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Ovarian Dysgerminomas Pathology Overview of OvarianDysgerminomas
Author: Florette K Gray Hazard, MD; Chief Editor: Ramya Masand, MD more...!dated: "#t $%, $%&'
"(er(ie) of "(arian Dys*erminomas
Differentiatin* "(arian Dys*erminomas
+aoratory Mar-ers
Gross and Mi#ros#o!i# Features
mmunohisto#hemistry
Mole#ular and Geneti# Features
/ro*nosis of "(arian Dys*erminomas
0ho) All
Multimedia +iraryReferen#es
"(er(ie) of "(arian Dys*erminomas
A dys*erminomais a tumor of the o(ary that is #om!osed of !rimiti(e, undifferentiated *erm #ells. Germ #elltumors arise from !rimordial *erm #ells of the o(ary and the testis; ho)e(er, !atho*enesis of the o(arian *erm#ell tumors is un-no)n. "f the o(arian lesions,123 are eni*n !roliferations 4ie, matureteratomas;theremainin* 53 are mali*nant.6&7
Germ #ell tumors may e distin*uished y their line of differentiation. /rimiti(e, uni!otential *erm #ells are the!re#ursors to o(arian dys*erminomas and their testi#ular analo*ue, the seminoma. Ho)e(er, !leuri!otential*erm #ells di(er*e alon* se(eral lines of differentiation: tro!holasts, #horio#ar#inoma; emryoni# #ells,emryonal #ar#inoma; e8traemryoni# #om!onents 4endoderm, mesoderm, e#toderm9, teratoma; !resomiteemryoid odies, !olyemryoma; and yol- sa#, yol- sa# 4endodermal sinus9 tumor.
Dys*erminomas are the most #ommon mali*nant *erm #ell tumor o##urrin* in theo(ary4see the follo)in*
ima*e9, and these lesions are found most #ommonly in adoles#ents and youn* adults; in fa#t, a!!ro8imately%3 of #ases are dia*nosed in !atients youn*er than $% years. 6$7 Common si*ns and sym!toms of o(ariandys*erminomas in#lude adominal!el(i# !ain 4''
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Go to "(arian Can#erand>orderline "(arian Can#erfor #om!lete information on these to!i#s.
Differentiatin* "(arian Dys*erminomas
?he #hief disorders in the differential dia*nosis of dys*erminoma are lym!homaleu-emia, yol- sa#tumor,emryonal #ar#inoma,and 0ertoli #ell tumor. +ar*e
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"(arian dys*erminoma histolo*y 4hemato8ylin
