Oxathiapiprolin: a new fungicide active ingredient for control of diseases caused by Oomycetes V. Mascarenhas, P. Kuhn, H. McLean, A. Tally, K. Teeter and S. Lowder 2016_TWC32_Mascarenhas.pdf TWC2016(47) - Document not peer-reviewed
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Oxathiapiprolin: a new fungicide active ingredient for control of diseases caused by
OomycetesV. Mascarenhas, P. Kuhn, H. McLean, A. Tally, K. Teeter and S. Lowder
2016
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Technical Features of Orondis Common name of active ingredient: Oxathiapiprolin Unique mode of action (FRAC U15): Targets oxysterol-binding protein
(OSBP) with essential function in fungal cells Systemic: Translaminar and xylem movement Highly effective fungicide for control of Oomycete diseases
o Late blight in potatoes and tomatoeso Downy mildew in cucurbits and leafy vegetableso Black shank in tobaccoo Phytophthora capsici blights in cucurbits and fruiting vegetables
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
LEAFY VEGETABLES
TOBACCOPOTATOES CUCURBITS FRUITING VEGETABLES
2016
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Technical Features of OrondisComparative Active Ingredient Use Rate
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
02468
101214161820
oz ai/
acre
10-100 times lower a.i. rate than other fungicides Low use rate reduces environmental load, exposure, and risk to non-target organisms
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Chart1
Chlorothalonil
Mancozeb
Copper
Propamocarb HCl
Ametoctradin
Cymoxanil
Mandipropamid
Fluopicolide
Mefenoxam
Oxathiapiprolin
oz ai/acre
oz ai/acre
17.99
17.13
12.85
8.42
2.43
1.91
1.83
1.7
1.57
0.17
Sheet1
gai/haozai/acre
Chlorothalonil1260
Macozeb1200
Copper900
Propamocarb HCl590
Ametoctradin170
Cymoxanil134
Mandipropamid128
Fluopicolide119
Mefenoxam110
Oxathiapiprolin15
oz ai/acre
Chlorothalonil17.99
Mancozeb17.13
Copper12.85
Propamocarb HCl8.42
Ametoctradin2.43
Cymoxanil1.91
Mandipropamid1.83
Fluopicolide1.7
Mefenoxam1.57
Oxathiapiprolin0.17
Sheet1
gai/ha
gai/ha
Sheet2
oz ai/acre
oz ai/acre
Sheet3
Technical Features of OrondisNew Mode of Action
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
Targets an oxysterol binding protein essential to fungal developmentThe only active ingredient (a.i.) in FRAC Group U15Single site action, thus Resistance Management is importantNo cross-resistance to any other fungicide a.i.Inhibits all stages in the fungal life cycle and with high intrinsic activity
Preventive, residual, and anti-sporulant activities
P. Infestans studies in vitro Oxathiapiprolin EC50 (ppb)
Zoospore release
Technical Features of OrondisSites where normal fungal growth is inhibited
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
Complete inhibition of zoospore germination at 6.4 ppb
Untreated Oxathiapiprolin
Inhibition ofSporangiaFormation atLess than 0.01 ppb
Source: Richard Bittner - NCSU
Untreated Oxathiapiprolin
OxathiapiprolinUntreated
Complete inhibition of mycelialgrowth at0.02 ppb
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Technical Features of OrondisSystemicity and Rainfastness
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
0
20
40
60
80
100
0.2 2
Dise
ase
cont
rol (
%)
Oxathiapiprolin (ppm)
Existing leaves
Expandingleaves
New growth
SystemicTranslaminar movement - across leaves to protect lower surfacesAcropetal movement in xylem - into growing tips and distal parts of leavesRedistribution to protect expanding leaf canopy
RainfastWithin 30 minutesQuickly binds to cuticle for uptake into leavesPrevents wash off of a.i. in the event of rainfallMitigates the need for retreatment
Control of late blight in potato plants treatedwith oxathiapiprolin (greenhouse test) foliar appl.
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Chart1
0.20.20.2
222
Existing leaves
Expanding leaves
New growth
Oxathiapiprolin (ppm)
Disease control (%)
80
90
94
92
98
100
Sheet1
Existing leavesExpanding leavesNew growth
0.2809094
29298100
Category 44.52.85
To resize chart data range, drag lower right corner of range.
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
15ga/ha oxathiapiprolin
15ga/ha oxathiapiprolin
untreated
untreated
17 days after application
1 day after application
Single drench application of oxathiapiprolin at 15ga/ha on tomato plants kept in greenhouse.
Repeated inoculation with Phytophthora infestans every 5-7 days following treatment.
Marker on plant shows new growth
Technical Features of OrondisSystemicity and Residual Control
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Orondis Gold 200 SC
Syngenta obtained marketing rights to Oxathiapiprolin from DuPont in 2013Agreement required product be used in mixtures in most marketsDevelopment program in tobacco focused on:Confirming rates and optimizing formulations (100 OD vs. 200 SC)Evaluating application timingsEvaluating tank mixture vs. single ai alternation programsDevelopment of a premixCrop safety
Regulatory program focused on:Obtaining registration on tobacco as Tier 1 cropSecuring special label to allow tank mixtures in 2016
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2015 Orondis on Farm Trial P. Peterson SC
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
0
10
20
30
40
50
60
70
1 2 3 4 5
Dise
ase
(%)
Orondis 100 OD formulation used in this trial evaluating single ai alternation programs The 9.6 oz rate of the OD is equivalent to the recommended 4.8 oz of the SC formulation
Effective Disease Management
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2015 Orondis on Farm Trial P. Peterson SC
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
Orondis 100 OD formulation used in this trial evaluating single ai alternation programs The 9.6 oz rate of the OD is equivalent to the recommended 4.8 oz of the SC formulation
0
500
1000
1500
2000
2500
3000
3500
1 2 3 4 5
Yiel
d (lb
/A)
Excellent Yield Protection
2016
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2015 Orondis BS Nursery Trial A. Mila NC
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
Orondis 100 OD formulation used in this trial evaluating single ai alternation programs The 9.6 oz rate of the OD is equivalent to the recommended 4.8 oz of the SC formulation
0
10
20
30
40
50
60
70
80
90
1/1 1/2 1/3 1/4
% In
fect
ed p
lant
s
Series1
Series2
Series3
Lay-
by
appl
icat
ion
Excellent performance from TPW flby Layby by both programs thru 28 days after layby
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2014 Orondis BS Nursery Regional Trial
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
Effective disease management from tank mix of Orondis + RD Gold at TPW fb Layby
30.5
48.7
83.4 82.9
55.3
78.9
98.1 99.6
1 2
Dis
ease
Con
trol
(%)
Series1 Series2 Series3 Series4
A. Csinos A. Mila B. Fortnum C. Johnson
UTC Disease Incidence
GA 91.8%
NC 19.3%
SC 76%
VA 48.7%
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2016 Orondis Commercial LaunchPackaging and Application
Multipack of two Black Shank effective active ingredients: oxathiapiprolin and mefenoxam
Target pathogen: Black Shank and Pythium Labeled use rates dependent on appl. timing:
TPW: 3.4 - 4.8 fl.oz/A Orondis + 5.7 - 8 fl.oz/A Ridomil Gold Post transplant: 4.8 fl.oz/A Orondis + 8 fl.oz/A Ridomil Gold
Application volume: TPW Ensure saturation of transplant root zone at 100 200 gal/A Post Transplant - apply 4- to 12-inch band at 20 40 gal/A and follow it
with cultivation or irrigation (0.5 to 1) Recommend Orondis component be used once in a growing season TPW or 1st Cultivation or Lay-by
Ridomil Gold application flexibility is unchanged Do not exceed 1.5 lb ai/A mefenoxam per season
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
Ridomil Gold SL
Two 80 fl.oz containers
Orondis Gold 200 SC
Two 48 fl.oz. containers
One case treats 20 - 24 acres
2016
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2016 Orondis Commercial Launch Regulatory Guidelines for 2016 will require the following: Orondis Gold 200 SC Sec 3 label RD Gold SL 24c label for transplant water 2ee label allowing the tank mixtures of both products
Recommended use rate and application timing: TPW: 4.8 fl.oz/A Orondis Gold + 8 fl.oz/A Ridomil Gold
Product Stewardship: Two MoA inhibition of OSBP binding and nucleic acid synthesis Use in combination with resistant varieties and proper field
rotation One and Done use pattern for Orondis component Preventative rather than curative
Anticipate Sec 3 label for premix in 2017:
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
Ridomil Gold SL
Two 80 fl.oz containers
Orondis Gold 200 SC
Two 48 fl.oz. containers
One case treats 20 - 24 acres
2016
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Summary of Orondis Benefits & BMP Unique mode of action (FRAC U15) Target Disease is Black Shank (P. nicotianae) No cross-resistance to other fungicides Highly effective at low use rates with good residual control Systemic: Translaminar and xylem movement Rainfast Should be used in combination with another effective MoA Ridomil Gold SL Should be used only once in a tobacco program including resistant varieties and
proper field rotation Flexible application timing: TPW or 1st Cultivation or Lay-by Recommended rate is 4.8 oz Orondis + 8 oz Ridomil Gold SL at TPW
2015 Syngenta. Important: Always read and follow label instructions. Some crop protection products may not be registered for sale or use in allstates or counties. Please check with your local extension service to ensure registration status. Orondis and other oxathiapiprolin-based fungicides are not registered for sale or use in the U.S. and are not being offered for sale. Orondis, the Alliance Frame, the Purpose Icon and the Syngenta logo
are trademarks of a Syngenta Group Company SLC 5229A 02-2015
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Oxathiapiprolin: a new fungicide active ingredient for control of diseases caused by OomycetesTechnical Features of OrondisTechnical Features of OrondisComparative Active Ingredient Use RateTechnical Features of OrondisNew Mode of ActionTechnical Features of OrondisSites where normal fungal growth is inhibitedTechnical Features of OrondisSystemicity and RainfastnessTechnical Features of OrondisSystemicity and Residual ControlOrondis Gold 200 SC2015 Orondis on Farm Trial P. Peterson SC2015 Orondis on Farm Trial P. Peterson SC2015 Orondis BS Nursery Trial A. Mila NC2014 Orondis BS Nursery Regional Trial 2016 Orondis Commercial LaunchPackaging and Application2016 Orondis Commercial LaunchSummary of Orondis Benefits & BMP
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