Novel amphiphilic nano-carrier based on PLA- polysaccharide for multi-drug encapsulation and controlled release. In Vitro evaluation A. Di Martino, P. Kucharczyk, Z. Kucekova, P. Humpolicek, V.Sedlarik Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, tr. T. Bati 5678, 76001 Zlin, Czech Republic
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Novel amphiphilic nanoparticles for controlled and sustained release
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Novel amphiphilic nano-carrier based on PLA-polysaccharide for multi-drug encapsulation and controlled release.
In Vitro evaluationA. Di Martino, P. Kucharczyk, Z. Kucekova, P. Humpolicek, V.Sedlarik
Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, tr. T. Bati 5678, 76001 Zlin, Czech Republic
«approaches, formulations, technologies for the targeted delivery and/or controlled release of therapeutic agents»
Safe Perform therapeutic function Convenient administration Simple to manufacture
- Zero order- Smart polymers and hydrogels- Peptide and protein- Nanoparticles
- Targeted delivery- Long term delivery systems - Minimal burst- In vitro-in vivo correlation (IVIVC)
Park. Journal of Controlled Release 190 (2014) 3–8
Nanoparticles as DDSWhy use Nanoparticles?
Dispersion or solid form Various morphologies – nanospheres, nanocapsules……. Drug(s) can be dissolved, entrapped, encapsulated or attached High Encapsulation and Loading Efficiency Protection Controlled and sustained release Side effects reduction