Islammiyah DY 1) , Wistiani 1) , Galuh H 1) 1) Department of Pediatric, Faculty of Medicine, Diponegoro University, Kariadi Hospital, Semarang, Indonesia Correlation between clinical manifestations and anti ds-DNA of patients with systemic lupus erythematosus
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Islammiyah DY1), Wistiani1), Galuh H1)
1) Department of Pediatric, Faculty of Medicine, Diponegoro University, Kariadi Hospital, Semarang, Indonesia
Correlation between clinical manifestations and anti ds-DNA of patients with systemic lupus
erythematosus
BACKGROUNDBACKGROUND
Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease with many clinical manifestations.
Anti ds-DNA antibody is a specific marker for this disease and correlate with disease activity.
OBJECTIVE
to determine the relationship between clinical manifestations and anti ds-DNA.
METHODS
Retrospective study Using medical records in Kariadi Hospital between January
2010 and June 2015 was done. Twenty six patients, age range 7-17 years old, were enrolled. Clinical features observed based on the American College of
Rheumatology criteria for SLE. Anti ds-DNA level was classified into ≤ 300 IU/ml and > 300 IU/ml.
Normality of data was analyzed by Shapiro-wilk. Statistic analysis was performed using exact fischer test.
Subject characteristic
Characteristic Deathn (%)
Surviven (%)
Totaln (%)
GenderFemale
Male
3 (11,54)
0 (0)
20 (76,92)3 (11,54)
23 (88,46)3 (11,54)
AgePrepuberty
Puberty
0 (0)
3 (11,54)
3 (11,54)20 (76,92)
3 (11,54)23 (88,46)
SeveritySevere
Mild
1 (3,85)2 (7,69)
10 (38,46)
13 (50)
11 (42,31)15 (57,69)
Antibody anti ds-DNA
PositifNegatif
1 (3,85)
0 (0)
14 (53,85)5 (19,23)
15 (57,69)5 (19,23)
Clinical description of pediatric with LES based on ACR Criteria Clinical Symptom Death