Novel BioResorbable Vascular Platforms from India Dr. Vimal Someshwar Head – Interventional Radiology Kokilaben Dhirubhai Ambani Hospital & Research Institure, Mumbai (India) DEEP DIVE SESSION: Lower limb interventions (part II) – Femoropopliteal, drug-eluting devices, and new technologies Time – 11:55am to 12:01pm
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Novel BioResorbable Vascular Platforms from India · Novel BioResorbable Vascular Platforms from India Dr. Vimal Someshwar Head –Interventional Radiology Kokilaben Dhirubhai Ambani
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Novel BioResorbable Vascular Platforms from India
Dr. Vimal Someshwar
Head – Interventional RadiologyKokilaben Dhirubhai Ambani Hospital & Research Institure, Mumbai (India)
DEEP DIVE SESSION: Lower limb interventions (part II) –Femoropopliteal, drug-eluting devices, and new technologies
Time – 11:55am to 12:01pm
Disclosure
I do not have any potential conflict of interest.
Current Tx of PVD – Metal Stent Technologies in Abundance
Limitation of Existing Technologies
Across Clinical Spectrum
The Intuitive Desire in Stenting
STEMI
Bifurcation
CTOs
Renal
Carotid
Iliac
The Intuitive Promise of BRS
• Un-caging the vessel & restoration of vascular function
• Avoid, positive remodeling of the treated vessel/malapposition
• Avoid/resolve late strut fractures
• Facilitation of repeat treatment – Surgical or Angioplasty
• Restoration of normal vessel curvature
• In-stent restenosis. No need to leave behind more metal
• Plaque regression. Reduced neoatherosclerosis
• Reduced costs on the system
• Imminent surgical cases
• Early discontinuation of DAPT
• MRI/CT imaging follow-up. No hospital admissions.
Credence BtK – Sirolimus Eluting BRS
Size Matrix – 63 SKUs
Diameters – 2.50, 2.75, 3.00, 3.25, 3.50, 4.00, 4.50 mm
Lengths – 8, 13, 16, 19, 24, 29, 32, 37, 40 mm
Data on file.
PLLA Degradation vs. Luminal Support
Hydrolysis randomly cleaves amorphous tie
chains, leading to a decrease in molecular weight
without altering radial strength
When enough tie chains
are broken, the device
begins losing radial
strength
Hydrolysis occurs via random chain scission of the ester bond
Credence BtK – Degradation• Credence BtK is manufactured from a high molecular weight of 275-300 kDa of PLLA.
• Degradation is led by hydrolysis and entire scaffold is consumed over a period of 2-3 years.
125
150
175
200
225
250
275
300
325
0 1 2 3 4 5 6 7
Mo
l. W
t. (
Kg/
Mo
l)
Time, (months)
Loss in Molecular Weight
10
14
18
22
26
0 1 2 3 4 5 6 7
Rad
ial S
tren
gth
( N
)
Time, (months)
Loss in Radial Strength
40.0
45.0
50.0
55.0
60.0
65.0
70.0
75.0
0 1 2 3 4 5 6 7
Cry
stal
linit
y %
Time, (months)
Change in Crystallinity
• Hydrolysis occurs via random chain scission of the ester bond.