Integrated Care Pathway for Adult Deceased Organ and Tissue Donation Specialist Nurse - Organ Donation Pager 07659 183664 NHS Highland November 2013 1 of 46 NHS HIGHLAND ORGAN DONATION PATHWAY NOVEMBER 2013 Ownership of Organ Donation Committee NHS Highland Responsibility of Clinical Lead in Organ Donation Reviewed Annually
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NHS HIGHLAND ORGAN DONATION PATHWAY€¦ · Deceased Organ and Tissue Donation 24 hr referral service 07659 183664 Identify potential organ donors as early as possible . Integrated
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Integrated Care Pathway for Adult Deceased Organ and Tissue Donation Specialist Nurse - Organ Donation Pager 07659 183664 NHS Highland November 2013
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NHS HIGHLAND
ORGAN DONATION
PATHWAY
NOVEMBER 2013
Ownership of Organ Donation Committee
NHS Highland
Responsibility of Clinical Lead in Organ
Donation
Reviewed Annually
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Early identification of potential donors Referral criteria as per NICE guidance (2011)2 The NICE referral criteria recognise that a proportion of the patients who are identified by these clinical triggers will survive.
2
Contact between the clinical team treating the potential donor and the SN-OD before the decision has been made to withdraw life-sustaining treatment is ethically acceptable.
3
HOSPITAL ADDRESSOGRAPH or Surname First Name Date of Birth CHI Number
Objective of Care: • To ensure all families are given the opportunity to consider organ and/or tissue donation where
appropriate, in line with GMC (2011) guidance.1
• To provide clinical guidelines for the management of the potential deceased organ and/or tissue donor.
Base identification on either of the following criteria, while recognising that clinical situations vary.
Whichever is the earlier, either:
• use defined clinical trigger factors in patients who have had a catastrophic brain injury: - the absence of one or more cranial nerve
reflexes (eg one fixed pupil) and - a Glasgow Coma Scale score of 4 or less
that is not explained by sedation unless there is a clear reason why the above clinical triggers are not met and/or
• a decision is made to perform brainstem death tests.
The intention to withdraw life-sustaining treatment in patients with a life-threatening or life-limiting condition which will, or is expected to, result in circulatory death.
Initiate discussions with the specialist nurse for organ donation at the time the above criteria are met. 2244 hhrr rreeffeerrrraall sseerrvviiccee 0077665599 118833666644
Ensure this is discussed with the consultant in charge.
Clinically stabilise the patient in an appropriate critical care setting while the assessment for donation is performed.
Provided that delay is in the patient’s overall best interests, life-sustaining treatments should not be withdrawn or limited until the patient’s wishes around organ donation
have been explored and the clinical potential for the patient to donate has been assessed in accordance with legal4 and professional1,7 guidance.
Integrated Care Pathway for the Referral and Consideration of Adult
Identify potential organ donors as early as possible
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Patient Name: NHS Number:
Supporting Documentation and Evidence Based Best Practice used within this Care Pathway: 1. GMC (2010) “Treatment and care towards the end of life.”
www.gmc-uk.org/guidance/ethical_guidance/end_of_life_care.asp 2. NICE (2011) “Organ Donation for Transplantation” http://guidance.nice.org.uk/CG135 3. UK DEC (2011) “An Ethical Framework for Controlled Donation after Circulatory Death”
4. Department of Health (2009) “Legal Issues Relevant to Non-heartbeating Organ Donation.” www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_108825
5. Academy of Medical Royal Colleges (2008) “A Code of Practice for the Diagnosis and Confirmation of Death” http://www.aomrc.org.uk/aomrc/admin/reports/docs/DofD-final.pdf
6. HTA (2009) “Code of practice 2 - Donation of solid organs for transplantation” http://www.hta.gov.uk/legislationpoliciesandcodesofpractice/codesofpractice/code2donationoforgans.cfm
7. DCD consensus meeting report, available from www.ics.ac.uk/intensive_care_professional/standards_and_guidelines/dcd
8. Report from the Organ Donation Taskforce (2008) “Organs for Transplant” http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_082122
9. Map of Medicine www.mapofmedicine.com
10. NHSBT (2011) “Working Draft: Guideline for the Management of the Organ Donor Following Brain Death.”
Guidance and Accountability Notes for Using this Care Pathway:
• This Care Pathway must be read in association with any local guidelines or policies. All drugs are the responsibility of the prescribing physician and must be checked against any local pharmacy guidance.
• This Care Pathway forms part of the patient’s record of care and is completed in addition to all other nursing and medical documentation. This Care Pathway should be stored within the patient’s medical notes.
• Care Pathways are heavily informed by clinical knowledge and expertise. They are designed to assist clinical judgement, not replace it.
• Patients fulfilling the NICE (2011) ‘Early identification of potential donors’ referral criteria as given at the front of this document, should be placed on this Care Pathway.
• If a care activity is not fully completed please give rationale in the Multi-Disciplinary Team (MDT) notes at the back of the document.
• This Care Pathway will be audited by the Specialist Nurse for Organ Donation (SN-OD) within the Trust.
All staff recording in this document must complete the signature box below so that initials or signature only are needed throughout the Pathway.
Print First Name and Surname
Role Signature Initial Pager / Bleep, Location/Extension
Integrated Care Pathway for Adult Deceased Organ and Tissue Donation Specialist Nurse - Organ Donation Pager 07659 183664 NHS Highland November 2013
• Discuss with SN-OD via 24 hour pager 07659183664 SN-OD spoken to: …………………………………….
– Ensure you have patient notes, including: NHS number/hospital number, date of birth, postcode, blood results and latest observations.
– If appropriate the SN-OD will check the Organ
Donation Register and advise on the patient’s status (or call 01179 757580)
– Member of SN-OD team will attend if agreed.
Patient Name: NHS Number:
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Please follow the appropriate Potential Donor Pathway below, as identified by the NICE ‘Early identification of potential donors’ referral criteria and
as agreed by the SN-OD and Consultant (or most senior doctor if delegated).
Date Time
Dr / Nurse / SN-OD
2
Donation after
Brain Death (DBD)
Pathway A decision is made to perform brainstem death tests (BSD).
Go to page 5
Donation after
Circulatory Death (DCD)
Pathway The intention to withdraw life-sustaining treatment in patients with a life-threatening or life-limiting condition which will, or is expected to, result in circulatory death.
Go to page 14
Referral Only
Following NICE defined clinical
trigger factors in patients who have had a catastrophic brain injury:
• the absence of one or more cranial nerve reflexes and
• a Glasgow Coma Scale score of 4 or less that is not explained by sedation
The SN-OD will note the referral. There is no further use of this Document until a decision is made to perform brainstem death tests OR it is the intention to withdraw life-sustaining treatment in patients with a life-threatening or life-limiting condition which will, or is expected to, result in circulatory death. If this situation is reached then ensure the SN-OD is aware and commence the appropriate Potential Donor Pathway.
Patient Name: NHS Number:
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Patient Name: NHS Number:
Donation after Brain Death (DBD) Pathway
Date and
Time Persons
Responsible
Activity Number
Activity
Signature/ Initials
Date
Time Dr / Nurse
DBD 1
Referral Check
• A decision is made to perform brainstem death (BSD) tests.
• Check SN-OD has been notified. – Member of SN-OD team will attend unit.
• If medically unsuitable for DBD, corneal donation may still be possible. Please contact the SN-OD on page 07659 183664. See Tissue Only Donation Pathway (page 20). SN-OD should still attend the unit for BSD testing.
Date Time
Dr / Nurse
DBD 2
Normal homeostasis is maintained until BSD testing is appropriate
• Maintain mandatory and protective ventilation (Tidal Volume (VT) 6-8mls/kg), PaCO2 5.0-6.5 Kpa, and PaO2 8-14 Kpa or SaO2 >95% on minimal FiO2.
• Maintain Mean Arterial Pressure (MAP) 60-80 mmHg. Consider insertion of central line and start inotropes. If central access is deemed inappropriate, start peripheral IV Metaraminol infusion.
• Aim Na 130-155mmol/L and monitor for signs of Diabetes Insipidis (DI): Prescribe DDAVP (1-4 micrograms) and consider IV fluids (eg Compound Sodium Lactate (Hartmann’s) solution, 5% glucose).
– If there are any plans to carry out ancillary investigations or drug levels,5 this should be explored early.
Date Time
Dr / Nurse
DBD 3
Discussion with family regarding plan for BSD testing.
• Doctor, Nurse and SN-OD plan the discussion with the family in advance and prepare for BSD tests.
• SN-OD (if present) introduces self to family where appropriate and agreed with clinician.
– Discussion of donation is not initiated at this time unless initiated by the family.
• BSD testing explained to family by Doctor and SN-OD.
• Family offered the option to witness BSD testing if appropriate.
• If BSD tests are not able to be performed, document the reasons.
– If life sustaining treatment is to be withdrawn, consider Donation after Circulatory Death (DCD) and
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start DCD pathway (page 14).
Patient Name: NHS Number:
Date
Time Dr / Nurse /
SN-OD
DBD 4
Preparation for BSD testing Refer to BSD testing form (appendix 1) • Prepare Equipment – Pen torch – Gauze/cotton wool – 50ml bladder syringe – Ice cold water (100mls) – Otoscope with ear pieces – Yankauer sucker – Suction catheter + oxygen tubing / waters circuit (if
PEEP required) – Blood gas syringes (pre and post apnoea test x2) Prepare the Patient • Pre-oxygenate on 100% FiO2 • Check Arterial Blood Gas (ABG) and adjust ventilator
settings to ensure PaCO2 >6 Kpa and pH < 7.4
Date Time
Dr / Nurse / SN-OD
DBD 5
• 1st BSD test undertaken
Date
Time Dr / Nurse /
SN-OD
DBD 6
1st Test Consistent with BSD? Yes • Nurse, Doctor and SN-OD inform family the outcome
of the 1st BSD test, as per plan.
• Family given time to accept the result. – Organ donation may be discussed at this stage if
deemed appropriate (see below). No – If the plan is to retest at a later time, it is advised to
start a new Deceased Donation Pathway. – If retesting not planned, consider Donation after
Circulatory Death (DCD) and start DCD Pathway (page 14).
Date
Time Dr / Nurse /
SN-OD
DBD 7
• 2nd BSD test undertaken
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Patient Name: NHS Number:
Date
Time Dr / Nurse /
SN-OD
DBD 8
2nd Test Consistent with BSD? Yes • Nurse, Doctor and SN-OD inform family the outcome
of the BSD test, and this means the patient has died. • Legal time of death is when the first test indicates
death due to the absence of brain-stem function but is pronounced only after the second test.
Legal Time of Death (conclusion first test): Date.……………………………Time.………………………
• Family given time to accept the diagnosis.
• When it is clear that the family have understood that death has occurred, Doctor or SN-OD will discuss the possibility of donation (see below).
No – If the plan is to retest at a later time, it is advised to
start a new Deceased Donation Pathway. – If retesting not planned, consider Donation after
Circulatory Death (DCD) and start DCD Pathway (page 14).
Absolute Contraindications to Deceased Organ Donation
A. Patients who have a suspected diagnosis of CJD B. Patients who are known to have HIV (in some cases donation may still be considered)
Date Time
Dr / Nurse / SN-OD
DBD 9
Approach regarding organ donation Prior to approach • The SN-OD will check the Organ Donation Register
and advise on the patient’s status, if not done so already.
• A multi-disciplinary team should plan the approach. This may include local faith representative(s) where relevant.
• Clarify any coronial / legal or safeguarding issues.
• Identify key family members.
• Identify a setting suitable for private and compassionate discussion.
The approach • Doctor, Nurse and SN-OD approach the family as
planned.
• Family given information on donation and allowed the opportunity to ask questions.
• SN-OD answers these and then leaves the family to discuss donation privately.
• SN-OD remains available to provide support to the
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PLEASE CONTINUE ON ONE OF THE FOLLOWING PATHWAYS Date Time
SN-OD
DBD 11
Proceeding with DBD
Continue Pathway
Tissue Only Donation Pathway
Go to page 20
No Donation Pathway
Go to page 21
staff.
Date Time
Dr / Nurse / SN-OD
DBD 10
Outcome of family decision
• SN-OD and Nurse return to family (as agreed) to answer further questions and hear outcome of family decision.
• Document outcome
• If patient’s next of kin (person ranking highest in the qualifying relationship as given by the HTA 2004) agree to proceed with organ donation, SN-OD will take consent and undertake patient assessment with patients family answering any outstanding questions.
Patient Name: NHS Number:
Date Time
Dr / Nurse / SN-OD
DBD 12
Consent and formal clarification of any outstanding coronial / legal or safeguarding issues.
• Further discussion with family, Nurse and SN-OD
• Consent and patient assessment paperwork completed.
• Dr and/or SN-OD will seek approval from Procurator Fiscal, if required and not previously clarified, and document any discussion in the medical notes.
Date Time
Dr / Nurse / SN-OD
DBD 13
Initial investigations SN-OD will advise on the quantity and blood bottles required. To assess organ function
• Send bloods for biochemistry ( amylase, magnesium, Gamma GT, AST and glucose results can be made available if specifically requested.)
• Send bloods for FBC and clotting
• Perform arterial blood gas (ABG). Firstly on current FiO2, then pre-oxygenate on 100% FiO2 for 20 minutes and repeat ABG. Repeat 2 hourly and give results to SN-OD. ABG should be performed with 5cm H2O PEEP (if tolerated).
To identify suitable recipients (hard copy is required for safety)
• Request a Group and save (if not already available). Ask SN-OD if cross match is required. Additional blood
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Proceed To Donor Management
samples for SN-OD, who will advise on quantity and will request and arrange transport to send to tissue typing and virology, (if not already taken).
Patient Name: NHS Number:
Date Time
Dr / Nurse / SN-OD
DBD 14
To assess cardiac and/or respiratory function (SN-OD will advise if not required)
• Request CXR and document findings. • ECG performed post BSD confirmation and reported
by a senior clinician. • ECHO is normally performed post BSD confirmation
and findings documented. In Raigmore the Cardiologists are usually agreeable to theses requests. Echo technician to clarify with SN-OD which measurements are required.
Date
Time SN-OD
DBD 15
SN-OD Activities
• Detailed physical examination completed by SN-OD.
• Patient registered with ODT duty office as a donor.
• Organ/tissue matching commenced (minimum 4 hours, often 6+ hours)
– Positive virology may limit or exclude donation, SN-OD to advise.
• External Organ Retrieval Teams organised plus Local Theatres and Anaesthetist.
– SN-OD to keep family informed and supported.
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Summary of Donor Management Targets • PaCO2 5.0-6.5 kpa
• PaO2 8-14 Kpa or SpO2 >95% on minimal FiO2
• MAP 60-80mmHg
• CVP 8-12mmHg
• Urine output 0.5-2.5mls/kg/hr
• BM 4-9 mmols/L
• Temperature 35.5-37.5 oC
Contact SN-OD if you need any advice or support
Patient Name: NHS Number:
Date Time
Dr / Nurse / SN-OD
DBD 16
Ventilation Goals To prevent aspiration and maintain respiratory function
• Stop NG feed, aspirate NG tube and leave on free drainage.
• Nurse in semi-recumbent position.
• Regular turning (minimum 4 hourly).
• Continue with chest physiotherapy (Physiotherapist or Dr to perform recruitment manoeuvre if appropriate and repeat as indicated).
• Regular suction (if purulent secretions send sample for MC&S)
• Protective ventilation (VT 6-8mls/kg)
• Maintain PaCO2 5.0-6.5 kpa
• Maintain PaO2 8-14 Kpa or SaO2 >95% on minimal FiO2
• Continue DVT prophylaxis
• Review current prescribed medication
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Summary of Donor Management Targets • PaCO2 5.0-6.5 kpa
• PaO2 8-14 Kpa or SpO2 >95% on minimal FiO2
• MAP 60-80mmHg
• CVP 8-12mmHg
• Urine output 0.5-2.5mls/kg/hr
• BM 4-9 mmols/L
• Temperature 35.5-37.5 oC
Contact SN-OD if you need any advice or support
Patient Name: NHS Number:
Date Time
Dr / Nurse / SN-OD
DBD 17
Cardiovascular Goals The focus of these therapies is to maintain general organ perfusion, rather than a high MAP and CPP required for the treatment of brain injury. This change of goal often results in a rapid reduction in cardiovascular support.
To avoid pulmonary oedema and maintain cardiovascular stability
• Stop crystalloid infusion.
• If CVC and arterial line are not insitu please insert RIJ CVC and left radial arterial line.
High dose catecholamine infusions (particularly noradrenaline) are associated with poor heart function post transplant
• Wean noradrenaline / other inotropes to achieve MAP 60-80mmHg. If unable to reduce commence vasopressin (see below). If no response on vasopressin at 10mls/hr speak to SN-OD
• If MAP >90mmHg prescribe and titrate Glyceryl Trinitrate infusion.
• Swan and cardiac output measurements only if monitoring already insitu.
If cardiothoracic organs are being donated, to improve cardiac stability and function consider the following, as advised by recipient team and as per local agreements
• Prescribe and commence T3 (Tri-iodothyronine) 20 micrograms made up to 20mls with water for injection (1microgram/ml). Give initial bolus of 4 micrograms (4mls) followed by an infusion of 3 micrograms/hr (3mls/hr).
• Prescribe and commence Vasopressin (if blood pressure labile or if other inotropes are in progress). Vasopressin (Pitipressin) 20units made up to 40mls with 5% glucose = 0.5 units/ml. Give an initial bolus of 1 unit (2mls) followed by an infusion of 0.5 unit/hr (1ml/hr) up to a maximum of 20 units/hr (10 mls/hr).
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Summary of Donor Management Targets • PaCO2 5.0-6.5 kpa
• PaO2 8-14 Kpa or SpO2 >95% on minimal FiO2
• MAP 60-80mmHg
• CVP 8-12mmHg
• Urine output 0.5-2.5mls/kg/hr
• BM 4-9 mmols/L
• Temperature 35.5-37.5 oC
Contact SN-OD if you need any advice or support
Patient Name: NHS Number:
Date Time
Dr / Nurse / SN-OD
DBD 18
Renal, Fluid, Endocrine and Electrolyte Goals Maintain good urine output for the kidneys
• Urine output 0.5-2.5mls/kg/hr DI occurs commonly in BSD resulting in polyuria, which may result in fluid loss and electrolyte disturbances and hypovolemia.
• If showing signs of DI (polyuria) treat with DDAVP 1-4 microgram bolus (repeated as required). Monitor and correct Na, consider 5% glucose.
Fluid overload makes lung transplantation unlikely
• Fluid balance should be maintained using colloid bolus as indicated (monitoring CVP, urine output, fluid balance and BP)
• If using 5% glucose monitor for hyperglycaemia. Endocrine goals
• Prescribe Insulin (Human Actrapid). Commence insulin sliding scale, as per local policy, to maintain blood sugar between 4-9 mmols/L.
• Prescribe and administer IV Methylprednisolone 15mg/kg (Add to 100ml Saline 0.9% and infuse over 1hour).
Electrolyte goals Na >150mmols/l can cause hepatic graft dysfunction
• Na 135-150mmols/L • K 4- 5.5 mmols/L
• Other electrolytes – Mg > 0.8 mmols/L – Corrected Ca 2.0-2.6mmol/L – Phosphate >0.8mmol/L
Temperature goals
• Temperature 35.5-37.5 (actively cool or warm as
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appropriate)
Patient Name: NHS Number:
Date Time
Nurse / SN-OD
DBD 19
Mementos • Mementos (handprints, and locks of hair offered). If
requested these are facilitated by the Nurse and SN-OD at an appropriate time.
Date Time
Nurse / SN-OD
DBD 20
Organ Retrieval
• Organ retrieval operation
• Last offices performed
• Family are given the option to return to see the patient following the retrieval and participate in last offices.
Date Time
Nurse / SN-OD
DBD 21
Final Activities • Patient transferred to the mortuary.
• If tissues to be donated this will be facilitated in the mortuary as agreed.
• SN-OD will provide donation outcome information to staff and family as agreed.
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Patient Name: NHS Number:
Donation after Circulatory Death (DCD) Pathway
Date and
Time Persons
Responsible
Activity Number
Activity
Signature/ Initials
Date
Time Dr / Nurse
DCD 1
The Withdrawal Decision
• The intention is to withdraw life-sustaining treatment in a patient with a life-threatening or life-limiting condition, which will, or is expected to, result in imminent circulatory death.
• Two senior doctors, who should both have been registered for at least five years, and at least one of whom should be a consultant, should verify that further active treatment is no longer of overall benefit to the patient.
• Do not resuscitate order in place.
• Ensure referring team informed of withdrawal of life sustaining treatment decision and referral for potential DCD.
• Doctor has documented the above clearly in the patient’s medical notes, including the planned method of withdrawal.
Date Time
Dr / Nurse / SN-OD
DCD 2
Referral Check • Check SN-OD has been notified.
• SN-OD will assess and advise on medical suitability for DCD
• If suitable, SN-OD will attend.
• If medically unsuitable for DCD, corneal donation may still be possible. Please contact the SN-OD 07659 183664. See Tissue Only Donation Pathway (page 20).
Absolute Contraindications to Deceased Organ Donation
A. Patients who have a suspected diagnosis of CJD B. Patients who are known to have HIV (in some cases donation may still be considered)
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Patient Name: NHS Number:
Date Time
Dr / Nurse / SN-OD
DCD 3
Family discussion regarding withdrawal decision
• SN-OD (if present) introduced to family where appropriate and agreed with clinician
• Doctor undertakes full explanation to the family of why the multidisciplinary team believe the withdrawal of life sustaining treatment is in the overall benefit of the patient.
• Doctor undertakes explanation of the withdrawal process.
• If family is accepting and in agreement with the withdrawal of life sustaining treatment an approach regarding DCD may be made at this time (see below).
Date
Time Dr / Nurse /
SN-OD
DCD 4
Approach regarding organ donation Prior to approach
(these activities are best explored before Activity Number DCD 3) • The SN-OD will check the Organ Donation Register
and advise on the patient’s status, if not done so already.
• A multi-disciplinary team should plan the approach. This may include local faith representative(s) where relevant.
• Clarify any Procurator Fiscal / legal or safeguarding issues.
• Identify key family members.
• Identify a setting suitable for private and compassionate discussion.
The approach • Doctor, Nurse and SN-OD approach the family as
planned.
• Family given information on donation and allowed the opportunity to ask questions.
• SN-OD answers these and then leaves the family to discuss donation privately.
• SN-OD remains available to provide support to the staff.
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PLEASE CONTINUE ON ONE OF THE FOLLOWING PATHWAYS Date
Time SN-OD
DCD 6
Proceeding with DCD
Continue Pathway
Tissue Only Donation Pathway
Go to page 20
No Donation Pathway
Go to page 21
Date Time
Dr / Nurse / SN-OD
DCD 5
Outcome of family decision • SN-OD and Nurse return to family (as agreed) to
answer further questions and hear outcome of family decision.
• Document outcome
• If patient’s next of kin (person ranking highest in the qualifying relationship as given by the HTA 2004) agree to proceed with organ donation, SN-OD will take consent and undertake patient assessment with patients family answering any outstanding questions.
Patient Name: NHS Number:
Date Time
Dr / Nurse / SN-OD
DCD 7
Consent and formal clarification of any outstanding coronial / legal or safeguarding issues.
• Further discussion with family, Nurse and SN-OD
• Consent and patient assessment paperwork completed.
• Dr and/or SN-OD will seek approval from the Procurator Fiscal, if required and not previously clarified, and document any discussion in the medical notes.
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Patient Name: NHS Number:
Date Time
Dr / Nurse / SN-OD
DCD 8
New care plan and treatment goals
• The patient will continue to be cared for as per local end of life guidelines and in accordance with GMC guidance.1
• The end of life care plan for a patient on the DCD pathway should include a plan for how to proceed if the time to death following treatment withdrawal is incompatible with successful transplantation, and families and all staff (donor and retrieval teams) should be fully informed.
• SN-OD and Consultant agree physiologic goals and limits of pre morbid interventions (e.g. inotropes & fluid for BP management, FiO2).
Goals and Limits agreed: ………………………………………………………………… A useful guide to timelines and responsibilities of the team can be seen in appendix 2.
• Any request for further investigations on behalf of the retrieval team (e.g. ABG on 100% O2, CXR) requires consultant approval (or most senior medical doctor if delegated) and possible further discussion with family.
• Bloods for tissue typing, virology and to accompany organs are taken (if not already taken). SN-OD will advise on the quantity and blood bottles required.
Date Time
SN-OD
DCD 9
SN-OD Activities • Detailed physical examination completed by SN-OD.
• Patient registered with ODT duty office as a donor.
• Organ/tissue matching commenced (minimum 4 hours, often 6+ hours)
– Positive virology may limit or exclude donation, SN-OD to advise.
• External Organ Retrieval Teams organised plus Local Theatres and Anaesthetist.
• If consent has been given for lung donation, discuss process of retrieval with Consultant and Anaesthetist. Process to be followed according to guideline – appendix 3.
• SN-OD to keep family informed and supported. – Family are kept informed of provisional timings to
enable them to prepare for treatment withdrawal.
Date Time
Dr / Nurse /
DCD 10
Mementos • Mementos (handprints, and locks of hair offered). If
requested these are facilitated by the Nurse and SN-
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SN-OD OD at an appropriate time.
Date Time
Dr / Nurse / SN-OD
DCD 11
Withdrawal • When retrieval team have arrived and are set up in
theatre, the nominated medical personnel will prepare the family for treatment withdrawal.
• Comfort measures to be administered or continued as per usual practice, local end of life guidelines and in accordance with GMC guidance.1
• Treatment withdrawn as per agreed plan. Time: Date.……………………………Time.………………………
• SN-OD will notify retrieval team of exact time of withdrawal.
• Family kept updated and supported throughout by the SN-OD and bedside nurse.
• SN-OD will make discrete observations of patient monitors.
• Family will be informed when asystole occurs to allow them enough time for family goodbyes.
Patient Name: NHS Number:
Date Time
Dr / Nurse / SN-OD
DCD 12
Confirmation of Death • Death will be diagnosed following a minimum period
of 5 minutes of monitored asystole and in accordance to the AoMRC Code of Practice5 (see appendix 4 for confirmation form).
Time of Death: Date.……………………………Time.……………………… – Prolonged time from withdrawal to asystole may
preclude solid organ donation. SN-OD will advise on this.
• Following confirmation of death, the patient may immediately be transferred to theatre, with the agreement of the family. The family may wish for an extension of this period for a further five minutes. Beyond this, it is unlikely that the donation will proceed.
Date Time
Nurse / SN-OD
DCD 13
Organ Retrieval • Organ retrieval operation
• After organ retrieval, last offices should performed according to standard nursing practice.
• Family are given the option to return to see the
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patient following the retrieval and participate in last offices.
Patient Name: NHS Number:
Date Time
Dr / Nurse / SN-OD
DCD 14
If the time to death following treatment withdrawal is incompatible with successful transplantation
• If the patient is to be transferred to the ward for continuation of end of life care, please contact the palliative care nurses (or equivalent) who may attend for handover of the care of the patient and meet the family if appropriate.
• Corneal donation may still be possible. See Tissue Only Donation Pathway (page 20).
Date Time
Dr / Nurse / SN-OD
DCD 15
Final Activities
• Patient transferred to the mortuary.
• If tissues to be donated this will be facilitated in the mortuary as agreed.
• SN-OD will provide donation outcome information to
staff and family as agreed.
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Patient Name: NHS Number:
Tissue Only Donation Pathway
Date and
Time Persons
Responsible
Activity Number
Activity
Signature/ Initials
Date
Time Dr / Nurse
TD 1
• Time of Asystole:
Date Time
Dr / Nurse / SN-OD
TD 2
• Further discussion with family, Nurse and SN-OD
Date
Time Dr / Nurse /
SN-OD
TD 3
• Consent and patient assessment paperwork completed if appropriate by SN-OD
Date Time
Dr / Nurse / SN-OD
TD 4
• Referral made by SN-OD or Nurse to Tissue Services 07659180773 and if appropriate, local Eye Retrieval Nurse
Date Time
Dr / Nurse / SN-OD
TD 5
• Mementos (handprints, and locks of hair offered). If requested these are facilitated by the Nurse and SN-OD at an appropriate time.
• Last Offices performed
• The deceased transferred to mortuary within 4 hours of death to enable corneal donation to occur.
Time of Transfer:
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Patient Name: NHS Number:
NO Donation Pathway
Date and
Time Persons
Responsible
Activity Number
Activity
Signature/ Initials
Date Time
Dr / Nurse / SN-OD
ND 1
• Family thanked for considering donation.
• Document outcome of discussion with family.
• If appropriate, inform local Eye Retrieval Nurse of family decision not to donate to prevent second contact.
Date Time
Dr / Nurse / SN-OD
ND 2
• Mementos (handprints, and locks of hair offered). If requested these are facilitated by the Nurse and SN-OD at an appropriate time.
• Life-sustaining treatment withdrawn.
• SN-OD may remain present to support family and staff/
Date Time
Dr / Nurse / SN-OD
ND 3
• Last Offices performed
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Date and Time
Activity Number
MDT Notes Signature /
Initial
Patient’s Name: NHS Number:
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Date and Time
Activity Number
MDT Notes Signature /
Initial
Patient’s Name: NHS Number:
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GLOSSARY ABG Arterial Blood Gas AoMRC Academy of Medical Royal Colleges AST Aspartate aminotransferase BM Boehringer Mannheim test BSD Brain Stem Death BP Blood Pressure Ca Calcium CJD Creutzfeldt–Jakob Disease CVC Central Venous Catheter CVP Central Venous Pressure CPP Cerebral Perfusion Pressure CXR Chest X-Ray DDAVP Desmopressin DCD Donation after Circulatory Death DI Diabetes Insipidus DVT Deep Vein Thrombosis ECG Electrocardiogram ECHO Echocardiography FBC Full Blood Count FiO2 Fraction of Inspired Oxygen GMC General Medicine Council GTN Glyceryl Trinitrate HTA Human Tissue Authority HTA (2004) Human Tissue Act (2004) HIV Human Immunodeficiency Virus K Potassium Kpa Kilopascal PaO2 Partial Pressure of Oxygen PaCO2 Partial Pressure of Carbon Dioxide PEEP Positive End Expiratory Pressure RIJ Right Internal Jugular MAP Mean Arterial Pressure MC&S Microscopy, Culture and Sensitivity MDT Multi-disciplinary Team Mg Magnesium mmHg Millimetres of Mercury Na Sodium NHSBT NHS Blood and Transplant NICE National Institute for Health and Clinical Excellence O2 Oxygen ODT Organ Donation & Transplantation SN-OD Specialist Nurse-Organ Donation SpO2 Pulse Oximeter Oxygen Saturation T3 Triiodothyronine VT Tidal Volume
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Appendix 1: Diagnosis of Death Using Neurological Criteria (BSD testing forms)
There are two versions of Guidance provided.
If clinicians judge that they are sufficiently acquainted
with DBD Criteria it is acceptable to use the
abbreviated guidance version (pages 36 to 40).
Alternatively, a full guidance version for the diagnosis
of death using neurological criteria (pages 26 to 35) is
provided.
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HOSPITAL ADDRESSOGRAPH or
Surname
First Name
Date of Birth
NHS Number
Full Guidance
This form is consistent with and should be used in
conjunction with, the AoMRC (2008) A Code of
Practice for the Diagnosis and Confirmation of Death
and has been endorsed for use by the following
institutions: Faculty of Intensive Care Medicine,
Intensive Care Society and the National Organ
Donation Committee.
Objective of Care
• To diagnose and confirm the death of a mechanically ventilated, severely brain injured patient in
coma, using neurological criteria.
Academy of the Medical Royal Colleges Definition of Human Death (2008).1
“Death entails the irreversible loss of those essential characteristics which are necessary to the
existence of a living human person and, thus, the definition of death should be regarded as the
irreversible loss of the capacity for consciousness, combined with irreversible loss of the capacity to
breathe. The irreversible cessation of brain-stem function whether induced by intra-cranial events
or the result of extra-cranial phenomena, such as hypoxia, will produce this clinical state and
therefore irreversible cessation of the integrative function of the brain-stem equates with the death
of the individual and allows the medical practitioner to diagnose death.”
Context
• National professional guidance advocates the confirmation of death by neurological criteria
wherever this seems a likely diagnosis and regardless of the likelihood of organ donation.2
• UK General Medical Council (GMC) guidance on end of life care (2010) states that national
procedures for identifying potential organ donors should be followed and, in appropriate cases,
the specialist nurse for organ donation (SN-OD) should be notified.3 NICE guidance recommends
that the specialist nurse for organ donation (SN-OD) should be notified at the point when the
clinical team declare the intention to perform brain-stem death tests.4
Date and time of referral to SN-OD:……………….……………………………………….
• Whilst most patients will already be in an Intensive Care Unit (ICU) when the diagnosis is
suspected, some patients may be in other areas, e.g. the Emergency Department. On such
occasions it is legitimate, if considered necessary, to transfer a patient to the ICU for the
diagnosis to be made.
• For many clinicians the diagnosis and confirmation of death using neurological criteria, will be a
relatively infrequent task and may be complicated by uncertainties regarding the nature of the
primary diagnosis, irreversibility and the availability of suitably experienced personnel.
Updated guidance on the diagnosis and confirmation of death by neurological criteria was
published by the Academy of the Medical Royal Colleges in 2008.1
Next of Kin
• The next of kin of the patient should be aware of the severity of the individual’s illness and the
implications of a diagnosis of death using neurological criteria. If next of kin are given the
opportunity to witness the neurological examination, they should be prepared for the possibility
of spinal reflexes and their relevance, as far as the diagnosis of death by neurological criteria is
concerned. Whether next of kin witness the clinical examination or not, the patient’s need for
dignity, privacy and spiritual support, remain paramount.
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1. Evidence for Irreversible Brain Damage of known Aetiology
Case records, past medical history including possibly contacting the GP, relevant imaging.
2. Exclusion of Reversible Causes of Coma and Apnoea
Standard ICU cardio-respiratory monitoring (to ensure haemodynamic stability), medication chart
and history, blood and urine drug assay results (where relevant), drug antagonists (e.g. flumazenil,
naloxone), peripheral nerve stimulator, recent serum glucose and biochemistry, thermometer,
patient warming device.
3. Tests for Absence of Brain-Stem Function
Brain-stem reflexes
Bright light source; small gauze sterile swabs, otoscope with disposable ear pieces, 50 ml luer lock
syringe and disposable quill, ice-cold water; a spatula, Yankauer sucker or laryngoscope,
The above goals are guidelines only and clinical assessment will be influenced by clinical
conditions and response to treatment.
mmHg
PaCO2 at time of testing? Normocarbia should be maintained (PaCO2 <6.0KPa).
During the apnoea test starting PaCO2 >6.0KPa (see
below).
kPa
kPa
PaO2 at time of testing? Hypoxia should be avoided (PaO2 >10KPa).
kPa
kPa
Arterial pH at time of testing? Acidaemia and alkalaemia should be avoided (pH 7.35 –
7.45).
pH=
pH=
1st Test 2nd Test
Dr Two
Yes
/
No
Dr One
Yes
/
No
Dr Two
Yes
/
No
Guidance
The patient should not have received any drugs that might be contributing to the unconsciousness, apnoea
and loss of brain-stem reflexes (narcotics, hypnotics, sedatives or tranquillisers); nor should they have any
residual effect from any neuromuscular blocking agents (atracurium, vecuronium or suxamethonium).
It remains the duty of the two doctors carrying out the testing to be satisfied that sufficient time has elapsed to
ensure that any remaining drug effect is non-contributory to the unconsciousness and loss of brain-stem
reflexes. This will be based on an assessment of the medications the patient has received and from knowledge
of the pharmacokinetics of these agents. Renal or hepatic failure may prolong metabolism / excretion of these
drugs.
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Is the coma or apnoea due to depressant drugs?
(To diagnose death using neurological criteria,
ALL answers should be NO)
Where there is any doubt, specific drug levels should be
measured (midazolam should be less than <10mcg/L,
thiopentone <5mg/L).
Dr One
Yes /
No
Drug levels (if
measured):
Drug levels (if
measured):
Antagonists such as flumazenil, naloxone and
neostigmine may be used but there is no specific
pharmacological data for predicting the dose effect of
these antagonists.
Drug antagonists
(if used):
Drug antagonists
(if used):
Residual neuromuscular blockade can be tested for, if felt
necessary, by peripheral nerve stimulation.
Train of Four (if
measured):
Train of Four (if
measured):
Body temperature at time of testing?
If core temperature is ≤ 34°C testing cannot be carried out.
oC
oC
1st Test 2nd Test
Dr Two
Yes /
No
Is the coma or apnoea due to a metabolic or
endocrine disorder? (To diagnose death using neurological criteria,
ALL answers should be NO)
Serum sodium (Na+) at time of testing? Serum sodium should be between 115-160mmol/L. Rapid rises or
falls in Na+ should be avoided.
Dr One
Yes
/
No
mmol/L
mmol/L
Serum potassium (K+) at time of testing?
Serum potassium should be > 2mmol/L.
mmol/L
mmol/L
Serum phosphate (PO43-) at time of testing?
Serum phosphate should not be profoundly elevated (>3.0mmol/L) or
lowered (<0.5mmol/L) from normal.
Serum magnesium (Mg2+) at time of testing?
Serum magnesium should not be profoundly elevated
(>3.0mmol/L) or lowered (<0.5mmol/L) from normal.
Dr Two
Yes
/
No
Dr One
Yes
/
No
Dr Two
Yes
/
No
mmol/L
mmol/L
mmol/L
mmol/L
Blood glucose at time of testing? Blood glucose should be between 3.0-20.0 mmol/L and
should be tested prior to each test.
mmol/L
mmol/L
If there is any clinical reason to expect endocrine
disturbances hormonal assays should be undertaken.
Hormone level (if
measured):
Hormone level (if
measured):
Dr One
Yes /
No
Dr Two
Yes /
No
Patient Name: NHS Number:
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Bra
in-S
tem
Re
fle
xe
s
Patient Name: NHS Number:
Is the apnoea due to neuromuscular blocking agents,
other drugs or a non brain-stem cause (eg. cervical
injury, profound neuromuscular weakness)?
(ALL answers should be NO)
Guidance
It remains the duty of the two doctors carrying out the testing to be satisfied that the only
explanation for the respiratory failure is due to the irreversible cessation of brain-stem function.
A train of four examination, using a peripheral nerve stimulator, may be required (see above).
Dr One
Yes
/
No
Dr Two
Yes
/
No
Dr One
Yes
/
No
Dr Two
Yes
/
No
Tests for Absence of Brain-Stem Function
Guidance A complete set of tests should be performed on each occasion, i.e., a total of two sets of tests will be performed. Doctor One may perform the tests while Doctor Two observes; this would constitute the first set. Roles may be reversed for the second set. The tests, in particular the apnoea test, are therefore performed only twice in total.
Dr One
Examining
Dr Two
Observing
Dr One
Observing
Dr Two
Examining
Is there any motor response in a
cranial nerve or somatic distribution
when supraorbital pressure is
applied? Cranial Nerves V,VII. Reflex
limb and trunk movements (spinal
reflexes) may be present.
Yes / No
Yes / No
Yes / No
Yes / No
Do the pupils react to light? The pupils are fixed and do not respond
to sharp changes in the intensity of
incident light. Cranial nerves II, III.
Yes / No
Yes / No
Yes / No
Yes / No
Is there any eye movement when each
cornea is touched in turn? Corneal reflex - Cranial nerves V,VII. The use of
sterile gauze is recommended.
Yes / No
Yes / No
Yes / No
Yes / No
Is there nystagmus or any eye movement
present when each ear is instilled with
50mls ice cold water over 1 minute with
the head at 30o? Each ear drum should be
clearly visualised before the test. Vestibulo-ocular
reflex - Cranial nerves III VI VIII.
Is the gag reflex present? Use a spatula or Yankauer sucker or laryngoscope
to stimulate the posterior pharynx. Cranial Nerves
IX, X.
Is the cough reflex response present when
a suction catheter is passed down the
trachea to the carina? Cranial Nerves IX, X.
Yes / No
Yes / No
Yes / No
Yes / No
Yes / No
Yes / No
Yes / No
Yes / No
Yes / No
Yes / No
Yes / No
Yes / No
Test 1 Test 2
Test 1 Test 2
To
dia
gn
ose
de
ath
us
ing
ne
uro
log
ica
l crite
ria, A
LL
an
swe
rs
sho
uld
be
NO
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Patient Name: NHS Number:
Ap
no
ea
Te
st
Tests for Absence of Brain-Stem Function
Guidance Recommended method: After pre-oxygenation, disconnect the patient from the ventilator and administer
oxygen via a suction catheter in the endotracheal tube at a rate of >6 L/minute. If oxygenation is a problem,
consider the use of a CPAP circuit (eg Mapleson B). The apnoea test is performed only twice in total.
1st Test 2nd Test
Arterial Blood Gas PRE apnoea test: Ensure the starting PaCO2 is greater than 6.0 kPa.
In patients with chronic CO2 retention, or those who have
received intravenous bicarbonate, ensure the PaCO2 >6.5
kPa.
1st Test
Starting paCO2:
kPa
Should be >6.0 kPa
2nd Test
Starting paCO2:
kPa
Should be >6.0 kPa
Preparation for the Apnoea Test
• Oxygenation and cardiovascular stability should be maintained through each apnoea test. To ensure
oxygenation throughout the apnoea test FiO2 should be 1.0 and the patient should be pre-oxygenated for a
minimum of 5 (five) minutes.
• End tidal carbon dioxide can be used to guide the starting of each apnoea test but should not replace the
pre and post arterial PaCO2.
• Cardiac pulsation may be sufficient to trigger supportive breaths if the patient remains connected to the
mechanical ventilator and on a spontaneous breathing mode. Performing the apnoea test whilst
remaining on mechanical ventilation is not recommended.
PRE Arterial Blood Gas pH: Ensure the starting pH is less than 7.4.
pH=
Should be < 7.4
pH=
Should be < 7.4
Start time: Time when apnoea test was commenced.
hr : min (24 hour clock)
hr : min
(24 hour clock)
Arterial Blood Gas POST apnoea test:
Ensure the PaCO2 has increased by greater than 0.5
kPa.
1st Test
Stopping paCO2:
kPa
Should have
increased by > 0.5
2nd Test
Stopping paCO2:
kPa
Should have
increased by > 0.5
Stop time: Time when apnoea test was ceased.
hr : min
(24 hour clock)
hr : min
(24 hour clock)
Was there any spontaneous respiration during a
minimum of 5 (five) minutes continuous
observation following disconnection from the
ventilator? (To diagnose death using neurological criteria,
ALL answers should be NO)
Dr One
Yes
/
No
Dr Two
Yes
/
No
Dr One
Yes
/
No
Dr Two
Yes
/
No
Co
nsid
er
ab
le a
tele
cta
sis de
ve
lop
s in
the
ap
no
eic
pe
rio
d. A
t the
co
nc
lusio
n o
f the
ap
no
ea
tes
t, ma
nu
al re
cr
uitm
en
t ma
no
eu
vr
es
sh
ou
ld b
e c
arr
ied
ou
t be
for
e r
es
um
ing
me
ch
an
ica
l ve
ntila
tion
.
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Patient Name: NHS Number:
Is there a need for any ancillary
investigations?
Dr One
Yes / No
If yes please outline the results of these investigations:
Guidance
Ancillary investigations are NOT required for the diagnosis and confirmation of death using
neurological criteria.
They may be useful however, where neurological examination is not possible (eg. extensive facio-
maxillary injuries, residual sedation and some cases of paediatric hypoxic brain injury), where a
primary metabolic or pharmacological derangement cannot be ruled out or in cases of high cervical
cord injury. In such cases a confirmatory test may reduce any element of uncertainty and possibly
foreshorten any period of observation prior to formal testing of brain-stem reflexes.
Any ancillary or confirmatory investigation should be considered ADDITIONAL to the fullest clinical
testing and examination (as outlined above) to the best of the two doctors capabilities in the given
circumstances.
The utility of any additional investigation is for the two testing doctors to decide and they should
seek further professional opinion from other specialities and other expert centres, where
appropriate. Some possible ancillary investigations are:
• Clinical
o Rotation of the head to either side should not produce any eye movement (absent doll’s eyes
response). This should NOT be performed if there is suspected or possible cervical spine injury.
o Administration of 2mg atropine should not lead to an increased heart rate (>3%).
• Neurophysiological demonstration of loss of bioelectrical activity in the brain (EEG, evoked
potentials).
• Radiological demonstration of absent cerebral blood flow or brain tissue perfusion (CT