Paper-based printed platform for electrochemical biosensing MOTIVATION Due to the rapid development in the areas of "Internet of Things" and ubiquitous sensor networks, more and more products with a short period of usage are emerging. In this context, aspects of environment-friendly production and disposal are becoming increasingly important. Particular attention has to be put on single-use products that are produced in very large volumes. Especially in this area, the paper and printing industry already has long standing expertise. At present, non-invasive point-of-care rapid tests are mostly available in the form of test strips using color indicators. The reading of these test strips is strongly influenced by the subjective visual perception and the results are, therefore, only qualitative. 1 Melnik, E.; 1 Raskovic, M.; 1 Schotter, J.; 1 Heer, R.; 1 Mutinati, G.C.; 1 Kataeva, N.; 1 Hainberger R.; 2 Heilmann, M.; 2 Ide, D.; 2 Padinger, F.; 3 Schobesberger, P.; 3 Sikic, B.; 3 Engelbrecht, G.; 4 Brunbauer, E.; 5 Holweg, G.; 5 Herndl, T.; 1 AIT Austrian Institute of Technology GmbH, H&E Department, BU Molecular Diagnostics, Vienna, Austria 2 SCIO Holding GmbH, Linz, Austria 3 DPI Holding GmbH, Vienna, Austria 4 Lenzing Papier GmbH, Lenzing, Austria 5 Infineon Technologies Austria AG, Design & Development Center, Graz, Austria METHODOLOGY We explore the integration of different processes to develop a paper-based biosensor platform for molecular diagnostic systems. For this purpose, suitable fabrication processes are developed: printing of electrodes, bioinks and hydrophobic barriers. The readout of the measurement values is accomplished contactless by integrating a small, battery-free near field communication (NFC) chip. This important aspect plays an essential role for environmentally disposal. Technologies Innovation example Integration Single step biofunctionalisation Electrochemical biosensing for the quantification of glucose and ketone bodies (beta-hydroxybutyric acid and acetoacetic acid) Urine test strips Plastic substrate Subjective visual perception No electronic data recording Not suitable e.g. for ketoacidosis PIONIER State of the art PIONIER demonstrator Paper substrate Quantitative results Contactless read-out Battery-free Automatic data recording Environment-friendly Printable bioink formulation Material inkjet printer Direct bioink printing process Project No. 848587 www.projekt-pionier.com Paper substrate Battery-free contactless readout Biosensing Microfluidic Electrodes [email protected] Key properties Viscosity Surface tension Biomolecule stability Chemical reactivity Paper manufacturing Cellulose matrix for biofunctionalisation Surface for electrodes Roll-to-roll printing Electrodes Hydrophobic barriers Microelectronics Printed antenna Assembly of bare dies Pattern data Ink Nozzle Ink droplet Piezo element Sensor surface - - + + - + - Silver printing on paper
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Paper-based printed platform for electrochemical biosensing
MOTIVATIONDue to the rapid development in the areas of
"Internet of Things" and ubiquitous sensor
networks, more and more products with a short
period of usage are emerging. In this context,
aspects of environment-friendly production and
disposal are becoming increasingly important.
Particular attention has to be put on single-use
products that are produced in very large volumes.
Especially in this area, the paper and printing
industry already has long standing expertise.
At present, non-invasive point-of-care rapid tests are
mostly available in the form of test strips using color
indicators. The reading of these test strips is strongly
influenced by the subjective visual perception and
the results are, therefore, only qualitative.
1Melnik, E.; 1Raskovic, M.; 1Schotter, J.; 1Heer, R.; 1Mutinati, G.C.; 1Kataeva, N.; 1Hainberger R.; 2Heilmann, M.; 2Ide, D.; 2Padinger, F.; 3Schobesberger, P.; 3Sikic, B.; 3Engelbrecht, G.; 4Brunbauer, E.; 5Holweg, G.; 5Herndl, T.; 1AIT Austrian Institute of Technology GmbH, H&E Department, BU Molecular Diagnostics, Vienna, Austria2SCIO Holding GmbH, Linz, Austria3DPI Holding GmbH, Vienna, Austria4Lenzing Papier GmbH, Lenzing, Austria5Infineon Technologies Austria AG, Design & Development Center, Graz, Austria
METHODOLOGY
We explore the integration of
different processes to
develop a paper-based
biosensor platform for
molecular diagnostic
systems. For this purpose,
suitable fabrication processes
are developed: printing of
electrodes, bioinks and
hydrophobic barriers. The
readout of the measurement
values is accomplished
contactless by integrating a
small, battery-free near field
communication (NFC) chip.
This important aspect plays an
essential role for
environmentally disposal.
Technologies
Innovation example
Integration
Single step biofunctionalisation
Electrochemical biosensing
for the quantification of
glucose and ketone bodies
(beta-hydroxybutyric acid and
acetoacetic acid)
Urine test strips
Plastic substrate
Subjective visual perception
No electronic data recording
Not suitable e.g. for
ketoacidosis
PIONIER
State of the art
PIONIER demonstrator
Paper substrate
Quantitative results
Contactless read-out
Battery-free
Automatic data recording
Environment-friendly
Printable bioink
formulationMaterial inkjet printer Direct bioink
printing process
Project No. 848587www.projekt-pionier.com
Paper substrate
Battery-free
contactless readoutBiosensing
MicrofluidicElectrodes
Key properties
Viscosity
Surface tension
Biomolecule stability
Chemical reactivity
Paper manufacturing
Cellulose matrix for
biofunctionalisation
Surface for electrodes
Roll-to-roll printing
Electrodes
Hydrophobic barriers
Microelectronics
Printed antenna
Assembly of bare dies
Pattern data
Ink
Nozzle
Ink droplet
Piezo element
Sensor surface
-
-+
+ -
+
-
Silver printing on paper
Related Documents
