PBL, Norwich Research Park, Colney Lane, Norwich, Norfolk NR4 7UH, UK Tel: +44(0)1603 456500 Fax: +44(0)1603 456552 www.pbltechnology.com Innovation in life sciences PBL News - Issue 29 - Dec 2015 IP protection Funds and manages patent filing and prosecution Builds complementary technology packages Markets technology to commercial users Concludes and monitors technology licences Manages and mentors the formation of new technology- based businesses Jul 2015: PBL Partners with Calyxt to Develop Disease Resistant Wheat Sep 2015: Photosynthesis Gene Can Help Crops Grow in Adverse Conditions Paul Jarvis and colleagues have published their most recent work on SP1 technology (PBL Tech ID ). The 13.568 paper which is published in Current Biology is entitled “Regulation of Chloroplast Protein Import by the Ubiquitin E3 Ligase SP1 Is Important for Stress Tolerance in Plants”. PBL is managing the commercial development of this important innovation. Please click for the Oxford University press release. here For more information please go the section of our website, or for commercial opportunities, 13.568 SP1 please contact Dr Jan Chojecki ( ). [email protected] Norwich, UK 1 December 2015 -- Plant Bioscience Ltd (PBL), a technology development and intellectual property (IP) management company, announced today that it has entered into a licensing agreement that grants Thermo Fisher Scientific a world-wide, non- exclusive license to the Baulcombe patents (US Patent Nos. 6,753,139, 7,704,688, 8,097,710, 8,258,285, 8,263,569, 8,299,235, 8,349,607, 8,759,102 and 8,779,236) for use in the field of research reagents and kits. Financial terms were not disclosed. Please click for the full press release or for a link to the Short RNA section on our website. here here For licensing enquiries, please contact Dr Lars von Borcke ( ). [email protected] All other enquiries to . [email protected] Medicago, PBL’s licensee of the Hyper Trans technology, announced today that it has received a task order from the Biomedical Advanced Research and Development Authority (BARDA) at the US Department of Health and Human Services (HHS) for three anti- Ebola virus monoclonal antibodies (mAbs) with expected performance comparable to that of ZMapp™, from Mapp Biopharmaceutical. Please click to read article in full. here For more information on CPMV technology, please contact Dr Lars von Borcke ( ). [email protected] PBL Tech ID: 05.386 / 07.439 Calyxt, Inc., a Minnesota-based company focusing on developing healthier food products, today announced that it has signed an exclusive license agreement with Plant Bioscience Limited (PBL) for a bread wheat trait generated using gene editing. The trait provides endogenous resistance to powdery mildew of wheat, a fungus widely distributed throughout the world, responsible for major grain and yield losses. Please click to read the article in full. here For more information, please contact Dr Jan Chojecki ( ). [email protected] 14.583 PBL Tech ID: PBL NEWS 2015 Highlights The Beneforté broccoli story was featured on BBC TV’s Countryfile programme on 25 October, and can be watched on the . Beneforté broccoli is now being grown commercially in the UK and BBC iPlayer elsewhere around the world and is available in a number of leading supermarkets in the UK including Marks & Spencer and Asda. Beneforté broccoli was bred, using conventional techniques, by Professor Richard Mithen at the John Innes Centre, and Professor Mithen is continuing his work on broccoli by studying potential health benefits of the broccoli, and glucoraphanin, at the Institute of Food Research. Research from human trials with 130 volunteers, and published earlier this year, showed that including this broccoli in the diet for 12 weeks reduced the levels of LDL-cholesterol by an average of about 6%: A diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: evidence from randomised controlled trials. Further human nutrition trials are ongoing. Patent News: . European Patent Office Decision confirms societal value and PBL’s patent on glucoraphanin-rich broccoli is valid validity of patents for innovative plant breeding (Patent No. EP1069819). For more information about the science behind broccoli, glucoraphanin, and the development of Beneforté visit the Super Broccoli website ( ), or the section of our website. www.superbroccoli.info Glucoraphanin Enriched Broccoli Oct 2015: Beneforté Broccoli Featured on BBC Countryfile Feb 2015: PBL's partner Medicago announces new contract to explore production of Ebola antibodies Dec 2015: PBL Signs Another License Agreement for Baulcombe & Hamilton RNAi patent