Opisthorchis viverrini Transmission Models Christine B¨ urli 1,2 , Helmut Harbrecht 2 , Peter Odermatt 1,2 , Somphou Sayasone 1,2,3 , Nakul Chitnis 1,2 1 Swiss Tropical and Public Health Institute, Basel, Switzerland 2 Universit¨ at Basel, Basel, Switzerland 3 National Institute of Public Health, Vientiane, Lao People’s Democratic Republic Swiss TPH Winter Symposium 2017 Helminth Infection – from Transmission to Control Basel, Switzerland, 8 December 2017 Department of Epidemiology and Public Health Infectious Disease Modelling Unit
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Opisthorchis viverrini Transmission Models
Christine Burli1,2, Helmut Harbrecht2, Peter Odermatt1,2, Somphou Sayasone1,2,3,Nakul Chitnis1,2
1Swiss Tropical and Public Health Institute, Basel, Switzerland2Universitat Basel, Basel, Switzerland3National Institute of Public Health, Vientiane, Lao People’s Democratic Republic
Swiss TPH Winter Symposium 2017Helminth Infection – from Transmission to ControlBasel, Switzerland, 8 December 2017
Department of Epidemiology and Public Health
Infectious Disease Modelling Unit
Opisthorchis viverrini
DogsCats
Humans
Eggs
SnailsCercariaeFish
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O. viverrini in South East Asia
Forrer et al. (2012)
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Modelling Framework
Basic Model
if
wh
is
Reservoir Host Model
if
wh
wc
wd
is
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Reproductive Numbers
The basic reproduction number R0 is the average number of new cases of an infection(or number of parasite offspring) caused by one typical infected individual (or oneparasite), from one generation to the next, in a population with no pre-existinginfections.
Type-reproduction numbers provide a threshold for whether certain host types canmaintain transmission on their own.