Rodríguez, F. , León-López, J. , Calderón, C. , Feriche, B. , Pérez-Sánchez, M. , Iglesias, X. Oxidative stress markers in different altitude training strategies in elite athletes. 18th Annual Congress of the European College of Sport Science, INEFC Barcelona. (Barcelona). [email protected]Sport Sciences Research Group INEFC Barcelona Grup de Recerca en Ciències de l'Esport INEFC Barcelona Grup Consolidat (SGR 2014–1665 GRC) Institut Nacional d’Educació Física de Catalunya Av. de l’Estadi, 12-22 08038 Barcelona (Spain) +34 93 425 54 45 http://inefcresearch.wordpress.com/ http://www.slideshare.net/ResearchINEFC [email protected]@Recerca_INEFC
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Oxidative stress markers in different altitude training strategies in elite athletes.
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Rodríguez, F. , León-López, J. , Calderón, C. , Feriche, B. , Pérez-Sánchez, M. , Iglesias, X. Oxidative stress markers in different altitude training strategies in elite athletes. 18th Annual Congress of the European College of Sport Science, INEFC Barcelona. (Barcelona).
Sport Sciences Research Group INEFC Barcelona Grup de Recerca en Ciències de l'Esport INEFC Barcelona Grup Consolidat (SGR 2014–1665 GRC) Institut Nacional d’Educació Física de Catalunya Av. de l’Estadi, 12-22 08038 Barcelona (Spain) +34 93 425 54 45 http://inefcresearch.wordpress.com/ http://www.slideshare.net/ResearchINEFC [email protected] @Recerca_INEFC
OXIDATIVE STRESS MARKERS IN DIFFERENT ALTITUDE TRAINING STRATEGIES IN ELITE ATHLETES Rodríguez F.A.1, León-López J.2, Calderón, C.3, Feriche, B.4, Pérez-Sánchez, M.5, Iglesias, X.1
1 GRCE, INEFC-Barcelona, Universitat de Barcelona (Barcelona, Spain), 2 Hospital Universitario San Cecilio (Granada, Spain), 3 CAR Sierra Nevada (Granada, Spain) 4 FCAFD, University of Granada (Granada, Spain), 5 Hospital Universitario Virgen de las Nieves (Granada, Spain)
Aim
Hypoxia is known to induce oxidative stress in animal models and humans due to increased oxygen uptake and electron drain at the mitochondrial respiratory chain, resulting in increased biological tissue oxidation (Guzy & Schumacker 2006).
During altitude training exposure two independent stimuli (intense exercise and hypoxia) may have a cumulative effect on oxidative stress (Pialoux et al., 2006).
We aimed to analyse the prooxidant-antioxidant balance during different strategies of moderate altitude training in elite athletes.
Methods
57 elite swimmers took part in four training camps at moderate altitude (CAR Sierra Nevada, 2320 m), living and training at “high” (Hi) or “low” (Lo) level, using different strategies during a period of four (LoLo, HiHi4, HiLo) or three weeks (HiHi3).
Biochemistry Prooxidant-antioxidant balance was evaluated before (pre) and once a week during the camp (wk1 to wk4, post in LoLo only) in peripheral blood samples by measuring with different commercially available kits:
Statistics Two-way RM ANOVA was used for group comparisons. p<0.05 was considered significant.
Results Conclusions
• Four weeks of training at altitude resulted in an increase of oxidative damage markers compared to comparable training at sea level
• The free radical NO increased in HiHi4 at the second week, indicating a higher risk of health disturbances when living and training at altitude in this group
• However, a seemingly adequate antioxidative defence was maintained, since intracellular GSH, the ratio GSSG/GSH, and the activity of GPx and GRd remained stable