Nicotinamide Riboside NiaCel NiaCel-250 · 2017. 12. 18. · *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose,

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Nicotinamide riboside, the active ingredient in NiaCel, is a nutritional precursor that increases NAD+ levels.* NAD+ is a catalyst for mitochondrial energy production and a sirtuin activator that promotes healthy aging.*

Helps increase the body's ability to produce energy* Supports cognitive function and provides neuroprotection* Supports healthy metabolic function, including insulin sensitivity and support for fatty liver* Promotes healthy aging through sirtuin activation*

Energy, Metabolism, and Neuroprotection*

P R AC T I T I O N E R R E F E R E N C E NiaCel® | NiaCel-250® Nicotinamide Riboside

ATP

Sirtuins PGC1-α

NAD+NiaCel (NR)

Promotes sirtuin function

Activate

GeneratesATP

Mitochondrial energyproduction

Mitochondrial biogenesis

Healthy aging

Nicotinamide riboside, the direct precursor of NAD+, promotes ATP generation and sirtuin activity, which synergistically supports energy production and healthy aging.*

NOWAVAILABLE WITH

2X the amount

of nicotinamideriboside

The Potential E�ects ofNicotinamide Riboside on Metabolism*

Increased SIRT1inhibits hepatic glucose formation in obesity*

limits hepatic lipid accumulation in the presence of elevated blood sugar*

promotes the production of good (HDL) cholesterol*

supports insulin release, improving overall glucose tolerance*

enhances leptin sensitivity*

Increased SIRT3

inhibits lipid accumulation in the liver*

increases mitochondrial biogenesis in skeletal muscle*

increases thermogenesis in brown fat stores*

NR can increase NAD+, which can upregulate SIRT1 and SIRT3.*

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Healthy aging

NAD+/NADH NAD+/NADH

SenescenceSurvival DNA RepairMetabolism

Sirtuins

Sirtuin Activity

NAD+

NAD+ upregulates sirtuin activity to improvemetabolism and support healthy aging.*

NiaCel®/NiaCel-250® promotes healthyaging through sirtuin activation*

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

The purpose of this Practitioner Reference is to provide current technical information to health-care practitioners. Practitioner References should not be distributed to patients.

The active ingredient in NiaCel® and NiaCel-250®, nicotinamide riboside, is backed by over 10 years of

scienti�c research:

R E F E R E N C E S

1. Canto C, Houtkooper R, Pirinen E, et al. The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab 2012;15:838-847.

2. Gong B, Pan Y, Vempati P, et al. Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models. Neurobiol Aging 2013;34:1581-1588.

3. Chi Y, Sauve A. Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with e�ects on energy metabolism and neuroprotection. Curr Opin Clin Nutr Metab Care 2013;16:657-661.

4. Lu S, Kato M, Lin S. Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae. J Biol Chem 2009;284:17110-17119.

5. Bogan K, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu Rev Nutr 2008;28:115-130.

6. Yang T, Sauve A. NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity. AAPS J 2006;8:E632-E643.

Your partner in managing your patients’ health, Thorne Research utilizes the latest scientific findings and o�ers the purest products available on the market, free of binders, unnecessary fillers, and flowing agents that can inhibit your patients’ ability to absorb essential nutrients... experience the Purity-to-Healing Relationship with Thorne Research.

P.O. BOX 25, DOVER, IDAHO 83825 TOLL-FREE 800.228.1966 EMAIL [email protected] WWW.THORNE.COM NiaCel-NiaCel250-PRACT-SSV3-4-21-16

SP64260 Vegetarian Capsules

SP64360 Vegetarian Capsules

Nicotinamide Riboside Chloride† 125 mg *

S u p p l e m e n t F a c t sServing Size: One Capsule

Each Capsule Contains: % DV

Daily Value (DV)

Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Leucine, Silicon Dioxide.Suggested Use: Take 1 capsule two times daily or as recommended by your health-care practitioner.

If pregnant, consult your health-care practitioner before using this product.

†This product contains ChromaDex Inc.’s proprietary Nicotinamide Riboside ingredient, Niagen®. Niagen is a registered trademark of ChromaDex, Inc.

NiaCel®

NiaCel-250®

Nicotinamide Riboside Chloride† 250 mg *

S u p p l e m e n t F a c t sServing Size: One Capsule

Each Capsule Contains: % DV

Daily Value (DV)

Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Leucine, Silicon Dioxide.

Suggested Use: Take 1 capsule two times daily or as recommended by your health-care practitioner.

If pregnant, consult your health-care practitioner before using this product.

†This product contains ChromaDex Inc.’s proprietary Nicotinamide Riboside ingredient, Niagen®. Niagen is a registered trademark of ChromaDex, Inc. Patent: See ChromaDexPatents.com.

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Patent: See ChromaDexPatents.com.

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