Opioid-Sparing Anesthesia Techniques: The Multimodal Wave Hawai’i ANA, March 2017 John P. McDonough, CRNA, EdD , Dr.( habil .) NScA , ARNP, FRSM Professor & Director, Graduate Nursing Programs Director, Nurse Anesthetist Program BROOKS COLLEGE of HEALTH SCHOOL of NURSING NURSE ANESTHETIST PROGRAM
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Opioid-Sparing Anesthesia Techniques: The Multimodal Wave · •Acute pain affects people of all ages1 • >80% of patients report pain after surgery2 – 75% of these patients report
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Opioid-Sparing Anesthesia Techniques: The Multimodal Wave
Hawai’i ANA, March 2017
John P. McDonough, CRNA, EdD, Dr.(habil.)NScA, ARNP, FRSM
Professor & Director, Graduate Nursing ProgramsDirector, Nurse Anesthetist Program
BROOKS COLLEGE of HEALTH
SCHOOL of NURSING
NURSE ANESTHETIST PROGRAM
• Acute pain affects people of all ages1
• >80% of patients report pain after surgery2
– 75% of these patients report moderate, severe, or extreme pain
• Postoperative pain is the primary concern of most patients prior to surgery2
• Pain is a major component of the recovery process3
Postoperative Pain Considerations
References: 1. Berry PH et al. Pain: current understanding of assessment, management, and treatments. Glenview,IL: American Pain Society; 2006. 2. Gan TJ et al. Curr Med Res Opin.
2014;30(1):149-160. 3. Pavlin DJ et al. J Clin Anesth. 2004;16(3):200-206.
Importance of Balancing Pain Management with Risk of Adverse Events•Most post-surgical patients in one study chose less pain relief than increased/more severe side effects (N=50)
Patients
Report
ing S
ele
cte
d P
rofile
(%
)
Gan TJ, Lubarsky DA, Flood EM, et al. Br J Anæsth. 2004; 92(5): 681-688.
* Mental cloudiness/dizziness
“Moderate” N +
“good”pain relief
“No” N +
“fair”pain relief
“Severe” D +
“excellent”pain relief
“Mild” D +
“good”pain relief
Pain Management Remains Suboptimal in the Acute Care Setting
0
10
20
30
40
50
60
70
80
90
Any Pain Slight Moderate Severe Extreme
Warfield 1995 Apfelbaum 2003 Gan 2014
77
8286
19
13
25
4947 45
2321
23
8
18
8
1. Warfield CA, Kahn CH. Anesthesiology. 1995; 83(5): 1090-1094. 2. Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Anesth Analg.
2003; 97(2): 534-540. 3. Gan TJ, Habib AS, Miller TE, White W, Apfelbaum JL. Curr Med Res Opin. 2014; 30 (1): 5149-160.
(N=500) (N=250) (N=300)
Pa
tie
nts
(%
)
Opioids have Historically been theFoundation for Acute Pain Management
• In a 2012 research database of 1,665,418 patients, 72% of inpatients treated with IV analgesia received IV opioid monotherapy
Data from the hospital research database maintained by the Premier healthcare alliance. July 17, 2013.
28% …
72% opioid …
n=459,674
n=1,205,744
Current versus ERAS
Business as Usual
• Avoidable readmissions
• Avoidable complications
• Unsubstantiated variation
• Current costs continue
• Current patient experience
• Current return to work
ERAS
• Minimized readmissions
• Minimized complications
• Evidence-based care
• Costs decreased
• ↑ satisfaction / ↓ suffering
• Increased productivity
or
Cost Per Hospital Day
1. Lee L, Mata J, Ghitulescu GA, et al. Ann Surg. 2014 Nov 3. [Epub ahead of print], 2. National Health Service. Personal Social Services Research Unit,
Unit Costs of Health & Social Care 2011. Available at: http://www.pssru.ac.uk/archive/pdf/uc/uc2011/section1.pdf. Accessed October 8, 2015.
1
191
UK$10532CAN
$4681
US$19601
Note: Costs converted to US dollars.
Chapman CR, Stevens DA, Lipman AG. Quality of postoperative pain management in American versus European institutions. J Pain Palliat Care
Pharmacother. 2013 Dec;27(4):350-8.
Pain Scores and Opioid Consumption in the United States versus Europe
• European patients reported significantly less pain on the first day after orthopedic surgery than American patients
• A larger proportion of American patients received opioids on the first postoperative day compared to Europeans 0
123456789
1011
Mean Worst Pain (+/- SD) Day 1
United States Europe
98.3%
70.2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Opioid Use on Post-Op Day 1
United States Europe
Multimodal Analgesia in the Era of Enhanced Recovery After Surgery
“The immediate challenge to improving the quality of surgical care is not discovering new knowledge, but rather how to integrate what we already know into practice.”11. Urbach DR, Baxter NN. BMJ. 2005; 330(7505):1401-1402.
Adapted from ERAS Society.
www.erassociety.org.
The Preoperative Piece: Prehabilitation and Education
• Timeframe
– Scheduling of surgery to arrival in pre-op holding
• Information management/Healthcare literacy/Expectation management
• Nutritional optimization and carbohydrate loading
• Exercise/ “prehabilitation”
• Mental health assessment
• As applicable, smoking cessation
Healthcare Literacy and Patient Factors
• A third of all patients function at or below a basic level of literacy1
• This complicates matters when these tasks are difficult1:
– Complete intake forms
– Follow written pre-op instructions
– Follow written prescriptions instructions or calculate a dose
• Only 63% of patients receive education on pain management prior to surgery2
151. Mitka M. JAMA. 2012; 307(7):653. 2. Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Anesth Analg. 2003; 97(2): 534-540.
Variable Any Education
Before surgery
Total (n=250) 63%
Inpatient (n=129) 63%
Outpatient (n=121) 63%
After surgery
Total (n=250) 66%
Inpatient (n=129) 70%
Outpatient (n=121) 61%
Patient Education
The Pre-op Piece: Enhanced Recovery
• Avoid N/G tubes
• Selective bowel prep
• Goal directed therapy
• Appropriate use of medications
• Use short acting anesthetics
• Avoid PONV
• Maximize use of MMA
The Intraoperative Piece: SCIP + Anesthetic Standardization
• Timeframe– Arrival in preop holding until discharge to ward
• Surgical Care Improvement Project (SCIP) Measures
American Society of Anesthesiologists (ASA) Task Force. Anesthesiology. 2012; 116(2): 248-273.
Multimodal Analgesia Sites of Action
• Multimodal analgesia combines two or more analgesic agents or techniques that act by different mechanisms to provide analgesia to optimize efficacy while minimizing risk of adverse events1
Opioids2
α2-agonists2
Acetaminophen3
NMDA antagonists4
Local anesthetics2
Opioids2
α2-agonists2
Local anesthetics2
NSAIDs2
COXIBs2
Redrawn with permission from Kehlet H, Dahl JB. The value of
multimodal analgesia in postoperative pain treatment. AnesthAnalg.
1993;77:1049. NMDA=N-methyl-D-aspartate.
1. American Society of Anesthesiologists. Anesthesiology. 2012: 116: 248-273. 2. Gottschalk A, Smith DS. Am Fam Physician.
2001; 63: 1979-1984. 3. Smith HS. Pain Physician. 2009; 12: 269-280. 4. Wu CL, Raja SN. Lancet. 2011; 377: 2215-2225.
Opioid Monotherapy vs. Multimodal Approach to Acute Pain Management
3. World Health Organization. Pain relief ladder. http://www.who.int/cancer/palliative/painladder/en/. Accessed September 10, 2014.
4. Ventafridda V, Tamburini M, Caraceni A, De Conno F, Naldi F. Cancer. 1987; 59: 850-856. 5. ASA Task Force. Anesthesiology. 2004; 100: 1573-1581.
+++
Opioids
+
Opioids
++
Opioids
Mild Pain
Moderate Pain
Severe Pain
1. Aubrun et al., 2003
Step 3
Steps 1 & 2 and
Local Anesthetic
Peripheral
Neural Blockade
and Sustained
Release Opioids
Step 1
Acetaminophen, NSAIDs, or COX-2 Selective Inhibitors
and
Local/regional anesthesia
Step 2
Step 2
Step 1 and
Low Doses of Opioids
Low Doses of Opioids
2. Crews 2002
3. WHO pain relief ladder
4. Ventafridda et al., 1987
5. ASA Task Force 2004
Opioid Monotherapy Multimodal Analgesia
Multiple Organizations Recommend a Non-Opioid Foundation to Multimodal Analgesia• Society Recommendations
– American Society of Anesthesiologists (ASA)1
– American Society of Pain Management Nursing (ASPMN)2
– American Society of PeriAnesthesia Nurses (ASPAN)3
– American Geriatrics Society (AGS)4
– Society for Critical Care Medicine (SCCM)5
– Surgical Societies (e.g., American Academy of Orthopaedic Surgeons)6
– Enhanced Recovery After Surgery (ERAS) Society7
• Accrediting and Quality Organizations– The Joint Commission (TJC)3
– Agency for Healthcare Research and Quality (AHRQ)3
1. ASA Task Force on Acute Pain Management. Anesthesiology. 2012; 116: 248-273. 2. Jarzyna D, Jungquist CR, Pasero C, et al. Pain Manage Nurs. 2011; 12:
118-145. 3. Wells N , Pasero C, McCaffery M. In Hughes RD, ed. Agency for Healthcare Research and Quality; 2008. 4. The American Geriatrics Society. Pain
management in the elderly. http://www.americangeriatrics.org/gsr/anesthesiology/pain_management.pdf. Accessed September 10, 2014. 5. Barr JU, Fraser GL,
Puntillo K, et al. Crit Care Med. 2013; 41(1): 263-306. 6. American Academy of Orthopaedic Surgeons. Management of hip fractures in the elderly: evidence-based
clinical practice guideline. September 5, 2014. Available at: http://www.aaos.org/Research/guidelines/HipFxGuideline_rev.pdf. Accessed March 23, 2015. 7.
Feldman LS, Delaney CP, Ljungqvist O, Carli F. (Eds.) The SAGES/ERAS ® Society Manual of Enhanced Recovery Programs for Gastrointestinal Surgery. Springer:
2015.
Treatment Considerations for Implementing Multimodal Analgesia
• Base multimodal analgesia decision on:
– Optimizing efficacy for procedure being performed1,2
– Side effects of individual medications2
– Patient factors3
– Type of surgery
– Expected severity of post-op pain
– Underlying medical conditions
– Risk-benefit ratio for the available MMA techniques
– Patient preferences or previous experience with pain
– Ease of use (around-the-clock vs as-needed)3
– Acquisition Cost vs Global Value4
1. Halawi MJ et al. Orthopedics. 2015; 38(7):616-625. 2. Buvanendran A. IARS Review Course Lectures. 2011; 58-62. Available at:
www.iars.org/assets/1/7/11_RLC_Buvanendran.pdf. Accessed October 7, 2015. 3. American Society of Anesthesiologists.
Anesthesiology. 2012; 116: 248-273. 4, Gora-Harper ML et al. Ann Pharmacother. 2001; 35(11):1320-1326.
Types of Non-Opioids Used inMultimodal Pain Treatment Plans
Local anesthetics NMDA receptor antagonists NSAIDs
bupivacaine
lidocaine
liposomal bupivacaine
ketamine
celecoxib
ibuprofen
ketorolac
diclofenac
Note: The agents listed above are commonly employed in the perioperative management of acute pain.
This list is not meant to be a comprehensive directory of all available analgesic agents.
Sample Protocol
Intervention Details Phase of care
NutritionNutritional assessment, and protein containing supplement 3x/day x 5 days pre-op
Pre-op
CHO Loading Gatorade/juice on morning of surgery Pre-op
StrengthIncentive spirometry for 1 week prior to surgery, increase exercise daily x 2 weeks
Pre-op
Bowel PrepStandardized for all surgeons doing similar procedure (mechanical/antibiotic)
Pre-op
PremedsAvoid sedatives in patients >70 or with dementia/confusion
Pre-op
Sample Protocol
InterventionDetails Phase of care
Goal Directed Fluid Therapy
• IV Fluids on pump throughout case
• Consider SVV/PPV monitoring for specific high-risk patients
Intra-Op
Anesthetic Optimization
• Use short-acting anesthetics (avoid volatile agents)• Ketamine infusion (0.5 mg/kg for induction, followed by
0.10-0.15 me/kg/hr)• IV lidocaine infusion (1.0-1.5mg/kg with induction followed
by 1-2mg/kg/hr until emergence)• Propofol infusion (dose as needed for induction, the 50-150
mic/kg/min• Use N2O as needed
Intra-Op
GlycemicControl
• Check HgbA1C on all patients 3d prior to surgery. Cancel if level is >9%.
• If elevated in non-diabetics: Check glucose on morning of surgery, Treat as you would a Type-2 patient
• Continue glycemic control throughout perioperative period
Pre/Intra/Post-Op
Education & Expectation Management
• All patients taught by ARNP with friend/family
• Appropriately written patient education brochure providedPre/Intra/Post-Op
Sample Protocol
Intervention Details Phase of Care
Multimodal Analgesia
• Thoracic epidurals for all scheduled open procedures
• Infiltrate all wounds
• Gabapentin 600mg preop, then 300mg TID for 3d (not PRN)
• Ketamine 0.5mg/kg IV with induction of anesthesia
• Ketorolac 30mg IV in OR, then 15mg q6hr for 3d (not PRN)
• Acetaminophen 1000mg IV in OR, then IV or po q6hr for 3d (not PRN)
Pre/Intra/Post-Op
Sample Protocol
Intervention Details Phase of Care
Nausea and Vomiting Control
• 1 risk factor: ondansetron 4mg prior to induction. 2 risk factors: Dexamethasone 4mg with induction. 3 risk factors: Scopolamine patch prior to surgery OR diphenhydramine 25mg OR droperidol 0.625mg OR metoclopramide10mg. 4 risk factors: Add from the list above.
• Postoperative prophylaxis with ondansetron 4mg q6hr x 24hr (not PRN)
• Patients encouraged to chew gum for nausea treatment ad lib
Intra/Post-Op
Early Removal of Tubes and
Catheters
• Nasogastric tubes avoided unless patients have activebowel obstruction
• Bladder catheters to be removed as soon as possible
• Avoid use of invasive drains for most procedures
Intra/Post-Op
Sample Protocol
Intervention Details Phase of Care
Early Feeding and Bowel Stimulation
• Clear liquids on evening of surgery
• Gum chewing encouraged after their surgery
• Regular/full diet day after their surgery
Post-Op
Early Mobilization and Conditioning
• Patients with weakness or instability or patients over 70 receive PT consult
• Out of bed to chair on evening of surgery
• Walk 20min 4x/d starting on POD 1
• Sit in chair 6-8 hours a day
• limb and breathing exercises per hour while awake