Pietro Favia (Sci. Resp.) Eloisa Sardella, Roberto Gristina, Giorgio Senesi, Loredana Detomaso, Riccardo d’Agostino Department of Chemistry, University of Bari, Institute of Inorg. Methods and Plasmas (IMIP) CNR Via Orabona 4, 70126, Bari, Italy Ph +39 080 5443430, fax +39 080 5443431 e-mail: [email protected]Non equilibrium plasma processes for biomedical applications and nanotechnology FIRB program “NANOBIO” Ravello, December 5-7, 2002 kick off meeting
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Non equilibrium plasma processes for biomedical applications … · 2019. 6. 18. · e-mail: [email protected] Non equilibrium plasma processes ... Prof. Riccardo d'AGOSTINO
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Pietro Favia (Sci. Resp.) Eloisa Sardella, Roberto Gristina, Giorgio Senesi,
Loredana Detomaso, Riccardo d’Agostino
Department of Chemistry, University of Bari, Institute of Inorg. Methods and Plasmas (IMIP) CNR
A small, privately-owned company, operates in the field of biomedical devicesand materials. The expertise includes study, characterization and modificationof surface properties of medical devices and materials, and their chemico-physical and biological characterization. Nobil Bio Ricerche operates on a contract-service basis for a number of biomedical companies.Contract activities include:
- studies aimed to improve surface properties of existing devices or to developnew surface modification treatments.
- characterization of composition/properties of medical devices and materials- custom surface treatments.
Typical works include surface modification of IOLs, prevention of post-surgicaladhesion to surgical meshes, surface modification of blood filters, immunologicplates, coronary catheters and stents.The facilities include a chemico-physical lab equipped with SEM, AFM, different spectroscopies, and two plasma reactors ((micro-wave and radio-frequency) in a class 10,000 clean room. Biological tests are performed in a microbiological lab, that allows growth culture of mammalian and bacterialcells, and the study of their interactions with medical materials and devices.
PE-CVD, Treatment, Etching processesContinuous and modulated processesPlasma and surface diagnosticsPlasma treatments of powdersRoll-to roll reactorPlasma-reactor design
Hydrophilic-hydrophobic surfacesImmobilization of biomoleculesCell-adhesive surfacesCell-repulsive (non fouling) surfacesMicro-patterning of polymersBacterial-resistant coatingsNano-rough functional surfacesConformal thin coatings on nano-structures
Permanently wettable teflonPlasma treatments inside small caliber tubesSuper-hydrophobic surfacesGas barrier coatingsImproving metal adhesion on polymers
“PRODUCTS”from
UNIBAfor the
biomedical field
Ageing trends for N-grafted PTFE with ( ) and without ( ) H2 plasma pre-treatment
0
26
52
78
104
130
0 10 20 30 40 50 60 70Storage Time (days)
θE (
degr
ees)
θE Untreated PTFE
Control of thehydrophobic recovery
in plasma-treated polymers
Pre-treatments(e.g., H2, Ar, …)
may be utilized to cross-linkthe surface of the polymer
before the grafting
HYDROPHILICPOLYMERS
IMMOBILIZED HEPARINE FOR BLOOD-COMPATIBLE
SURFACES
Non activated rabbit plateletsonto HyalS3.5 immobilizedon plasma-processed PE