ARTICLES https://doi.org/10.1038/s41564-020-0752-7 Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase Robert M. Cox 1 , Julien Sourimant 1 , Mart Toots 1 , Jeong-Joong Yoon 1 , Satoshi Ikegame 2 , Mugunthan Govindarajan 3 , Ruth E. Watkinson 2 , Patricia Thibault 2 , Negar Makhsous 4 , Michelle J. Lin 4 , Jose R. Marengo 3 , Zachary Sticher 3 , Alexander A. Kolykhalov 3 , Michael G. Natchus 3 , Alexander L. Greninger 4 , Benhur Lee 2 and Richard K. Plemper 1 ✉ 1 Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. 2 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 3 Emory Institute for Drug Development, Emory University, Atlanta, GA, USA. 4 Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA, USA. ✉ e-mail: [email protected]SUPPLEMENTARY INFORMATION In the format provided by the authors and unedited. NATURE MICROBIOLOGY | www.nature.com/naturemicrobiology
13
Embed
Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus …10.1038/s41564-020-075… · Paramyxovirus L sequence alignments. Covered are confirmed GHP-88309 resistance
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Articleshttps://doi.org/10.1038/s41564-020-0752-7
Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymeraseRobert M. Cox 1, Julien Sourimant 1, Mart Toots1, Jeong-Joong Yoon 1, Satoshi Ikegame2, Mugunthan Govindarajan3, Ruth E. Watkinson2, Patricia Thibault2, Negar Makhsous4, Michelle J. Lin4, Jose R. Marengo3, Zachary Sticher 3, Alexander A. Kolykhalov3, Michael G. Natchus3, Alexander L. Greninger4, Benhur Lee2 and Richard K. Plemper 1 ✉
1Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. 2Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 3Emory Institute for Drug Development, Emory University, Atlanta, GA, USA. 4Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA, USA. ✉e-mail: [email protected]
SUPPLEMENTARY INFORMATION
In the format provided by the authors and unedited.