Patrick J. Bolan Assistant Professor Center for Magnetic Resonance Research, Dept Radiology University of Minnesota Center for MR Research UM Medical Center – Fairview Radiology/BME collaborators: Mike Garwood, Kamil Ugurbil, Greg Metzger, Tommy Vaughan Clinical collaborators: Mike Nelson, Tim Emory, Doug Yee, radiology residents My group: Timo Liimatainen (postdoc), Leighton Warmington (BPhys MS), Avani Chandresekaran (CS MS)
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Patrick J. Bolan Assistant Professor Center for Magnetic Resonance Research, Dept Radiology
Patrick J. Bolan Assistant Professor Center for Magnetic Resonance Research, Dept Radiology University of Minnesota. Radiology/BME collaborators: Mike Garwood, Kamil Ugurbil , Greg Metzger, Tommy Vaughan Clinical collaborators: Mike Nelson, Tim Emory, Doug Yee, radiology residents - PowerPoint PPT Presentation
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Patrick J. BolanAssistant Professor
Center for Magnetic Resonance Research, Dept RadiologyUniversity of Minnesota
Center for MR Research UM Medical Center – Fairview
Radiology/BME collaborators: Mike Garwood, Kamil Ugurbil, Greg Metzger, Tommy Vaughan
Clinical collaborators: Mike Nelson, Tim Emory, Doug Yee, radiology residents
My group: Timo Liimatainen (postdoc), Leighton Warmington (BPhys MS), Avani Chandresekaran (CS MS)
Areas of Research
• Breast MR imaging and spectroscopy
• Evaluating cancer treatment response
• High-field Body MR Technique
3T 4T 7T
Breast MR Spectroscopy
lipids
suppressed water
lipid
Cholinecompounds
(tCho)
Frequency (ppm)
Single-Voxel 1H MRS
invasive ductal carcinoma
Contrast-enhanced MRI
High [tCho] cancer (proliferation, cell density, upgragulated transport & kinase activity)
A) GRE signal strength B) Simulated Bolus Gd Concentrations
C) Arterial Signal Intensity D) Tissue Signal Intensity
0 1 2 3 4 5 6 7 80
0.05
0.1
0.15
0.2
0.25
[Gd] (mM)S
ign
al in
ten
sity
(a.u
.)
No T2* effect
1.5T blood
3T blood
7T blood
1.5T tissue
3T tissue
7T tissue
0 50 100 150 200 250 3000
1
2
3
4
5
6
7
time (s)
[Gd]
(m
M)
AIF
cancer
normal PZ
time (s)
0 50 100 150 200 250 3000
0.02
0.04
0.06
0.08
0.1
0.12
0.14
0.16
0.18
0.2
Sig
nal i
nten
sity
(a.
u.)
Ignoring T2*
T2* blood @ 7T
0 50 100 150 200 250 3000
0.01
0.02
0.03
0.04
0.05
0.06
0.07
0.08
Sig
nal i
nten
sity
(a.
u.)
Cancer, ignoring T2*
Cancer, w/tissue T2*
Normal PZ, ignoring T2*
Normal PZ, w/tissue T2*
Figure 11 – Simulations showing that R2* effects of Gd-based contrast agents increase at ultra-high field, and substantially impact both blood and tissue signal intensity. See text for details.