NSAID, antirheumatics, antipyretics Notes for Pharmacology II practicals This study material is exclusively for students of general medicine and stomatology in Pharmacology II course. It contains only basic notes of discussed topics, which should be completed with more details and actual information during practical courses to make a complete material for test or exam studies. Which means that without your own notes from the lesson this presentation IS NOT SUFFICIENT for proper preparation for neither tests in practicals nor the final exam. Doc. PharmDr. Jan Juřica, Ph.D. Mgr. Barbora Ondráčková MUDr. Jana Nováková, Ph.D. PharmDr. Jana Rudá-Kučerová, Ph.D. MVDr. Leoš Landa, Ph.D.
41
Embed
NSAID, antirheumatics, antipyretics Notes for Pharmacology II practicals This study material is exclusively for students of general medicine and stomatology.
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
NSAID, antirheumatics, antipyretics
Notes for Pharmacology II practicals
This study material is exclusively for students of general medicine and stomatology in Pharmacology II course. It contains only basic notes of discussed topics, which should be completed with more details and actual information during practical
courses to make a complete material for test or exam studies. Which means that without your own notes from the lesson this presentation IS NOT SUFFICIENT for
proper preparation for neither tests in practicals nor the final exam.
Doc. PharmDr. Jan Juřica, Ph.D.
Mgr. Barbora Ondráčková
MUDr. Jana Nováková, Ph.D.
PharmDr. Jana Rudá-Kučerová, Ph.D.
MVDr. Leoš Landa, Ph.D.
Non-opioid analgesics
Analgesics-antipyretics
Nonsteroidal antiinflammatorydrugs
• Analgesics-antipyretics (A-A) drugs against fever and pain
• Nonsteroidal antiphlogistics (NSAIDs) - against inflammation, fever and pain
A-A and NSAIDs overlap partially
• Antiuratics – gout therapy
Mechanism of action
• all of them have similar mechanism of action– inhibition of eicosanoids synthesis (with higher or lower selectivity and strength)
• NSAIDs differ in the strength of COX1/COX2 inhibition and the incidence of typical AE (ulcer disease, bleeding)
4. Propionic acid derivativesibuprofen • Good analgesic and antiphlogistic effec• Used often for acute pain therapy • Low AE incidence, well tolerated NSAID, indicated for
childrenketoprofenflurbiprofennaproxen
tiaprofenic acid – good penetration to synovial fluid joints diseases
5. Acetic acid derivatives• efficient drugs which differs in the incidence of
AE
diclophenac• antiphlogistic, analgesic, weak antipyretic ef.• bioavailability 30-70 %• short biological halftime retarded DDF• daily dose 50-150 mg• more AE than ASA, less than indomethacin