1 Dermatology 2006 SNU Dermatolory Lab Bioinformatics for Genomic Medicine 2006 Dermatology Lab Yoonkyung Kim Term Project Proposal Presentation 2006. 06. 12
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1 Dermatology 2006 SNU Dermatolory Lab
Bioinformatics for Genomic Medicine
2006 Dermatology Lab
Yoonkyung Kim
Term Project Proposal Presentation
2006. 06. 12
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Database :
Online Mendelian Inheritance in skin
with OMIM DB
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Introduction
Online Mendelian Inheritance in Man (OMIM)
OMIM is a continuously updated catalogue of human genes and genetic disorders. OMIM focuses primarily on inherited, or heritable, genetic diseases. It is considered to be a phenotypic companion to the human genome project. OMIM is based upon the text Mendelian Inheritance in Man, authored and edited by Dr. Victor A. McKusick and a team of science writers and editors at Johns Hopkins University and elsewhere. Mendelian Inheritance in Man(MIM) is now in its 12th edition.
See McKusick, V.A.: Mendelian Inheritance in Man. 12th ed.,Baltimore: Johns Hopkins University Press, 1998.
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Purpose
- Limitation of datas about skin genetic disorders in OMIM - the updated data in other databases is considerably insufficient. OMIK(Online Mendlian Inheritance in Korea) : information is simple and Page error
국립보건원 < 유전질환 DB> : late update
Korea Cytogenetic DB : page error
- All of the database is not up to date ( old ) - Databases include overlapped cytogenetic DB - contents of the databases are insufficient for professional and accuracy
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Method
OMIM
Get id from html pages(/omimhtml) ( skin search )Method : python 2.4Searched results with skin : 2189
Raw data
Download the pages(/omimsubhtml) with id Method : python 2.4
html data
Extract the datas from downloaded pages Method : python 2.4
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extracted data
Method
insert datas (text file) to the data tableMethod : MS Access !! but except data if data is too large to insert to the table
Datatable
Make form for the table
form
Coding to add search function with visual basicMethod : MS Access (visual basic)
Skin DB
Method : MS Access
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Result
search
Title OMIM id
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Result
In the Searched data
If click the OMIMlink,
If click the Genelocus,
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Discussion
- Skin database can be used to search genetic disorders in skin.
- The information in this database is easier to see and understand through visualization datas and picture informations than previous OMIM DB.
- DB is not linked to the web.
- But this skin DB have limitations. Most part of the information in DB exist in OMIM DB. Earning the pictures about genetic disorder is difficult. ( shortage of knowledge)
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Term Project Proposal Presentation
9 Dermatology 2006 SNU Dermatolory Lab
Discussion
- Skin database can be used to search genetic disorders in skin.
- The information in this database is easier to see and understand through visualization datas and picture informations than previous OMIM DB.
- DB is not linked to the web.
- But this skin DB have limitations. Most part of the information in DB exist in OMIM DB. Earning the pictures about genetic disorder is difficult. ( shortage of knowledge)
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