OPC3 Main Presentation National Convention 2009

8/8/2019 OPC3 Main Presentation National Convention 2009

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Discovered the involvement ofvitamin C in scurvy

Found that citrus fruits bear othermaterial stabilizing blood vessels

Introduced the term vitamin Pfor flavonoids

Dr. Szent Gyrgi


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Protection from oxidative environment

Protection from microbial decay Protection from insects

The highest amounts are found in a plant's surface:the peel, the bark


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OH

OH

OH

Resveratrol is atri-hydroxy-stilbene

Resveratrol is suggested to have potent anti-aging activity


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O+

OH

OH

R2

OH

OH

R1

Bilberry has been shown to support night-time vision

Effective for strengthening retinal capillaries


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O

OH

OH

OHOH

OH

OHOH

O

OH

OH

OH

O

OH

OH

OHOH

OH


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The maritime pine tree growsfor 30-50 years in anunspoiled environment:

no pesticides no fertilizers no pollution

Ideal botanical source:

mono-culture no seasonal influence


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15/4430 years ago

tomorrow


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UV exposure leads to free radical production and inflammationin the skin producing serious damage to skin cells


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0%

20%

40%

60%

80%

100%

Lipidssavedfrom

oxidation

vit C lipoicacid

vit E grapeseed

Pycnogenol

Chida et al., Ophthal Res 31: 407-415, 1999


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Clinical study with

healthy volunteers.

More UV radiation is

required to cause a

sunburn when taking

Pycnogenol.

While not a sunblock,

Pycnogenol does help

protect the skin from

sunburn by its

antioxidant and anti-inflammatory actions.


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Kyriazi et al., Cancer Letters 2005 237: 234-241, 2006

weeks

0 5 10 15 20 25M

icebearin

gpapillom

a

0%

20%

40%

60%

80%

100%nude albino mice nude pigmented mice

pigmented mice

with Pycnogenol

albino mice

+Pycnogenol


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Mean pigmented area size: - 37.7 %Mean intensity index: - 22.4 %

Ni et al., Phytother Res 16: 567-571, 2002

Hyper-pigmentationAreasize[mm2 ]

0

10

20

30

40

50

60

70

Beforetreatment

Aftertreatment

30 women with hyperpigmentation:

25 mg Pycnogenol 3x daily for 30 days


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mitochondria

DNA

Enzymes

cell wall


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mitochondria

DNA

Enzymes

cell wall


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Wei et al., Redox Report 3: 219-224, 1997

SOD Glutathione Catalase

Presence of anti-oxidant enzymes in endothelial cellsafter 8 hour exposure to Pycnogenol


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Devaraj et al., Lipids 37: 931-934, 2002

1

2

3

4

baseline 3 and 6 weeks

Pycnogenol4 weeks

wash-out


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Ryan et al., J Psychopharmacol, in print 2008

101 elderly participants(aged 60-85 years)

Presenting with impairedcognitive function

Memory improvementshown after 3 months


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Cardiovascular disease : disorders of the heart and blood vessels

Coronary heart disease (heart attacks)Cerebrovascular disease (stroke)Cholesterol abnormalitiesRaised blood pressure (hypertension)Peripheral vascular disease (clotting, edema)Heart Failure

Major causes: tobacco use, physical inactivity, and an unhealthy diet

Facts: #1 cause of death globally17.5 million people died from cardiovascular disease in 200530 % of all global deaths7.6 million heart attacks5.7 million strokes

http://www.who.int/topics/cardiovascular_diseases/en/


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arginine

+ O2

blood platelets blood stream

NO NO

NO

NO

NO

NO

endothelial cells of blood vessel wall

Fitzpatrick et al., J Cardiovasc Pharm 32: 509-515, 1998


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Kohama, Progress in Medicine 24: 1503-1510, 2004

22% Mild

Improvement


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Hosseini et al., Nutrition Res 21: 1251-1260, 2001

p


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3 weeks

200 mg a day

3 weeks

100 mg a day

3 weeks

50 mg a day

Liu et al., Diabetes Care 27: 839, 2004


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Increase ofantioxidantimpact rate

units/ minute

10min

20min

30min

40min

50min

60min

70min

80min

90min

2h

2h

3h

3h

4h

0

1

2

3

Cesarone et al., Phytother Res, in print 2008


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Cesarone et al., Angiology 2008


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OPC3 Main Presentation National Convention 2009

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