PendoTECH TFF Process Control & Data Acquisition System · PendoTECH TFF Process Control ... • Control system has customized software interface for optimal integration of scales
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Product Information
PendoTECH TFF Process Control & Data Acquisition System
• Ideal for many applications in biopharmaceutical processing: —Ultra-Filtration/diafiltration(UF/DF)ofproteinsandviruses —Clarification• Adds automation, in-line process monitoring and data collection to your processes• Complete batch control with 6 built-in programable recipes•SysteminteractionviaaPC-basedGraphicalUserInterface•Realtimetrendingandalldataiswrittentoafileforpermanentrecord•FeaturesuseofPendoTECHPressureSensorsTMthatareavailable
from a luer size to 1 inch inner diameter that can be cleaned and re-usedextensively;alsoavailableinSanitaryFlanges
• No process scale limitations• Integrates with different types of pumps and different brands of scales•Builtinconductivity,pH&temperaturemeasurements•Optionsforfiltrateflow/fluxmeasurementinadditiontoabilitytomeasure otherprocessparametersviaconfigurableinputs•Severaladvancedfeaturesaffordadditionalsystemutility•Built-indataservertoexchangedatawithOPCclientsoftwaresuchas PI from OSI soft® •IQ/OQtemplatesavailable
•DatacollectiontoafilethatisopenedwithExcel• Alarms for all process parameters that shut-down the pumps• Alarm features include a delayed detection on the minimum inlet pressure that canstopthesystemiftheinletpressuredropsduetoaflowpathproblem
• Automation and alarm features allow the system to be operated with minimal user interaction
• Stainless steel design with completely sealed front panel for use in clean environmentswherefrequentwipe-downisrequiredandNaOHisused•Processcontrolviaintegrationofindustrystandardscalesandpumps• Can be used at any process scale•pHprobeinputviaaBNCconnectorthatcanaccommodatestandardpHprobesandtheGUIincludesaneasytouseprobecalibrationwizard
•Conductivityprobe/flowcellinputtoembeddedconductivitytransmitter with temperature display and compensation
• Air detector end-point can be used for “Fed-batch” process where product is fedtothemainvesselanddynamicallyconcentratedviadiafiltrationmode•Filtrateflowmeterinputforoptionalrotaryflowmeter, ultrasonicflowmeter,orotherthatincludestheabilitytototalizeflow
•ThesystemmaybecontrolledremotelyviaaPC,iPadorsmartphoneby using3rdpartysoftware.Processdetailsarevisualizedonthegraphical interfaceandthesysteminteractionisviathePCsoremotecontrolis possiblebysimplyaccessingthePC•Notificationsappearonsoftwarescreenwhenparametersareoutofrangeand with built-in email client can send email/text message alerts.•Retentateflowmaybecontrolledbyuseofaretentateflowmeter•SystemhasTMPoutputsignalthatcanbeconnectedtoexternal non-invasivecontrolvalvetocontrolsystemTMP•Built-indataservertoexchangedatawithOPCclientsoftwaresuchas PIfromOSIsoft®
•CEtestedforEMCandLVD
Graphical User Interface - Simplifies Control System InteractionTheGUIisdesignedforusewithamouseortouch-screenoperation.Clickinganumericfieldisfollowedbyappearanceofapop-upkeypadfordataentry.Valuesenteredthatareoutofrangearerejectedwithamessage.Therearefourtabsforeasynavigation:
4TabsforFastandEasyNavigation
(systemviewshown)
Notes-Clickhereandapop-upboxappears where an electronic note can be entered. Thenoteiswrittentothedatafileonetime
Information is written to header of data filewhendata
collectionisstarted; then it becomes
uneditable
System
Setup
Abilitytosave/recallfrequentlyusedrecipes
WhenStartProcessData Collection is selected,
a dialog box appears so afilenameandlocationcanbe
entered. All process data issavedtoaCSVfile
that can be opened later insoftwaresuchasExcel.
Recipe Info
Estimatedflowratecan be calculated by an
algorithm based on the changeinfiltrate
scale rate.Pumpsrotatewhile running
Externalsensor
readings
Indicators in blue can be changed while running by clickingontheindicator
Flow only appears if flowmeterconfigured
Allprocessvariablesaredisplayed including
calculatedvaluessuch asTMPandDeltaP
6optionsavailable
Filtrate pump appears here only if enabled
6Diafiltrationendpointoptionslisted
Pumpsprogrammed for different steps
Settings for selected recipe are entered heree
Alarms set-pointswill stop pumps
Notificationpoints (createnoaction)
Viewcurrentprocessvalues andchangepumpflowrates
Gaugerangessetbymin/max alarm set
points
Configurenotificationemail or text message
alerts
4www.pendotech.com Tel: +1-609-799-2299
Trends
Maintenance
Options to select Auto-scale or Manualscaleonallaxes
Slidetochangecursorvalue
Powerfultoolstozoom,export an image of
the current trend and much more
Quicklycomparecurrentvalues tocursorvalue
Exportthecurrenttrendonly to open in software
suchasExcel
Ability to change plot update rate
pHwizardzoom
Functions Include:• Zero pressure sensors•Enable/disablefiltratepump•Selectconductivityrange•CalibratepH• Set units of measure• Set-up pumps•Selectgraphicdisplayforfilter•Configuretheflowmeter•Zeroflowmetertotal• Set range of external signals•Enable/disableDiafiltrationValves•Exitprogram
Thevalvereceivesthepressuresignalfrom the control system and controls backpressurebyvaryingtheflowpatharea by only contacting the outside of thetubingwithoutthevalvecontactingthefluid.Itincludesone-touchreal-timeadjustment of the proportional setting for thePIDcontroltoaccountfordifferentpumps and system setups.
•MostscaleswithRS232communicationcanbeused • Control system has customized software interface for optimal integration of scales to enhance performance • A scale selection menu on the process control system is used toquicklyconfiguretheRS232parametersforthedifferent scale brands.
ForretentateflowwheretheremaybeashiftinviscosityflowmustbemeasuredbyothertypesofflowmeterssuchasthePendoTECH CoriolisFlowMeterormagneticflowmeasurementtechnology.Thereare3modelsofthePendoTECHCoriolisFlowMetercoveringtherangefrom5to24,000g/minuteandtheE+HPromagcanmeasurefrom2to45L/minute.TheseflowmetersconnectintotheAnalogInput2connectoronthebackpanelwhichisa4-20mAanaloginputsignal.The4mAand20mAoutputrangeoftheflowmeterinL/minuteis entered into the software. Connecting to this input, integrates the reading into the option Retentate Flow Control algorithm.
www.pendotech.com Tel: +1-609-799-2299
Low Flow Ultrasonic Leviflow Sensor
Montor
Integration Options
Pressuresensorcablesprovidedwiththesystemacceptthe PendoTECHPressureSensors(below).Eventhoughthesearecalled single use, they are robust enough to be re-used for process developmentworkwherecross-contaminationisnotaconcern.Sizesavailableluer,1/4”,1/2”,3/8”,1/2”,3/4”and1”hosebarb, alsoinsanitaryflange.Ultrasecuretubingretainersareavailablefor higher pressure operations.
Pump Options
Pump Cable (Masterflex Pump
Cable Shown)
Example of Pump Back Panel with remote interface
connector
Interface Connector
Pressure Sensors
• Any pump with a remote speed control input can be used- no process scale limitations! •Peristaltic,rotarylobe,diaphragmpump,andother •PumpSetupfunctionusedtoquicklyenterthepumpparameters •MasterflexpumpselectionguideavailablefromPendoTECH • Thepumpcablesaresuppliedtointerfacetotheremote control connector on the user selected pumps as shown in the example below.
Following is a selection of just some of the pumps that can be integrated to the system
Other sensors such as Stainless Steel transducers with full bridge-4wireoutputmaybeused.
Built-inconductivitymonitoralsomeasures temperature and performs temperature compensation.Thereisasimpleone-stepcalibration procedure and probes with constantsofK=1orK=10maybeused.Therangeisselectablefromeither0-19.99mSor0-199.9mS.Differentflowcellordipprobeoptionsareavailable.
pH
Epoxy dip probe
Small scale with luer or barb inlet/outlet
Flange probe
Stainless probe in flow cell with either barb or flange
Diafiltrationvalvesworkwiththeairdetectorend-pointandcanbe used for “Fed-batch” process where product is fed to the main vesselanddynamicallyconcentratedviadiafiltrationmode.Aftertheconcentrationstepthevalvesswitchtobufferandthe diafiltrationpumpwillthendrawinbufferforthatstep.
Diafiltration Valves
Vessel Detail - 2 Liter Vessel shown
BufferFeed& Retentate tubes
can be positioned todeliverliquidto the bottom
Topandbaseattached by
sanitary clamps
Stand with adjustable legs
for different stir plates
Removablecollars for tube
adjustment/removal
Spare hole forventingor recycle
Vesselmadeof polysulfone - easilyremoved
for cleaningConical base with
low point drain
Stir bar locator in the center of the base
PendoTECH Vessel Options
2L 500mL 125mL
VesselswithLowHoldupVolume-thekeytominimizingoverallsystemholdup.Allhaveaconicalbottomwithmixing and a low point drain.