Out With the Old and In With the New, Again?

Out With the Old and In With the New, Again?

Out With the Old, In With the New

Current Standard of Care

NEUTRINO and FISSION SOF + RBV ± pegIFN for Treatment-naive Patients

NEUTRINO and FISSION SOF + RBV ± pegIFN for Treatment-naive Patients

FUSIONSOF + RBV ± pegIFN in Treatment-experienced Patients With G2,3 HCV

VALENCESOF + RBV for 12 Weeks or 24 Weeks in G2 or G3 HCV Infection

QUEST 1 and 2Q80K Variant Adversely Affects SVR12 of SMV-based Therapy

COSMOS SOF + SIM ± RBV for G1 HCV-infected Patients by Fibrosis Stage

2014 AASLD HCV Treatment Guidelines

ION-1On the Road to IFN-free Therapy for G1 HCV

Infection

ION-3 8 Weeks or 12 Weeks of SOF/LDV for Treatment-

naive G1 HCV Infection

ION-2SOF/LDV in G1 HCV-infected Patients Failing

PegIFN/RBV ± DAA

HALLMARK-DUALPhase 3 Trial of the All-oral Regimen DCV + ASV

for G1b HCV Infection

SAPPHIRE IABT-450/r/Ombitasvir + Dasabuvir (3D) + RBV

for G1 HCV Infection

SAPPHIRE IIABT-450/r/Ombitasvir + Dasabuvir + RBV (3D)

G1 HCV

TURQUOISE IIABT-450/r/Ombitasvir + Dasabuvir (3D) + RBV in

Cirrhosis

The Past And Future of HCV Therapy

Abbreviations

Abbreviations (cont)

Abbreviations (cont)

References

References (cont)

References (cont)

References (cont)