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ISSN 1344-7661
PEPTIDE SCIENCE
2014
st
Proceedings of the 51 Japanese Peptide Symposium
October 22-24, 2014
Tokushima University
Otsuka Memorial University Auditorium
Tokushima
Edited by
Akira Otaka
Tokushima University
Published by
THE JAPANESE PEPTIDE SOCIETY
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CONTENTS
<JPS Akabori MemorialA ward >
A RaPID Way to Discover Bioactive Natural Product-like Peptides -Akabori
Memorial Award Lecture-
Hiroaki Suga
<JPS Young Investigator Award Lecture >
Development of Peptide-Based Tools for Detecting Behaviors of Membrane
Proteins
Yoshiaki Yano
<JPS Young Investigator Award Lecture >
Development of Stabilized Short Helical Peptides and Their Functionali/ation
Yosuke Demizu
The First Non-enzymatic Dynamic Kinetic Resolution of Racemic 2-(l//-Pyrrol-
l-yl)alkanoic Acids by the Asymmetric Esterification Using Chiral Acyl-transfer
Catalyst
Takayoshi Nakahara, Atsushi Tengeiji, Eri Tokumaru, Isamu Shiina
Development of Efficient Synthetic Methodologies of Chloroalkene DipcptidcIsosteres
Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura
Solid Phase Synthesis of Cyclic Fragment of the Homophymine B
Yoshinori Tokairin, Ryo Yoshino, Sho Takeda, Hiroyuki Konno
Synthesis and Function of Mycobacterium Cell Wall Peptidoglycan (PGN)
Fragments
Qianqian Wang, Yusuke Matsuo, Yukari Fujimoto, Koichi Fuka.se
Development of 8-Azacoumarin-4-ylmethyl-type Photolabile Protecting GroupsBased on Amide-Alkene Isosterism
Hikaru Takano, Tetsuo Narumi, Nami Ohashi, Wataru Nomura, Toshiaki Furuta,
Hirokazu Tamamura
The Direct Use of Peptidyl A^-alkylcysteine for the Native Chemical Ligation
Yuya Asahina, Kei Nabeshima, Hironobu Hojo
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Development of a Novel Neurokinin-3 Receptor Selective Agonist with Highly
Biological Stability
Ryosuke Misu, Shinya Oishi, Ai Yamada, Koki Yamamoto, Taro Noguchi, Hiroaki
Ohno, Takashi Yamamura, Hiroaki Okamura, Fuko Matsuda, Satoshi Ohkura,
Nobutaka Fujii 23
Postsynthetic Modification of Fully Unprotected Peptides via S -TritylationReaction
Masayoshi Mochizuki, Hajime Hibino, Yuji Nishiuchi 25
Structural and Functional Analysis of the Endogenous Peptide Inhibiting Snake
Venom
Narumi Shioi(Aoki), Yoshitestu Handa, Seijiro Shioi, Shigeyuki Terada 29
Novel Peptide Sequence for Endosome Disruption Derived from Natural
Hemolytic PeptideMisao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Shiroh Futaki 33
Development of Chemiluminescent Enzyme Immunoassays for Three
Endogenous Molecular Forms of Atrial Natriuretic Peptide in Human Plasma
Chiaki Nagai, Naoto Minamino 35
Insulin Fibrillation by Shaking Under Neutral pH Conditions: Examination of
Insulin Analogs Modified at Dimer-Foming Interface
Hiromu Yoshihara, Ayaka Tanabe, Takuma Amada, Toshinari Asakura, Kouki
Kilagawa, Shinichi Asada 37
Bisphenol A-Induced Substantial Peak Decay of Drosophila Circadian
Neuropeptide hugin mRNA ExpressionShotaro Umeno, Ayaka Matsuo, Yutaka Matsuyama, Masayuki Nakamura, Keita
Koga, Xiaohui Liu, Ayami Matsushima, Miki Shimohigashi, Yasuyuki Shimohigashi 41
Difference between In Vitro, Ex Vivo, and In Vivo Angiotensin I Converting
Enzyme Inhibition by Antihypertensive Peptides from Fermented Buckwheat
Sprout
Masahiro Koyama, Syo Okitsu, Akira Watanabe, Kozo Nakamura 43
Total Synthesis and 3D Structural Analysis of PF1171A, C, F, and G
Yuichi Masuda. Ren Tanaka, Kenji Kai. A. Ganesan, Takayuki Doi 47
Next Generation AJIPHASE *; Development of One-pot Peptide Synthesis Using
Liquid-Liquid Extraction
Daisuke Takahashi, Tatsuji Inomata 49
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Chemical Syntheses with QC-methods of Peptides Consisting of N- Methyl
pyrrole and A^-Methyl Imidazole Residues and Elucidation of Their
Microheterogeneity
Kiyoshi Nokihara, Akiyoshi Hirata, Yuki Tominaga, Atsushi Kitagawa, Takeshi
Kasama 51
Structure-Function Relationships of Spinoxin, a Peptide Neurotoxin from
Scorpion Venom
Sieve Peignew; Yoko Yamaguchi, Chihiro Kawano, Takeru Nose, Selvanayagam
Nirthanan, Ponnampalam Gopalakrishnakone, Jan Tylgal, Kazuki Sato 55
Locking the Transmembrane Helices of a Eukaryotic P-glycoprotcin Homolog
Using a Macrocyclic Peptide Ligand
Christopher John Hipolito, Atsushi Kodan, Tomohiro Yamaguchi, Toru Nakatsu,
Keita Sakiyama, Akane Fujioka, Ryo Hirokane, Yasuhisa Kimura, Kalsumitsu Veda,
Hiroaki Kato, Hiroaki Suga 57
Discovery of Human Neuromedin U Receptor Type 2-Selective Hexapcptidc
Agonists
Kentaro Takayama, Kenji Mori, Koji Taketa, Akihiro Taguchi, Fumika Yakushiji.Naoto Minamino, Mikiya Miyazato, Kenji Kangawa, Yoshio Hayashi 59
Role of the Tenascin-C-Derived Peptide TNIHA2 in the Formation of
Atherosclerotic Foam Cell
Takuya Iyoda, Mika Kazama, Koujiro Takeda, Fumio Fukai 61
Exosome-Mediated Cytosolic Delivery System Using Cationic Lipids and pH-Sensitive Fusogenic PeptideIkuhiko Nakase, Shiroh Futaki 65
Membrane Translocation of Arginine-rich Peptides and the Effect of Membrane
Curvature
Shiroh Futaki, Tomo Murayama, Silvia Pujals, Sayaka Kalayuma, Hisaaki Hirose,
Hiroki Miyamae, Ikuhiko Nakase 67
Amyloid-Selective Oxygenation by Photo-Catalyst
Atsuhiko Taniguchi, Yusuke Shimizu, Kounosuke Oisaki, Youhei Sohma. Motomu
Kanai 69
Functional Analysis of Liposome Anchoring Peptide Selected by Complementary
DNA Display (cDNA Display)
Naoto Nemoto, Yuki Yoshikawa, Toshiki Miyajima, Shota Kohuyashi 71
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Synthesis and Characterization of Tandem Hairpin Polyamide for Telomeres
Visualization
Akiyoshi Hirata, Kiyoshi Nokihara, Yusuke Kawamoto, Toshikazu Bando, Kazuhiro
Maeshima, Asuka Sasaki, Satoru Ide, Hiroshi Sugiyama 73
Design and Synthesis of Trivalent CXCR4 Ligands Utilizing Polyproline Linkers
Wataru Nomura, Taisuke Koseki, Takaaki Mizuguchi, Hirokazu Tamamura 75
Synthesis and Properties of Ni(II) Complexes Derived from a Family of New a-
(Phenyl)ethylamine-based LigandsHiroki Moriwaki, Daniel Resch, Hengguang Li, Iwao Ojima, Ryosuke Takeda, Jose
Luis Acena, Vadim A. Soloshonok 11
New a-(Phenyl)ethylamine-derived Chiral Ligand for Chemical Resolution of a-
Amino Acids
Ryosuke Takeda, Akie Kawamura, Aki Kawashima, Tatsunori Sato.Hiroki Moriwaki,
Jose Luis Acena, Vadim A. Soloshonok 81
Selective Detection of Aminothiols Using Fluorescent DihydrobenzofuranDerivative
Kouhei Shimada, Yohei Okada, Yoshikazu Kitano, Kazuhiro Chiba 85
Modified Deazaguanines for the Synthesis of PNA
Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki
Kurihara, Masashi Takano, Atsushi Kittaka 87
Study on the Peptide Sepration Using Pulverized Beads of Monolithic Silica for
Flash Chromatography
Riichi Miyamoto, Mika Watanabe, Teruhiko Kanno, Hong-zhi Bai, Takashi Ohtani,
Kazuki Nakanishi 89
Elucidation of the Disulfide Bonding Pattern of the Insecticidal Peptide LaIT2
Isolated from the Liocheles Australasiae Scorpion Venom
Ryo Ando, Masahiro Miyashita. Yoshiaki Nakagawa, Hisashi Miyagawa 93
Trapping Mechanism of Bioactive Conformation by Intra-molecular Chaperone
Yukihito Yokoyama, Masaki Okumura, Shigeru Shimamoto, Hiroshi Yamaguchi, Yuji
Hidaka 95
Purification and Characterization of Calcitonin-Related Peptide from the
Starfish, Asterina Pectinifera
Hye-Jin Go. Hye Young Oh. Mi Jeong Jo, Chan-Hee Kim, Gun-Do Kim. Nam GyuPark 97
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Isolation and Characterization of a Novel Bioactive Eicosapcptide from the
Starfish, Asterina Pectinifera
Hye-Jin Go, Tae Young Kim, Chan-Hee Kim, Nam Gyu Park 99
Isolation of a Novel Antimicrobial Peptide from Sea Anemone, Urticina
Crassicornis
Ye Jin Lee, Hye Young Oh, Hye-Jin Go, Chan-Hee Kim, Sung Soo Kim, Byung-WooLee, Nam Gyu Park 101
Development of Dimeric Peptide Derivatives Based on gp41 Fragments as HIV-1
Fusion Inhibitors
Yuzuna Honda, Takaaki Mizuguchi, Wataru Nomura, Hirokazu Tamamura 103
Studies on Lactam Formation of Arginine Derivatives
RinaAkashi, Toshiyuki Inazu 105
Preparation of Transmembrane Peptides Using a Mobile Phase Containing 2,2,2-
Trifluoroethanol; Analysis and Prevention of Potential Side Reactions Due To
Formic Acid
Yue Huang, Toshiaki Hara,,Akihiro Ito, Toru Kawakami, Hironobu Hojo, Michio
Murata 107
Facile Preparation of an jV-acetylglucosaminated Asparagine Derivative Useful
for Glycopeptide Synthesis
Hidekazu Katayama 111
TV-Sulfanylethylanilide (SEAlide) Peptide as a Versatile Intermediate for Protein
Chemical Synthesis Using Native Chemical LigationKohei Tsuji, Kohei Sato, Mitsuhiro Eto, Yusuke Tsuda, Tsubasa Inokuma. Akira
Shigenaga, Akira Otaka 113
Phenacyl Group as a Protecting Group for Thiol in the Use of Recombinant
Peptides as Building Blocks for the Peptide Ligation StrategyToru Kawakami, Hironobu Hojo 117
Aqueous Microwave Assisted Peptide Synthesis Using Fmoc-Amino Acids
Nanoparticles: Synthesis of His-containing Peptides
Keiko Hojo, Koushi Hidaka, Natsuki Shinozaki, Yuko Tsuda, Yoshinohu Fukumori,
Hideki Ichikawa, John D. Wade 119
Liquid Phase Total Synthesis of Human Insulin: Using a Hydrophobic TAG
Masahilo Takahashi, Kazumi Shimizu, Kazuhiro Chiha 121
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Synthesis of a Hydrophobic Tag for C-Terminally Amidated Peptide Synthesis
Emiko Matsumoto, Yoshikazu Kitano, Kazuhiro Chiba 123
Synthesis of Conjugated Oligonucleotide in Solution-Phase Using an Alkyl Chain
Soluble Support
Takao Shoji, Shokaku Kim, Kazuhiro Chiba 125
An Electrochemical Approach for the Intramolecular Cross-linking of Peptides
Keisuke Ogami, Yohei Okada, Yoshikazu Kitano, Kazuhiro Chiba 129
Synyhesis of Thermosensitive Peptides Using a Hydrophobic Tag Strategy
Yuko Dehari, Yuko Fujita, Shokaku Kim, Kazuhiro Chiba 133
Attempts at in Vitro Reconstitution of a Post-translational Dehydrogenasetoward Synthesis of Azole-containing PeptidesYasuharu Kato, Yuki Goto, Hiroaki Suga 137
Preparation of Mercaptoacyl-tRNAs for Ribosomal Thioester Bond Formation
Ryo Takatsuji, Takayuki Katoh, Hiroaki Suga 139
Accurate Assignment of a Nonproteinogenic Amino Acid and Valine to the
Valine GUN Codon Box
Yoshihiko Iwane, Azusa Hitomi, Yuki Goto, Takayuki Katoh, Hiroshi Murakami,
Hiroaki Suga 141
Chemical Synthesis of Head-to-Tail Cyclized Anti-VEGF Microantibody
Kentaro Takahashi, Masataka Michigami, Ikuo Fujii 143
Synthesis and Biological Evaluation of PF1171F Analogues
Yuichi Masuda, Ren Tanaka, Kenji Kai, A. Ganesan. Takayuki Doi 145
Identification of Novel CXCR7 Selective Ligands with Cyclic PentapeptideScaffold
Tomoko Kuroyanagi, Shinya Oishi, Tatsuhiko Kubo, Yuka Kobayashi, Ryosuke Misu,
Hiroaki Ohno, Nicolas Montpas. Nikolaus Heveker, Yasushi Yoshikawa, Toshio
Furuya. Nobutaka Fujii 147
Development of Stabilized Short Helical Peptides with Cell-Membrane
Penetrating Ability
Hiroko Yamashita,, Yosuke Demizu, Takashi Misawa, Makoto Oba, Masakazu
Tanaka, Masaaki Kurihara 149
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Curvature Sensitive Membrane Disruption by Antphipathic Peptides Derived
from Adenovirus Protein VI
Tomo Murayama, Silvia Pujals, Shiroh Fulaki 151
Role of Glycosaminoglycan Interaction in Biological Membrane Penetration of
Arginine-rich Cell-Penetrating PeptideYuki Takechi, Yuto Yanagisawa, Kazuchika Nishitsuji, Kenji Uchimura, Toru
Kawakami, Keiichiro Okuhira, Hiroyuki Sailo 153
Development of a Cell-Penetrating Peptide as a Transcriptional Inhibitor of the
Estrogen Receptor
Takaya Nagakubo,, Yosuke Demizu, Takashi Misawa, Yukiko Sato, Yusimari Kaiuia,
Keiichiro Okuhira, Yuko Sekino, Mikihiko Nailo, Masaaki Kurihara, 155
Cyclic RGD-MAP (Aib) Conjugate for Delivery of Small Interfering RNA
Shun-ichi Wada, Yuka Ozaki, Takashi Ozaki, Masashi Iwata, Junsuke Hayashi,Hidehito Urata 157
Roles of Individual Disulfide Bridges in the Conformation and Activity of
Spinoxin, a Peptide Neurotoxin from Scorpion Venom
Yoko Yamaguchi, Steve Peignew, Selvanayagam Nirthanan, Ponnumpulum
Gopalakrishnakone, Jan Tytgat, Kazuki Sato 159
Design of Nanodisc Scaffold Peptide (NSP)
Hirokazu Kariyazono, Wataru Shinmura, Kohei Tsuji, Teruhiko Baba, Akira
Shigenaga, Akira Otaka, Hiroyuki Saito 161
Studies on Identification of Active Sites of an Inhibitory Cyclic Peptide againstEGF Receptor Dimerization
Takaaki Mizuguchi, Ryunosuke Ninomiya, Yukako Yamazaki, Kazuya Kobaya.shi,Honami Ooe, Mika Iida, Kazuki Saito, Kenichi Akaji, Hirokazu Tamamura 163
Quantum Chemical Calculations of Structure of Antitumor Cyclic HexapeptideRA-VII
Yoh Noguchi, Hironao Yamada, Sakiko Mori, Takeshi Miyakawa, Ryota Morikawa,
Satoshi Yokojima, Yukio Hitotsuyanagi, Koichi Takeya, Masako Takasu 165
Intermodular Interaction of Human Prion Protein Fragment Peptides
Toshifumi Akizawa, Masanari Taniguchi, Aya Kojima, Takaya Nakai, Motomi
Konishi 169
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Transmembrane Peptide Oligomerization of JC Virus Agnoprotein Facilitated
by a Disulfide Bridge
Koushi Hidaka, Keiko Hojo, Shio Fujioka, Souichi Nukuzuma, Yuko Tsuda 173
Structure-Activity Relationships of Mitocryptide-3 on the Activation of
Neutrophilic Cells
Kenta Nakashima, Takayuki Marutani, Tatsuya Hattori, Kosuke Noguchi, Yoshiaki
Kiso, Hidehito Mukai 175
Investigation of Ligand Recognition Mechanisms of Receptors for Mitocryptide-1
Koki Tsutsumi, Takayuki Marutani, Tatsuya Hattori, Yoshiaki Kiso, Hidehito Mukai \ 77
Activation of Silkworm Torso, a Recently-Identified Receptor for
Prothoracicotropic Hormone
Tadafumi Konogami, Yiwen Yang, Mari H.Ogihara, Juri Hikiba, Hiroshi Kataoka,
Kazuki Saito 179
Quantitative Analysis of p53 Hetero-tetramers for Dominant Negative Effect in
Transcriptional ActivityYu Toguchi, Madoka Kanno, Toshiaki Imagawa, Kazuyasu Sakaguchi 181
Methylation of the Tetramerization Domain in Tumor Suppressor Protein p53 byPRMT5
Natsumi Nakagawa, Junya Wada, Rui Kamada, Kazuyasu Sakaguchi 183
Application of the Axial Iron Ligand-Mutant of Heme Oxygenase for Heme-
Binding Analysis
Hideyuki Komatsu, Shinpei Yamamoto, Masataka Okuda, Hiroshi Sakamoto 185
Effect of Glycogen Synthase Kinase 3 on the Complex Forming between Growth
Factor Receptor Bound Protein 14 and Insulin ReceptorJunichi Taira, Hiroshi Sakamoto, Yuichiro Higashimoto 187
Digestion of a-Synuclein Fragment Peptides with Matrix Metalloproteinases and
Inhibitory Effect of Copper Ion
Toshifumi Akizawa, Aya Kojima, Chika Matsumura, Reiko Hirose, Masanari
Taniguchi, Motomi Konishi, Hidenao Toyoda, YukoNagai 191
Elucidating the Topology in the Interaction of Calmodulin-derived HLH3 and
HLH4 Peptides
Akihiko Oku, Toshihide Takeuchi, Daisuke Noshiro, Miki Imanishi, Shiroh Futaki 195
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Functional Evaluation of Proline Periodic Peptide That Induces Formation of
Cell AggregationYudai Futaki, Yasuhiko Iwasaki. Yasuhiko Tabata. Yoshiaki Hirano ] 97
The Molecular Switching of ORL1 Nociceptin Receptor in
Activation/Inactivation
Hirokazu Nishimura, Jinglan Li, Kaname Isozaki, Yuuki Takesue. Xiaohui Liu. ShogoInamine, Ayami Matsushima, Tommaso Costa, Yasuyuki Shimohigashi 201
GPCR Functional Role of Phe269 and Phe221 in the Molecular Switching of
ORL1 Nociceptin Receptor Activation
Yuuki Takesue, Hirokazu Nishimura, Xiaohui Liu, Ayami Matsushima, Yasuyuki
Shimohigashi 203
Receptor Selectivity and Specificity of a Series of Opioid Peptides Latent in the
Proenkephalin Precursor Protein
Yudai Motomatsu, Hirokazu Nishimura, Yuka Maisumoto, Yumi Kuramitsu, ShogoInamine, Ayami Matsushima, Yasuyuki Shimohigashi 205
Design, Synthesis and Evaluation of Water Soluble Curcumin Analogs for
BACE1 Inhibitors
Hiroyuki Konno, Yuri Nikaido, Mamiko Nakadate, Hiioshi Endo, Satomi Ise, Akira
Sanjoh, Kazuya Kobayashi, Yasunao Hattori, Kenichi Akaji 207
Study on the Plasmin Inhibitors: Replacement of the P2 and PI' Residues
Ayako Suzuki, Koushi Hidaka,, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko
Tsuda 209
Structural Analysis of SARS 3CL Protease Complexed with Containing Aza-
decalin Isomer
KentaTeruya, Yasuhiro Shimamoto, Yasunao Hattori, Kazuya Kobayashi, Akira
Sanjoh, Eiki Yamashita, Atsushi Nakagawa, Kenichi Akaji 211
Structure Analysis of GLP-1 in DPC Micelle
Sakiko Mori, Hironao Yamada, Yoh Noguchi, Takeshi Miyakawa, Ryota Morikawa,
Takuya Watanabe, Masako Takasu 213
Synthesis and Conformational Analysis of Helical Oligomers with a ChangeableChiral Acetal Moiety
Ryo Eto, Makoto Oba, Atsushi Veda, Naoko Ishikawa, Masaaki Kurihara, Yosuke
Demizu, Hiroshi Suemune, Mitsunobu Doi, Masakazu Tanaka 217
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Estimation of a-Helix Stability in Water Using Molecular Dynamics Simulation
Koji Inai, Masahito Oka 219
Theoretical Reflection on the Conformation Characters of Polypeptides Having
Charged Side-Chain Groups
Koji Inai, Yoshiaki Hirano, Masahito Oka 223
Theoretical Reflection on the Conformation Characters of Proline-Rich
Periodic Polypeptides
Koji Inai, Yoshiaki, Hirano Masahito Oka 227
Metastable Ions of Peptides Observed in MALDI-TOFMS — Applications for
Protein Identification
Yang Wang, Yoshihito Okamura, Etsuko Nakajima, Toshifumi Takao 231
2+Infrared Study of the Ca -bound Coordination Structure of Tobacco
Calmodulin: Synthetic Peptide Analogues Corresponding to the Site I-Iv
Masayuki Nara, Takuya Miyakawa, Masaru Tanokura, Kazuyuki Kuchitsu, Takashi
Shimizu, Hisayuki Morii 235
Synchrotron-Infrared Microscopy Analysis of Amyloid Fibrils of Calcitonin
Peptide Irradiated by Free-Electron Laser Tuned to Amide I Band
Takayasu Kawasaki, Toyonari Yaji, Takayuki Imai, Toshiaki Ohta, Koichi Tsukiyama 237
Optimization ofNeurokinin-3 Receptor (NK3R)-Selective Agonists
Koki Yamamoto, Shinya Oishi, Ryosuke Misu, Taro Noguchi, Hiroaki Ohno, Takashi
Yamamura, Hiroaki Okamura, Nobutaka Fujii 241
Development of Cyclic Didehydrodipeptide-type Novel Anti-microtubule Agents
Possessing 2-PyridyI and Benzophenone Structures
Yoshiki Hayashi, Haruka Takeno, Daiki Nakazawa, Takumi Chinen, Kyohei
Muguruma, Kohei Okuyama, Akihiro Taguchi, Kentaro Takayama, Fumika Yakushiji,Masahiko Miura, Takeo Usui, Yoshio Hayashi 243
Preparation of Disulfide Type Prodrug of Plinabulin for Antibody-drug
ConjugateKyohei Muguruma, Ryosuke Kawamata, Daichi Akiyama, Risako Arima, Akihiro
Taguchi, Kentaro Takayama, Fumika Yakushiji, Takeshi Fukuhara, Tetsuro Watabe,
Yuji Ito, Yoshio Hayashi 245
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Structure-Activity Relationship Studies of the Peptidic Inactivators of Histone
Demethylase LSD1
Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh, Takayoshi Suzuki 247
Truncation Studies of Histone H3 Peptide Analogs as Lysinc-Specific
Demethylase 1 Inactivators
Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh. Takayoshi Suzuki 249
A Novel Detection Method for Pathogens Using Antimicrobial Peptides
Tatsuyuki Koshiyama, Satoshi Tomisawa, Takashi Kikukawa, Yasuhiro Kumaki.
Masakatsu Kamiya, Keiichi Kawano, Makoto Demura, Tomoyasu Aizawa 251
Identification of Proglucagon (proGL) Secreted from a Duodenal Cancer Cell
Line
Naoki Sakura, Tomomi Ide, Kanako Wakabayashi-Nakao, Keiichi Ohshima, Keiichi
Hatakeyama, Shun-ichiro Ogura Tohru Mochizuki 253
Exploring of Peptides with Affinity to HER2 from Random Peptide Libraries
Using Radioisotope: Random Hexapeptide Libraries with Fixed Amino Acid
Sequence at 1 and 2 Positions
Ichiro Sasaki, Hirofumi Hanaoka, Keiichi Yamada, Shigeki Watanabe, Yumi Sugo,Yasuhiro Ohshima, Hiroyuki Suzuki, Noriko S. Ishioka 257
Cell Adhesion-Mediated Drug Resistance (CAM-DR) in Acute MyelogenousLeukemia Cells and its Abrogation by the Antiadhesive Peptide FNIII14
Taro mizunuma, Takuya Iyoda, Fumio Fukai 261
Development of Universal Phage Vaccine Displaying Extracellular Domains of
M2e Derived from Human Influenza A Viruses
Ryohei Shioya, Ryuji Miyahara, Yoshitsugu Shoji.Kazuhisa Sugimura, Shuhei
Hashiguchi 265
Synthesis of Multicyclic Library for Finding Strong Target-Specific Binders
Yoshinari Arai, Masumi Taki 267
Artificial Macrocycle as a Functional-Equivalent of Catalytic Antibody
Hiroaki Inoue, Rika Asano, Masumi Taki 269
Design of Helix-Loop-Helix Peptide Inhibitor for p53-HDM2 Interaction
Hidekazu Kitada, Masahiro Oguri, Daisuke Fujiwara, Ikuo Fujii 271
Tumor Growth Inhibition by Anti-VEGF Microantibody
Masatak Michigami, Zhengmao Ye, Yasuhiko Koezuka, Ikuo Fujii 273
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Epitope Mapping of Monoclonal Antibodies Targeting the Loop Region of
Plasmodium falciparum Enolase
Hiroyuki Oku, Risa Onishi, Utako Arai, Yudai Kimoto, Keiichi Yamada, Kazuo
Shinozuka, Kazuhiko Yano, Shigeyuki Kano 275
Regulation of ILKAP Phosphatase Activity by Lipid Molecules
Nanase Tsukahara, Yuhei Kiyota, Yukiko Shirahata, Kazuyasu Sakaguchi 279
An in silico Genomic Search of Endomorphin-Like Opioid Peptide
Ayami Matsushima, Kanako O. Koyanagi, Hirokazu Nishimura, Shogo Inamine,
Yudai Motomatsu, Yasuyuki Shimohigashi 281
Identifying Membrane Proteins Involved in Cellular Uptake of Octaarginine
Peptide by Photocrosslinking
Yoshimasa Kawaguchi, Keiko Kuwata, Toshihide Takeuchi, Shiroh Futaki 283
Interation of Acidic Liposome with TV-Lauroyl Membrane Affinity Peptide
Tetsuya Marume, Akihiro Tashiro, Junko Kuwahara, Hajime Mita 285
Design of Protease-Activable Cyclic Peptide Nucleic Acid
Seiji Sakamoto, Yasuyuki Araki, Takehiko Wada 287
Synthesis and Analysis of Intracellular Molecular Dynamics of a Novel
Fluorescent Probe Having a Myristoylated PeptideShuhei Toyofuku .Haruka Morita ,Setsuko Ando ,Kentaro Okuma, Noriyoshi
Nagahora, Yasunori A izawa,Hiroyuki Nakagawa,Kosei Shioji 289
18The Study of Labeling Method Using [ F] Fluoromethionine for Peptide Imaging
Hiroshi Yamaguchi 293
Detection of Boron-Containing Amino Acids and Peptides Using Fluorescent
Boron-Sensor
Yoshihide Haitori, Miki Ishimura, Youichirou Ohta, Hiroshi Takenaka, Mitsunori
Kirihata 295
Evaluation of a Specific Peptide Substrate for Membrane-Type 1 Matrix
Metalloproteinase
Masanari Taniguchi, Ryuji Iemura. Aya Kojima, Motomi Konishi, Toshifumi Akizawa 299
In vitro Studies on Cellular Binding and Stability of MCu-Labeled Peptide for
Tumor Imaging
Yumi Sugo, Yasuhiro Ohshima, Ichiro Sasaki, Noriko S. Ishioka 303
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Infrared Studies on Amyloid Structure of Insulin
Hisayuki Morii, Masayuki Nara, Shu Konakahara, Takashi Tsuji. Takashi Shimizu 307
P-Amyloid Aggregation Inhibitors Possessing a Turn Mimic Template
Yoshio Hamada, Naoko Miyamoto, Yoshiaki Kiso 309
Molecular Design of Protein Kinase Inhibitors: Conjugation of ATP-CompctitiveMolecules with Kinase Surface-Targeted Peptides
Isolation of Anti-VEGF Neutralizing Microantibodies from Phage-displayed
Peptide Library
Effect of Spacer, Between Peptide and Polysaccharide, on the Biological Activityof Peptide-Polysaccharide Matrices
Jun Kumai, Fumihiko Katagiri, Kentaro Hozumi, Yamalo Kikkawa Motoyoshi Nomizu 317
Endothelial Cell Adhesion on ePTFE Substrate Immobilized with REDV Peptide
via Tyrosine Residue
Sachiro Kakinoki, Atsushi Mahara, Tetsuji Yamaoka 321
Coacervation Property and Structural Analysis of Synthetic Dimer Peptides of
Aromatic Amino Acid Containing Elastin-Derived Peptides
Keitaro Suyama, Daiki Tatsubo, Suguru Taniguchi, Hitoshi Kesamaru, Iori Maeda,
Takeru Nose 323
Site-Specific Mineralization of Silica and Calcium on DNAs Using a Designed
Peptide
Kenji Usui, Hiroto Nishiyama, Aoi Yamada, Makoto Ozaki, Takaaki Tsuruoka, Kin-ya
Tomizaki 325
Development of Functional Silk Fiber Using a Silk-Binding Peptide, YN42
Megumi Sumitani, Rika Fujii-Muramatsu, Ai Asaoka, Masaomi Minaha, Hirofumi
Watanabe, Ken-ichi Nakajima, Tetsuya Iizuka, Ken-ichiro Talemal.su, Hideki Sezul.su,
Jun Ishibashi 327
Amphiphilic Photofunctional Pigments by Introduction of Hydrophilic Moieties
into the 17-Propionate Residue of Chlorophyll Derivatives
Yoshitaka Saga, Naoya Takahashi, Shogo Nagata, Hiroshi Okazaki 329
Ubiquitination on an Artificial RING Finger as an E3 Ligase
Kazuhide Miyamoto 3 31
Ryo Takayama, Daisuke Fujiwara, Ikuo Fujii 313
Miho Suzuki, Masataka Michigami, Zhengmao Ye, Ikuo Fujii 315
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Meta-Analysis of Pigment-Binding Amino Acid Residues in PhotosyntheticProteins
Toru Oba, Hitoshi Tamiaki
Directed Evolution of tRNA-Aminophosphonating Ribozymes for Ribosomal
Phosphono-Peptide Synthesis
Takashi Kawakami
Proteomic Mapping of Biological Complexes Using Directed Ligand Evolution
and Ultra-High Sensitive Mass SpectrometryTakashi Kawakami, Shungo Adachi, Koji Ogawa, Tomohisa Hatta, Tai Kubo, Naoki
Goshima, Tohru Natsume
Elucidation of Influential Factors for Heterologous Productivity of the
Antimicrobial Peptide, Cecropin PI Using Escherichia coli
Chiharu Abe, Taichi Nakazumi, Beak Mihwa, Masakatsu Kamiya, Takashi Kikukawa,
Keiichi Kawano,, Makoto Demura Tomoyasu Aizawa
Alternative Polyadenylation Analyses of Neuropeptide Genes in Bisphenol A-
exposed Hypoactive Mouse Brain
Makiko Sugiyama, Shouta Kajiyama, Tatsuya Saito, Eriko Uchimura, Yudai
Motomatsu, Ayaka Matsuo, Ayami Matsushima, Yasuyuki Shimohigashi
Structural and Molecular Evolutionary Analysis of the Ligand-Binding Domain
of Forty-Eight Human Nuclear Receptors
Yutaka Matsuyama, Hirokazu Nishimura, Xiaohui Liu, Ayami Matsushima, Yasuyuki
Shimohigashi
A Novel Method to Identify and Quantify the Coactivator Proteins that Couplewith Human Nuclear Receptor: The Use of Interacting Interface a-Helix Peptidefor Quantitative Inhibition
Xiaohui Liu, Ayami Matsushima, Yasuyuki Shimohigashi
Synthesis of Water-Soluble Cyclophane Derivatives Having Four Peptide Chains
Kotaro Matsuki.Oasmu Hayashida, Setsuko Ando
Keyword Index
Author Index
XX