NovioTech BV Technology to the Market From Glucose Sensor to Hydrogel Hans Hanssen (CTO) Presented 30 June 2011 to Valorisation UMC Radboud
NovioTech BV
Technology to the MarketFrom Glucose Sensor to Hydrogel
Hans Hanssen (CTO)
Presented 30 June 2011 to Valorisation UMC Radboud
About NovioTech BV
• Shareholders:• Tweehuysen Holding BV
• Hanssen Investment and Consultancy BV
• Prof. Jan van Hest
• Prof. Alan Rowan
• Scientific Advisor: Prof Roeland Nolte
www.noviotech.com
About the Speaker: Hans Hanssen
• Former CEO of MCTEC
• Co-Founder of DSE BV, Eyetube BV, MCTEC BV, NovioTech BV
• Business Advisor to EPFlex GmBH, Nano4Imaging BV, Encapson BV
Outline of the Talk
• NovioSense – Glucose Sensor Technology
• NovioHelix – Novel Thermogel Technology
Diabetes
• At this moment World Health Organization estimates 5-7% of the worldpopulation has diabetes.
• This will increase within the next 20 years to 300 million.
• Diabetes can lead to:
– Heart disease and stroke
– High blood pressure
– Blindness
– Kidney disease
– Nervous system disease (Neuropathy)
– Amputation
Standard sensors
• Involves finger-pricking for sampling
• Not-continuous monitoring
Concept sensor
AV
Counter Electrode
WorkingElectrode
ReferenceElectrode
Electrochemical reactions E°/VWE: H2O2 2H+ + O2 + 2e-0.695CE: 2H+ + ½O2 + 2e- H2ORE: Ag(s) + Cl- AgCl(s) 0.22233
y = 5.36E-07x + 2.10E-07
R2 = 9.96E-01
0.00E+00
1.00E-07
2.00E-07
3.00E-07
4.00E-07
5.00E-07
6.00E-07
7.00E-07
8.00E-07
9.00E-07
0 0.5 1
Glucose conc. (mM)
Cu
rre
nt
(A)
The resulting current is linear within the concentration regime of glucose levels in tear fluid
Semi-Continuous Glucose Monitoring
Sending signal to receiver in glasses
Amplifying signal and transmition to insulin pump
Project Status
Patent Pending: NovioTech Assignee
Contact with Major Players in the Glucose Management Industry
Raised €1.1M of Inter Regional Funding
Goal is Functional Prototypes in 12 Months From Now
Warm
Cool
Gel formation at up to 99.98% water
Programmable transition temperatures
Optically Transparent
Biocompatible
Forms Nano-Pores (100-250nm)
Stiffness from (10 - 1000Pa)
Market Opportunities Based on Bulk Properties
Low Hanging Fruit: NanoWipe
Contacts with Potential End Users (DSM Resolve) and Instrument Manufacturers (NanoSight UK)
3D Tissue Culture Medium
Wound Care
Project Status
Identified Dedicated Project Manager
Patent Pending: NovioTech has Exclusive License
Promising New Thermo Responsive Nano Material
Identify Most Promising Market Areas
Early Prototype NanoWipe
Proof of Principle BioMedical Applications Underway
Wound Management