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What do we need to do to bring commercially viable,
consumer acceptable reduced risk products to
market?
The Product/Risk Continuum
Risk to user
High
LowHigh LowToxicants:nicotine
Con
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aret
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t-B
urn
Cig
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Low
Tox
ican
t S
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Non
-tob
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Nic
otin
e P
rodu
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Com
bust
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PR
EP
s
Consumer acceptance of
smokeless
PREP development &
assessment
Public Health, Scientific &
Regulatory support
Our Global Harm Reduction Programme- Progress over the last year
Snus test market expansion in South Africawith new products
First clinical studies on modified combustible prototypes underway in Germany
http://www.controlled-trials.com/ISRCTN72157335
To compare the exposure levels of selected smoke constituents as determined by biomarkers of exposure, filter analysis, sensory perception and other parameters when smokers using commercial cigarettes are switched to novel cigarettes
•The cartridge nicotine loadings claimed by Ruyan were similar to that measured by BAT, with the exception of the 0mg cartridge which was measured in the range of 0.4-2.9mg nicotine
•Nicotine yields per puff were similar irrespective of the cartridge nicotine loading or puffing regime
•All Hoffmann analyte yields were below the BAT analytical Limit of Quantification (LOQ)
•The E-Cigarette does not generate Carbon Monoxide
•The vapour & particulate phases from the e-cigarette contained less compounds than those from conventional cigarettes, however the presence of plasticisers, PG derivatives, flavour compounds and nicotine derivatives was confirmed
Figure 1. Nicotine yields per puff
Electronic cigarettes are currently the biggest business in ANP
~20
N/a<0.5~2 <0.50.5 - 1
>100Yearly worldwide sales volume
2007, USD millions
ESTIMATES
ANP category Electronic cigarettes
Nicotine / tobacco gum
Nicotine / tobacco pills
Nicotine / tobacco inhalators
Nicotine / tobacco gel
Nicotine drinks and food
Nicotine film and others
Number of brands 20+ 1 2 2 2 1 0
Number of manufacturers
50+ 1 1 2 2 1 0
Major markets • China
• USA
• EU states
• Japan
• Sweden
• USA • USA
• UK
• USA
• EU states
• Worldwide online
• USA • Not available yet (some brands failed)
The biggest worldwide ANP market is for electronic cigarettes, which only started up
less than 3-4 years ago. Other ANP categories, although being longer on the market
don’t show signs of rapid expansion
The traditional boundaries of tobacco / nicotine products are starting to blur
* Or nicotine substitute** Pfizer, Johnson & Johnson, GSK, Novartis
Tobacco (and nicotine) Nicotine only*
Combustion (or heat) Smoke-free
•Cigarettes• Machine made• Hand made (roll-your-own)
•Cigars• Large• Little
•Pipe tobacco
•Nasal tobacco• Moist• Dry
•Oral tobacco• Loose leaf• Plug• Twist, roll• Other traditional (e.g. Guthka, Toombak, Ipco Creamy Snuff, etc.)