Page 1 A new method to measure 10 B uptake in lung adenocarcinoma in hospital BNCT D. Bolognini, E.M. Donegani, A. Mattera, M. Prest, S. Hasan E. Capelli, P. Chiari A. Zanini G. Giannini, E. Vallazza F. Basilico, P. Mauri F. Borasio P. Cappelletti, M. Frigerio, S. Gelosa, A. F. Monti
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Page 1 A new method to measure 10 B uptake in lung adenocarcinoma in hospital BNCT D. Bolognini, E.M. Donegani, A. Mattera, M. Prest, S. Hasan E. Capelli,
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Page 1
A new method to measure 10B uptake in lung adenocarcinoma in hospital BNCT
D. Bolognini, E.M. Donegani, A. Mattera, M. Prest, S. Hasan
E. Capelli, P. Chiari
A. Zanini
G. Giannini, E. Vallazza
F. Basilico, P. Mauri
F. BorasioP. Cappelletti, M. Frigerio, S. Gelosa, A. F. Monti
Page 2
BNCT
The INFN PhoNeS project
An innovative approach to Boron Imaging
Neutron Autoradiography
Measurements and results
Conclusion
Outline
Page 3
Boron Neutron Capture Therapy
BNCT could become useful for highly-fatal tumours:
•Extended (e.g. liver, lung)•Radioresistant (melanoma)•Localized near vital organs
(glioblastoma)
10B (n,α,γ) 7Libinary technique high LET particles
Page 4
High intensity thermal-epithermal
neutron beam(5·108 n/cm2 s1)
< 10 keV energy range
Gamma contamination < 2 ·10-13 Gy cm2 / n
Low toxicity
High specificity
Non-persistence in the bloodstream
BSH
BPA
Difficulties for BNCT applications
Page 5
Neutron Autoradiography
Nuclear reactor Solid state track detector (CR 39) Sometimes cryogenic temperature during the irradiation Optic microscope for identification and count
Nuclear reactor Solid state track detector (CR 39) Sometimes cryogenic temperature during the irradiation Optic microscope for identification and count
Hospital-based neutron source Real time detector
Hospital-based neutron source Real time detector
Page 6
PhoNeS (PhotoNeutronSource)Neutron flux in the treatment cavity: Φ = (1.3 ± 0.1) x 107 n cm-2 s-1
γ-contamination: reduced of 97%
Page 7
Real-time Neutron Autoradiography
0.5 cm CERROBEND
photonconversion
6 cm PMMA
thermalization
IRON BOX
•Samples
•DetectorNeutron flux: Φ = (1.5 ± 0.1) x 105 n cm-2 s-1
Page 8
The imaging detector
Silicon Dimensions (9.5 x 9.5) cm2
Hamamatsu Microstrip Silicon Detector 768 strips
Readout pitch 242 μm
Read-out by 3 self-triggering TAA1 ASICs
Counts vs position
Page 9
The Data Acquisition System
• INTER-BUNCH acquisition
• UNDEPLETED silicon detector
to detect α-particles from boronated samples down to 25 ng of 10B
18 MeV electrons
Bunches of 5 μs
Frequency 100 - 300 Hz
Page 10
SPECIMEN SUPPORT
-plastic support (liquid solution)evaporation
-glass slide (blood samples)coagulation process
to prevent crystallizationand self-absorption ofthe α-particles by the sample itself