Non-Hodgkin’s lymphomas- definition and epidemiology 1. Definition: malignant disease of the lymphoid system, highly heterogeneous, both histologically and clinically. 2. Epidemiology: - annual incidence: 5-10 new cases per 100 000 persons, - age distribution: middle-age patients and the elderly, - males are affected more often than females (1.5:1.0).
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Non-Hodgkin’s lymphomas-definition and epidemiology 1. Definition: malignant disease of the lymphoid system, highly heterogeneous, both histologically.
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Non-Hodgkin’s lymphomas-definition and epidemiology
1. Definition: malignant disease of the lymphoid system, highly heterogeneous, both histologically and clinically.
2. Epidemiology:
- annual incidence: 5-10 new cases per 100 000 persons,
- age distribution: middle-age patients and the elderly,
- males are affected more often than females (1.5:1.0).
Non-Hodgkin’s lymphomas-Clinical features
1. Constitutional symptoms (fever, night sweats, weight loss)
REAL /Revised European-American Lymphoma/-WHO classification of
non-Hodgkin’s lymphomas
• Peripheral B cell lymphomas /continued/
- Follicle center cell lymphoma
- Plasma cell myeloma/plasmocytoma
- Diffuse large B cell lymphoma
- Burkitt’s lymphoma
- Splenic marginal zone B cell lymphoma
REAL /Revised European-American Lymphoma/-WHO classification of
non-Hodgkin’s lymphomas
• Precursor T cell lymphomas
- Acute lymphoblastic leukemia
-Lymphoblastic lymphoma
REAL /Revised European-American Lymphoma/-WHO classification of
non-Hodgkin’s lymphomas
• Peripheral T cell lymphomas– T cell chronic lymphocytic leukemia– T cell chronic prolymphocytic leukemia– Large granular lymphocyte leukemia /LGL/– Mycosis fungoides /Sézary syndrome– Peripheral T cell lymphomas, unspecified
REAL /Revised European-American Lymphoma/-WHO classification of
non-Hodgkin’s lymphomas
• Peripheral T cell lymphomas/continued/– Angioimmunoblastic T cell lymphoma– Angiocentric lymphoma– Intestinal T cell lymphoma– Adult T cell lymphoma/leukemia– Anaplastic large cell lymphoma
Very aggressive non-Hodgkin’s lymphomas
• B-, T-cell acute lymphoblastic leukemia
• B-, T-cell lymphoblastic lymphomas
• Burkitt’s lymphoma
• Adult T cell lymphoma/leukemia
High risk aggressive non-Hodgkin’s lymphomas
1. Age abowe 60 years.
2. Disease stage III and IV.
3. Extranodal involvement of more than 1 site.
4. Serum LDH concentration >1 x normal.
5. Performance status < 80%.
Treatment results of aggressive non-Hodgkin’s lymphomas according to the risk group