Diseases of Skeletal Muscle December 9 th , 2008 1. Describe the morphologic effects of denervation (and reinnervation) on skeletal muscle. 2. Apply the “reading frame hypothesis” to the pathogenesis of dystrophinopathies. 3. Discuss the limitations of routine muscle biopsy in the diagnosis of: 1)Muscular dystrophies 2)Mitochondrial diseases 4. Describe the pathologic features that distinguish dermatomyositis and inclusion body myositis from “polymyositis”.