ǶȘȋȈȕȐȏȈȞȐȧ ȘȈȉȖȚȣ ȗȖ șȖȏȌȈȕȐȦ ȘȍȒȖȔȍȕȌȈȞȐȑ ȖșțȡȍșȚȊȓȍȕȈ ǵȈȞȐȖȕȈȓȤȕȣȔ ȜȖȕȌȖȔ ȗȖȌȌȍȘȎȒȐ ȗȘȖȜȐȓȈȒȚȐȟȍșȒȖȑ ȔȍȌȐȞȐȕȣ ©ǷǸǶǼǴǭǬǼǶǸǻǴª ǷȘȐ ȘȍȈȓȐȏȈȞȐȐ ȗȘȖȍȒȚȈ ȐșȗȖȓȤȏȖȊȈȕȣ șȘȍȌșȚȊȈ ȋȖșțȌȈȘșȚȊȍȕȕȖȑ ȗȖȌȌȍȘȎȒȐ ȊȣȌȍȓȍȕȕȣȍ Ȋ ȒȈȟȍșȚȊȍ ȋȘȈȕȚȈ ǶȉȡȍȘȖșșȐȑșȒȖȑ ȖȉȡȍșȚȊȍȕȕȖȑ ȖȘȋȈȕȐȏȈȞȐȍȑ ©dzȐȋȈ ȏȌȖȘȖȊȤȧ ȕȈȞȐȐª ȗȖ ȐȚȖȋȈȔ ȒȖȕȒțȘșȈ ȗȘȖȊȍȌȍȕȕȖȋȖ Ȋ șȖȖȚȊȍȚșȚȊȐȐ ș ȘȈșȗȖȘȧȎȍȕȐȍȔ ǷȘȍȏȐȌȍȕȚȈ ǸȖșșȐȑșȒȖȑ ǼȍȌȍȘȈȞȐȐ ȹ Șȗ ȖȚ ȔȈȧ ȋȖȌȈ ©Ƕȉ ȖȉȍșȗȍȟȍȕȐȐ Ȋ ȋȖȌț ȋȖșțȌȈȘșȚȊȍȕȕȖȑ ȗȖȌȌȍȘȎȒȐ ȕȍȒȖȔȔȍȘȟȍșȒȐȝ ȕȍȗȘȈȊȐȚȍȓȤșȚȊȍȕȕȣȝ ȖȘȋȈȕȐȏȈȞȐȑ țȟȈșȚȊțȦȡȐȝ Ȋ ȘȈȏȊȐȚȐȐ ȐȕșȚȐȚțȚȖȊ ȋȘȈȎȌȈȕșȒȖȋȖ ȖȉȡȍșȚȊȈª ǷȘȐ ȘȍȈȓȐȏȈȞȐȐ ȗȘȖȍȒȚȈ ȐșȗȖȓȤȏȖȊȈȕȣ șȘȍȌșȚȊȈ ȊȣȌȍȓȍȕȕȣȍ Ȋ ȒȈȟȍșȚȊȍ ȞȍȓȍȊȣȝ ȉȓȈȋȖȚȊȖȘȐȚȍȓȤȕȣȝ ȗȖȎȍȘȚȊȖȊȈȕȐȑ DzȖȔȗȈȕȐȑ $EERWW /DERUDWRULHV //& TAKEDA Ȑ ȗȘȐ șȗȖȕșȖȘșȒȖȑ ȗȖȌȌȍȘȎȒȍ ȒȖȔȗȈȕȐȑ ǶǶǶ ©ǵȖȊȈȘȚȐș ǼȈȘȔȈª 3¿]HU ǵȈȞȐȖȕȈȓȤȕȣȑ ȜȖȕȌ ȗȖȌȌȍȘȎȒȐ ȗȘȖȜȐȓȈȒȚȐȟȍșȒȖȑ ȔȍȌȐȞȐȕȣ ©ǷǸǶǼǴǭǬǼǶǸǻǴª
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TAKEDA
4
5
I.
III.
VIII.
XII.XIII.
6
7
8
9
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screening
B
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+ + + +
+ +
+ + + +
+ + + +
+ + + ++ +
+ + +
+ + +
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5
7
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IIb C
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2
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44
45
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B
B
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49
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--
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B
B
B
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54
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B
B
B
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56
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B
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59
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--
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--
64
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-.
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7575
57
5555555555
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1
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