Ovarian Cancer

STANISLAV ALVARO CARDONAMEDICINE STUDENT

INTEGRATED ANALYSES OF THE OVARIAN CANCER GENOME

CDK1 INHIBITION SENSITISES AND TUMOURS WITH WILD TYPE BRCA1 TO PARP INHIBITION

FOLDING

FOLDING

The ovarian cancer is one of the most

common in women. Some molecular

particles are important to stop it.

Inhibitors of the enzyme poly (ADP-ribose polymerase),

or PARP, in a study to stop the

development of some tumours

INTEGRATED ANALYSES OF THE OVARIAN CANCER GENOME

  July 4th 2011

INTEGRATED ANALYSES OF THE OVARIAN CANCER GENOME

Ovarian cancer is a malignant tumor that arises in any part of the ovary due to mutation and cell

proliferation influenced by genetic, environmental or hereditary factors.

Its prognosis is good, on the rare occasions when diagnosed early

Ovarian cancer is the fifth most common cancer in women in the UK,

all over the world, representing approximately 4% of all cancers

diagnosed in women

INTEGRATED ANALYSES OF THE OVARIAN CANCER GENOME

INTEGRATED ANALYSES OF THE OVARIAN CANCER GENOME

There are several genes involved in the development of this pathology as

BRCA1 BRCA2

RB1NF1

FAT3CSMD3

GABRA6CDK12

INTEGRATED ANALYSES OF THE OVARIAN CANCER GENOME

This was determined by a genome study of women with ovarian cancer

which showed mutations in the mRNA during protein synthesis

I think that this is an important

step in the science, because

this would be the beginning of the treatment of

many pathologies

Understanding the genetic

material allows find the

answers for many medical

riddles

OBSERVATION

CDK1 INHIBITION SENSITISES TUMOURS WITH WILD TYPE BRCA1 TO PARP INHIBITION

  July 4th 2011

CDK1 INHIBITION SENSITISES TUMOURS WITH WILD TYPE BRCA1 TO PARP INHIBITION

Inhibitors of the enzyme poly (ADP-ribose) polymerase, or PARP, are among the most

promising drugs currently in development as anti-tumour agents.

CDK1 INHIBITION SENSITISES TUMOURS WITH WILD TYPE BRCA1 TO PARP INHIBITION

BRCA1 "breast cancer 1"BRCA1 "breast cancer 1" is a tumor suppressor gene, which regulate the cell cycle and prevent

uncontrolled proliferation.

CDK1CDK1is a highly conserved protein that

functions as a serine / threonine kinase, is encoded by the gene cdc2.

Phosphorylation of these proteins control cell cycle progression

CDK1 INHIBITION SENSITISES TUMOURS WITH WILD TYPE BRCA1 TO PARP INHIBITION

A combination of a PARP inhibitor with a Cdk1 inhibitor also showed

reduced tumour growth and prolonged survival compared to treatment with one or no inhibitors in a mouse model

of lung adenocarcinoma.

CDK1 INHIBITION SENSITISES TUMOURS WITH WILD TYPE BRCA1 TO PARP INHIBITION

Inhibition of Cdk1 is likely to sensitise tumours with wild type BRCA1 to PARP inhibition, and that a combination of inhibitors of these two

enzymes may be a useful treatment for these tumours

That experiments are fundamental to

know how the human life is

affected begging in the littlest process

that define the whole life

OBSERVATION

MEDICAL UTILITY

MEDICAL UTILITY

The study of the human genome could shed any information about each

individual and that is where the solution begins each pathology

to develop it.

MEDICAL UTILITY

New experiments with enzymes have led to cures for various types of

cancer, starting with the molecular basis of such tumors which involve cell division and proper transfer of

genetic information.

Molecular biology is the basis for understanding the processes that lead to

cause such conditions, so find a solutions or improvements to the health of people

BIBLIOGRAPHY

• http://www.ecancermedicalscience.com/news-insider-news.asp?itemId=1857

• http://www.ecancermedicalscience.com/news-insider-news.asp?itemId=1858

• MARTINEZ SANCHEZ, LINA MARIA. , ET ALL. Biología Molecular, libro de clase. Sexta Edición. Universidad Pontificia Bolivariana. Medellín 2011

THANK YOU…