Of the top neurology drugs with the highest reported adherence on Medisafe, GSK and Biogen each hold two spots. Parkinson’s Parkinson’s Epilepsy Epilepsy Relapsing MS Epilepsy MS MS MS Seizures Sinemet Requip Depakene Keppra Tecfidera Ativan Avonex Gilenya Rebif Lamictal Merck Glaxo Smith Kline AbbVie UCB Biogen Valeant Biogen Novartis EMD Serono Glaxo Smith Kline Brand Condition Company 84% 87% 93% 93% 91% 78% 78% 83% 84% 70% Adherence ? 9 1#,65C 5% Worried about side effects 1% Worried about cost 12% Ran out of meds 35% Forgot/med not nearby 25% Didn’t need dose 22% Other Neuro medication adherence peaks in the morning hours - but unlike some therapeutic areas it stays relatively high throughout the day. 6 4 5 7 8 9 10 11 1 2 1 2 3 4 5 6 7 8 9 10 AM PM 85% 80% 75% 65% Mexico 78% Brazil 80% Switzerland Belgium Argentina 83% Australia 79% 79% 79% Russia 84% Germany Turkey 77% 78% 78% USA The U.S. trails other nations in reported neuro medication adherence on Medisafe. S M T T W F S 79% 79% 79% 79% 78% 77% 76% Like many therapeutic areas, Saturday and Sunday prove the most challenging for neuro medication adherence. 50% Average adherence across all therapeutic classes without Medisafe 2 82% 80% 78% 76% 74% Epilepsy | Migraines Anticonvulsants Multiple Sclerosis Alzheimer’s / Dementia Parkinson’s Worldwide medication adherence rates for most neurology conditions average 78% on Medisafe. M7K V.K 86% T0K 84% Q3K 81% O5K N6K 79% 78% 77% K9K 75% Top Neuro Companies by Highest Adherence Top Neuro Meds with Highest Adherence Adherence Rates by Type of Neuro Treatment How Day of Week Affects Neuro Adherence Top Adherent Countries for Neuro Meds Medisafe Reported Neurology Drug Adherence by Company Medisafe Reported Neurology Drug Adherence by Drug Name 5 Medisafe Reported Neurology Drug Adherence by Condition Medisafe Reported Neurology Drug Adherence by Geography Medisafe Reported Neurology Drug Adherence by Day How Hour of Day Affects Neuro Adherence Medisafe Reported Neurology Adherence by Hour Why Neuro Patients Say They Miss Doses Medisafe Members’ Reported Reasons for Skipping a Dose Medisafe, the leading personalized medication management platform addressing all major causes of non-adherence, delivers better medication adherence 1 , with more than 750M doses managed. Neurology Adherence Data: Real-time stats on Medisafe that pharma should know Medisafe is the leading personalized medication management platform addressing all major causes of non-adherence. Far more than a pill reminder app, Medisafe is a cloud-based platform that personalizes content, resources and interventions — such as educational videos, coupons and motivational messages — based on each user’s regimen, condition and specific circumstance. Visit medisafe.com/pharma for more information. 1) Medisafe demonstrates up to 20% increase in med adherence in IMS study, presented at ISPOR. 2) Medication Adherence in developed countries averages 50%, and is lower in developing regions (WHO). Source: http://www.who.int/chp/knowledge/publications/adherence_full_report.pdf 3) Medisafe reported adherence of active users that approved notification with more than 3 doses taken from the first take to the last take in relation to scheduled doses. 4) Patients are generally considered adherent to their medication if their medication adherence percentage, defined as the number of pills absent in a given time period (“X”) divided by the number of pills prescribed by the physician in that same time period, is greater than 80%. (NIH). Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068890/#R6 5) Some neurology medications are only infused at a medical center or physician’s office over weekly or monthly intervals, and thereby not represented in this adherence data. Find out how you can get behavioral insights and answers from the 4 million patients who are using Medisafe’s medication management platform. Looking for additional insights? medisafe.com/insights