WWW.OXSTEM.CO.UK AN INTRODUCTION TO OXSTEM NOVEL APPROACHES TO CELL THERAPIES AND REGENERATIVE MEDICINE MARCH 2017
WWW.OXSTEM.CO.UK
AN INTRODUCTION TO OXSTEM
NOVEL APPROACHES TO CELL THERAPIES AND REGENERATIVE MEDICINE
MARCH 2017
WWW.OXSTEM.CO.UK
AGENDA
1. OUR MISSION
2. OUR GROUP
3. OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE
4. THE “STEMS”
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WWW.OXSTEM.CO.UK
OXSTEM
• OXSTEM IS A DEVELOPER OF CELL PROGRAMMING THERAPIES, WORKING IN CLOSE COLLABORATION WITH THE UNIVERSITY OF OXFORD.
• OXSTEM’S UNIQUE APPROACH TO REGENERATIVE MEDICINE WILL:
Ø DELIVER SMALL MOLECULE THERAPEUTICS THAT ACTIVATE REPAIR MECHANISMS THAT ALREADY EXIST WITHIN THE BODY
Ø EXPLOIT A DEEP UNDERSTANDING OF THE CHEMICAL UNDERPINNINGS OF STEM AND PROGENITOR CELL FUNCTION AND DIFFERENTIATION
Ø GENERATE A COLLECTION OF DRUG CANDIDATES TO AWAKEN ENDOGENOUS CELLS TO REPAIR TISSUES AFFECTED BY DISEASE OR INJURY
• TO BETTER HUMAN HEALTH BY DIRECTLY IMPACTING THE QUALITY AND DURATION OF LIFE • OXSTEM WILL REVOLUTIONIZE THE REGENERATIVE MEDICINE FIELD BY DEVELOPING UNIQUE CELL
PROGRAMMING THERAPIES TO TREAT DEGENERATIVE DISEASES WITH HIGH UNMET NEED
WHAT WE DO
OUR PURPOSE
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WWW.OXSTEM.CO.UK
AGENDA
1. OUR MISSION
2. OUR GROUP
3. OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE
4. THE “STEMS”
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WWW.OXSTEM.CO.UK
PROFESSOR STEVE DAVIES WAYNFLETE PROFESSOR OF CHEMISTRY
OXFORD UNIVERSITY
PROFESSOR ANGELA RUSSELL ASSOC. PROFESSOR OF CHEMISTRY & PHARMACOLOGY
OXFORD UNIVERSITY
PROFESSOR DAME KAY DAVIES DR LEE’S PROFESSOR OF ANATOMY
OXFORD UNIVERSITY
DR MICHAEL STEIN CHAIRMAN & CHIEF EXECUTIVE OFFICER
RAYMOND SPENCER, CFA CHIEF FINANCIAL OFFICER
EXECUTIVE FOUNDERS
SCIENTIFIC FOUNDERS
FOUNDING TEAM
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WWW.OXSTEM.CO.UK
“SPIN-IN”
RAISED £16.9M IN MAY 2016
ACUTE MYELOID LEUKEMIA AND MYELO-DYSPLASTIC SYNDROME
ALZHEIMER’S DISEASE TRAUMATIC BRAIN INJURY
AGE RELATED MACULAR DEGENERATION
MYOCARDIAL INFARCTION / HEART FAILURE
“OxStem 4D”
3D STEM CELL SUSPENSION CULTURE
GROUP STRUCTURE
ALL >90% OWNED SUBSIDIARIES
SPIN-OUT
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WWW.OXSTEM.CO.UK
INITIAL FUNDRAISE AND EARLY SUCCESS TIMELINE FOR YEAR 2016
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MAY 2016: £16.9M ($20M) RAISED, A RECORD FOR OXFORD UNIVERSITY SPIN-OUTS
MAY 2016: ESTABLISHMENT OF OXSTEM ONCOLOGY AND LAUNCH OF OXSTEM 4D
OCTOBER 2016: WINNER OF THE NATIONAL BEST BIOTECHNOLOGY START-UP AT THE OBN AWARDS, UK
DECEMBER 2016: PROOF-OF-PRINCIPLE DEMONSTRATED. FIRST EVER SMALL-MOLECULE DEMONSTRATING CELL-TO-WHOLE ANIMAL EFFICACY IN NEUROGENESIS
AUGUST 2016: ESTABLISHMENT OF OXSTEM NEURO AND OXSTEM OCULAR
NOVEMBER 2016: ESTABLISHMENT OF OXSTEM CARDIO
2016
WWW.OXSTEM.CO.UK
AGENDA
1. OUR MISSION
2. OUR GROUP
3. OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE
4. THE “STEMS”
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WWW.OXSTEM.CO.UK
PLAGUED WITH TOLERANCE ISSUES AND REJECTION; REQUIRE SPECIALIST FACILITIES FOR THERAPEUTIC DELIVERY
INTRODUCTION TO CELL THERAPY AND REGENERATIVE MEDICINE CURRENT THERAPEUTIC PARADIGMS TISSUE ENGINEERING THERAPY
VIA IMPLANTATION CELL TRANSPLANTATION THERAPY VIA IMPLANTATION
SOURCE: CULME-SEYMOUR ET AL., REGEN. MED. 2012
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WWW.OXSTEM.CO.UK
DRUG HERE TO INFLUENCE PROGRESS
DRUG HERE TO INFLUENCE PROGRESS
NATURALLY OCCURRING COMMITTED ADULT STEM CELLS
NATURALLY OCCURRING ADULT STEM CELLS
FUNCTIONAL CELLS FOR REGENERATIVE TREATMENT
NATURALLY OCCURRING ADULT STEM CELLS
OXSTEM’S APPROACH: PROGRAMMABLE CELL CHEMISTRY
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WWW.OXSTEM.CO.UK
ACTIVATION OF RESIDENT CELLS IN VIVO TO ALLEVIATE DISEASE
• SALAMANDERS, AND OTHER AMPHIBIANS, REGENERATE TISSUE AND REGROW DETACHED LIMBS
• IN HUMANS MANY CELL TYPES ARE CONTINUOUSLY REPLACED INTO ADULTHOOD: Ø BLOOD/BONE Ø GUT EPITHELIUM Ø SKIN/HAIR
• OTHER TISSUES RETAIN A LIMITED REGENERATIVE CAPACITY (IN RESPONSE TO INJURY): Ø CARDIAC MUSCLE Ø NEURONS Ø RETINA
• IN ONCOLOGY, CANCER STEM-LIKE CELLS BECOME ABERRANT à UNLIMITED GROWTH AND/OR
ARREST OF DIFFERENTIATION
OXSTEM WILL ACTIVATE AND ENHANCE NATURAL REPAIR PROCESSES IN THE BODY, THAT ARE USUALLY VERY SLOW BY USING SMALL MOLECULE DRUGS AS WELL AS REDIRECTING CANCER STEM-LIKE CELLS TOWARDS A BENIGN (DIFFERENTIATED) PHENOTYPE
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WWW.OXSTEM.CO.UK
AGENDA
1. OUR MISSION
2. OUR GROUP
3. OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE
4. THE “STEMS” – SEE WEBSITE: WWW.OXSTEM.CO.UK
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