OSTEOPOROSIS IN SAUDI OSTEOPOROSIS IN SAUDI ARABIA ARABIA ANOTHER EPIDEMIC ANOTHER EPIDEMIC WAITING TO HAPPEN ? WAITING TO HAPPEN ? • MONA A FOUDA NEEL ,MBBS, MRCP(UK),FRCPE MONA A FOUDA NEEL ,MBBS, MRCP(UK),FRCPE • ASSOCIATE PROFESSOR OF MEDICINE ASSOCIATE PROFESSOR OF MEDICINE • CONSULTANT ENDOCRINOLOGIST CONSULTANT ENDOCRINOLOGIST • COLLEGE OF MEDICINE COLLEGE OF MEDICINE • KING SAUD UNIVERSITY KING SAUD UNIVERSITY
23
Embed
OSTEOPOROSIS IN SAUDI ARABIA ANOTHER EPIDEMIC WAITING TO HAPPEN ? MONA A FOUDA NEEL,MBBS, MRCP(UK),FRCPE MONA A FOUDA NEEL,MBBS, MRCP(UK),FRCPE ASSOCIATE.
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
OSTEOPOROSIS IN SAUDIOSTEOPOROSIS IN SAUDI ARABIA ANOTHER EPIDEMIC ARABIA ANOTHER EPIDEMIC WAITING TO HAPPEN ? WAITING TO HAPPEN ?
• MONA A FOUDA NEEL ,MBBS, MRCP(UK),FRCPEMONA A FOUDA NEEL ,MBBS, MRCP(UK),FRCPE• ASSOCIATE PROFESSOR OF MEDICINEASSOCIATE PROFESSOR OF MEDICINE• CONSULTANT ENDOCRINOLOGISTCONSULTANT ENDOCRINOLOGIST• COLLEGE OF MEDICINECOLLEGE OF MEDICINE• KING SAUD UNIVERSITYKING SAUD UNIVERSITY
• The magnitude of the problemThe magnitude of the problem
•The relationship to vitamin D The relationship to vitamin D status in the countrystatus in the country
Lumbar BMD of 830 postmenopausal Saudis according to Lumbar BMD of 830 postmenopausal Saudis according to ageage
CategoryCategoryNumberNumber (%) (%)
BMD BMD ++ SD SD
T-T-ScoreScore
Age 50-59 yrs.Age 50-59 yrs. NormalNormal OsteopeniaOsteopenia OsteoporosisOsteoporosisLow BMDLow BMD
BMD – Bone Mineral DensityBMD – Bone Mineral DensitySD-Standard DeviationSD-Standard Deviation
Femur BMD In All Patients (50-80 Femur BMD In All Patients (50-80 Yrs)Yrs)
Prevalence of osteopenia and osteoporosis in Saudis (50 years), using US/European and Saudi reference data. Data are presented as percentages with osteopenia (> -2.5 SD to < -1 SD below young adult BMD) and osteoporosis (< -2.5 SD below young adult BMD), for spine (L2-L4) and femur (total).
(Ardawi MSM, et al. Osteoporosis Int 2005; 16: 43-55)
1980 PTS20-79 AGEM 915
F 1065
The proportion of Saudis aged 50 years with lower than -2.5 SD,
stratified by body weight quartiles and sex.
(Ardawi MSM, et al. Osteoporosis Int 2005; 16: 43-55)
•VITAMIN D LEVELS VITAMIN D LEVELS BELOW 20 NMOL/L BELOW 20 NMOL/L EXCLUDEDEXCLUDED !!
• Bone mineral density of the spine and Bone mineral density of the spine and femur in healhy saudi females femur in healhy saudi females : relation to vitamin D status, : relation to vitamin D status, pregnancy, and lactationpregnancy, and lactation
• N N GHANNAM ETAL calcif Tissue int N N GHANNAM ETAL calcif Tissue int 1999 1999
• 321 females 321 females
• 25 vit D 24.5+17.2 25 vit D 24.5+17.2
• Severe hypovitaminosis D (25 OHD less Severe hypovitaminosis D (25 OHD less than 20 nmol/l )= 52% than 20 nmol/l )= 52% Osteopenia and osteoporosis in subjects Osteopenia and osteoporosis in subjects more than 31=18-41 %, 0-7%more than 31=18-41 %, 0-7%
(Sadat-Ali M & AlElq AM. Ann Saudi Med 2006; 26: 450-454)
(Sadat-Ali M & AlElq AM. Ann Saudi Med 2006; 26: 450-454)
(El-Desouki MI & Sulimani RA. Saudi Med J 2007; 28: 774-777)
(El-Desouki MI & Sulimani RA. Saudi Med J 2007; 28: 774-777)
•Resurection of vitamin D Resurection of vitamin D deficiency and ricketsdeficiency and rickets
•Michael Holick JCI 2006Michael Holick JCI 2006• Severe chronic vitamin D deficiency { 25 (OH) D Severe chronic vitamin D deficiency { 25 (OH) D
less than 15 ng/ml } leads to overt skeletal less than 15 ng/ml } leads to overt skeletal abnormalities in children typically defined as abnormalities in children typically defined as ricketsrickets
• A large number of children and adolescents who A large number of children and adolescents who have vitamin D insufficiency have no apparent have vitamin D insufficiency have no apparent skeletal or calcium metabolism abnormalitiesskeletal or calcium metabolism abnormalities
• Lee J.M. et al 2006Lee J.M. et al 2006
• Of 40 healthy mother-infant pairs Of 40 healthy mother-infant pairs predominantly non-white, 73% of predominantly non-white, 73% of mothers and 80% of infants had (25 mothers and 80% of infants had (25 OH)D levels of less than 20 ng/m OH)D levels of less than 20 ng/m ldespite the fact that 80% of mothers ldespite the fact that 80% of mothers were taking prenatal multivitaminswere taking prenatal multivitamins
• Sullivan et al 2005Sullivan et al 2005
• 48% of white girls aged 9-11 years in 48% of white girls aged 9-11 years in main had 25(OH)D levels than 20 main had 25(OH)D levels than 20 ng/ml by end of summer and 17% ng/ml by end of summer and 17% remained vitamin D deficient and the remained vitamin D deficient and the end of summerend of summer
• Due to avoidance of exposure to sun and Due to avoidance of exposure to sun and lack of fortification of many foods, upward lack of fortification of many foods, upward of 35-80% of children in many sunny of 35-80% of children in many sunny countries,Saudi Arabia, India,Turkey, countries,Saudi Arabia, India,Turkey, Egypt, HongKong, China, Lebanone, Egypt, HongKong, China, Lebanone, Spain……etc are vitamin D deficientSpain……etc are vitamin D deficient
• When the deficiency occurs during fetal When the deficiency occurs during fetal life it may increase risk of hip fratures and life it may increase risk of hip fratures and bone loss later in lifebone loss later in life
optimal 25hydroxyvitamin D
values45-50 nglml or
115-128 nmol/lNormal 25-
hydroxyvitamin D values20-56 ng/ml or
50-140 nmol/l
Table: Threshold values for vitamin D insufficiency based on different outcomes and study types. A common threshold value of 50 nmol/l has been proposed for vitamin D insufficiency, whereas vitamin D deficiency is characterized by values < 25 nmol/l.
Increase in bone Increase in bone turnoverturnover
Seasonal variations in Seasonal variations in PTHPTH
Suppressible P-PTHSuppressible P-PTH
30-8030-80
Increases with Increases with ageage
3030
6060
9090
5050
Cross-Cross-sectionalsectional
Cross-Cross-sectionalsectional
Cross-Cross-sectionalsectional
Cross-Cross-sectionalsectional
InterventionIntervention
Dawson-Hughes Dawson-Hughes et al.et al. 19911991
Ooms 1994Ooms 1994
Ooms Ooms et al.et al. 1995 1995
Chapuy Chapuy et al.et al. 1997 1997
Guillemant Guillemant et al.et al. 1999 1999
Jesudason Jesudason et al.et al. 2002 2002
Vieth Vieth et al.et al. 2003 2003
Ooms Ooms et al.et al. 1995 1995
Jesudason Jesudason et al.et al. 2002 2002
Krall Krall et al.et al. 1989 1989
Malabanan Malabanan et al.et al. 1998 1998
Lips 2001Lips 2001
(Mosekilde L. Clin Endocrinol 2005; 62: 265-281)
Figure: Prevalence of vitamin D inadequacy in all subjects. The percentage of subjects with serum 25(OH)D concentrations below predefined cutoffs of less than 9, less than 15, less than 20, less than 25, and less than 30 ng/ml.
Factors associated with vitamin D deficiency:-Age-BMI >25-Daily intake of vitamin D <400 IU (63%)-Medications affecting vitamin D metabolism-Race-Education level-Limited daily activity-Discussion with physician about vitamin D and bone health (28% had no counseling)
• The population under study is classified into 3 The population under study is classified into 3 categories according to vit D nutritional categories according to vit D nutritional status: deficient (status: deficient ( 5 ng/ml), low (5-10 ng/ml) 5 ng/ml), low (5-10 ng/ml) and adequate (and adequate ( 10 ng/ml). 10 ng/ml).
• The frequency of low 25-OHD concentration (5-The frequency of low 25-OHD concentration (5-10 ng/ml) is high (22% in total children and 10 ng/ml) is high (22% in total children and 20% in total adults) in the Saudi population, 20% in total adults) in the Saudi population, while the frequency of vit D deficiency (25-while the frequency of vit D deficiency (25-OHD level OHD level 5 ng/ml) is 3.4% in total children 5 ng/ml) is 3.4% in total children and 5.5% in total adults. This is true whether and 5.5% in total adults. This is true whether the population is urban or rural.the population is urban or rural.
• 26% of female children or female adults have 26% of female children or female adults have low vit D status in comparison with 19% and low vit D status in comparison with 19% and 17% for male children and male adults, 17% for male children and male adults, respectively.respectively.
STUDY OF VITAMIN D STATUS AND FACTORS LEADING TO ITS DEFICIIENCY IN SAUDI ARABIA
SALEH SEDRANI ET AL
• The problem of osteoporosis in Saudi The problem of osteoporosis in Saudi Arabia has been overlooked until now.Arabia has been overlooked until now.
• It is of paramount importance to identify It is of paramount importance to identify the magnitude of the problem of the magnitude of the problem of osteoporosis and its related fractures in osteoporosis and its related fractures in Saudi Arabia.Saudi Arabia.
• This will be the cornerstone of setting up This will be the cornerstone of setting up programs for screening high risk groups programs for screening high risk groups through non-invasive techniques and through non-invasive techniques and treatment at early stages of the disease treatment at early stages of the disease with the aim of limiting disability and its with the aim of limiting disability and its impact on the national health resources.impact on the national health resources.
ABDULRAHMAN ALNUAIM,MD,FRCPC,FACPANNALE OF SAUDI MEDICINE,VOL 13,NO 1,1993