Neurotox – Pesticides – 9/8/05 Neurological and Long-Term Effects of Pesticides Exposure A Small Dose of Pesticide “Out of Harm’s Way: Preventing Toxic Threats to our Children’s Health” October 15, 2005 Spokane, WA Steven G. Gilbert, PhD, DABT www.asmalldoseof.org
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Neurological and Long-Term Effects of Pesticides Exposure
Neurological and Long-Term Effects of Pesticides Exposure. A Small Dose of Pesticide. “Out of Harm’s Way: Preventing Toxic Threats to our Children’s Health” October 15, 2005 Spokane, WA. Steven G. Gilbert, PhD, DABT www.asmalldoseof.org. - PowerPoint PPT Presentation
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Neurotox – Pesticides – 9/8/05
Neurological and Long-Term Effects of
Pesticides Exposure
A Small Dose of Pesticide
“Out of Harm’s Way: Preventing Toxic Threats to our Children’s Health”
October 15, 2005Spokane, WA
Steven G. Gilbert, PhD, DABTwww.asmalldoseof.org
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
Definition - Simple
The function of a pesticide is to kill or
harm some form of life.
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
Definition - EPA
“…a pesticide is any substance or mixture of substances intended for preventing, destroying, repelling, or mitigating any pest.”
“…a pest is any harmful, destructive, or troublesome animal, plant or microorganism.”
US Environmental Protection Agency (EPA)
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
Definition - FIFRA
“… any substance or mixture of substances intended for preventing, destroying, repelling or mitigating any insects, rodents, nematodes, fungi, or weeds or any other form of life declared to be pests. … and any substance or mixture of substances intended for use as a plant regulator, defoliant or desiccant.”
Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA – 1947)
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
Pesticide Application
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
Key Words
Risk =
Hazard X Exposure
Dose / Response
Individual Sensitivity
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
What Is This Pesticide?
N
NN
N
CH3
CH3
CH3
O
O
1
3
7
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
N
CH3N
What Is This Pesticide?
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
Effects of Amount on Response
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
Effects of Size on Response
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
Neurotoxicological and Statistical Analyses of a Mixture of Five Organophosphorus Pesticides Using a Ray DesignV. C. Moser, M. Casey, A. Hamm, W. H.
Carter, Jr., J. E. Simmons, and C. Gennings
TOXICOLOGICAL SCIENCES 86(1), 101–115 (2005)
Multiple Exposures
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
Epigenetic Transgenerational Actions of Endocrine Disruptors and Male FertilityMatthew D. Anway, Andrea S. Cupp,*
Mehmet Uzumcu,.Michael K. Skinner
SCIENCE 3 JUNE 2005 VOL 308
“The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology.”
Multiple Generational Effects
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
Worker Exposure Issues
• Cholinesterase Levels – depressed by CPF and other
organophosphate/carbamate pesticides
• Monitoring indicates that works have depressed cholinesterase levels
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
Acute effects are major concern for pesticides used widely in WA agriculture
Chronic effects of concern, too. Children of workers as well as workers are
exposed and are at greater risk. Multiple exposures are occurring,
potentially increasing risks. There may be multiple generation effects. Precaution is a prudent approach
Health & Pesticide - Summary
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
A Small Dose of ™ Pesticide
A Small Dose of Toxicology Neurotox – Pesticides – 9/8/05
Additional Information WSU – Washington State Pest Management
Resources Service (WSPMRS) - http://wsprs.wsu.edu/
UW – Welcome to the Pacific Northwest Agricultural Safety and Health Center (PNASH) - http://depts.washington.edu/pnash/
Pesticide ActionNetwork North America- http://www.panna.org
Washington Toxics Coalition- http://www.watoxics.org