Penn Center for Musculoskeletal Disorders Scientific Symposium/Retreat Louis J. Soslowsky, PhD Professor of Orthopaedic Surgery and Bioengineering Vice Chair for Research, Dept. of Orthopaedic Surgery
Jan 13, 2016
Penn Center for Musculoskeletal Disorders
Scientific Symposium/Retreat
Louis J. Soslowsky, PhD
Professor of Orthopaedic Surgeryand Bioengineering
Vice Chair for Research, Dept. of Orthopaedic Surgery
PCMD Aims
Enhance and advance research productivity with a focus on tissue injury and repair using small animals through development of:– 3 research core facilities– Pilot and feasibility grant program– Educational, training, and research
enrichment programs
Penn Research Base• Membership
– Established investigators: Current research program
– New investigators: Strong potential to develop research program
• 50 faculty investigators from 5 schools (>100 RSVP’d for today)
• Over $38,000,000 – annual research grant direct costs
Penn Facilities
• Penn ranked highly in NIH funding– >1,000 NIH grants– >$450,000,000 annual NIH funding
• Infrastructure: physical space, common facilities, research cores, centers, and institutes
• High quality investigators• Facilities on a single campus
Center Program Overview
• Promote cooperative interaction• Enrich ongoing research• Promote new research• Research cores, enrichment
programs, and P&F grants• 3 Core Areas with funds available
– Microarray– Structure-Function Biomechanics– Small Animal Imaging
Center Program Overview
• Microarray Core: builds on exisiting Core facility, but would provide dedicated resources for musculoskeletal researchers
• Structure-Function Biomechanics: builds on McKay Orthopaedic Lab facility, but with wider capabilities, expertise, and dedicated resources
• Small Animal Imaging: builds on expertise in Radiology, providing “centralization” and dedicated resources
Admin. Core: Enrichment Program
• Scientific Symposium/Retreat• Seminar Series• Core Open Houses• Roundtable Lunch Discussion Group• Center Website• E-mail Distribution List• Intramural Grant Review Program
Pilot & Feasibility Grant Program
• Eligible Investigators
– Established – departure from previous work in musculoskeletal disorders
– Established – new to research in musculoskeletal disorders
– New investigator – never PI on NIH R01, R29, P01, R55 or similar grant
Pilot & Feasibility Grant Program
• Lead to funding through independent, extramural mechanisms
• Use R03 (small grants) format
Pilot & Feasibility Grant Program
• Christopher S. Chen, MD, PhD: Mechanotransduction in mesenchymal stem cells
• Robert L. Mauck, PhD: Meniscus repair with a novel aligned nanofiber scaffold
• Pedro K. Beredjiklian, MD: The role of hyaluronic acid receptors in tendon healing
Pilot & Feasibility Grant Program
• Pedro K. Beredjiklian, MD: The role of hyaluronic acid receptors in tendon healing (funded by NIH R21)
• Robert J. Pignolo, MD, PhD: Stem cell rescue of the osteoporotic phenotype in a mouse model of accelerated aging
Summary
• NIH/NIAMS Center grant (7/1/06 for 5 years)
• Feedback is critical (my e-mail address is in your books)
• Today’s program….
Thank You
www.med.upenn.edu/pcmd