HighResolu,on MicroCT Imaging & Image Analysis Services Specialty Preclinical CRO Numira combines innova,ve tools and technologies to provide unique solu,ons to a wide variety of preclinical drug discovery efforts. By choosing Numira as your CRO, you get more informa,on from each specimen and answers faster than ever before, saving your team valuable ,me and resources. Let us demonstrate the feasibility of our novel technology through a small, lowcost pilot study. Accelerating Drug Discovery Bone: Car,lage and osteochondral defects, developmental biology, biologics, orthopedics (drill, segmental, and window defects, closed fracture, and spinal bone fusion models), osteoarthri,s, osteoporosis, rheumatoid arthri,s Pulmonary: Fibrosis, COPD/emphysema, pulmonary arterial hypertension, lung tumors Cardiovascular: Atherosclerosis, septal defects, stents within coronary arteries Vasculature: Vascular imaging and analysis of tumors and any/all organs, including bone vasculature Biomedical Devices: Metallic and nonmetallic stents/devices, wound healing material, bone implant material (organic and inorganic) Image Analysis: Analysis using proprietary algorithms for microCT, MRI, ECG, and histology data Our proprietary so2 3ssue contrast agent will stain a variety of 3ssue and lesions and is nondestruc3ve. The same 3ssue can be re analyzed via histology to further characterize the observed 3ssue or lesions. Osteoarthri,s Rheumatoid Arthri,s Pulmonary Cardiovascular Vasculature Specialized Histology Services (GLP or nonGLP) RouDne & Specialized Histology: Plas,c, paraffin, frozen, EXAKT ground sec,ons Histopathology: CNS, bone, oncology, pulmonary, gastrointes,nal, renal Histomorphometry: GLPvalidated Osteomeasure systems Immunohistochemistry (IHC): Custom stain development, coexpression and double labeling ExperDse in ocular, renal, and CNS histology services Coronary Stent (Masson's Trichrome) Rat Tibia Growth Plate (Safranin O) Rat Kidney (Glepp1) Mouse Eye (CD4)