Alnix® [film-coated tab] Westmont [ Westmont ] MIMS Class : Antihistamines & Antiallergics See related Alnix film-coated tab information Content s Cetirizine diHCl Indicati ons Sympomatic relief of allergic rhinitis eg sneezing , runny & itchy nose, watery eyes; allergic conjunctivitis ; skin symptoms of allergy eg itch & rash . Dosage Tab Adult & childn >12 yr 1 tab once daily. Childn 6-12 yr ½ tab bid or 1 tab once daily. Syrup Childn 6-12 yr 10 mL (2 tsp) once daily or 5 mL (1 tsp) bid, 2-5 yr 5 mL (1 tsp) once daily or 2.5 mL (½ tsp) bid. Oral drops Childn 2-5 yr 2 mL once daily or 1 mL bid, 12 mth-<2 yr 1 mL once or bid. Infants 6 mth-<12 mth 1 mL once daily. Overdosag e View Alnix overdosage for action to be taken in the event of an overdose. Administra tion May be taken with or without food Contraindicat ions [Click For Detailed Information] Special Precautions May cause drowsiness and may affect ability to drive/operate machines. Patients w/ kidney or liver disease.
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Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not
demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Storage View Alnix storage conditions for details to ensure optimal shelf-
life.
Mechanism of Action
View Alnix mechanism of action for pharmacodynamics and
pharmacokinetics details.
MIMS Class Antihistamines & Antiallergics
ATC Classification
R06AE07 - Cetirizine ; Belongs to the class of piperazine
stomach 1 hr before or 2 hr after meals, & at bedtime.).
Contraindications Patients on dialysis.
Adverse Drug Reactions
Constipation, diarrhea, nausea, GI discomfort, indigestion; dry
mouth; rash, pruritus; back pain; dizziness, drowsiness & vertigo.
View ADR Monitoring Website
Drug Interactions May inhibit absorption of ciprofloxacin HCl, norfloxacin & other
new quinolones.
View more drug interactions with Iselpin
Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not
demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
MIMS Class Antacids, Antireflux Agents & Antiulcerants
ATC Classification
A02BX02 - Sucralfate ; Belongs to the class of other drugs used in
the treatment of peptic ulcer and gastro-oesophageal reflux
disease (GERD).
Poison Schedule Rx
Presentation/Packing
Randin® [amp]
Pasteur Pharma [ Scheeling Pharma Care Link / Deutsche Lab ]
MIMS Class : Antacids, Antireflux Agents & Antiulcerants
Dosage IV Adult 50 mg slow inj diluted to 20 mL for 2 min, may be
repeated 6-8 hrly, intermittent IV infusion at 25 mg/hr for 2 hr
repeated 6-8 hrly. IM 50 mg 6-8 hrly. Prophylaxis of upper GI
hemorrhage from stress ulcer Prime dose of 50 mg slow IV
followed by continuous IV infusion of 0.125-0.25 mg/kg/hr.
Mendelson's syndrome 50 mg IM/IV 45-60 min before general
anesth. Renal impairment 25 mg.
Contraindications Hypersensitivity.
Special Precautions
Gastric carcinoma, renal & hepatic impairment, history of acute
porphyria. Pregnancy & lactation. Childn.
Adverse Drug Reactions
Changes in liver function tests, hepatitis, blood count changes.
View ADR Monitoring Website
Drug Interactions Diazepam, lignocaine, phenytoin, propanolol, theophylline &
warfarin.
View more drug interactions with Randin
Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not
demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
MIMS Class Antacids, Antireflux Agents & Antiulcerants
ATC Classification
A02BA02 - Ranitidine ; Belongs to the class of H2-receptor
antagonists. Used in the treatment of peptic ulcer and gastro-
oesophageal reflux disease (GERD).
Poison Schedule Rx
Presentation/Packing
Lorid® [tab]
Unique [ Ambica ]
MIMS Class : Antihistamines & Antiallergics
See related Lorid tab information
Contents Loratadine
Indications Symptomatic relief of allergic conditions including rhinitis & chronic
urticaria.
Dosage Tab Adult 1 tab once daily. Syr Childn 6-12 yr, 2-12 yr (>30 kg) 2
tsp once daily, 2-12 yr (<30 kg), 2-5 yr 1 tsp once daily. Hepatic
or renal impairment Initially 1 tab on alternate days.
Overdosage View Lorid overdosage for action to be taken in the event of an
overdose.
Administration May be taken with or without food
Contraindications [Click For Detailed Information]
Special Precautions
Pregnancy & lactation.
Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not
demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Storage View Lorid storage conditions for details to ensure optimal shelf-
life.
Mechanism of Action
View Lorid mechanism of action for pharmacodynamics and
pharmacokinetics details.
MIMS Class Antihistamines & Antiallergics
ATC Classification
R06AX13 - Loratadine ; Belongs to the class of other
antihistamines for systemic use.
Poison Schedule Rx
Presentation/Packing
Essential Prescribing Information
Furide® [amp]
Duopharma (M) Sdn Bhd [ International Apex ]
MIMS Class : Diuretics
See related Furide amp information
Contents Furosemide
Indications Treatment of edema associated w/ CHF, cirrhosis of the liver &
renal disease including nephrotic syndrome. IV Acute pulmonary
edema.
Dosage Adult Initially 20-40 mg IM/IV as single dose. Acute pulmonary
edema 40 mg slow IV followed by another 40 mg dose 1-1½ hr
later. Infants & childn Initially 1 mg/kg IM/IV, may be increased
by 1 mg/kg ≥2 hr after the previous dose.
Contraindications Anuria, hepatic coma & electrolyte deficiency. Pregnancy.
Special Precautions
Severely impaired renal function. Diabetes.
Adverse Drug Reactions
Dermatitis including urticaria. Anemia, leukopenia, aplastic anemia
Furosemide-induced diuresis accompanied by weakness, fatigue,
lightheadedness or dizziness, muscle cramps, thirst, increased
perspiration, urinary bladder spasm & symptoms of urinary
frequency. Transient pain at inj site after IM inj.
View ADR Monitoring Website
Drug Interactions Potentiation of hypotensive or diuretic effect of antihypertensives
or alcohol. Amiodarone, amphotericin B, anticoagulant, NSAIDs,
lithium, chloralhydrate, probenecid.
View more drug interactions with Furide
Pregnancy Category (US FDA)
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
if used in gestational HTN.
Category D: There is positive evidence of human foetal risk, but
the benefits from use in pregnant women may be acceptable
despite the risk (e.g., if the drug is needed in a life-threatening
situation or for a serious disease for which safer drugs cannot be
used or are ineffective).
MIMS Class Diuretics
ATC Classification
C03CA01 - Furosemide ; Belongs to the class of high-ceiling
sulfonamide diuretics.
Poison Schedule Rx
Presentation/Packing
Strumazol® [tab]
Organon [ Zuellig ]
MIMS Class : Antithyroid Agents
See related Strumazol tab information
Contents Thiamazole
Indications Mild to severe hyperthyroidism, treatment of Grave's disease, prep
of hyperthyroid patients for thyroidectomy & use as an adjunct to
radioactive iodine therapy.
Dosage Monotherapy Titrate according to hormone levels. Combination
hepatotoxicity, vasculitis, LE (lupus erythematosus) syndrome,
aplastic anemia, thrombocytopenia, nephrotic syndrome, loss of
the sense of taste.
View ADR Monitoring Website
Drug Interactions As Strumazol leads to a change in the metabolism, it may be
necessary to adjust the dosage of other drugs.
View more drug interactions with Strumazol
Pregnancy Category (US FDA) Category D: There is positive evidence of human foetal risk, but
the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
MIMS Class Antithyroid Agents
ATC Classification
H03BB02 - Thiamazole ; Belongs to the class of sulfur-containing
imidazole derivative agents. Used in the management of thyroid
diseases.
Poison Schedule Rx
Presentation/Packing
Essential Prescribing Information
Aero-Vent® [nebules]
Cipla [ Phil Pharmawealth ]
MIMS Class : Antiasthmatic & COPD Preparations
See related Aero-Vent nebules information
Contents Salbutamol sulfate
Indications Treatment of acute severe asthma & in routine management of
chronic bronchospasm unresponsive to conventional therapy.
Dosage Adult & childn 2.5-5 mg. May repeat qid by nebuliser. Delivery of
aerosol may be by face mask of "T" piece. Use undiluted. For
prolonged delivery time, dilute w/ sterile water or normal saline for
inj.
Overdosage View Aero-Vent overdosage for action to be taken in the event of
an overdose.
Contraindications [Click For Detailed Information]
Small increase in heart rate, peripheral vasodilation, fine tremor of
skeletal muscle.
View ADR Monitoring Website
Side Effects View Aero-Vent side effects
Drug Interactions Cyclopropane, halothane, other halogenated anesthetics. Cardiac
glycosides, quinidine, tricyclic antidepressants.
View more drug interactions with Aero-Vent
Pregnancy Category (US FDA) Category C: Either studies in animals have revealed adverse
effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage View Aero-Vent storage conditions for details to ensure optimal
shelf-life.
Description View Aero-Vent description for details of the chemical structure
and excipients (inactive components).
Mechanism of Action
View Aero-Vent mechanism of action for pharmacodynamics and
pharmacokinetics details.
MIMS Class Antiasthmatic & COPD Preparations
ATC Classification
R03AC02 - Salbutamol ; Belongs to the class of adrenergic
inhalants, selective beta-2-adrenoreceptor agonists. Used in the
treatment of obstructive airway diseases.
Poison Schedule Rx
Presentation/Packing
clobetasol
MIMS Class : Topical Corticosteroids See available brands of clobetasol
See related clobetasol information
Indication Corticosteroid-responsive dermatoses.
Dosage Adult: Topical As 0.05% cream/oint: Apply twice daily.
Click to view Dosage by Indications
Contraindications Childn <12 yrs. Long-term treatment of ulcerative conditions,
rosacea, pruritus; presence of acute infections. Hypersensitivity.
impairment; psychoses; childn and elderly. Should not enter eyes.
If infection exists, treat with specific anti-infectives. Pregnancy,
lactation.
Adverse Drug Reactions
Perioral dermatitis, striae esp in flexures. Dermal and epidermal
atrophy esp on the face, steroid purpura.
Potentially Fatal: Prolonged usage of large amount of clobetasol
propionate can lead to sufficient systemic levels to produce
adrenal suppression, Cushing's syndrome, diabetes and
hypertension.
Drug Interactions
Click to view more Drug Interactions
Pregnancy Category (US FDA) Category C: Either studies in animals have revealed adverse
effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage For special storage condition to ensure optimal shelf-life of
medicine... click to view
Mechanism of Action
For details of the mechanism of action, pharmacology and
pharmacokinetics and toxicology ... click to view
MIMS Class Topical Corticosteroids
ATC Classification
D07AD01 - clobetasol; Belongs to the class of very potent (group
IV) corticosteroids. Used in the treatment of dermatological
diseases.
Related clobetasol information:
Platexan® [tab]
Apotex [ Patriot ]
MIMS Class : Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not
demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Storage View Platexan storage conditions for details to ensure optimal shelf-
life.
Mechanism of Action
View Platexan mechanism of action for pharmacodynamics and
pharmacokinetics details.
MIMS Class Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
ATC Classification
B01AC04 - Clopidogrel ; Belongs to the class of platelet aggregation
inhibitors excluding heparin. Used in the treatment of thrombosis.
Poison Rx
Schedule
Presentation/Packing
ursodeoxycholic acid
MIMS Class : Cholagogues, Cholelitholytics & Hepatic Protectors See available brands of ursodeoxycholic acid
See related ursodeoxycholic acid information
Indication Listed in Dosage.
Dosage Adult: PO Dissolution of cholesterol-rich gallstones 6-12
mg/kg/day as a single dose at bedtime after radiological
disappearance of stones. Max: 15 mg/kg. Primary biliary
cirrhosis 10-15 mg/kg/day in 2-4 divided doses. Prevention of
gallstones in patients undergoing rapid wt loss 300 mg twice
daily.
Click to view Dosage by Indications
Administration Should be taken with food.
Contraindications Calcified and pigment gallstones, radio opaque gallstones.
Nonfunctioning gall bladders; chronic liver and peptic ulcer
disease. Inflammatory disease of colon and small intestine.
Pregnancy.
Special Precautions
50% of successfully treated patients will develop further gallstones
Drug Interactions Cholestyramine, charcoal and antacids may reduce effectiveness.
Aluminum-based antacids may reduce absorption. Oestrogens
and clofibrate may counteract effectiveness of ursodeoxycholic
acid by increasing cholesterol elimination in bile. Possible increase
in ciclosporin serum concentration. Decreased effectiveness of
dapsone. Possible decrease in serum ciprofloxacin and
nitrendipine.
Click to view more Drug Interactions
Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not
demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Mechanism of Action
For details of the mechanism of action, pharmacology and
pharmacokinetics and toxicology ... click to view
MIMS Class Cholagogues, Cholelitholytics & Hepatic Protectors
ATC Classification
A05AA02 - ursodeoxycholic acid; Belongs to the class of bile