NHGRI Cloud Computing talk

Scien&fic  Compu&ng  with  Amazon  Web  ServicesDeepak  Singh

NHGRI  Cloud  Compu&ng  Mee&ng,  Bal&more,  2010

AWS + science = win

scale has implications

data management

data processing

data sharing

Image: Chris Dagdigian

amazon web services

the cloud

has_many :definitions

infrastructure as a service

ComputeAmazon Elastic Compute

Cloud (EC2)- Elastic Load Balancing- Auto Scaling

StorageAmazon Simple

Storage Service (S3)- AWS Import/Export

Your Custom Applications and Services

Content DeliveryAmazon CloudFront

MessagingAmazon Simple

Queue Service (SQS)

PaymentsAmazon Flexible Payments Service

(FPS)

On-Demand Workforce

Amazon Mechanical Turk

Parallel ProcessingAmazon Elastic

MapReduce

MonitoringAmazon CloudWatch

ManagementAWS Management Console

ToolsAWS Toolkit for EclipseAWS Toolkit for .NET

Isolated NetworksAmazon Virtual Private

Cloud

DatabaseAmazon RDS and

SimpleDB

• Lower pricing tiers for Cloudfront • AWS Management Console

• New SimpleDB Features • FPS General Availability

• EC2 Reserved Instances • EC2 with Windows • EC2 in EU • AWS Toolkit for Eclipse

• Reserved Instances in EU • Elastic MapReduce • SQS in EU

• AWS Import/Export • Monitoring, Auto Scaling, and Elastic Load Balancing • CloudFront adds access logging

•  AWS Security Center • Console support for Cloudfront

• Elastic MapReduce in EU

• AWS Multi Factor Authentication • Virtual Private Cloud private beta • Lower Reserved Instance Pricing • Console Support for CloudWatch

• EBS Shared Snapshots • SimpleDB in EU • Monitoring in EU • Auto Scaling in EU • Elastic Load Balancing in EU • AWS Solutions Provider program

• RDS Launched • High Memory Instances • Reduced EC2 Pricing • EMR Apache Hive support

• SAS 70 Type II Audit • AWS SDK for .NET • CloudFront Private Content • APAC announced

• Boot from EBS • US West Region • VPC Unlimited Beta • ELB Support in Console • CloudFront streaming • EC2 Spot Instances • Windows 2008 Support • Lowered Prices • AWS Economics Center

elasticity

3000 CPU’s for one firm’s risk management application

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scale

> 1PB of data in S3

highly availability

Image: Chris Dagdigian

“Everything fails, all the time”-- Werner Vogels

“Things will crash. Deal with it”-- Jeff Dean

2-4% of serverswill die annually

Source: Jeff Dean, LADIS 2009

1-5% of disk drives will die every year

Source: Jeff Dean, LADIS 2009

human errors

human errors~20% admin issues have unintended consequences

Source: James Hamilton

scalable & available

assume sw/hw failure

design apps to be resilient

automation & alarming

US East Region

Availability Zone A

Availability Zone B

Availability Zone C

Availability Zone D

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elastic load balancing

CloudWatch

auto scaling

elastic block store

elastic IP

SQS

flexibility

on-demand instancesreserved instances

spot instances

some implications

computing platforms

http://cyclecomputing.comhttp://wiki.github.com/documentcloud/cloud-crowd

sudo gem install cloud-crowd

http://www.rightscale.com

Input  S3  bucket

Output  S3  bucket

Amazon S3

Hadoop

Amazon EC2 Instances

Input dataset

outputresults

Deploy Application

Web Console, Command line tools

End

Notify

Get ResultsInput Data

Amazon Elastic MapReduce

Hadoop Hadoop

Hadoop

Hadoop

Hadoop

Elastic MapReduce

Elastic MapReduce

application platforms

http://heroku.com

http://chempedia.com/

Image: O’Reilly Radar

software distribution

http://www.cloudbiolinux.com/

http://bitbucket.org/galaxy/galaxy-central/wiki/Home

data distribution

http://aws.amazon.com/publicdatasets/

to conclude

built for scale

built for availability

shared dataspacescommon namespaces

task-based resources

new software architectures

new computing platforms

Data Platform

App Platform

available today

http://aws.amazon.com/education

[email protected]  Twi2er:@mndoci  Presenta7on  ideas  from  James  Hamilton,  @mza,  and  @lessig

Thank  you!