NuSoothe Brochure

Personalized Solutions for Pain Management

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Benefits of theNuSoothe Series

Faster, More Complete ReliefUses the only base proven to bring 4 drugs simultaneously through the skin for faster, more effective pain management.

Faster Return to Daily LivingMay reduce the need for oral pain medications that affect the entire body. This puts patients back on their feet faster, completing daily activities sooner (like driving).

Prolonged Patient ReliefAnesthetic bupivacaine lasts longer than the more commonly used tetracaine and lidocaine. 1

Fewer Side E�ectsAvoids the side effects of oral pain medications, like digestive issues, drowsiness, loss of driving ability, addiction and overdose.

Safer And Avoids Patient ErrorTube dispenses the appropriate, premeasured amount of cream for a single dose.

Can be used up to 5 times per day.

Tube contains UV protection to prevent chemical breakdown.

NuSoothe SeriesThe NuSoothe series consists of three transdermal

creams formulated in a Lipoderm® base that

drives multiple drugs simultaneously through the

skin. NuSoothe achieves faster drug delivery and

better absorption for improved pain relief.

plantar fasciitis

NuSoothe PF is designed to alleviate pain caused by plantar fasciitis and other inflammatory conditions of the foot. The drug combination helps loosen the tight bundle of fascia at or near the site of the patient’s pain.

NuSoothe™ PF

FlurbiprofenGabapentinDiphenhydramineCyclobenzaprineBupivacaine

10%6%5%2%1%

pain, inflammation & muscle spasms

The original NuSoothe formulation treats pain, inflammation and muscle spasms locally. It contains four drugs with different mechanisms of action to quickly and effectively alleviate discomfort.

NuSoothe™

FlurbiprofenGabapentinCyclobenzaprineBupivacaine

10%6%2%1%

30%

neuropathic pain

NuSoothe Plus is used to treat neuropathic pain, such as that caused by diabetic neuropathy. It can be prescribed in addition to NuSoothe and NuSoothe PF to help with difficult-to-treat nerve pain.

NuSoothe™ Plus

Ketamine

Breakthrough Studies of Lipoderm®The First Transdermal Base to Undergo Rigorous Testing

According to the latest competitive studies, NuSoothe’s Lipoderm transdermal base

delivers ketoprofen (NSAID) more quickly and with better absorption. In addition,

Lipoderm is the only base proven to bring 4 drugs simultaneously through the skin.

This means faster relief and the potential for better outcomes.

Delivers Ketoprofen Better and Faster

Percutaneous Absorption Flux Profileof Ketoprofen Mean from 3 Donors as µg/cm2/hr

• This formulation delivered ketoprofen more rapidly than all other formulations.

Flu

x (µ

g/c

m2 /

hr)

Mid Time (hr)

Competitor

Lipoderm®

14.5%Lipoderm®

5.5%PLO

• Percent of ketoprofen dose delivered completely through human skin in vitro was significantly better with Lipoderm versus PLO.

Percent Permeation of Ketoprofen Through Human Skin and Into Receptor SolutionUsing human skin in vitro

Only Base Proven to Deliver 4 Drugs Simultaneously

Percent Permeation of Multiple Drugs Beyond Stratum CorneumThrough ex vivo human skin

• Lipoderm delivered ketamine HCl, gabapentin, clonidine HCl and baclofen simultaneously and intact.

•Drugs were selected due to their frequent use in topical pain formulations.

Ketamine Clonidine Baclofen Gabapentin

4% 4%

45%

21%

NuPulse®Provides iceless cold compression, DVT prophylaxis and thermal contrast therapy to ease pain, reduce swelling and speed healing.

iCPM™“Smart” continuous passive motion improves range of motion for knees, shoulders, hips, elbows and more.

Our Continuum of CareNuLife Med’s Continuum of Care consists of a range of cutting-edge, robust therapies

that work together to improve patient outcomes after surgery or injury.

All therapies are provided with in-home, concierge service, 7 days per week, with no

unexpected cost to the patient.

WARNING: If patient is allergic to any of the ingredients in NuSoothe™, patient should not use the medication. Patient should contact the pharmacy/physician immediately. SIDE EFFECTS: If allergic, patients may respond negatively to any of the medications represented in this therapy. Although absorption of an appreciable amount of the active ingredients is uncommon, some can occur in rare situations. Absorption, if it does occur, will typically result in stomach upset (anti-inflammatory) and drowsiness (muscle relaxant, nerve pain suppressant or anesthetics). If patient experiences any of these side effects (or other events that they feel are abnormal), patient should contact clinical staff. OVERDOSE: If an overdose is identified, please contact the pharmacy toll-free at 800-850-2101. Poison control can also be reached at 1-800-222-1222. MISSED DOSE: The patient may apply a missed dose as soon as he/she recognizes that is has been missed. Please allow a minimum of 4 hours between applications unless otherwise directed by a healthcare professional. STORAGE: Store this medication in a cool, dry place. Avoid exposure to excessive heat, sunlight or dampness.

250NorthCommercialStreet,Suite3003,Manchester,NH03101•[email protected]

1. Annals of Emergency Medicine. 1987, 16(7); 752-757

NuSoothe™Transdermal analgesic cream treats pain, swelling and muscle spasms locally without the side effects of oral medications.

Bone Growth Stimulator30-minute daily treatment with combined magnetic fields helps heal persistent fractures and non-unions.

Additional TherapiesNuLife Med also offers transcutaneous

electrical nerve stimulation (TENS), muscle stimulation and select

immobilizing braces.