Novel Vaccines for Defense Against Pneumonic Plague

7/22/2019 Novel Vaccines for Defense Against Pneumonic Plague

1/43

Kcscl Tcoomk`s dfr E`d`ks`

Cacmkst Zk`unfkmo Zlcau`

E`v`ke`r Huncr

33-33-9:33


2/43

Cohkfwl`ea`n`kts

N`tza`r Lci2

Er. E`kkms N`tza`r

Er. Amrmsg Hmrmnckb`swcrc

Er. H``r _uk

Nmog`ll` Qylcke-F'Irm`k

_gcrfk _clnfk

_gckkck Rml`s

Yfi`rts _`ck

Mnnukflfay Ofr`2

Er. @enuke Afss`lmk

]mlm Lmk

E`pcrtn`kt fd Og`nmocl cke Imflfamocl

@kamk``rmka2

Er. Iclcbm Kcrcsmngck

Er. Ir`t Plr`y

E`pcrtn`kt fd T`t`rmkcry Nmorfimflfay cke

Zr`v`ktmv` N`emomk`2

Er. Nmogc`l B. Qckk`nu`gl`r

Er. Cnckec @. Ycn`r-Ucmt

E`pcrtn`kt fd Nmorfimflfay cke

Mnnukflfay 2

Er. K`bct @amln`z


3/43

Qfrlewme` e`ctgs drfn nuofscl mkd`otmfks


4/43

Qgy mktrckcscl mnnukmzctmfk6

Kcscl pcssca` ms ncbfr pfrtcl fd`ktry dfr luka pctgfa`ks

A`k`rct` nuofscl cke syst`nmo

mnnukmty A`k`rct`s mnnukmty ct ftg`rnuofscl surdco`s

Mnnuk` r`spfks`s foour ctpctgfa`k-`ktry smt`

Zr`v`kts mkd`otmfks

@cs` fd cenmkmstrctmfk/Ncssvcoomkctmfk


5/43


6/43

Icot`rmflfay ]`rsmkmc p`stms

]`rsmkmc p`stms Cktmquc

]`rsmkmc p`stms Nèm`vclms

]`rsmkmc p`stms Frm`ktclms

3-9n x :.0n, smkal` o`ll fr sgfrt ogcmk

Arcn-kàctmv`, Impflcr stcmkmka

Dcoultctmv` ckc`rfi`

Kfknftml`, kfkspfrulctmka

Octclcs`+, fxmecs`-, ur`cs`-

Cil` tf arfw 5-5:O, fptmnun 97 O

Dlfooulckt arfwtg mk irftg

Ar`y-wgmt` trcksluo`kt oflfkm`s fk Ilffe

Cacr. Drmè àa cpp`crcko` mk fle`r

oflfkm`s fk IC

Mnc `s2 K] _tct` E` crtn`kt fd G`cltg-Qceswfrtg O`kt`r, ZGML-OEO


7/43

Lor

1:hi

T Ca

Y`smstcko` tf pgcafoytfsms

_urvmvcl mk ncorfpgca`

]fps

Zgcafoytfsms

Zlct`l`t caar`actmfkMkdlnnctfry r`spfks`

pDrc

33:hi

D3 Ca

Cktmpgcafoytmo

Zst

=.0hi

Zlc

E`arce` dmirmk

& ftg`r `xtrco`llulcrprft`mks

LZ_

EMO

@keftfxmo sgfoh

Tmrul`ko` Dcotfrs

Ceg`smks


8/43

Ug` Alficl Emstrmiutmfk fd Zlcau`

Drfn2 Zlcau`2 Zcst, Zr`s`kt, cke Du tur`_t`ks`tg KO, Ctsgcicr II, Iàf k N, I`lncmk _Y, I`rtg`rct @, t cl. ZLf_ Nèmomk ` Tfl. 0, Kf. 3, ? efm23:.3?13/bfurk cl.pnè.::0:::?
http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050003http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050003


9/43

_ynptfns

gttp2//`k.wmhmp`emc.fra/wmhm/Ps`r2Nmhc`lVGaastrn/Emcarcns


10/43

Zlcau` Zctgfa`k`sms

Gunck

Nmo`

Gunck

Kfrncl Luka Mkd`ot`e lukas

Nmo`


11/43

Zfssmil` Cmrifrk` Urcksnmssmfk Zctgwcys fd ]. p`stms

cdt`r Mts Mkt`ktmfkcl C`rfsfl Y`l`cs`

N`tza`r Lci, 9:3:8 gttp2//www.fp`kolmpcrt.fra/

3::-0:: ODP

G Z Z m Zl 6


12/43

Gfw tf Zr`v`kt Zkùnfkmo Zlcau`6

Kckfpcrtmol`sQgfl`-hmllè O`lls _fluil` Cas Nmorfpcrtmol`s

Kcturcl imf-pcrtmol`s

Imfnmn`tmo

Nultmpl` crrcys fd Ca

Cssurcko` fd mkcotmvmty

rD3-Tp3:

rLsrI

rCml

rNclIr]cpN

rD3-Tp3:

Ofktrfllè r`l`cs`

_mkal`-efs`

Lfka-t`rn prftòtmfkImfeàrcecil`

Nfemdmcil` tf sumt Ca r`l`cs`

Tcoomk`s

Cebuv

ckts

Mkt`rlùhmk-39 Nfkfpgfspgfryl Lmpme C

ULY-5 cafkmst

_cd`

Kfk-tfxmo

Ca pr`s`ktctmfk

@kgcko`s o`llulcr

cke gunfrcl mnnukmty

_cd` iy m.k. rfut`

@stcilmsgè `ddmocoy


13/43

Mkcotmvct`e ]`rsmkmc p`stms OF=9

Tcoomk` (m]p)


14/43

Ug` m.k. Zrmn`-Iffst cke Ogcll`ka` _trct`ay dfr

m]p Tcoomk`

Ecy : m.k. m]p + ML-39 / m]p/ ZI_

Ecy 93 m.k. m]p + ML-39 / m]p/ ZI_

Ecy 7: m.k. ]. p`stms OF=9

Ecy =5 @ke fd survmvcl stuey


15/43

Cenmkmstrctmfk fd m.k. m]p + ML-39 ms _cd`

cke Q`ll-Ufl`rct`e

: 9 5 4 7 3: 39=:

=0

3::

*

Z


16/43

Cenmkmstrctmfk fd m.k. m]p + ML-39 Zrftòtè

cacmkst Zrmncry Zkùnfkmo Zlcau`

: 0 3: 30 9: 90:

90

0:

10

3::

3:1m]p+ML-39

3:1m]p

ZI_

ks

**

Z>:.::3

7.0 x 3:9

ODP, m.k.

Ecys pfst-ogcll`ka`

ICLI/o nmo`.

Z`ro`kts

urvmvcl

C.

I.

Ecys : 93 7:

3. 3:1

m]p + :.0a ML-39

9. 3:1

m]p

?. ZI_

ICLI/o nmo`,M.k. vcoomkctmfk

Zrmnmka Iffstmka

=5

]. p`stmsOF=9ogcllcka`, m.k.,

7.03:9ODP@ke fd survmvcl

fis`rvctmfk


17/43

ML-39 @kgcko`e tg` Zrfeuotmfk fd Cktm-]. p`stms

Cktmifem`s

: 3: 9: ?: 5: 0:3

9

?

5

0

*** *** ***

Z :.:5

Ecy ?0, pfst-vcoomkctmfk

CktmifeyUmt`rs(lfa3:

)

C. I. O.


18/43

Ug` m]p + ML-39 Zrmn`-Iffst iy m.k. Yfut`

Zr`v`kt`e Zulnfkcry Oflfkmzctmfk fd ]. p`stms


19/43

Ug` m.k. m]p + ML-39 Zrmn`-Iffst Mkeuo`e O`llulcr

Caar`actmfks mk Zulnfkcry Zcr`kogync

m]p + ML-39 ZI_

Ecy?0

pfst-vcoomkctmfk

C.

I.

Ecy97

pfst-vcoomkctmfk

I99: I99:

Ug m m] ML 39 Z m I Z e


20/43

19gpfst-ogc

ll`ka`

m]p + ML-39 ZI_

Ug` m.k. m]p + ML-39 Zrmn`-Iffst Zr`v`kt`e

E`v`lfpn`kt fd Zulnfkcry Zctgflfay

Ug` m k m]p + ML 39 Zrmn` Iffst Zr`v`kt`e E`v`lfpn`kt fd


21/43

Ug` m.k. m]p + ML-39 Zrmn`-Iffst Zr`v`ktè E`v`lfpn`kt fdZulnfkcry Zctgflfay

Ug` m k m]p + ML 39 Zrmn` Iffst Mkeuoè Zrftòtmfk ms


22/43

Ug` m.k. m]p + ML-39 Zrmn`-Iffst Mkeuoè Zrftòtmfk msCssfomctè wmtg Lfw`r L`v`ls fd Zulnfkcry Oytfhmk`s Cdt`r

m.k. Ogcll`ka`ML-4

m]p + ML-39 ZI_ Pkmkdòtè:

3

9

?

5

0*** ***

Z< :.::3 Z< :.::3

pa/nl(lfa3:)

ML-3:

m]p + ML-39 ZI_ Pkmkdòtè:.7

:.=

3.:

3.3

3.9 m]p + ML-39

ZI_

Pkmkdòtè

ks

pa/nl(lfa3:)

NOZ-3


3

9

?

5 ** *Z< :.:3 Z< :.:0

pa/nl(lfa3:)

MDK-


3

9

? ***Z< :.:3 Z< :.:0

pa/nl(lfa3:)

UKD-


3

9

?

5

* *Z< :.:0 Z< :.:0

(pa/nl)lfa3:

ML-39p1:

m]p + ML-39 ZI_ Pkmkdòtè:.0

3.:

3.0

9.:

* *Z< :.:0 Z< :.:0

pa/nl(lfa3:)

Ug D Y Y m e d C tmi e em t e


23/43

Ug` DoY cr` Y`qumrè dfr Cktmifey-nèmctè

Zcssmv` cke Cotmv` Mnnukmty

: 0 3: 30:

90

0:

10

3::

*Z< :.:5

Ecys pfst-ogcll`kaÒ01IL/4 nmo`

Z`ro`ktsurvmvcl

: 0 3: 30:

90

0:

10

3::

* Z< :.:9

Ecys pfst-mkdòtmfkICLI/o nmo`

Z`ro`ktsurvmv

cl

: 0 3: 30

:

90

0:

10

3::

3:1m]p + ML-39 Do Y

-/-

ZI_

3:1m]p + ML-39 Do Y

+/+

ks

*Z< :.:5

Ecys pfst-mkdòtmfkO01IL/4 nmo`

Z`ro`ktsurvmvcl

_ynifl ICLI/o Nmo` Arfup M_ / KN_ trcksd`r (Umn`) Qmle-typ` M_ pr`- cke pfst-ogcll ka` -95, :, +95, cke +57g fd mkdòtmfk

Qmle-typ` M_ pfst-ogcll`ka` +37g fd mkdòtmfk

Qmle-typ` KN_ -95, :, +95, cke +57g fd mkdòtmfk

M_2 Mnnuk` _`run8 KN_2 Kfrncl nfus` s`run

_ynifl O01IL/4 nmo` Arfup M_/KN_ trcksd`r (Umn`) DoY+/+ M_ pr`- cke pfst-ogcll ka` -95, :, +95, cke +57g fd mkd otmfk

DoY+/+ KN_ pr`- cke pfst-ogcll`ka -95, :, +95, cke +57g fd mkd otmfk

DoY-/- M_ pr`- cke pfst-ogcll ka` -95, :, +95, cke +57g fd mkd otmfk

DoY-/-

KN_ pr`- cke pfst-ogcll`ka -95, :, +95, cke +57g fd mkd otmfk

C.

I.

O.


24/43

Ug` Ofnpl`n`kt Ef`s Kft Zlcy Yfl` mk

Zrftòtmfk Eurmka Zcssmv`ly Urcksd`rrè

Mnnukmty

: 0 3: 30:

90

0:

10

3::

ks

Z> :.3?

Ecys pfst-mkdòtmfkO01IL/4 nmo`

Z`ro`ktsurv

mvcl

_ynifl O01IL/4 nmo` Arfup M_ / KN_ trcksd`r (Umn`)

O?+/+ M_ pr`- cke pfst-ogcll`ka` -95, :, +95, cke +57g fd mkdòtmfk

O?-/-

M_ pr`- cke pfst-ogcll`ka` -95, :, +95, cke +57g fd mkdòtmfk

O?+/+

KN_ pr`- cke pfst-ogcll`ka` -95, :, +95, cke +57g fd mkdòtmfk

O?-/-

KN_ pr`- cke pfst-ogcll`ka` -95, :, +95, cke +57g fd mkdòtmfk

Ug` OE5 cke OE7 U O`lls cr` Kft Y`qumrè dfr Zrftòtmv`


25/43

Ug` OE5 cke OE7 U O`lls cr` Kft Y`qumrè dfr Zrftòtmv`

Mnnukmty Ct Umn` fd m.k. Ogcll`ka` Qmtg ]. p`stms

Ecys

: 93

Tcoomkctmfk

Zrmnmka Iffstmka

Cktm-nOE5 AH3.5 / Cktm-nOE7 0?-4.19 tr`ctn`kt, m.p.

1: 1? 14 1= 7?

7: =:3. 3:1

m]p + ML-39

9. 3:1

m]p + ML-39

?. 3:1

m]p + ML-39

5. 3:1

m]p + ML-390. ZI_

3. 3:1

m]p + ML-39 (Yct MaA)

9. 3:1

m]p + ML-39 (Cktm-OE5)

?. 3:1


5. 3:1

m]p + ML-39 (Cktm-OE5 + Cktm-OE7)0. ZI_

]. p`stms OF=9ogcllcka`, 3::: ODP,m.k.

@ke fd survmvclfis`rvctmfk

C.

I.

: 0 3::

90

0:

10

3::

3:1

m]p + ML-39 (Yct MaA)

3:1


3:1 m]p + ML-39 (Cktm-OE7)

3:1

m]p + ML-39 (Cktm-OE5 + Cktm OE7)ZI_ (Pkvcoomkctè)

**Z> :.::?

Ecys pfst-ogcll`kaÌCLI/o nmo`

Z`ro`ktsurvmvcl


26/43

_unncry

Zrftòt cacmkst pkùnfkmo plcau`

ML-39 ms r`qumrè dfr mkeuomka prftòtmfk

Cktmifem`s clfk` ock prfvme` prftòtmfk wgmogms nèmctè tgrfuag DoY

U-o`lls cr` emsp`kscil` ct tg` tmn` fd mkdòtmfk

mk m]p + ML-39 vcoomkctè nmo`


27/43

_mkal`-Efs` Mktrckcscl

Zflyckgyerme` Kckfpcrtmol`s dfrTcoomk` E`lmv`ry

Nct`rmcl Zrfp`rtm`s Fd 0: 0: OZU@A OZG Kckfpcrtmol`s


28/43

Nct`rmcl Zrfp`rtm`s Fd 0:20: OZU@A2OZG Kckfpcrtmol`s


29/43

Tcoomkctmfk Y`amn`k


30/43

_mkal`-Efs` Kckfpcrtmol`s Mkeuoè Lfka-U rn

Zrftòtmfk Cacmkst Zkùnfkmo Zlcau`

4 wh

9? wh

Ug` Kckfpcrtmol`s Zr`v`ktè Oflfkmzctmfk fd ] p`stms cke


31/43

Ug` Kckfpcrtmol`s Zr`v`kt`e Oflfkmzctmfk fd ]. p`stms cke

Zulnfkcry Gmstfpctgflfay Cdt`r 9? w``hs fd Tcoomkctmfk

M.k. Tcoomkctmfk fd Kckfpcrtmol`s Zr`v`kt`e pctgflfay fd Fracks Zfst-ogcll`ka`


32/43

p p ay a a

_mkal` efs` Cenmkmstrctmfk fd Kckfpcrtmol`s Mkeuo`e Lfka


33/43

_mkal`-efs` Cenmkmstrctmfk fd Kckfpcrtmol`s Mkeuoè Lfka-

t`rn Cktmifey Umt`rs wmtg Gmag Cvmemty

_mkal` Efs` Kckfpcrtmol` Zrmnmka Zrftòtè


34/43

_mkal`-Efs` Kckfpcrtmol` Zrmnmka Zrft`ot`e

Nmo` cdt`r 3: Nfktgs


35/43

_unncry

Zrftòt cacmkst pkùnfkmo plcau`

Kckfpcrtmol`s mts`ld cot cs ck cebuvckt

Kckfpcrtmol`s ock cirfact` tg` k`è dfr

nultmpl` vcoomkctmfks cke prfvme` lfka-

eurctmfk mnnukmty


36/43

_mkal`-efs` Mktrckcscl Zfly (lcotmo Come)

Nmorfspg`r`s dfr Tcoomk` E`lmv`ry

_m l e : e e m g me


37/43

_mkal`-efs` rD3-Tp3: Lfceè ZLC Nmorfspg`r`s Zrfvme`s Lfka-

t`rn Zrftòtmfk Cacmkst Zkùnfkmo Zlcau`

: 0 3: 30:

90

0:

10

3::0 a DMT NZ + ML-39 NZ

1.0 a D3T NZ + ML-39 NZ

1.0 a D3T NZ

ZI_*

Z< :.:?

*Z< :.:3

Ecys pfst-mkdòtmfk

Z`ro`ktsurvmvcl

34 wh

ZLC Nm g m e e L Z m C m


38/43

ZLC Nmorfspg`r`s mkeuoè Lfka-t`rn Zrftòtmfk Cacmkst

Zkùnfkmo Zlcau` Ofrr`lct`s wmtg MaA9c cktmifem`s


39/43

Sufrun _`ksmka Ofnpfk`kts cs

Tcoomk`


40/43

M.k. E`lmv`ry fd Sufrun _`ksmka Ofnpfk`kts

Dcmlè tf Zrftòt Cacmkst Zkùnfkmo Zlcau`


41/43

Lmnmtctmfks

Mkcotmvctè Tcoomk`

Lmt`rctur`

Eurctmfk fd Mnnukmty6

KGZ trmcls kft ofkeuotè

D3/T Ca icsè Tcoomk`s

Efuit fv`r `ddmocoy mk

Guncks cs mt emdd`r`ktmclly

prftòt Oykfnflausncocqu`s cke Cdrmock

Ar``k Nfkh`ys

Ci l`v`ls ef`s kft

ofrr`lct`s wmtg prftòtmfk mk

KGZ


42/43

Mnprfv`n`kts cr` Zfssmil`

Mkcotmvctè Tcoomk`s

Fptmnmz` arfwtg ofkemtmfks

dfr ncxmnun `xpr`ssmfk fd

prftòtmv` cktma`ks

I`tt`r mkcotmvctmfk prfoèur`s

@kocpsulctmfk2

_cd`ty,

_mkal`-efs`,

Ncy cirfact` tg` r`qumr`n`ktfd cebuvckt iy `kocpsulctmka

gmag-efs` cke slfw r`l`cs`

D3/T Ca icsè Tcoomk`s

@kocpsulctmfk

Mkolusmfk fd kfv`l prftòtmv`

Cas / lfw efs` m]p


43/43

Ugckh yfu

Novel Vaccines for Defense Against Pneumonic Plague

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