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Leading by Excellence Since 1983Certified to ISO 9001:2008
Introducing our latest section, which includes over 4500 new
products!NEW!
01CustomPeptide
Synthesis
02CustomOrganic
Synthesis
SpecialtyProducts &
Technologies
01CustomPeptide
Synthesis
02CustomOrganic
Synthesis
SpecialtyProducts &
Technologies
07CosmeticPeptidesTools forPeptide
Synthesis
01CustomPeptide
Synthesis
01CustomPeptide
Synthesis
02CustomOrganic
Synthesis
01CustomPeptide
Synthesis
02CustomOrganic
Synthesis
SpecialtyProducts &
Technologies
07CosmeticPeptides
Product Catalog - 11.1
Edition
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Dear Customers:
Throughout its many years of service, the team at Peptides
International has maintained a commitment to offer a continuous
stream of innovative products to facilitate ever-expanding areas of
peptide research. In our current catalog you will find hundreds of
new products re-flecting the increased expertise of our staff.
These new offerings range from useful tools for making peptides
(e.g. orthogonally protected amino acids and derivatives for Click
chemistry) to a plethora of biologically active peptides such as
Mambalgin-1 and activated KLH (Keyhole Limpet Hemocynanin) for
peptide antigen conjugation. Since publication of a catalog
cap-tures just one point in time, we invite you to look for our
latest product additions at PEPNET.COM under the New Products
tab.Investment in additional state-of-the-art automated synthesis
equipment now allows us to produce milligram to kilogram quantities
of peptides even more efficiently. All of our produc-tion and
distribution operations have also been certified to the ISO
9001:2008 International Quality System Standard, reflecting
commitment to the quality of our products and the satis-faction of
our customers. New additions to our peptide chemistry team include
experts that can handle all of your discovery and development
needs, whether your project involves com-plex organic chemistry or
standard solid-phase techniques. Scale-up and smooth technol-ogy
transfer into drug API products under full-cGMP is also available
without any disruption from our cGMP partner, Peptisyntha.
We thank you for your interest in our products and services and
invite you to search for your peptide needs in our exciting new
catalog. Should you require larger quantities than are listed,
additional savings may be available by requesting a bulk quotation.
We are confident that you will find all of our products
competitively priced while giving you extraordinary value and
quality that will lead to success in your research.
Sincerely,
Peptides International
Michael W. Pennington, Ph.D.President and Chief Executive
Officer
Jackie B. SpatolaChair, Board of Directors
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Since 1983, Peptides International, Inc. has been an established
provider of catalog products and custom chemistry services,
supporting peptide research and development around world. Built on
a passion for excellence, the company has become recognized as a
trusted source of high purity, quality products, and cost effective
custom chemistry services.The companys Louisville facility consists
of multiple self-contained laboratory suites, a kilo-scale pilot
plant, fully equipped quality control laboratories, and supporting
quality assurance and business departments. Peptides International
is now Certified to ISO 9001:2008, reflecting its commitment to the
quality of its products and satisfaction of its customers.Peptides
International specializes in biologically active peptides and
peptide-related products, glyco-conjugates, defined-length
PEGylations, enzyme substrates and inhibitors, amino acid
derivatives, combinatorial peptide libraries, and a variety of
resins and reagents. Purification of custom-produced products is
carried out by conventional techniques such as solvent-solvent
extractions, crystallizations, and by preparative chromatographic
instrumentations column sizes to 110mm diameter suitable for
ion-exchange, flash-chromatography and reverse phase HPLC
methodologies. Whether it is milligram or kilogram scale-up
quantities, Peptides International has the expertise and technology
to support your drug discovery, development, and manufacturing
objectives.
Peptides International, Inc.Physical Address 11621 Electron
Drive Louisville, Kentucky 40299
Mailing Address P. O. Box 99703 Louisville, Kentucky
40269-0703
Phone 1-502-266-8787 (Local and International Callers)
1-800-777-4779 (Toll-free USA and Canada only)
Fax 502-267-1329
Email [email protected]
Website
Social Media
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ii Order Hotline 1-800-777-4779 502-266-8787
Subsections in Bold Introduction
Peptide Institute
...........................................................................................................................viiDistributors
..................................................................................................................................viiicGMP............................................................................................................................................
ixQuality
...........................................................................................................................................
xProduct Information
.....................................................................................................................
xiProduct Packaging
.......................................................................................................................xiiCommunication
...........................................................................................................................xixPurchasing
..................................................................................................................................
xxUsing the Catalog
......................................................................................................................xxii
Terms and Conditions
...............................................................................................................xxiii
Custom Peptide Synthesis
.....................................................................................................
xxviii Technology Platforms
...............................................................................................................
xxx
Biologically Active Peptides
......................................................................................1Adrenomedullins
and Related
Peptides.......................................................................................2
Amylins
..........................................................................................................................................9
Amyloid -Protein Related Peptides
............................................................................................9
Angiotensin and Related Peptides
.............................................................................................13
Arg-Gly-Asp "RGD" Peptides
.....................................................................................................20
Bradykinin and Related Peptides
...............................................................................................27
Defensin Peptides
.......................................................................................................................39Endothelins..................................................................................................................................47Enkephalins
.................................................................................................................................51Experimental
Autoimmune Encephalomyelitis Products
...........................................................54Galanins
and Related
Peptides..................................................................................................57
Ghrelin and Related Peptides
....................................................................................................59
Growth Hormone Releasing Factor (GRF, GH-RH) and Growth Hormone
Related Peptides
....................................................................................64Guanylins
and Uroguanylins
.....................................................................................................65Hepcidin
......................................................................................................................................67
Kisspeptins/Metasins
..................................................................................................................72
Melanin-Concentrating Hormone and Related Peptides
.........................................................77Neuroendocrine
Regulatory Peptides
........................................................................................82Parathyroid
Hormone (PTH) and Related Peptides
..................................................................93
Protease-Activated Receptor (PAR) Peptides
.........................................................................101
RF Amide Related Peptides
.....................................................................................................107
Stresscopins / Urocortin and Related Peptides
.......................................................................
110 Substance P and Related Peptides
.........................................................................................
111Toxins
........................................................................................................................................
114Urotensin II and Related Peptides
...........................................................................................133Vasoactive
Intestinal Peptide (VIP)
..........................................................................................134
Vasopressin, Vasotocin, and Related Peptides
.......................................................................135
Table of Contents
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Order Hotline 1-800-777-4779 502-266-8787 iii
Enzyme Inhibitors and SubstratesAssay Methods Substrates
.....................................................................................................137
Enzyme Inhibitors
.......................................................................................................................143Angiotensin
I Converting Enzyme Inhibitors
............................................................................145
Caspase Inhibitors
....................................................................................................................147
Cathepsin and Thiol Protease Inhibitors
..................................................................................151
Chymotrypsin and Chymotrypsin-like Inhibitors
......................................................................154
Collagenase / MMP / Stromelysin Inhibitors
............................................................................155
Elastase Inhibitors
.....................................................................................................................157Ubiquitin
Proteasome System Inhibitors
..................................................................................161
Examples of Proteolytic Enzymes and Their Inhibitors
...........................................................163
Enzyme Substrates & Related Compounds
............................................................................164ADAM-17
Substrates
.....................................................................................................................164
Aminopeptidases Substrates
........................................................................................................165
Calpain Substrates
........................................................................................................................169
Caspase Substrates
......................................................................................................................170
Cathepsin and Thiol Protease Substrates
....................................................................................172
Chymotrypsin and Chymotrypsin-like Protease Substrates
........................................................174
Coagulation Factor Substrates
.....................................................................................................175
Collagenase / MMP / Stromelysin Substrates
..............................................................................178
Elastase
Substrates.......................................................................................................................181
Furin and Carboxyl Side of Paired Basic Residue Cleaving Enzyme
Substrates ......................183 Ubiquitin Proteasome System
Substrates
....................................................................................196FRETs
Peptides Library
................................................................................................................199Polypeptides
..................................................................................................................................205
Oligopeptides
.................................................................................................................................205
Dipeptides
...............................................................................................................................205
Tripeptides
..............................................................................................................................206
Tetrapeptides
..........................................................................................................................207
Specialty Products and Services Click Chemistry
...........................................................................................................................209Specialty
Biologically Active Peptides
.....................................................................................
211
Derivatizable Cell Penetrating Peptides (CCPs)
.....................................................................
211Other Specialty Peptides
..........................................................................................................
211
Carbohydrates
.............................................................................................................................212Glycosidase
Inhibitors
...............................................................................................................212
Endotoxins (Synthetic)
..............................................................................................................216
Antiproliferative Factor
..............................................................................................................217Maleimide
activated-KLH
..........................................................................................................219
Specialty Tools for Peptide Synthesis
.................................................................................221mini-PEG
...............................................................................................................................221
CLEAR-OXTM
............................................................................................................................222CLEARTM
...................................................................................................................................226
Peptide Antisera
..........................................................................................................................228Antisera
of Amyloid -Protein Related
Peptides......................................................................229Endothelin
Antisera
...................................................................................................................233
Table of Contents (cont.)
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iv Order Hotline 1-800-777-4779 502-266-8787
Tools for Peptide SynthesisAmino Acids
.................................................................................................................................240
Click Chemistry Amino Acids
....................................................................................................240
l-Amino Acids
............................................................................................................................245
d-Amino Acids
...........................................................................................................................244
Amino Acid Esters
.....................................................................................................................245
Side Chain Derivatives of Amino Acids
....................................................................................246
Boc-Protected l-Amino Acids
...................................................................................................247Boc-Protected
d-Amino
Acids...................................................................................................250
Unusual Boc-Amino Acids
........................................................................................................251
Boc-N-Methyl Amino Acids
.......................................................................................................258Boc-Amino
Acid Esters
.............................................................................................................258
Fmoc-Protected l-Amino Acids
................................................................................................259
Fmoc-Protected d-Amino Acids
................................................................................................263
Unusual Fmoc-Amino Acids
.....................................................................................................264
Fmoc-N-Methyl Amino Acids
....................................................................................................270
Z-Protected l-Amino Acids
.......................................................................................................271
Unusual Amino Acids
................................................................................................................273
Resins
...........................................................................................................................................274Unsubstituted
Resins for Solid Phase Synthesis
....................................................................274
Chlorotrityl Resins
.....................................................................................................................276
Boc-Amino Acid-Pam Resins
...................................................................................................279
Fmoc-Amino Acid-Wang Resins
..............................................................................................281
Fmoc-Amino Acid-Rink-Amide MBHA Resins
.........................................................................283
TentaGel Resins
........................................................................................................................285
Reagents
.......................................................................................................................................291Condensation
Reagents, Additives, Linkers, and Other Reagents for Peptide
Synthesis ....291 Boc-Amino Acid-Pam Linker Reagents
...................................................................................293
Protein Ligation Synthesis Reagents
.......................................................................................294
PyClocK
...................................................................................................................................295dPEG
.......................................................................................................................................296
Laboratory Equipment
................................................................................................................
311Tubing and Connectors
............................................................................................................
311 Specialty Glassware
.................................................................................................................
311 Replacement Screw Caps and Septa
......................................................................................313HF
Apparatus and Parts
...........................................................................................................313
Recombinant ProteinsCytokines and Growth Factors
.................................................................................................314
Clusterins
..................................................................................................................................320Defensins
..................................................................................................................................323GH
(Growth Hormone)
.............................................................................................................
368IFI30 (-Interferon-Inducible Lysosomal Thiol Reductase)
.....................................................
379Interlukins
..........................................................................................................................388-429IL1F7
(Human Interleukin Family 1, Member
7)......................................................................
429IL1F10 (Human Interleukin Family 1, Member 10)
.................................................................
430Insulin
........................................................................................................................................
431
Table of Contents (cont.)
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Order Hotline 1-800-777-4779 502-266-8787 v
Recombinant Proteins (continued)Leptin
.........................................................................................................................................
433Midkines
....................................................................................................................................
445 Pleiotrophin
...............................................................................................................................
462Prolactin.....................................................................................................................................
465RBP1 (Recombinant Human Retinol Binding Protein-1)
........................................................ 474SCF
(Stem Cell Factor)
............................................................................................................
477 TNF (Tumor Necrosis Factor)
..................................................................................................
489
Chemokines
.................................................................................................................................
510Hormones
.....................................................................................................................................
556Enzymes
.......................................................................................................................................
562Protein Kinases
...........................................................................................................................
614Recombinant and Natural Proteins
..........................................................................................
629Heat Shock Proteins
...................................................................................................................
753Allergy Proteins
...........................................................................................................................
758Maleria Proteins
...........................................................................................................................
758Mumps Protein
.............................................................................................................................
758Shiga Like Pprotein
.....................................................................................................................
758Viral Antigens SARS Proteins
...................................................................................................
758Viral Antigens SARS Proteins Borrelia Protein
......................................................................
759Viral Antigens - Chagas Protein
................................................................................................
760Viral Antigens - Herpes Simplex Virus
.....................................................................................
760Viral Antigens - Chlamydia Trachomatis
.................................................................................
761Viral Antigens - Hepatitis C Virus
..............................................................................................
762Viral Antigens - Hepatitis A Virus
..............................................................................................
767Viral Antigens - Hepatitis B Virus
..............................................................................................
768Viral Antigens - Hantaan Virus
..................................................................................................
768 Viral Antigens -Feline Leukemia Virus
.....................................................................................
768Viral Antigens - Hepatitis D Virus
..............................................................................................
768Viral Antigens - Hepatitis E Virus
..............................................................................................
768Viral Antigens - Hepatitis B Surface Antigens
........................................................................
769Viral Antigens - Cytomegalo Virus
............................................................................................
770Viral Antigens - Varizella Zoster Virus
......................................................................................
771Viral Antigens - Toxoplasma Gondii Proteins
.........................................................................
771Viral Antigens - Treponema Pallidum Proteins
.......................................................................
771Viral Antigens - Human Immunodeficiency
Virus...................................................................
772Viral Antigens - Human T-Lymphotrophic Virus
.....................................................................
775Viral Antigens - Human Papillomavirus Virus
.........................................................................
776Viral Antigens - Epstein-Barr Virus
...........................................................................................
776Viral Antigens - Encephalitis Virus
...........................................................................................
777Viral Antigens - Measles Virus
.................................................................................................
778Viral Antigens - Rubella Virus
....................................................................................................
778Viral Antigens - Chikungunya Virus
.........................................................................................
778Viral Antigens - Parvovirus
........................................................................................................
778Viral Antigens - Influenza Virus
................................................................................................
778Viral Antigens - West-Nile Virus
................................................................................................
781Viral Antigens - Dengue Virus
...................................................................................................
781
Table of Contents (cont.)
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vi Order Hotline 1-800-777-4779 502-266-8787
Table of Contents (cont.)Recombinant Proteins (continued)Anti -
Human Cytokines
.............................................................................................................
784Monoclonal Antibodies, Anti-Human Chemokines
................................................................
789Monoclonal Antibodies, Anti-Human Lymphocytes
...............................................................
790Monoclonal Antibodies, Anti-Mouse Cytokines
......................................................................
792Monoclonal Antibodies, Anti-Mouse Lymphocytes
...............................................................
793Monoclonal Antibodies, Anti-Viral
............................................................................................
794Polyclonal Antibodies, Anti-Human
..........................................................................................
795Monoclonal Antibodies, Anti-Human Heat Shock Proteins
.................................................. 797Monoclonal
Antibodies, Anti-Human Enzymes
......................................................................
797Monoclonal / Polyclonal Antibodies, Miscellaneous Antibodies
......................................... 804
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From its very inception, Peptides International has been proud
to distribute the superb products manufactured by the Peptide
Institute of Osaka, Japan. The biologically active peptides
synthesized by the Peptide Institute are well known for their
excellent quality. In addition to its historic link with the
Peptide Institute, Peptides International works with other key
suppliers around the world to supplement its own manufactured
products to provide a complete portfolio of peptides and related
products, as well as tools for peptide synthesis and research.
The Peptide Institute is a leading supplier of biologically
active peptides, enzyme substrates and inhibitors, and peptide
antisera. Customers in Japan may wish to contact this company
directly.Peptide Institute, Inc.4-1-2 Ina Minoh-Shi Osaka 562
JapanPhone (0727) 29-4121Fax (0727) 29-4124
http://www.peptide.co.jp
Order Hotline 1-800-777-4779 502-266-8787 vii
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In Japan:
http://www.peptide.co.jp Osaka, Japan
Email: [email protected]://www.peptide.co.jp
In Switzerland:
Lucerne, SwitzerlandEmail: [email protected]://www.lubio.ch/
In Benelux:
Huissen, The Netherlands
Email: [email protected]://www.bio-connect.nl/
In Europe, Latin America, Australia, and New Zealand:
San Diego, CA USA
Email: [email protected]://www.axxora.com/index.php
viii Order Hotline 1-800-777-4779 502-266-8787
Distributors
-
Expertise & Reliability for YOUR cGMP Peptides
Peptides International and Peptisyntha have partnered to create
a seamless stream of technology and expertise, allowing you to
focus on the project, not project management.
Order Hotline 1-800-777-4779 502-266-8787 ix
cGMP Partner
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x Order Hotline 1-800-777-4779 502-266-8787
Quality PolicyIt is Peptides International's goal is to achieve
complete customer satisfaction by addressing customer needs and
delivering what we promise. The company is committed to the Quality
Management Sysyem and through review of quality objectives and
metrics, is working towards its improvement and effectiveness.
Specifications and Purity AssaysEach product is accompanied by a
detailed lot-specific analytical data sheet contain-ing all
specifications. In addition to specification data, additional test
results can be made available upon customer request. Product
integrity is assured using techniques that include thin layer
chromatography, high performance liquid chromatography, opti-cal
rotation, nuclear magnetic resonance, IR spectroscopy, and mass
spectrometry.
Peptide InstituteProducts from the Peptide Institute of Osaka,
Japan are manufactured under strict quality control standards and
are accompanied by analytical data sheets directly from the
Institute. Peptide International products are designated by a -PI
suffix to distinguish them from those produced by the Peptide
Institute.
Now Certified to ISO 9001:2008
Quality
-
Order Hotline 1-800-777-4779 502-266-8787 xi
Product Information
Net Peptide WeightSome products from the Peptide Institute are
distributed in premeasured vials. These are indicated by the suffix
-s, or -v in their catalog number. The net peptide weight is
precisely determined by amino acid analysis after acid hydrolysis,
HPLC, and/or UV absorption, and the value is indicated clearly on
the vial label. The indicated weight is only for the net peptide
molecule, and the weights of any constituents (water or acetic
acid) are excluded from the quantity. The amount of usable peptide
meets and may exceed its advertised quantity.
Stability and StorageComplex peptides and antisera should
generally be kept dry and frozen to prevent unnecessary
deterioration, although they are stable at ambient temperature for
sev-eral days. Almost all biologically active peptides are readily
soluble in water or any suitable buffer solution. Stability of
peptides in solution is relatively low even below -20 C. Therefore
a peptide solution, once prepared, should be used as soon as
possible. If the solution must be stored overnight, it should be
kept in a freezer at temperatures lower than -20 C. When prolonged
storage has occured, homogene-ity of the peptide in the solution
should be reconfirmed prior to use. Please refer to the following
table and to our website for additional information regarding
stability and storage conditions.
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xii Order Hotline 1-800-777-4779 502-266-8787
Product Information
Product Storage ConditionsProduct Series Number Storage
ConditionL- & D-Amino Acids 2700 & 2800 RTBoc-Amino Acids
2000 & 5000 4 CFmoc-Amino Acids 1700, 1800, & 5000 4
CUnusual Amino Acids 5000 4 CReagents 1000 Varies:
RT, 4 C,
or -20 C
Unsubstituted Resins 1000 & 9000 RTSubstituted Resins 1000,
10000, 1100, 11000,
1200, 12000, 1300, 1400, & 9000
4 C
All CLEAR Resins 1200, 12000 4 CPeptides 3000 & 4000 -20
CInhibitors 3000 & 4000 -20 CSubstrates 3000 -20 CAntisera
8000, 80000, & 14000 -20 CCarbohydrates 24000 -20 C
RT = Room Temperature4 4 C = Refrigerator -20 C = Freezer
All products (except RT) are stored in freezers for inventory
purposes.
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Order Hotline 1-800-777-4779 502-266-8787 xiii
All of the products listed in this catalog are rigorously tested
and the purity of the products is guaranteed according to the
following criteria:
1000 SeriesThese reagent grade chemicals are of a quality
confirmed by our chemists in Japan and the USA to be acceptable for
peptide synthesis.
1100, 1200, 1300,1400, 10000, 11000 and 12000 SeriesThese
substituted resins are manufactured in our Louisville, Kentucky
facility. The parameters, described on the analytical data sheet
included with each resin, are substitution, percent racemization
(where appropriate), bead size, and percent cross-linking.
1700 SeriesFmoc-Amino Acids of the 1700 Series: No free amino
acid is detectable by TLC when 100 micrograms is applied to the
plate. Purity determined by HPLC analysis is higher than 98%.
2000 SeriesAmino acids of the 2000 Series: The homogeneity of
the amino acids is moni-tored by thin layer chromatography (TLC)
and is guaranteed to yield a single spot when 50 micrograms is
applied to the plate. The optical purity of amino acids is higher
than 99.9% except in the case of serine, which is frequently
con-taminated by more than 1% enantiomeric serine; data are
available on request. Optical purity is determined by
Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC)
using chiral derivatizing reagents.
Product Information
-
Product Information
xiv Order Hotline 1-800-777-4779 502-266-8787
Amino Acid Esters and Side Chain Derivatives of the 2000 Series:
The following letters are used to designate the different
grades:AA: A single spot is always detectable by two different TLC
systems when
200 micrograms is applied to the plate. Homogeneity higher than
99% as determined by paper electrophoresis is guaranteed.
A: A trace of impurity might be detectable by TLC, but the
maximum range is less than 2%.
B: Contamination of less than 3% might be detectable.
Boc- and Z-Amino Acids of the 2000 Series:The optical purity of
the component amino acids is always higher than 99.9%, and
contamination by the sec-butyl group is guaranteed to be less than
0.05%. The following letters are used to designate the different
grades:AA: A single spot is detectable by TLC when 200 micrograms
is applied to
the plate. The amount of contamination detectable by HPLC, if
any, is less than 0.5%.
A: A trace of impurity might be detectable by TLC, but the
maximum range determined by HPLC is less than 1%.
B: Contamination of less than 2% might be detectable by
HPLC.AA-A: This compound is synthesized as material of grade AA,
but may gradu-
ally decompose to grade A within one year, even under cold
storage conditions.
A-B: This compound is synthesized as material of grade A, but
may gradu-ally decompose to grade B within one year, even under
cold storage conditions.
-
Product Information
Order Hotline 1-800-777-4779 502-266-8787 xv
3000 SeriesAmino Acids and Peptide Derivatives of the 3000
Series: The following letters are used to designate the different
grades:AA: A single spot is detectable by TLC when 100 micrograms
is applied to
the plate. The amount of contamination detectable by HPLC is
less than 1%.
A: A trace of impurity might be detectable by TLC when 100
micrograms is applied to the plate. The amount of contamination
detectable by HPLC is less than 2%.
B: Contamination of less than 4% might be detectable by
HPLC.A-B: This compound is synthesized as material of grade A, but
may gradu-
ally decompose to grade B within one year, even under cold
storage conditions.
4000 SeriesBiologically Active Peptides of the 4000 Series: All
of these peptides are chemically synthesized using carefully
selected amino acid derivatives from our products, and strictly
purified to come up to our quality standards. Impurities detectable
by ordinary gradient HPLC systems are less than 1% and a single TLC
spot upon application of 50 micrograms is detected in almost all of
our peptides, except Met-containing peptides. Some additional minor
peaks on HPLC or minor spots on TLC are detectable with
Met-containing peptides since they may be easily oxidized to
Met-sulfoxide even during analysis. The peptides which are followed
by the words Purity Information and letter symbols, such as Purity
Information: QP in this catalog, can be explained as follows:
-
Product Information
xvi Order Hotline 1-800-777-4779 502-266-8787
QP: These compounds have some inherent instability. During
storage, even under freezer conditions, a trace of impurity may
become visible by TLC analysis. The amount of impurity determined
by HPLC is less than 1%.
QE: These compounds have some inherent instability. Their purity
is guar-anteed to be higher than 97% by HPLC.
QX: The purity of these compounds is guaranteed to be higher
than 97% by HPLC.
QZ: The purity of these compounds is guaranteed to be higher
than 95% by HPLC.
5000, 6000, and 53000 Series These unusual amino acids, amino
acid derivatives, and other offerings rep-resent an expansion of
quality products from Peptides International and are synthesized
under appropriately high purity criteria.
14000 Series Peptide Antisera are sold in vials as amorphous
powders which are obtained after lyophilization from 0.001 M
Phosphate Buffer (pH 7.0). The specificity and sensitivity are
determined by the enzyme immunoassay technique specified; the data
for each vial are given on an attached sheet.
Bacterial Enzyme Inhibitors The microbial enzyme inhibitors
(Microbial Products) listed in this catalog are isolated from
cultured media of microorganisms. Many of these compounds are
inherently unstable and thus difficult to categorize using our
normal standards of purity. The homogeneity of these compounds
cannot be guaranteed except for their specific inhibitory
activities. Additional data for these series of compounds are
available upon request.
-
Product Packaging
Order Hotline 1-800-777-4779 502-266-8787 xvii
The biologically active peptides listed in this catalog are sold
primarily as amorphous powders which have been lyophilized from
aqueous or dilute acetic acid solutions. They are available in two
package forms: screw-capped bottles (indicated as Bulk) and
injection vials (indicated with a -v or s suffix at the end of each
catalog code number).
Screw-capped BottlesThe amorphous powder of each peptide is
thoroughly dried over desiccant in vacuo and then weighed in a
bottle. The weight indicated on the label represents the gross
weight of the amorphous powder, which includes the peptide as well
as the accompanying water and acetic acid, if any. The amount of
water and acetic acid in each amorphous powder is precisely
determined by elemental analysis, Karl Fischer titration or gas
chromatography. In some cases, peptides contain hydrochloride or
ammonia instead of acetic acid. The observed values of such
accompanying constituents are given in the structural formula of
the respective peptide described in this catalog. For example, code
PBK-4002 Bradykinin is described as follows:
PBK-4002 Bradykinin Bulk 100
mgArg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg 2AcOH 3H2O(M.W. 1060.2 120.10
54.05)
The total molecular weight of this amorphous powder is
calculated to be 1234.4, which consists of 1060.2 for the net
bradykinin molecule, 120.10 for two mol-ecules of acetic acid and
54.05 for three molecules of water. This means that 100 mg of this
powder contains a net weight of 85.9 mg of bradykinin molecules.
Amounts of the accompanying water and acetic acid vary with the
lot; the exact value in the purchased peptide is available on
request.
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Product Packaging
xviii Order Hotline 1-800-777-4779 502-266-8787
VialsPeptides with constant weights are lyophilized and sealed
under nitrogen in indi-vidual vials. Net peptide weights are
precisely determined by amino acid analy-sis after acid hydrolysis,
HPLC analysis and/or UV absorption measurement, and is clearly
indicated on the label of each vial. The indicated weight is only
the net peptide molecule and does not include the weight of any
additional con-stituents (water, acetic acid, etc.). For example,
code PBK-4002-v Bradykinin is described as follows:
PBK-4002-v Bradykinin Vial 0.5
mgArg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg (M.W. 1060.2)
This indicates that each vial contains ca. 0.5 mg of Bradykinin
and the exact weight is indicated on the label (for example, 0.53
mg) and the analytical data sheet (for example, 0.53 mg, 0.50
micromol). The weight is precisely determined by quality control,
insuring the quantity in each vial even if the content seems to be
quite small. A peptide solution of a known concentration can be
easily prepared by injecting a given volume of a suitable solvent
into the vial using a calibrated syringe and dissolving the
contents thoroughly. The peptide content in each vial is relatively
small and accurately measured, and the peptide should not be taken
out of the vial to prepare a solution with a guaranteed
concentration.
-
Communication
Order Hotline 1-800-777-4779 502-266-8787 xix
PEPNET NewsletterPeptide chemistry is constantly changing. The
PEPNET newsletter will keep you abreast of many of the exciting new
developments arising in the expanded field of peptide chemistry.
PEPNET has been published regularly since 1987.
Our web site offers online ordering, new products, and other
use-ful information. There are also scientific references, and
links to industry organizations.
Social Media Just as peptide chemistry is ever-changing,
Peptides International knows the way it conveys these changes will
also vary over time. Look for us on Facebook, Google+, LinkedIn,
Twitter, and other new outlets as they appear. If you wish to
receive your own copy of this catalog or to be entered onto the
subscription list for the newsletter, please place a request by
contacting the company via telephone, fax, or email
([email protected]).
Custom services to stimulate inhibitor innovations
As a complement to these catalog offerings, Peptides
International also provides custom synthesis services to
meet
structural requirements of specific enzyme or disease
targets.
Peptides International has a wealth of chemical expertise
and
know-how especially applicable to the design and synthesis
of complex enzyme inhibitors and substrates. These include
cyclic compounds (BQ-123), complex mimetics (BQ-788),
peptide aldehydes (Ac-LLN), hydroxamic acid derivatives
(TAPIs), alkylating moieties and others.
P.O. Box 24658Louisville, KY 40224 USA Phone: 502-266-8787Fax:
502-267-1329
A Newsletter from Peptides International
Volume 23, No. 1, 2010
Peptides International, Inc.
1-800-777-4779 E-mail: [email protected]
Enzymes Gone Wild! Inhibitors to the Rescue!
Enzyme inhibitors continue to generate strong research
interest...
Product Quality and Value Strict Confidentiality Proactive
Project Management Friendly Service
Enzyme inhibitors and related products
Peptides International has long had a strong product focus
in the area of enzyme inhibitors that includes both syn-
thetic and microbial-derived materials. These include, for
example, popular matrix metalloprotease inhibitors (TAPI-0,
TAPI-1, TAPI-2), ubenimex, and actinonin. In addition, we
also offer other key products, such as chymostatin,
elastati-
nal, leupeptin and epoxomicin, through our long-standing
distribution relationship with the Peptide Institute of
Osaka.
These are available in multiple vials or in bulk quantities
that
offer considerable savings.
Enzymes are essential in almost all biological processes and
aberration of enzyme activity is implicated in many disease states.
Therefore
modulation of enzyme function represents a well-researched route
for drug development, a point underscored by the fact that
enzyme
inhibitors represent almost half the drugs in clinical use
today. Design, development and study of enzyme inhibitors continue
to be a
major focus of pharmaceutical research. Therefore, this issue of
PEPNET highlights this important area of research and includes
key
articles devoted to proteasome and MMP inhibitors. We hope you
will find our comprehensive collection of reagents for enzyme
research
and custom synthesis services valuable for your innovations in
this area.
Custom Synthesis ServicesPeptide aldehydes, ketones,
hydroxy-isosteres
Cyclic compounds: termini / side chain / disulfide
Biotin, aminohexanoic acid, defined length PEGylations
Custom designed FRET substrates and libraries
Dabcyl, Dabsyl, Dansyl, EDANS, Farnesyl
Coumarin derivatives, Rhodamines, TAMRA
Glycosylated, Phosphorylated, Sulfated (Ser, Thr, Tyr)
Isotopically-labeled derivatives:
13C, 15N
Peptide International specializes in providing:
Exploratory compound sets and libraries
Multi-gram to pilot-scale preparations for
development and diagnosticsPlease contact our technical experts
to discuss your specific
needs and to learn about our cost effective and value added
services.
A comprehensive list of Peptides International enzyme
inhibitors (The Enzyme Inhibitor Guide), complementary
substrates (The Enzyme Substrate Guide) and related
literature are available from www.pepnet.com or by
contacting
us via email [email protected] or by phone 800-777-4779.
Crystal structure of TACE (TNF-a Converting Enzyme) in complex
with inhibitor
TAPI-2 (TNF-a Protease Inhibitor-2). TAPIs are proprietary TACE
inhibitors sold by
Peptides International under license from US Patents: 5,387,610;
5,616,605; 5686,422.
Source:
http://www.ebi.ac.uk/pdbe-srv/view/images/entry/2ddf600.png by J.
Swaminathan &
MSD staff at the European Bioinformatics Institute
http://www.ebi.ac.uk/
Pennington Joins PI Team as CTO
Peptides International proud-ly announces the addition of Dr.
Michael Pennington to the companys executive team as Chief
Technical Officer effec-tive December 1st, 2010. Background
Dr. Pennington has spent over 20 years in research and
devel-opment management with the Bachem Group and was most recently
President and COO of Bachem Bioscience Inc., the companys King of
Prussia (Pennsylvania) facility.
He is the author of nearly 100 technical publications,
has served on the editorial boards of several industry
journals, and is on the Scientific Advisory Boards of a
number of drug development companies. He is also
a co-principal investigator on several NIH grants and
serves as an adjunct faculty member in the Department
of Chemistry at Villanova University. Mike and his
wife Michelle have recently moved to Kentucky and
are enjoying their new property in horse country.
ChangesDr. Pennington's addition has had an immediate
impact at PI. Along with a broadened custom peptide
emphasis, many new initiatives, products, and quality
procedures have been introduced or implemented. At
the same time, Dr. Channa Basava, who had been lead-
ing the company's technical and commercial organiza-
tions, has expanded his efforts in the areas of specialty
products and technologies, business development, and
sales and marketing management.
A Newsletter from Peptides International
Volume 24, No. 1, 2011
Product Quality and Value Strict Confidentiality Proactive
Project Management Friendly Service
The custom peptide business has become com-
moditized in recent years as more and more low-cost,
quick turnaround sources appear around the world.
Yet researchers pursuing peptide-based drug devel-
opment projects increasingly seek more complex
structures and services that often exceed the capa-
bilities of many of these service providers. Peptides
International, with a long history of providing custom peptides,
has
just completed a major commitment in personnel and equipment
that will allow it to satisfy the custom chemistry needs of the
most
demanding researchers and their ever increasing challenges.
Addition of the new resources has resulted in the designation
of
complex custom peptides as PIs newest Technology Platform
(see
PEPNET Vol. 22 No. 2). This designation provides an
integrated,
company-wide effort that not only meets customers immediate
synthetic needs, but can offer additional services in areas such
as
analytical testing, technology/process development, and
scale-up.
Leading this effort is Dr. Michael Pennington, a well-known
peptide
industry expert with over 20 years of experience meeting just
such
challenges (see inset). Joining Dr. Pennington and PIs
existing
team of research, production, and QC scientists are Dr.
Satendra
Chauhan and Dr. Rommel Talan (see page 2), who bring unique
breadth and experience to this team. PI laboratories,
updated
and expanded in 2007, are now further enhanced with with
state-
Growing AcCUSTOMed to New Challenges
PI Debuts New Technology Platform...
Dr. Michael PenningtonChief Technical Officer, Peptides
International
Biotin
FITC
TMR
Linker
Not only is PI able to synthesize native ShK and custom
analogs,but
our scientists can also attach labels such as fluorophores
(TAMRA
and FITC) or Biotin with mini-PEGTM spacers, as shown.
Special
CUSTOM
Issue
ShK - A
35 amino acid peptide isolated from
the Caribbean sea anemone, Stichodactyla helianthus
see PI Debuts..., page 3
Lys-22
ShK
Arg-1
PRESORTEDSTANDARD U.S. PostagePAIDPEPTIDES INTERNATIONAL
P.O. Box 99703 Louisville, KY 40224-0658
USAAddress Service Requested
P.O. Box 99703Louisville, KY 40224-0658 USAPhone:
502-266-8787Fax: 502-267-1329
Peptides International, Inc.
1-800-777-4779 E-mail: [email protected]
In This Issue
As in years past, we are including
a Kentucky Derby commemorative
glass with orders of $500 or more.
These glasses are highly collectable
and are often seen displayed during
visits to customers' labs and offices.
This year's edition will make a nice
addition (or start) to your collection. Order soon and don't
miss out! (No additional charge for shipping.)
By request and while quantities last. Limit one per
laboratory,
please.
It's a Tradition: The 2011 Derby Glass
News and Notes
Going Beyond Custom Synthesis
Malemide-Activated KLH Carrier
Protein New Products from the Peptide
Institute Employee Spotlight(s)
This issue of PEPNET highlights Peptides International's
recently
increased capabilities and offerings. We hope you enjoy
perusing
this PEPNET edition. We look forward to hearing from you!
Coming Soon! Cell Penetrating Peptides, HDAC Products, New
Building Blocks/Synthetic Tools and much more.
The 22nd APS will be held June 25 - 30, 2011 in beautiful
San
Diego, CA at the Sheraton Hotel and Marina in San Diego,
California.. Peptides International will be there and we hope
you can stop by and say "hello"!
See You Soon...
20 th American Peptide Symposium On behalf of the American
Peptide Society, we are pleased to invite you to the 20th
jubilee of the American Peptide
Symposium, "Peptides for Youth" to be
held in Montreal, Canada from June 26 to
30, 2007. This symposium will serve to
remember the accomplishments of society
members since Professors Saul Lande and
Boris Weinstein organized the First
American Peptide Symposium at Yale
University in 1968. Moreover, "Peptides
for Youth" will strive to attract Young Investigators to
participate in a meeting that
recognizes and highlights their achievements, and incites their
interests with a stimulating
scientific program, featured in a vibrant city, Montreal. The
night life and quality of
entertainment in Montreal are world renown and by holding the
Meeting around the
time of the Montreal Grand Prix and Montreal Jazz Festival,
participants can enjoy
mixing quality Science with fast motorcar racing, great music
and fun. Bilingual, multi-
cultural and safe, Montreal offers outstanding facilities,
hotels, restaurants and
entertainment centers for a memorable meeting.
Co-chairs: Emanuel Escher William D. Lubell
Universit de Sherbrooke Universit de Montral For More
Information Please Contact
[email protected] Coordinator: Susan Seaman (514) 343-6111
ext 3907
Peptides International would like to acknowlege two former
employees with whom many customers and researchers
have had contact over the years: Dr. DeAnna W. Long, who was
Director of Business
Development, but during her tenure at PI wore many
hats, has moved on to a new role in academia.
Lisa Civello, who was Product Manager, has taken a
position in the non-profit sector in marketing.
They will be missed and we wish both of them well in their
future endeavors!Lastly, please note our recent mailing address
change:
P.O. Box 99703
Louisville, KY 40224-0658
USAOur physical location address remains the same.
PEPNET.COM What's New Look for Peptides International at the APS
2011
TM
Look who's citing us!Literature citations of PI products &
services!1,200 and counting...
PRA=Propargyl-Gly) while using the other with a labeling
molecule (e.g. Azido-PEG). The possibilities employing this
type of strategy allow for almost limitless selective label
incorporation. Peptides International now offers a new
assortment of these types of building block tools to aid in
the application of Click chemistry to many different
systems.
Clickable Cell-Penetrating PeptidesCell-penetrating peptides
(CPP) have received considerable
interest for drug discovery applications because of their
abili-ty to permeate the cell membrane and allow for payload or
cargo molecules to be deliv-ered into the cytosol. These peptides
were initially discovered from the venom of wasps and the TAT
(Trans-Activator of Transcription) protein derived from HIV. They
typically have a high content of argi-nine residues. CPPs can be
functionalized with alkynes or azido groups which allow for the
transport of cargo molecules such as cytotoxic drugs, siRNA
molecules or kinase inhibitor sequences. Peptides International is
pleased to offer a new CPP derived from
HIV, TAT (49-57) (TAT-3733-PI, TAT-3734-PI, and
TAT-3735-PI).
A Newsletter from Peptides International
Volume 24, No. 2, 2011
Product Quality and Value Strict Confidentiality Proactive
Project Management Friendly Service
What is Click Chemistry?Selective orthogonal labeling of
peptides has
been limited by the need to use thiol and
amine groups in the target peptide to interact
with maleimido, halo-acetyl and NHS-esters
of the desired labeling molecule. When more
than one thiol or amine is present in a specific
peptide, it is difficult to get selective incorporation
without
using special protecting groups to minimize side reactions.
Click chemistry, the name popularized by Nobel Laureate
Dr. Barry Sharpless of the Scripps Research Institute,
involves
the incorporation of groups that other-wise do not occur in
biological molecules into both the peptide and labeling mol-ecules.
These groups then react - or "click", achieving high selec-tivity
under mild conditions.
Clickable Building
Block ToolsThe most popular use of Click chemistry for
biological molecules involves a cyclo-addi-tion reaction using an
azido-containing component and an alkyne-containing component that
react in the presence of Cu(I) to form a 1,4
disubstituted 1,2,3 triazole (see figure). For peptide chemistry
applications, the
number of possibilities can be increased by incorporating
one of the respective components within a peptide chain
(e.g.
Meet "The Clickables"
CLICK Chemistry
Issue
see Meet..., page 3
PRESORTEDSTANDARD U.S. PostagePAIDPEPTIDES INTERNATIONAL
P.O. Box 99703 Louisville, KY 40269-0703
Address Service Requested
P.O. Box 99703Louisville, KY 40269-0703 USAPhone:
502-266-8787Fax: 502-267-1329
Peptides International, Inc.
1-800-777-4779 E-mail: [email protected]
In This Issue Meet "The Clickables" The Clickables: RGD Peptides
NEW Feeding & Regulatory Peptides
New Items from the Peptide Institute
Advanced Equipment Installed Employee Spotlight(s)
This issue of PEPNET highlights Peptides International's
entry
into the exciting area of Click Chemistry, as well as its use in
cell
penetrating peptides, building blocks and RGD peptides. We
hope
you enjoy perusing this PEPNET edition. We look forward to
hear-
ing from you!Coming Soon! Toxins, Enzyme Inhibitors &
Substrates and much
more.APS Wrap
Up: Thanks to all those who
stopped by and took time to visit the Peptides
International booth in San Diego. Also, con-
gratulations to Dr. Aleksandr Rabinovich,
at right, who was the winner of our Kindle
giveaway there. It was , by all accounts, a very
successful meeting. See you at Number 23!
CA Representation: Speaking of San Diego, please be aware
that PI has a business consultant dedicated to California.
Dr.
Smita Yadav, at left, conveniently located in the San Diego
area, has many years of experience in the
peptide, chemistry and biology fields.
She would love to discuss your current
(or future) peptide projects and needs.
She can be reached directly by email at
[email protected], or by phone at 858-
361-4175. If you are located in California,
please contact Dr. Yadav today to discuss
the ways Peptides International can create value for your
peptide projects.
Benefits of Being Social: The
Peptides International page is
an up-to-the-minute resource
where you'll find all the latest
announcements, offers, and events related to Peptides
International and the field of peptide chemistry.
News and Notes
Peptides International Introduces New Product Line
Peptide CO
CHNH
2
CH2CH2C CH
N N N
[Cu]+
O
RKKRRQRRR NH2
+Alkyne Component
Azido-TAT Peptide (TAT-3734-PI)
"Clicked" TAT
CLICK
O
RKKRRQRRR NH2
CH CH2CH 2
CO
NH2
Peptide
NN
N
AzidoComponent
Alkyne-Containing Labeling Molecule
PEPNET.COM Stichodactyla Toxin (PSK-4287-s)
PEPNET.COM Stichodactyla Toxin (PSK-4287-s)
NP2D.COM Invited Speakers
Peptides International's Chief
Technical Officer, Dr. Michael
Pennington, is slated to be a keynote
speaker at the Natural Peptides To
Drugs 5th International Congress,
held from December 4 - 7, 2011, in
Zermatt, Switzerland. His topic,
Advancing ShK Peptide Into the Clinic for Treatment of
Multiple
Sclerosis, has particular topicality for Peptides
International:
ShK (Stichodactyla Toxin (PSK-4287-s)) is one of PI's
extensive
toxins offerings. Following the conference, there will be
a "Conodays" event December 7 - 9. If you are attending,
please look up Peptides International while there! Look for
an in-depth review of peptide toxins in the next edition of
the
PEPNET newsletter.
PI CTO @ NP2D (translation below)2D
NP
Scan here for a special offer!
-
Purchasing
xx Order Hotline 1-800-777-4779 502-266-8787
Peptides International's customer service representatives are
prepared to help process your orders, assist with product
information, and answer technical questions. Orders can be placed
by mail, telephone, fax, or email.
Address: Mailing Address Physical AddressPeptides International
or Peptides InternationalP. O. Box 99703 11621 Electron
DriveLouisville, Kentucky 40269-0703
Louisville, Kentucky 40299-3861
USA USA
Telephone: 1-502-266-8787 (Local and International Callers)
1-800-777-4779 Toll-free (USA and Canada) Customer service
representatives are available during the following times to
assist you: Monday through Thursday - 8:30 AM - 6:00 PM (EST /
EDT time) Friday - 8:30 AM - 5:00 PM (EST / EDT time)
Fax: 1-502-267-1329 Email: [email protected]
Web site:
-
Purchasing
Order Hotline 1-800-777-4779 502-266-8787 xxi
OrdersWhen placing an order please specify: Customer ID Number
Company or Institution Billing Address Shipping Address Purchase
Order Number or
Credit Card information Catalog Code Number Quantity and
Product
Description Quote Number, if applicable Telephone Number Fax
Number Email Address Shipping Requirements VAT, if applicable
Minimum OrdersPeptides International does not require a minimum
order but encourages repeat customers to combine small orders, when
possible, to minimize handling and shipping costs.
Confirming OrdersPlease mark all confirming orders clearly to
avoid duplication.
Back OrdersShould an item be temporarily out of stock, this will
be indicated in the back order column of the customers invoice.
Most back order are shipped within two weeks.
-
Using the Catalog
xxii Order Hotline 1-800-777-4779 502-266-8787
Catalog Key This catalog has been designed to provide unique,
concise information for
each product, with the intention of enabling easy navigation and
ordering. For further information or specific questions regarding a
product, please
contact a Peptide International customer service
representative.Biologically Active Peptides (All Are Acetate Form
Unless Otherwise Indicated)
1. Major Product Section, designated as Biologically Active
Peptides, Enzyme Inhibitors & Substrates, Specialty Products
& Technologies, or Tools for Peptide Synthesis.2. Subsection
Heading 3. Product Section (may include article and / or
references)4. Product Name5. Product Code6. Unit Size7. Price (in
US Dollars)
8. Alternate Name (when applicable)9. Storage Temperature (see
page for key)10. Synthetic, Originally From... (when applicable)
11. Sequence (when applicable/available)12. Molecular Weight,
Formula, and CAS Number (when available)13. Description (when
applicable/available) 14. References (when available)
Peptides International strives to give accurate content,
including product information, quantities, and pricing. Policies,
pricing, and item availability are subject to change without
notice. While Peptides International makes a good faith effort to
ensure that the information displayed is accurate, we are not
responsible for typographical errors or technical
inac-curacies.
Toxinsw-AgatoxinsB.M. Olivera, G.P. Miljanich, J. Ramachandran,
and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review) O.D.
Uchitel, Toxicon, 35, 1161 (1997). (Review)
-Agatoxin IVA -Aga-IVA(Funnel Web Spider, Agelenopsis
aperta)
PAG-4256-s-20 C
0.1 mgvial
380
Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-Cys-Ser-Ile-Met-Gly-Thr-Asn-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala
(Disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and
Cys27-Cys34) (M.W. 5202.2) C217H360N68O60S10 P-type Ca2+ Channel
Selective BlockerI.M. Mintz, V.J. Venema, K.M. Swiderek, T.D. Lee,
B.P. Bean, and M.E. Adams, Nature, 355, 827 (1992). (Original) T.J.
Turner, M.E. Adams, and K. Dunlap, Science, 258, 310 (1992).
(Pharmacol.) H. Nishio, K.Y. Kumagaye, S. Kubo, Y.-N. Chen, A.
Momiyama, T. Takahashi, T. Kimura, and S. Sakakibara, Biochem.
Biophys. Res. Commun., 196, 1447 (1993). (Chem. Synthesis &
Biological Activity) This compound is distributed exclusively
through Peptides International under license agreement with the
University of Utah.
95
11
12
1413
12
3
48
7
10
6
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Order Hotline 1-800-777-4779 502-266-8787 xxiii
Applicable TermsThese Terms and Conditions of Sale shall become
part of every order, sale, and purchase agreement between buyer and
Peptides International.With the placement of an order, the buyer
agrees to accept the Terms and Conditions of Sale. Peptides
International shall not be bound by the purchasing conditions of
the buyer, even if not explicitly stated. Orders containing addenda
or statements that are worded differently or provide for further
condi-tions will not be accepted unless spe-cifically agreed to in
writing by Peptides International.The UN Convention on the
International Sale of Goods shall not apply.
QuotationsQuotations must be requested for the following special
situations: Custom synthesis of materials not listed in Peptides
Internationals website or catalog (custom quotations) Quantities of
specific materials that exceed those listed in Peptides
Internationals website or catalog (bulk quotations) Packaging
alternatives, such as custom vialing, that are not offered in
website or catalog listings Large purchases of multiple items where
a discount is requested (core quotations)Unless otherwise stated,
quotations are valid for 30 days from date of issue.Quotation
prices are valid only for indi-cated product(s) in the quantity,
quality, salt form, and lead time specified in the quotation. Lead
times for custom quotations are from date of receipt of an approved
purchase order. Lead times for catalog products are subject to
inventory status on date of receipt of an approved pur-chase
order.Quotations are considered confidential
Terms and Conditions
-
xxiv Order Hotline 1-800-777-4779 502-266-8787
and are specific to the product(s) and customer. If appropriate,
Non Disclosure Agreements may also be requested. Quotations are not
transferable to other parties without express permission from
Peptides International. Purchases based on accepted quota-tions
remain subject to all other Terms and Conditions of Sale.
PricesAll prices are quoted in US Dollars and do not include
value-added and/or sales tax, which may be invoiced separately as
required. Prices include inner and outer packaging unless
specifically noted oth-erwise. If the prices in Peptides
Internationals printed literature vary from the prices published on
the Peptides International website (www.pepnet.com), then the
prices on the website shall prevail.Shipping and handling charges
apply to all shipments and Peptides International reserves the
right to add a surcharge for any special shipment requirements
(e.g. dry ice, inert gas).All product prices are subject to change
without notice prior to confirmation of an order, but no product
will be shipped at increased prices without prior notifica-tion.
Peptides International reserves the right to charge a re-assaying
and restocking fee on returned goods.
Order PlacementOrders may be placed by telephone, fax, email,
letter or online using Peptides Internationals website
(www.pepnet.com).
Orders resulting from a prior quotation must reference the
specific quotation number. Orders placed verbally or by electronic
transmission shall become legally bind-ing only if they have been
confirmed by receipt of an invoice number from Peptides
International. Orders received by Peptides International are firm
and binding upon the buyer and do not release the parties from
their obligation(s) to deliver or to accept deliv-ery, nor release
them from their financial obligations to Peptides International.
Custom orders should be reviewed carefully for structures,
sequences, and other particulars before placing orders. Peptides
International may at its discre-tion accept change orders under
condi-tions that provide for recovery of already incurred costs and
any additional costs arising from the agreed upon changes.
Delivery and AcceptanceAgreed upon delivery deadlines refer to
the shipment date of the goods. If the delivery deadline is
extended by buyer, buyer shall specify an appropri-ate period for
acceptable late delivery of the shipment. If the delivery deadline
is extended by Peptides International, buyer will be notified of
such extension prior to the original shipment deadline. Peptides
International reserves the right to decline orders in the event the
product can no longer be made or the customer is in arrears with
any commitments or payments.Buyer is responsible for complying with
national or international laws or regula-tions applicable to
shipment, delivery, storage, processing or trading of any
Terms and Conditions
-
Order Hotline 1-800-777-4779 502-266-8787 xxv
specifically designated products.Force majeure of any kind,
unforesee-able operational disruptions, short-falls or failures in
delivery by Peptides Internationals suppliers, shortages of raw
materials, power supplies and/or manpower, strikes, lockouts,
problems in procuring means of transport, traffic obstructions,
war, political unrest, acts of terrorism, natural disasters and
order of higher authorities exempt the party concerned from the
obligation to deliver or to accept delivery for the duration of the
disruption and for any consequential damages arising therefrom, but
shall not exempt such party from any financial obligations arising
from any goods or services already supplied.
Warranty and Warranty DisclaimerAll Peptides International
biochemicals are extensively tested for purity. Each shipment is
accompanied by a detailed lot-specific Analytical Data Sheet (ADS).
Peptides International warrants the purity, identity and content of
its prod-ucts at the time of sale in accordance with the results
listed in the ADS. The buyer shall visually inspect and test
products immediately upon receipt to determine whether the
condition and quantity of the goods conforms to the ADS and the
applicable contractual agreement. All claims must be received in
writing within 14 days from date of delivery of the product to the
customer and failure to do so shall constitute a waiver by buyer
for any and all such claims. Claims must include proof of
non-compliance, specifically naming the product, the lot number,
and the invoice number.
Peptides International shall ship replace-ment product for
claims for which proof is submitted and which are received within
the time period specified above. If the replacement delivery is
also non-con-forming to the contractual agreement, then the buyer
has the right to cancel the order or contract. Products that are
the subject of com-plaint may be sent back only with Peptide
Internationals agreement and shipping arrangements for the return
must be agreed upon by both parties in advance. Peptides
Internationals sole obligation is to replace material up to the
extent of the purchase price, or provide a refund or credit.
Peptides International makes no other warranties, express or
implied, including, but not limited to, any implied warranty of
merchantability or fitness for a particular purpose or implied
warranty arising out of a course of dealing, cus-tom, or usage of
trade.
Use and Limitation of LiabilityAll products sold by Peptides
International are intended solely for laboratory and research use
and should not be used in or on human subjects. Peptides
International sup-plies such products only for the pur-poses of
public research as conducted at experimental and teaching
institutes, technical facilities and commercial enti-ties.It is the
responsibility of the buyer to determine the adequacy of all
materials for any intended or specific purpose or use. Peptides
International makes no warranties as to use for an intended or
specific purpose.
Terms and Conditions
-
xxvi Order Hotline 1-800-777-4779 502-266-8787
Peptides International expressly forbids the distribution of
dangerous substances to private individuals and draws atten-tion to
the fact that the absence of a hazard warning sign does not
indicate that the product concerned is harmless. Peptides
International shall therefore not accept any liability for damage
that could arise from the inappropriate handling or from any use in
household applications or in humans and animals. Peptides
International shall not be liable for any damage as a result of
improper use or storage of its products. This limitation of
liability also includes products that have been tampered with or
altered by accident or negligence. Peptide Internationals liability
with respect to non-fulfillment or delay of delivery shall be
limited to the invoice amount of the goods. All information
contained in catalogs, brochures, publications and other printed or
electronic media is compiled to the best of Peptide Internationals
knowl-edge. Peptides International hereby disclaims any liability
for any possible errors or misprints. Peptides International shall
not under any circumstances be liable to buyer for any direct,
indirect, special, incidental, or consequential loss or damages
(includ-ing, but not limited to, loss of profits, revenue,
business, research, research results, opportunity or goodwill)
aris-ing from or in any way related to the products or Peptides
Internationals sale of products, regardless of the legal or
equitable theory under which such loss or damages are sought,
including breach of warranty or contract, negligence, or strict
liability.
Title and Proprietary RightsUntil full payment of the purchase
price, including all secondary claims, the sup-plied products
remain the property of Peptides International (reservation of
title). If the buyer fails to pay for products despite receipt of
late notices, Peptides International reserves the right to
with-hold any further deliveries to the buyer and to require the
return of the unpaid goods, unused and in original packag-ing, at
the buyers expense.
Terms of PaymentTerms of payment are net 30 days for qualified
buyers. A service charge of 1.5% per month (18% ANNUAL RATE) will
be added to all balances which are 30 or more days past due.
Discount deductions on invoices are not allowed. Reductions in
Peptides Internationals invoices may not be made without a credit
invoice or note and if made without such, shall be considered a
late or short payment. Peptides International reserves the right to
change the terms of payment to payment in full or in part in
advance of shipment. After an order is accepted or a sale
com-mitment is made, any increase in, and all new taxes, excises,
duties, or other governmental charges (except taxes on income)
imposed on the production, sale, transportation, import or export
of products sold to buyer which Peptides International is required
to pay will be added to the price paid by customer for
products.
Terms and Conditions
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Order Hotline 1-800-777-4779 502-266-8787 xxvii
Payment may be made by one of the following methods: Check: Send
a check, including
any clearing, processing, or other bank charges or fees to:
Peptides International, Inc.P.O. Box 99703Louisville, KY 40269
Wire Transfer: If not already in US dollars, arrange for
conversion of the currency to US dollars, includ-ing shipping and
handling charges (included on all invoices). Wire the total amount
to the following account:Bank ABA # 083900680Account #
5183479840SWIFT # BRBTUS33BB&T401 West Main St.Louisville, KY
40202 USA Contact: Nell Prince Phone (502)-562-7902
Credit Card: Peptides International accepts MasterCard, Visa,
and American Express.
Important: After completing one of the steps above please email
or fax a con-firming note to Peptides International indicating the
date and amount of your payment. You should also include your
invoice number or purchase order num-ber to insure proper
credit.
Patent Claims, Protection Rights, Consultancy
With any purchase, the buyer acquires the product but no other
rights asso-ciated with the product. Peptides International remains
in possession of all intellectual property rights related to the
manufacturing and composition of the product. The use of trademarks
in offers does not provide for the use of such trademarks.
Permission for such use must always be obtained from Peptides
International in advance and in writing. Peptides International
makes no guaran-tee that the use or resale of its products will not
violate the protection or patent rights of third parties. Peptides
International agrees to offer its customers technical support to
the best of its knowledge. All comments or proposals for the use,
application, or suitability of the products shall not be
interpreted as an explicit guarantee of success.
Applicable Laws Any legal dispute involving these Terms and
Conditions will be governed by the laws of the Commonwealth of
Kentucky.If a provision in these conditions of sale or a provision
in the context of other agreements are or become legally
unenforceable, only that provision shall become null and void and
all remaining provisions shall remain enforceable and in
effect.
Terms and Conditions
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xxviii Order Hotline 1-800-777-4779 502-266-8787
Custom Products and ServicesIf peptides or other products you
need are not listed in this catalog, we invite you to try our
custom synthesis services. Peptides International has earned the
reputation of providing exceptionally high quality custom peptide
synthesis products to the research community. We specialize in 5 to
100 mg quantities (or greater) with purity levels of at least 95%.
Amino acid analysis ratios, mass spectral data, and analytical HPLC
chro-matograms are provided with custom peptides. Areas of
expertise include: Multi-Disulfide PeptidesInterested in
mini-proteins with multiple disulfide bonds? Peptides International
researchers have extensive experience folding these highly
complicated molecules to their biologically active forms. Examples
include native molecules and analogs of conotoxins, defensins,
hepcidins, chemokines, ion channel blockers (ShK, HwTX4,
charybdotoxin, iberiotoxin, margatoxin, ProTx-II, mu-conotoxins,
etc). They can also customize with labels such as TAMRA, FITC or
Biotin using a mini-PEG spacer.Peptide-Protein
ConjugatesPeptide-protein conjugates have a variety of
applications, including the stimulation of antibodies for
immunization. These conjugates can be customized as needed,
includ-ing combinations with proteins such as Albumin, Ovalbumin,
and Ferritin. Selective het-erobifunctional crosslinkers allow for
selective attachment of a Cys-containing peptide to the protein of
your choice. Using KLH-MCC will help streamline this reaction, and
the product (KLH-6000-PI) is conveniently kept in stock at all
times.Peptide DerivativesFluorescence resonance energy transfer
(FRET) occurs when excitation energy is transferred from an excited
fluorescent donor to a quenching acceptor in a distance-dependent
manner. Cleavage of a scissile peptide bond within a fluorescence
quenched substrate leads to separation of the intramolecular
donor-acceptor pair, thus allowing an increase in fluorescence. The
fluorescence increase is proportional to the amount of peptide
hydrolyzed. To design a substrate for a newly discovered enzyme
Custom Peptide Synthesis
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Order Hotline 1-800-777-4779 502-266-8787 xxix
or application, contact our specialists to begin a customized
Substrates by Design project.Post Translation
ModificationIncluding: Glycosylation, Phosphorylation, Fatty Acid
Acylation, Pegylation, Cyclization, and Disulfide BondsPeptide
SynthesisIncluding: Classical/Solution, Solid-Phase, Native
Chemical Ligation, and Dendrimeric RGD
PlatformsPeptidomimeticsIncluding: Hydroxyethylene Isostere,
Reduced Peptide Bonds, Aldehydes, Chloro-methylketones,
Depsipeptides, and PhosphonatesMulti-step Organic
SynthesisIncluding: Novel Amino Acid Derivatives, Stereo Selective
Synthesis, Special Protecting GroupsOther ServicesPeptides
International is an excellent source for production of unusual
amino acids and offers rapid, thorough, and cost effective hydrogen
fluoride (HF) cleavage proce-dures. Please inquire for additional
analytical services. ConfidentialityAll customer requests will be
treated with strict confidentiality and non-disclosure agreements
can easily be put in place. We offer molecular design
consultations, project management and technology transfer for
scale-up production.
Custom Peptide Synthesis
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Order Hotline 1-800-777-4779 502-266-8787 xxx
Technology Platforms
As additional value, Peptides International has developed
technology platforms that assure an intergrated company-wide effort
that not only meets researcher's immedi-ate synthetic needs, but
can offer additional services in such areas as analytical testing,
technology/process development, and scale-up. Peptides
International's RGD Technology Platform, is a natural outgrowth of
its extensive catalog offerings, custom RGD experience, and
technological expertise.
T e c h n o l o g y P l a t f o r m
RGDComplex Organic
Derivatives
MultimersConjugates
Industry Leading Catalog Portfolio
Defined-Length PEGylations
Process Scale-up Multi-gram Synthesis
Applications and Potential Benefits to Researchers: Integrin
related RGD research NCEs and cancer drug development Useful to
prepare radiolabeled agents
Tumor targeting, imaging and diagnostics Novel biomaterial
research & development Tissue repair and wound healing
studies
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xxxi Order Hotline 1-800-777-4779 502-266-8787
Technology Platforms
The Custom Services Portfolio Platform spans a wide range of
technologies rang-ing from traditional solution and solid phase
synthesis to peptidomimetics as illus-trated by depsi-peptide bond
formation and HET isostere incorporation. Expertise in multi-step
organic synthesis and peptide modi-fication offer a virtually
limitless range of custom options extending from glycosylation to
fluorescent and isotopic labeling, cyclization, phosphorylation,
and more.
Peptidomimetics
Post TranslationalModifications
Multi-disulfidePeptides
PeptideSynthesis
Multi-stepOrganic
SynthesisPeptide- Protein
Conjugates
Peptide Derivatives
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PEPTIDES INTERNATIONALBIOLOGICALLY
ACTIVE PEPTIDES
Order Hotline 1-800-777-4779 502-266-8787 1
PRODUCT CODE QTY PRICE Biologically Active Peptides (All Are
Acetate Form Unless Otherwise Indicated)Ac-Asp-GluAc-Asp-Glu H2O
(Bulk)
(M.W. 304.26 18.02) C11H16N2O8 H2O [3106-85-2]Endogenous
Excitatory Neurotransmitter
PDE-4167-20 C
25 mg100 mg
55155
K.L. Reichert and F. Fonnum, J. Neurochem., 16, 1409 (1969).
(Original) K.J. Koller and J.T. Coyle, Eur. J. Pharm., 98, 193
(1984). (Characterization of Receptor) K.J. Koller, R. Zaczek, and
J.T. Coyle, J. Neurochem., 43, 1136 (1984). (Localization in
Brain)J.H. Neale, T. Bzdega, and B. Wroblewska, J. Neurochem. 75,
443 (2000). (Review)
ACV (Delta-(l-Alpha
aminoadipyl)-l-Cysteinyl-Bis-d-Valine)Bis-ACV
Delta-(l-a-aminoadipyl)-l-Cysteinyl-Bis-d-Valine (M.W. 724.86)
C28H48N6O12S2Precursor for Biosynthesis of Penecillin
PAC-3860-PI-20 C
25 mg100 mg
395995
Adjuvant PeptideAdjuvant Peptide
N-Ac-Mur-Ala-d-Glu-NH2 (Mur: Muramic acid) (M.W. 492.48)
C19H32N4O11 [53678-77-6]
PAD-4031-v-20 C
0.5 mg vial
45
Adjuvant Peptide (Bulk) N-Ac-Mur-Ala-d-Glu-NH2 2H2O (Mur:
Muramic acid) (M.W. 492.48 36.03 ) C19H32N4O11 2H2O [53678-77-6]
Muramyl Dipeptide
PAD-4031-20 C
25 mg 850
F. Ellouz, A. Adam, R. Ciorbaru, and E. Lederer, Biochem.
Biophys. Res. Commun., 59, 1317 (1974). (Original) S. Kotani, Y.
Watanabe, F. Kinoshita, T. Shimono, I. Morisaki, T. Shiba, S.
Kusumoto, Y. Tarumi, and K. Ikenaka, Biken J., 18, 105 (1975).
(Chem. Synthesis and Immun. Activity)
Adrenocorticotropic Hormone (ACTH)
ACTH (Human, 1-24) Adrenocorticotropic Hormone (Human, 1-24)
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-
Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro (M.W. 2933.4)
C136H210N40O31S [16960-16-0]
PAC-4109-v-20 C
0.5 mg vial
275
B. Riniker, P. Sieber, W. Rittel, and H. Zuber, Nature (New
Biol.), 235, 114 (1972). (Original; Structure)
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2 Order Hotline 1-800-777-4779 502-266-8787
PEPT
IDES
INTE
RNAT
IONA
LBI
OLOG
ICAL
LY AC
TIVE
PEP
TIDE
S PRODUCT CODE QTY PRICE Adrenomedullins and Related
Peptides
K. Kitamura, K. Kangawa, H. Matsuo, and T. Eto, Drugs, 49, 485
(1995). (Review) D.A. Schell, R.C. Vari, and W.K. Samson, Trends
Endocrinol. Metab., 7, 7 (1996). (Review)M. Julin, M. Cacho, M.A.
Garcia, S. Martin-Santamaria, B. de Pascual-Teresa, A. Ramos,