. B. Wilson. 2011. Glycomarkers in parasitic infections and allergy. Biochem Soc Trans (39): 360-364.

3,989 St.

sum 7,420

c) Invited Articles & Reviews without IF: n = 0

d) Book contributions: n = 0 e) Abstracts, printed in periodicals: n = 11 1. van den Driesche, S., W. Witarski, S. Pastorekova, H. Breiteneder, C. Hafner, M.J.

Vellekoop. 2011. A label-free indicator for tumor cells based on the CH(2)-stretch ratio. J Invest Dermatol (131): 123.

2. Somkuti, J., M. Bublin, H. Breiteneder, L. Smeller. 2011. Unfolding of the cod parvalbumin Gad m 1 allergen by high pressure. Eur Biophys J Biophy (40): 60.

3. Ackerbauer, D., B. Gepp, W. Hemmer, M. Bublin, H. Breiteneder. 2011. Recombinant scFv antibodies against chimeric proteins of Bet v 1 and Api g 1 for IgE epitope mapping. 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011. Allergy 66 suppl. 94: 723

4. Smole, U., N. Balazs, Y. Sobanov, C. Radauer, M. Bublin, K. Hoffmann-Sommergruber, E. Jensen-Jarolim, D. Mechtcheriakova, H. Breiteneder. Lipid raft mediated uptake of the major birch pollen allergen Bet v 1.0101 activates Th2 polarising signaling pathways in dendritic cells of allergic donors. 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011. Allergy 66 suppl. 94: 54

5. Wallner, M., H. Michael, M. Himly, S. Wagner, C. Asam, U. Pichler, R. Sanovic, H. Breiteneder, J. Thalhammer, P. Lackner, A. Hartl, F. Ferreira. Non-allergenic structural homologues of Bet v 1 may help to unravel the mystery of allergenicity. 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011. Allergy 66 suppl. 94: 92.

6. Gepp B., Balazs N., Hemmer W., Radauer C., Breiteneder H. Epitope grafting reveals patient specific IgE binding profiles to the major birch pollen allergen Bet v 1. 30th



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Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011. Allergy 66 suppl. 94: 99.

7. Nandy, A., F. Ferreira, H. Breiteneder, A. Pomés. A bioinformatics approach to allergen nomenclature applied to the group 1 ragweed allergens: Amb a 2 renamed as Amb a 1.05. 30th Congress of the European Academy of Allergy and Clinical Immunology. Istanbul, Turkey, June 11-15, 2011. Allergy 66 suppl. 94: 143.

8. Guhsl, E., B. Gepp, N. Balazs, G. Hofstetter, W. Hemmer, H. Breiteneder, C. Radauer. IgE cross-reactivity between Bet v 1 and cytokinin-specific binding protein from mung bean, a homologous protein outside the PR-10 subfamily. 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011. Allergy 66 suppl. 94: 521.

9. Marchart, K., J. Schinnerl, K. Peter, H. Breiteneder, Y. Ma. 2011. Qualitative analysis of Chinese medical herbs for the prevention and therapy of age related diseases. Die Ernährung/Nutrition. 2011 Oct;35(10):387.

10. Ma, Y., K. Peter, J. Liu, J. Schinnerl, D. Shi, H. Breiteneder. 2011. Traditional Chinese herbal medicine for prevention and therapy of heart failure. Die Ernährung/Nutrition. 2011 Oct;35(10):387-388.

11. Teubl, R., T. Founé, Y. Ma. 2011. Acceptance of Traditional Chinese Medicine in the treatment of obesity and metabolic disorders in western medicine. Die Ernährung/Nutrition. 2011 Oct; 35(10):389.

f) Abstracts, in congress proceedings or abstract books: n = 16 66. Gepp B., N. Balazs, W. Hemmer , C. Radauer, H. Breiteneder. Epitope grafting

reveals patient specific IgE binding profiles to the major birch pollen allergen Bet v 1. 7th PhD Symposium, Vienna, Austria, June 15-16, 2011

67. Gepp B., N. Lengger, W. Hemmer, C. Radauer, H. Breiteneder. Grafting of Bet v 1 epitopes onto its homologue Api g 1 reveals patient-specific IgE recognition profiles. ÖGAI 2011 – Annual meeting of the Austrian Society of Allergy and Immunology, Graz, Austria, September 15-17, 2011. 15.

68. Guhsl E., B. Gepp, G. Hofstetter, N. Lengger, W. Hemmer, H. Breiteneder, C. Radauer. IgE cross-reactivity between Bet v 1 and the mung bean proteins cytokinin-specific binding protein and Vig r 1 in patients with birch pollen-associated allergy to mung bean sprouts. ÖGAI 2011 – Annual meeting of the Austrian Society of Allergy and Immunology, Graz, Austria, September 15-17, 2011. 19.

69. Smole U., N. Balazs, C. Radauer, Sobanov Y., M. Bublin, S. Gaier, K. Hoffmann-Sommergruber, E. Jensen-Jarolim, D. Mechtcheriakova, H. Breiteneder. Allergic sensitization to the major birch pollen allergen Bet v 1.0101 – a result of differential signal processing and signal translation in dendritic cells of allergic and healthy individuals? ÖGAI 2011 – Annual meeting of the Austrian Society of Allergy and Immunology, Graz, Austria, September 15-17, 2011. 46.

70. Berneder M., S. Claus, M. Worm, K. Hoffmann-Sommergruber K. Food anaphylaxis diagnosis using the allergen CHIP approach. ÖGAI 2011 – Annual meeting of the Austrian Society of Allergy and Immunology, Graz, Austria, September 15-17, 2011. 5.

71. Hoflehner E., K. Hufnagl, I. Schabussova, K. Hoffmann-Sommergruber, B. Bohle and U. Wiedermann. ÖGAI 2011 – Annual meeting of the Austrian Society of Allergy and Immunology, Graz, Austria, September 15-17, 2011. 21.

72. Gepp B., N. Lengger, W. Hemmer, C. Radauer, H. Breiteneder. Grafting of Bet v 1 epitopes onto its homologue Api g 1 reveals patient-specific IgE recognition profiles.


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WAC 2011 – XXII World Allergy Congress, Cancun, Mexico, December 4-8, 2011.

73. Radauer C., E. Guhsl, M. Bublin, H. Breiteneder. Pollen Allergens Differ From Non-Allergenic Pollen Proteins by Their Lower Extent of Evolutionary Conservation. WAC 2011 – XXII World Allergy Congress, Cancun, Mexico, December 4-8, 2011.

74. Breiteneder H., P. Rozynek, M. Raulf-Heimsoth, R. Goodman and C. Radauer. Bioinformatic Approach to Allergen Nomenclature Applied to Allergens From the Non-Biting Midge Chironomus Thummi Thummi. WAC 2011 – XXII World Allergy Congress, Cancun, Mexico, December 4-8, 2011.

75. Guhsl E., B. Gepp, G. Hofstetter, N. Balazs, W. Hemmer, H. Breiteneder and C. Radauer. IgE From Birch Pollen Allergic Patients Cross-Reacts with Two Distinct Bet v 1 Related Proteins in Mung Beans: Vig r 1 and Cytokinin-Specific Binding Protein. WAC 2011 – XXII World Allergy Congress, Cancun, Mexico, December 4-8, 2011.

76. Smole U., N. Balazs, C. Radauer, Y. Sobanov, M. Bublin, S. Gaier, K. Hoffmann-Sommergruber, E. Jensen-Jarolim, D. Mechtcheriakova and H. Breiteneder. Specific Recognition of the Major Birch Pollen Allergen Bet v 1 Programs Dendritic Cells to Induce Either Th2 or Tolerogenic Responses. WAC 2011 – XXII World Allergy Congress, Cancun, Mexico, December 4-8, 2011.

77. Bublin M., M Kostadinova, D Ackerbauer, C Ebner, C Radauer and H. Breiteneder. Recombinant Scfv Antibodies for IgE Epitope Mapping and Detection of Parvalbumins. WAC 2011 – XXII World Allergy Congress, Cancun, Mexico, December 4-8, 2011.

78. Ma Y. Development of a Curriculum for Chinese Medicine Education at the Medical University of Vienna. 2nd World Education Congress of Chinese Medicine, Beijing, China, October 29-31, 2011.

79. Forstenlechner P., Hoffmann-Sommergruber K., Milić D., Matković-Čalogović D., Ecker C., Cichna-Markl M. Expression, purification and crystallization of wheat profilin (Tri a 12). EAACI Food Allergy and Anaphylaxis Meeting FAAM February 17–19 2011, Venice, Italy.

80. Hoffmann-Sommergruber K., Gehört es schon zum guten Ton? Allergieneigung und Häufigkeit in der Bevölkerung. Jahrestagung des Verbandes der Ernährungswissenschafter Österreichs: 5.5.2011, BM für Gesundheit; Vienna, Austria.

81. Hoffmann-Sommergruber K., Neue Nahrungsmittelallergene“ und deren Relevanz 24. Allergie-Kolloquium am 7. Mai 2011, Forschungszentrum Borstel, Germany.

g) Teaching Scripts and Books, n = 28 Breiteneder Heimo

Lehrunterlagen für die Vorlesung Nahrungsmittelallergie 502.362, VO 2 St.

1. Skriptum - Nahrungsmittelallergene: Proteinfamilien und Kreuzreaktivitäten, Teil A 2. Skriptum - Nahrungsmittelallergene: Proteinfamilien und Kreuzreaktivitäten, Teil B 3. Skriptum - Gentechnisch veränderte Nahrungsmittel und Allergie 4. Skriptum – Physikalische chemische Eigenschaften von Nahrungsmittelallergenen Bublin Merima: Lehrunterlagen für die Vorlesung Nahrungsmittelallergie 502.362, VO 2 St.

1. Das mukosale I(mmunsystem) 2. IgE-vermittelte Nahrungsmittelallergie: Epidemiologie, Symptome, Diagnose, Therapie,

Prävention 3. Nicht IgE-vermittelte Nahrungsmittelunverträglichkeiten 4. Methoden zur Identifizierung und Charakterisierung von Nahrungsmittelallergenen


78

Hoffmann-Sommergruber Karin: Lehrunterlagen für die Vorlesung NM-Allergien und Intoleranzen 514.074 NM Allergien und Intoleranzen (gemeinsam mit Priv. Doz. Dr. Merima Bublin) VO 2 St.

1. Einführung: Immunsystem, Grundlagen und Pathomechanismus der allergischen Reaktion

2. NM Allergien: Symptome, Prävalenz 3. Allergene 4. Diagnostik von NM-Allergien und Fallbeispiele 5. NM-Intoxikationen, Immunmediierte NM-Allergien - Zöliakie; NM- Intoleranzen;

Fallbeispiele 6. NM Allergien: Genetische Aspekte; Umwelteinflüsse bei Allergieentstehung;

Hygienehypothese 7. Präventionsmaßnahmen: Allergenkennzeichnung 8. NM-Allergien: Therapienansätze Lehrunterlagen für die Vorlesung Ausgewählte Kapitel der medizinischen Biotechnologie

648.401 (gem. mit . Doz. Wagner, Doz. Radauer, Pro .Breiteneder und Doz Bublin) VO 2 St. 1. Vakzine und Adjuvantien 2. GM-Food 3. GM-Food and PMPs Radauer Christian: Lehrunterlagen für die Vorlesung Nahrungsmittelallergie 502.362, VO 2 St.

1. Skriptum: Molekulare und zelluläre Grundlagen der IgE-vermittelten Allergie 2. Skriptum: Ursachen allergischer Erkrankungen 3. Skriptum: Probleme in der Allergiediagnostik; Allergene und Kreuzreaktionen pflanzlicher

und tierischer Nahrungsmittel 4. Skriptum: Allergenität verarbeiteter Nahrungsmittel; Versteckte Allergene und

Lebensmittelkennzeichnung

Lernunterlagen für die Vorlesung "Ausgewählte Kapitel der medizinischen Biotechnologie"; 648.401; VO 2 St.

1. Skriptum: Design von Antikörperderivaten für Diagnostik und Therapie 2. Skriptum: Kombinatorische Methoden zur Entwicklung neuer Wirkstoffe Wagner Stefan: Lernunterlagen für die Vorlesung "Ausgewählte Kapitel der medizinischen Biotechnologie"; 648.401; VO 2 St.

1. Immuntherapie von Krebserkrankungen mit monoklonalen Antikörpern 2. Immuntherapie von Krebserkrankungen auf zellulärer Basis 3. Sonstige Ansätze zur Immuntherapie von Krebserkrankungen h) Articles in Medical Journals: n = 1 Breiteneder Heimo: 1. Ärzte Woche, Professur für Medizinische Biotechnologie, .Ärzte Woche 21/2011.


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i) Public Activity: n = 9 Breiteneder Heimo:

1. Medizinische Universität Wien, Heimo Breiteneder: „Pionier der Allergenforschung“ erhält Professur für Medizinische Biotechnologie, http://www.meduniwien.ac.at/homepage/news-und-topstories/?tx_ttnews[tt_news]=1892&cHash=b4615a5848, Wien 05/17/2011.

2. SpringerMedizin.at, Breiteneder wird Biotech-Professor der MedUni Wien, http://www.springermedizin.at/artikel/22227-breiteneder-wird-biotech-professor-der-meduni-wien, 05/17/2011.

3. I.G.A.V., „Pionier der Allergenforschung“ erhält Professur für Medizinische Biotechnologie, http://www.allergenvermeidung.org/index.php?aid=387, 5/2011.

4. Studium.at Der Online-Tutor, „Pionier der Allergenforschung“ erhält Professur für Medizinische Biotechnologie, http://www.studium.at/45155-pionier-der-allergenforschung-erhaelt-professur-fuer-medizinische-biotechnologie-der-meduni-wien, 05/17/2011.

5. APA, Breiteneder wird Biotech-Professor der MedUni Wien, http://www.zukunftwissen.apa.at/cms/zukunft-wissen/fti-und-wissenschaft/zukunft-wissen-topnews.pdf?id=CMS1305627557234, 5/2011.

6. Zentrum für Pathophysiologie, Infektiologie und Immunologie, Heimo Breiteneder Professor für Medizinische Biotechnologie, http://www.meduniwien.ac.at/hp/cepii/news/singleview/heimo-breiteneder-professor-fuer-medizinische-biotechnologie/f8ebe5dc42/, 5/2011.

7. Lebensweise-Magazin, Allergie-Frust statt Frühlingslust, http://www.lebensweise-magazin.at/2011/03/11/allergie-frust-statt-fr%C3%BChlings-lust/ 08/03/2011.

8. AlumniClubMUW auf Twitter, „Pionier der Allergenforschung“ erhält Professur für Medizinische Biotechnologie, http://twitter.com/#!/AlumniClubMUW/status/70523920322789376, 05/17/2011.

Ma Yan:

1. People Magazin Ausgabe 01/2011: Menschen und Medizin im Wiener AKH. Erster TCM-Lehrgang gestartet, S.6.

1.4.2. Research Awards: n = 10 Ackerbauer Daniela:

1. Poster Prize at the EAACI 2011 – 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011.

2. Poster Prize, 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology at the Medical University of Vienna, Sept. 27, 2011.

Gepp Barbara:

3. Junior Poster Prize at the EAACI 2011 – 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011.

4. Poster Prize of the Austrian Society of Allergology and Immunology (ÖGAI), Annual Meeting of the Austrian Society of Allergology and Immunology, Graz 2011.

5. Travel Grant of the World Allergy Organization (WAO), 22nd World Allergy Congress in Cancun, Mexico, 4-8 December, 2011.

http://www.meduniwien.ac.at/homepage/news-und-topstories/?tx_ttnews%5btt_news%5d=1892&cHash=b4615a5848

http://www.meduniwien.ac.at/homepage/news-und-topstories/?tx_ttnews%5btt_news%5d=1892&cHash=b4615a5848

http://www.springermedizin.at/artikel/22227-breiteneder-wird-biotech-professor-der-meduni-wien

http://www.springermedizin.at/artikel/22227-breiteneder-wird-biotech-professor-der-meduni-wien

http://www.allergenvermeidung.org/index.php?aid=387

http://www.studium.at/45155-pionier-der-allergenforschung-erhaelt-professur-fuer-medizinische-biotechnologie-der-meduni-wien



http://www.zukunftwissen.apa.at/cms/zukunft-wissen/fti-und-wissenschaft/zukunft-wissen-topnews.pdf?id=CMS1305627557234

http://www.zukunftwissen.apa.at/cms/zukunft-wissen/fti-und-wissenschaft/zukunft-wissen-topnews.pdf?id=CMS1305627557234

http://www.meduniwien.ac.at/hp/cepii/news/singleview/heimo-breiteneder-professor-fuer-medizinische-biotechnologie/f8ebe5dc42/

http://www.meduniwien.ac.at/hp/cepii/news/singleview/heimo-breiteneder-professor-fuer-medizinische-biotechnologie/f8ebe5dc42/

http://www.lebensweise-magazin.at/2011/03/11/allergie-frust-statt-fr%C3%BChlings-lust/

http://www.lebensweise-magazin.at/2011/03/11/allergie-frust-statt-fr%C3%BChlings-lust/

http://twitter.com/#!/AlumniClubMUW/status/70523920322789376


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Guhsl Eva:

6. Poster Prize, 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology at the Medical University of Vienna, Sept. 27, 2011.

7. Travel grant of the ÖGAI (Austrian Society for Allergology und Immunology) for the 22nd WAO Congress 2012 in Cancun, Mexico, December 04-08, 2011.

Smole Ursula:

8. Travel grant of the European Academy of Allergy and Clinical Immunology, 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011.

9. Travel grant of the World Allergy Organization for the 22nd World Allergy Congress, Cancun, Mexico, December 4-8, 2011.

10. WAO Junior Abstract Award of the World Allergy Organization for the 22nd World Allergy Congress, Cancun, Mexico, December 4-8, 2011.

1.4.3. Invited lectures: n = 27 Breiteneder Heimo: 1. Wiener Allergiekurs 2011. „Allergene und Allergenquellen“. 1/28/2011, Hotel Strudlhof

Vienna, Austria. 2. 6. Tiroler Allergietagung. Gentechnik & Allergologie – Konsequenzen für den

Nahrungsmittelallergiker. 3/26/2011, Villa Blanka, Innsbruck, Austria. 3. 30th Congress of the European Academy of Allergy and Clinical Immunology (EAACI).

Latex allergy – New molecules in diagnosis and cross-reactivity. 6/15/2011, Istanbul, Turkey.

4. Immunity in cancer & allergy symposium. What makes proteins allergenic? 7/1/2011, University Salzburg, Austria.

5. Allergietag zum Thema: „Molekulare Allergiediagnostik mittels Chiptechnologie: Anwendung & Interpretation.“ Grundlagen der molekularen Allergiediagnostik. 11/5/2011, Wilhelminenspital Vienna, Austria.

6. Workshop: Molekulare Allergologie. Allergene: Definition, Nomenklatur und Datenbanken. 11/18/2011, Arcotel Kaiserwasser Vienna, Austria.

7. XXII World Allergy Congress. A bioinformatic approach to allergen nomenclature applied to allergens from the non-biting midge Chironomus thummi thummi. 12/5/2011, Cancun, Mexico.

Hoffmann-Sommergruber Karin: 1. EAACI Food Allergy and Anaphylaxis Meeting (FAAM). Food Allergen protein families

and their structural characteristics: New data from EuroPrevall at Workshop 7: Characterisation of Food Allergens and clinical Implications. 2/18/2011, Venice, Italy.

2. VEÖ: Jahrestagung des Verbandes der Ernährungswissenschafter Österreichs: „Gehört es schon zum guten Ton? Allergieneigung und Häufigkeit in der Bevölkerung“. 5/5/2011, BM für Gesundheit; Vienna, Austria.

3. 24. Allergie-Kolloquium Forschungszentrum Borstel. Neue Nahrungsmittelallergene und deren Relevanz. 5/7/2011, Forschungszentrum Borstel, Germany.

4. 30th Congress of the European Academy of Allergy and Clinical Immunology. Food. Allergy: “Emerging allergens – new ones and old friends revisited”. Symposium on Food Allergy. 6/15/2011, Istanbul, Turkey.


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5. 30th Congress of the European Academy of Allergy and Clinical Immunology. “Determining the clinical relevance of allergen food-cross reactivity: Food-Food versus Food- Pollen”. 6/11/2011, Istanbul, Turkey.

6. 30th Congress of the European Academy of Allergy and Clinical Immunology. Introductory lecture: New recombinants in the diagnosis of food Allergy, Oral Abstract session. 6/13/2011, Istanbul, Turkey.

7. Ernährungsakademie: Gentechnisch veränderte Lebensmittel: Vermeidbares Risiko oder Segen für den Konsumenten? 9/17/2011, Vienna, Austria.

8. Weiterbildung Fachtoxikologe/Fachtoxikologie DGPT, Kurs „Lebensmitteltoxikologie“. Lebensmittelallergien und Unverträglichkeiten. 10/14/2011, TU Kaiserslautern, Kaiserslautern, Germany.

9. Allergietag zum Thema: „Molekulare Allergiediagnostik mittels Chiptechnologie: Anwendung & Interpretation: Allergenchip: Pro und Contra: Dermatol. Abteilung Wilhelminenspital. 11/5/2011, Vienna, Austria.

10. Advanced Therapies Gene therapy and recombinant proteins (FH Krems, within Master studies regulatory affairs, 12/17/2011, Krems, Austria.

11. Science Day – MedUniWien: “Allergisch aufs Essen??“ Vortrag und Poster im Rahmen des Science Day, 10/7/2011, Vienna, Austria.

Ma Yan: 1. Effects of a traditional Chinese herbal medicine formula on myocardial infarction in a rat

model. TCMIRI - MEETING, 04/28/2011, China-Zentrum der Universität Salzburg, Austria.

2. Effects of Si Ni Tang, a Chinese Medical Formula, on Early Cardiac Remodeling in Rats, Post-acute Myocardial Infarction. TCM Evaluierungsmeeting an der China Academy of Chinese Medical Sciences in Zusammenarbeit mit BMWF und BMG, 05/30/2011, Beijing, China.

3. Quality control of Chinese medical herbs for the prevention and therapy of age related diseases. Workshop "Quality Requirements of Herbal Drugs and Herbal Medicinal Products" 06/01/2011, Beijing, China.

4. Warum wird in der Traditionellen Chinesischen Medizin nicht operiert? 07/18/2011, KinderUni 2011, Vienna, Austria.

5. Development of a Curriculum for Chinese Medicine Education at the Medical University of Vienna. 2nd World Education Congress of Chinese Medicine, 10/29/2011, Beijing, China.

Radauer Christian: 1. Pirquet-Club, organized by the Austrian Society of Allergology and Immunology. "Das

Latex-Frucht-Syndrom: Neue Daten zum molekularen Hintergrund" 2/21/2011, Vienna, Austria.

2. Seminar Nahrungsmittelallergien 2011, Veranstaltet vom Verband der Diätologen Österreichs. Allergene und Kreuzreaktionen pflanzlicher und tierischer Nahrungsmittel. 10/20/2011, Salzburg, Austria.

Wagner Stefan: 1. "Erfahrungen mit Tiermodellen für humane Melanome". ÖAW-Symposium "Das

Melanom - der 'schwarze Tod' der Neuzeit". Veterinärmedizinische Universität. 07/20/2011, Vienna, Austria.

2. "Auswirkungen der Umsetzung eines Qualitätsmanagementsystems nach ISO 9001:2008 an einem Forschungsinstitut". Naturwissenschaftliche Fakultät, Universität Salzburg. 11/15/2011, Salzburg, Austria.


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1.4.4. Congress organization Division member

Name: National congress

Name, date Function

Intern. Congress, Name, date

Function

Hoffmann-Sommergruber

Karin

EAACI Food Allergy and Anaphylaxis Meeting

FAAM February 17 – 19 2011, Venice, Italy.

Member of the Organising Committee


division member Speaker´s name Affiliation Date

Ma Yan Prof. Dr. Zhao Yansong

Beijing University of Chinese Medicine & Pharmacology

04/12/2011 – 07/31/2011

Ma Yan Prof. Dr. Liu Min Beijing University of Chinese Medicine

02/19/2011 – 05/19/2011

Ma Yan Dr. Su Rui China Academy of Chinese Medicine Sciences

09/12/2011 - 16/12/2011

Ma Yan Prof. Dr. Chang Jingling

Beijing University of Chinese Medicine

12/01/2011 – 02/29/2012

1.4.6. Mobility

Name Program University, Land Time frame Division In Out

Alcocer Marcos Sabbatical University Nottingham, UK

04/04/2011 – 04/20/2011

4 X

Ashjaei Kazem Financial supported by the Tabriz

University of Medical Sciences, Iran

Tabriz University of Medical

Sciences, Iran

04/19/2010 – 06/30/2013

4 X

Liu Min Eurasia-Pacific Uninet Scholarship Award

University of TCM Beijing, China

02/19/2011 – 05/19/2011

4 X

Zhao Yansong Eurasia-Pacific Uninet Scholarship Award

University of Beijing, China

04/12/2011 – 07/31/2011

4 X

Chang Jingling Eurasia-Pacific Uninet Scholarship Award

University of Beijing, China

12/01/2011 – 02/29/2012

4 X


Name Society/Institute/Journal Function

Breiteneder Heimo International Union of Immunological Societies,

Allergen Nomenclature Sub-committee

Chair and Member


83

Breiteneder Heimo International Union of Immunological Societies,

Allergen Standardization Sub-committee

Member

Breiteneder Heimo AllFam Database of Allergen Families

Member of Scientific Advisory Board

Breiteneder Heimo SDAP Structural Database of Allergenic Proteins


Bublin Merima AllFam Database of Allergen Families


Hoffmann-Sommergruber Karin IG Food Allergy Chair

Hoffmann-Sommergruber Karin Pirquet Club Scientific secretary

Ma Yan Consortium for Globalization of Chinese Medicine

Expert of Education Session

Ma Yan World Federation of Chinese Medicine

Member of Cardiovascular Specialist Committee

Ma Yan The World Federation of Chinese Medicine Societies

Member of Testing and Assessment Committee

Ma Yan Eurasia-Pacific Uninet Represent Member of Board of Directors

Ma Yan ASEAN-European Academic University Network

Represent Member of Board of Directors

Ma Yan Austrian Society for Medical Anthropology

Member of the Scientific Council

Ma Yan TCM Research Cluster Austria Member of the Scientific Council

Radauer Christian International Union of Immunological Societies,

Allergen Nomenclature Sub-committee

Member

Radauer Christian AllFam Database of Allergen Families

Project Manager and Administrator

Wagner Stefan AllFam Database of Allergen Families




Breiteneder Heimo International Archives of Allergy and Immunology

Member of Editorial Board

Breiteneder Heimo Allergy Member of Editorial Board

Hoffmann-Sommergruber Karin International Archives of Allergy and Immunology

Member of Editorial Board


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Heimo Breiteneder Doctoral Thesis Sonja Gaier

Heimo Breiteneder Doctoral Thesis Ursula Smole

Hoffmann-Sommergruber Karin Doctoral Thesis Sofia Sirvent, Madrid, E, 2011

Hoffmann-Sommergruber Karin HESI-ILSI Report: on: IFBiC Task Force 10;


Name Patent


FWF-SFB Molecular, immunological and structural characterization, and modifications of plant-food and latex allergens for diagnosis, prevention and specific immunotherapy.

Heimo Breiteneder

FFG Strukturelles Engineering der Hauptallergene der Erdnuss für die allergenspezifische Immuntherapie.

Heimo Breiteneder

European Community

Biomedical engineering for cancer and brain disease diagnosis and therapy development.

Heimo Breiteneder

FWF-SFB Molecular, immunological and structural characterization and modifications of plant-food and latex allergens for diagnosis, prevention and specific immunotherapy.

Heimo Breiteneder

Roche Austria GmbH

The effect of mimotope vaccine induced antibodies specific for CSPG4 and BRAF inhibitor on melanoma cells.

Heimo Breiteneder

Padia Reinigung und Charakterisierung von 5 mg des Walnussallergens Jug r 2.

Heimo Breiteneder

FWF Conformational immunoglobulin E epitopes of Bet v 1. Christian Radauer

WKO Wien Allergenchips für Diagnose von Lebensmittelanaphylaxie. Karin Hoffmann- Sommergruber

Bundesministerium für Gesundheit, Familie und Jugend (BMGFJ) / Bundesministerium für Wissenschaft und Forschung (BMWF)

TCM and Age Related Diseases. Yan Ma

Medizinische Universität Wien

Universitätslehrgang Grundlagen und Praxis der TCM.

Yan Ma

Medizinische Universität Wien

Universitätslehrgang Grundlagen und Praxis der TCM Nachtrag.

Yan Ma

Eurasia Pacific Uninet

TCMIRI - MEETING, China-Zentrum der Universität Salzburg.

Yan Ma

Eurasia Pacific Uninet

TCM Evaluierungsmeeting an der China Academy of Chinese Medical Sciences in Beijing.

Yan Ma

European Community EDQM

Informationskonzept für Patienten/Konsumenten zu Anwendungen der TCM.

Yan Ma

OEAD Technologiestipendien Ost- / Zentral- / Südasien (Postdoc) Yan Ma (Chang)


85

OEAD Technologiestipendien Ost- / Zentral- / Südasien (Postdoc) Yan Ma (Liu)

OEAD Technologiestipendien Ost- / Zentral- / Südasien (Postdoc) Yan Ma (Zhao)

1.4.12. Career Developments a) Habilitations: n = 0 b) Habilitations in progress: n = 0 c) Professorships: n = 1

Breiteneder Heimo 01/05/2011, Medical Biotechnology

d) Qualification Agreement: n = 0

1.4.13. Teaching Wahlbeispiele und Schulpraktika

Altmann Johanna: Reinigung von Ber e 1, aus Paranuss. Wahlbeispiel f. Mol Biologie, Uni Wien, 1. Juli – 31. Juli 2011.

Milanovic Sveta: Austesten von kolloidalem Coomassie für Gelfärbung. Schulpraktikum, HBLVA, Rosensteingasse, 1. Juli – 31. Juli 2011. a) Bachelor students: n = 3 Limberger Tanja: Isolation, Purification and characterization of Jug r 4, a seed storage protein from walnut. (Wahlbeispiel/BachelorArbeit f. Biotechnologie, BOKU), 4. April - 13. Mai 2011.

Stary Tamara: Extraction, Purification and Identification of Jug r 3, the non specific Lipid Transfer protein from Walnut (Juglans regia). FH Technikum Wien, 10. Jänner – 22. 4. 2011.

Huber Benjamin: Gewinnung und Charakterisierung von rekombinanten Antikörpern gegen Nahrungsmittelallergene. FH- Campus Wien, (Applied Life Sciences), 10. Jänner – 27. 5. 2011. b) Diploma, MDiploma and Master students: n = 8 Ackerbauer Daniela: Diploma thesis. Generation of recombinant human single chain antibodies against inhalative and food allergens using phage display. (10/2010 – in progress).

Christiane Agreiter: Purification of lipid transfer proteins and 2S albumins from tree nuts and peanut and their range of cross-reactivity – implication for the nut allergic patient. (10/2011 - in progress).

Berneder Maria:


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Diploma thesis. From the allergic sensitization to the effector phase: Methods to follow allergen uptake by dendritic cells, allergen characterization and evaluation of allergen chips . (01/2011 – in progress).

Founé Tanja: Diploma thesis. Inwieweit wird die Traditionelle Chinesische Medizin in der Behandlungsmethode des metabolischen Syndroms in der westlichen Medizin akzeptiert? (15.12.2011).

Hinterhölzl Elisabeth: Diploma thesis. Effects of acupuncture on chronic non-specific back pain. (11/2010 – in progress).

Kühebacher Maria: Diploma thesis. Reinigung und immunologische Charakterisierung des Lipid Transfer proteins Cor a 8 und komponentenspezifische Allergiediagnostik bei Haselnussallergikern. (04/2011 – in progress).

Marchart Kristina: Diploma thesis. Qualitative und quantitative analysis of Chinese medical herbs for the prevention and therapy of acute myocardial infarction and diabetes. (30.11.2011).

Teubl Roswitha: Diploma thesis. Inwieweit wird die Traditionelle Chinesische Medizin in der Behandlungsmethode des metabolischen Syndrom in der westlichen Medizin akzeptiert? (15.12.2011). c) PhD, MDSci, MD students: n = 7 Ashjaei Kazem: PhD thesis. Influence of allergens on human dendritic and basophil cells. (4/2010 – in progress).

Gaier Sonja: PhD thesis. Generation of a polymimotope vaccine against malignant melanoma. (7.3.2011).

Gepp Barbara: PhD thesis. Identification of allergenic determinants of Bet v 1 homologs using dendritic cells as read-out system. (4/2010 – in progress).

Guhsl Eva: PhD thesis. Identification of conformational immunoglobulin E epitopes of the major birch pollen allergen, Bet v 1: their cross-reactivities and clinical relevance in the birch pollen-plant food syndrome. (10/2010 – in progress).

Peter Karoline: PhD thesis. Effects of traditional Chinese herbal medicine on age related diseases (10/2009 – in progress).

Kostadinova Maria: PhD thesis: Entwicklung einer Vakzine gegen Erdnussallergie. (3/2009 – in progress).

Smole Ursula: PhD thesis. The interaction of allergenic and non-allergenic Bet v 1 homologues with human dendritic cells. (13.5.2011).

1.4.14. Exams a) Oral examinations n = 28


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Bublin Merima n = 4

Hoffmann-Sommergruber Karin n = 4

Ma Yan n = 20 b) Diploma and Thesis-Examinations: n = 7 Breiteneder Heimo:

Gaier Sonja. Thesis-Examination. Examiner. 03/07/2011.

Smole Ursula. Thesis-Examination. Examiner. 05/13/2011.

Hoffmann-Sommergruber Karin:

Arthold Susanne. Diploma Examination. Examiner. 12/13/2011.

Ma Yan:

Founé Tanja. Diploma-Examination. 12/15/2011.

Teubl Roswitha. Diploma-Examination. 12/15/2011.

Marchart Kristina. Diploma-Examination. 11/30/2011.

Radauer Christian:

Gaier Sonja. Thesis-Examination. Examiner. 03/07/2011. c) Exam supervising: n = 4 Hoffmann-Sommergruber Karin. SIP. 04/12/2011.

Hoffmann-Sommergruber Karin. Beisitz Kommissionelle Prüfung. 05/16/2011.

Hoffmann-Sommergruber Karin. Beisitz Kommissionelle Prüfung Funkt Pathophysiologie (Nostrifizierung) 11/11/2011.

Radauer Christian. SIP 5, 07/04/2011.


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SS 2011 Breiteneder Heimo 2,00 0,40 648.401 Ausgewählte Kapitel der medizinische Biotechnologie

Breiteneder Heimo 2,00 2,00 514.057 Dissertanten- und Diplomandenseminar: Anleitung zu Wissenschaftlichen Arbeiten

Breiteneder Heimo 2,00 2,00 901.768 Journal Club und Progress Report

Hoffmann-Sommergruber Karin 4,00 0,50 808.004 SSM 3-Projektstudie (Wahlpflichtteil)

Hoffmann-Sommergruber Karin 2,00 0,40 648.401 Ausgewählte Kapitel der medizinische Biotechnologie

Hoffmann-Sommergruber Karin 2,00 1,00 514.074 Nahrungsmittelallergien und -Intoleranzen

Hoffmann-Sommergruber Karin 2,00 2,00 648.037 Journal Club und Progress Report

Wagner Stefan 1,00 1,00 652.000 Senior-Mentoring Humanmedizin

Wagner Stefan 2,00 0,40 648.401 Ausgewählte Kapitel der medizinische Biotechnologie

Ma Yan 4,00 0,50 808.004 SSM 3-Projektstudie (Wahlpflichtteil)

Ma Yan 0,50 0,50 891.007 M1 - Einführung in die Medizinische chinesische Fachsprache und Kultur (1)

Ma Yan 0,40 0,60 891.008 Kaisers Kanon der Medizin

Ma Yan 0,40 0,60 891.009 Abhandlung von exogenen fieberhaften Krankheiten

Ma Yan 2,67 3,20 891.011 Klinische Observation

Ma Yan 2,27 2,72 891.017 Chinesische Materia Medica

Ma Yan 0,93 1,12 891.018 Einführung in die Rezeptkunde der TCM

Ma Yan 0,27 0,32 891.019 Synopsis der Goldenen Kammer

Ma Yan 0,54 0,64 891.020 Saisonale fieberhafte Erkrankungen

Ma Yan 0,54 0,64 891.021 Forschung in der TCM

Radauer Christian 2,00 0,40 648.401 Ausgewählte Kapitel der medizinische Biotechnologie

Bublin Merima 2,00 1,00 514.074 Nahrungsmittelallergien und -Intoleranzen

Sum 21,94

WS 2011/12 Breiteneder Heimo 2,00 0,60 502.362 Nahrungsmittelallergie

Breiteneder Heimo 2,00 2,00 514.057 Dissertanten- und Diplomandenseminar: Anleitung zu Wissenschaftlichen Arbeiten

Breiteneder Heimo 1,00 1,00 514.073 Neueste molekularbiologische Techniken - (Privatissimum)

Breiteneder Heimo 2,00 2,00 648.007 Journal Club and Progress Report

Hoffmann-Sommergruber Karin 2,00 0,70 502.362 Nahrungsmittelallergie

Hoffmann-Sommergruber Karin 2,00 2,00 648.008 Journal Club und Progress Report


89

Hoffmann-Sommergruber Karin 2,00 2,00 648.009 Anleitungen zu wiss. Arbeiten

Hoffmann-Sommergruber Karin 2,20 0,53 803.003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Ma Yan 0,67 1,00 891.009 Einführung in die Medizinische chinesische Fachsprache und Kultur (3)

Ma Yan 0,50 0,50 891.007 M2 - Einführung in die Medizinische chinesische Fachsprache und Kultur (2)

Ma Yan 2,67 4,00 891.013 Akupunktur-Behandlung und Moxibustion

Ma Yan 1,34 2,00 891.015 Innere Medizin in der TCM

Ma Yan 0,67 1,00 891.016 Experimentelle Akupunktur

Ma Yan 0,13 0,20 891.017 Klassische Literatur der Akupunktur und Moxibustion

Ma Yan 2,67 4,00 891.018 Klinische Observation in China oder in Österreich

Radauer Christian 2,00 0,70 502.362 Nahrungsmittelallergie

Radauer Christian 2,20 0,53 803.003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Sum 24,76 Total sum SS+WS 46,70

Performance Report 2011 - MedUni Wien · Performance Report 2011 ... important to understand the pathophysiology of disease. The Institute of Pathophysiology ... Kathrin Burger, ...

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